| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Donald Sikazwe, Mikhail L Bondarev, Małgorzata Dukat, Jagadeesh B Rangisetty, Bryan L Roth, Richard A Glenno. Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. Journal of medicinal chemistry. vol 49. issue 17. 2006-10-03. PMID:16913710. |
sulfonamides, sulfones) bind at human 5-ht6 serotonin receptors, but it has been difficult relating the binding mode(s) of such agents to one another, even though many possess a common so2 moiety, to identify a common pharmacophore model(s). |
2006-10-03 |
2023-08-12 |
human |
| Marion Raoul, Dominique Patigny, Frédréic Fabis, Françis Dauphin, Sylvain Rault, Janos Sapi, Jean-Yves Laronz. N-arylsulfonyl-2-vinyltryptamines as new 5-HT6 serotonin receptor ligands. Journal of enzyme inhibition and medicinal chemistry. vol 21. issue 3. 2006-09-28. PMID:16918072. |
several new 2-vinyl-nb,nb-dimethyltryptamines were prepared using fischer indole synthesis followed by simple functional group transformations and evaluated on 5-ht4, 5-ht5, 5-ht6 and 5-ht7 serotonin receptors. |
2006-09-28 |
2023-08-12 |
Not clear |
| Uma Siripurapu, Renata Kolanos, Małgorzata Dukat, Bryan L Roth, Richard A Glenno. Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors. Bioorganic & medicinal chemistry letters. vol 16. issue 14. 2006-09-25. PMID:16709453. |
binding of methoxy-substituted n1-benzenesulfonylindole analogs at human 5-ht6 serotonin receptors. |
2006-09-25 |
2023-08-12 |
human |
| Dietrich E Lorke, Gang Lu, Eric Cho, David T Ye. Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients. BMC neuroscience. vol 7. 2006-08-23. PMID:16640790. |
serotonin 5-ht2a and 5-ht6 receptors in the prefrontal cortex of alzheimer and normal aging patients. |
2006-08-23 |
2023-08-12 |
Not clear |
| John C Talpos, Lawrence S Wilkinson, Trevor W Robbin. A comparison of multiple 5-HT receptors in two tasks measuring impulsivity. Journal of psychopharmacology (Oxford, England). vol 20. issue 1. 2006-03-29. PMID:16204332. |
to test this hypothesis, behavioural effects of three partially selective serotonergic (5-ht) ligands, ketanserin (5-ht2(a, c) receptor antagonist), ser-082 (5-ht2(c, b) receptor antagonist) and sb-270146-a (5-ht6 receptor antagonist) were compared in two tests of impulsivity. |
2006-03-29 |
2023-08-12 |
Not clear |
| Ellen S Mitchell, John F Neumaie. 5-HT6 receptors: a novel target for cognitive enhancement. Pharmacology & therapeutics. vol 108. issue 3. 2006-03-24. PMID:16005519. |
over the past decade, there has been increasing interest in the role of serotonin 6 (5-ht6) receptors in higher cognitive processes such as memory. |
2006-03-24 |
2023-08-12 |
Not clear |
| Lee E Schechter, Robert H Ring, Chad E Beyer, Zoë A Hughes, Xavier Khawaja, Jessica E Malberg, Sharon Rosenzweig-Lipso. Innovative approaches for the development of antidepressant drugs: current and future strategies. NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics. vol 2. issue 4. 2006-03-23. PMID:16489368. |
in between, there are many approaches that range from directly targeting serotonin receptors (5-ht2c, 5-ht6) to targeting the multiplicity of potential mechanisms associated with excitatory (glutamate, nmda, mglur2, mglur5) or inhibitory amino acid systems (gaba) or peptidergic systems (neurokinin 1, corticotropin-releasing factor 1, melanin-concentrating hormone 1, v1b). |
2006-03-23 |
2023-08-12 |
Not clear |
| Kurt Rasmussen, Mark J Benvenga, Frank P Bymaster, David O Calligaro, Ilene R Cohen, Julie F Falcone, Susan K Hemrick-Luecke, Fionna M Martin, Nicholas A Moore, Laura K Nisenbaum, John M Schaus, Sarah J Sundquist, David E Tupper, Todd R Wiernicki, David L Nelso. Preclinical pharmacology of FMPD [6-fluoro-10-[3-(2-methoxyethyl)-4-methyl-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene]: a potential novel antipsychotic with lower histamine H1 receptor affinity than olanzapine. The Journal of pharmacology and experimental therapeutics. vol 315. issue 3. 2006-01-23. PMID:16141369. |
fmpd [6-fluoro-10-[3-(2-methoxyethyl)-4-methyl-piperazin-1-yl]-2-methyl-4h-3-thia-4,9-diaza-benzo[f]azulene] is a potential novel antipsychotic with high affinity for dopamine d2 (ki= 6.3 nm), 5-ht(2a) (ki= 7.3 nm), and 5-ht6 (ki= 8.0 nm) human recombinant receptors and lower affinity for histamine h1 (ki= 30 nm) and 5-ht2c (ki= 102 nm) human recombinant receptors than olanzapine. |
2006-01-23 |
2023-08-12 |
human |
| Manik Pullagurla, Uma Siripurapu, Renata Kolanos, Mikhail L Bondarev, Małgorzata Dukat, V Setola, B L Roth, Richard A Glenno. Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors. Bioorganic & medicinal chemistry letters. vol 15. issue 23. 2006-01-23. PMID:16183286. |
binding of amine-substituted n1-benzenesulfonylindoles at human 5-ht6 serotonin receptors. |
2006-01-23 |
2023-08-12 |
human |
| Georgina Perez-García, Alfredo Menese. Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task. Pharmacology, biochemistry, and behavior. vol 81. issue 3. 2005-09-26. PMID:15964617. |
these data support the notion that endogenously 5-ht acting, via 5-ht6 receptor, improves memory consolidation. |
2005-09-26 |
2023-08-12 |
Not clear |
| Kenji Okamura, Osamu Shirakawa, Naoki Nishiguchi, Hisae Ono, Hideyuki Nushida, Yasuhiro Ueno, Kiyoshi Maed. Lack of an association between 5-HT receptor gene polymorphisms and suicide victims. Psychiatry and clinical neurosciences. vol 59. issue 3. 2005-08-02. PMID:15896229. |
the high affinity of some antipsychotic and antidepressant drugs to serotonin 6 (5-ht6) receptors, and the predominant localization of 5-ht6 receptors in some limbic regions, suggest that 5-ht6 receptors play a role in the pathogenesis of suicide. |
2005-08-02 |
2023-08-12 |
Not clear |
| Jörg Holenz, Ramon Mercè, José Luis Díaz, Xavier Guitart, Xavier Codony, Alberto Dordal, Gonzalo Romero, Antoni Torrens, Josep Mas, Blas Andaluz, Susana Hernández, Xavier Monroy, Elisabeth Sánchez, Enrique Hernández, Raquel Pérez, Roger Cubí, Olga Sanfeliu, Helmut Buschman. Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands. Journal of medicinal chemistry. vol 48. issue 6. 2005-05-03. PMID:15771424. |
medicinal chemistry driven approaches toward novel and selective serotonin 5-ht6 receptor ligands. |
2005-05-03 |
2023-08-12 |
Not clear |
| E A Abourashed, U Koetter, A Brattströ. In vitro binding experiments with a Valerian, hops and their fixed combination extract (Ze91019) to selected central nervous system receptors. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 11. issue 7-8. 2005-02-16. PMID:15636177. |
binding affinities could be demonstrated at some of the screened melatonin (ml1 and ml2) and serotonin (5-ht4e, 5-ht6 and 5-ht7) receptor subtypes. |
2005-02-16 |
2023-08-12 |
Not clear |
| Manik R Pullagurla, Richard B Westkaemper, Richard A Glenno. Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors. Bioorganic & medicinal chemistry letters. vol 14. issue 17. 2005-02-09. PMID:15357994. |
the model suggests that 5-ht6 antagonist arylsulfonyltryptamines might bind differently than that of the agonist serotonin. |
2005-02-09 |
2023-08-12 |
human |
| Steven P Vickers, Colin T Douris. Serotonin receptor ligands and the treatment of obesity. Current opinion in investigational drugs (London, England : 2000). vol 5. issue 4. 2004-07-01. PMID:15134278. |
the recent development of selective ligands and knockout mice for other 5-ht receptors, including the 5-ht2b and 5-ht6 receptors, has also suggested a role for these receptor subtypes in eating behavior. |
2004-07-01 |
2023-08-12 |
mouse |
| M Garcia-Alloza, W D Hirst, C P L-H Chen, B Lasheras, P T Francis, M J Ramíre. Differential involvement of 5-HT(1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 2. 2004-04-27. PMID:14571255. |
differential involvement of 5-ht(1b/1d) and 5-ht6 receptors in cognitive and non-cognitive symptoms in alzheimer's disease. |
2004-04-27 |
2023-08-12 |
Not clear |
| Michelle McGuire, Yi Zhang, David P White, Liming Lin. Serotonin receptor subtypes required for ventilatory long-term facilitation and its enhancement after chronic intermittent hypoxia in awake rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 286. issue 2. 2004-02-27. PMID:14551171. |
collectively, these data suggest that ventilatory ltf requires 5-ht2 receptors and that the cih effect on ltf requires non-5-ht2 serotonin receptors, probably 5-ht6 and/or 5-ht7 subtype(s). |
2004-02-27 |
2023-08-12 |
rat |
| Mark D Lindner, Donald B Hodges, John B Hogan, Anitra F Orie, Jason A Corsa, Donna M Barten, Craig Polson, Barbara J Robertson, Valerie L Guss, Kevin W Gillman, John E Starrett, Valentin K Gribkof. An assessment of the effects of serotonin 6 (5-HT6) receptor antagonists in rodent models of learning. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12975483. |
an assessment of the effects of serotonin 6 (5-ht6) receptor antagonists in rodent models of learning. |
2003-12-10 |
2023-08-12 |
mouse |
| Mark D Lindner, Donald B Hodges, John B Hogan, Anitra F Orie, Jason A Corsa, Donna M Barten, Craig Polson, Barbara J Robertson, Valerie L Guss, Kevin W Gillman, John E Starrett, Valentin K Gribkof. An assessment of the effects of serotonin 6 (5-HT6) receptor antagonists in rodent models of learning. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12975483. |
antagonists of serotonin 6 (5-ht6) receptors have been reported to enhance cognition in animal models of learning, although this finding has not been universal. |
2003-12-10 |
2023-08-12 |
mouse |
| A Menese. Role of 5-HT6 receptors in memory formation. Drug news & perspectives. vol 14. issue 7. 2003-10-22. PMID:12813582. |
since ro-04-6790 facilitatory effect was unaffected by 5-ht(1a), 5-ht(2a/2b/2c), 5-ht(3), 5-ht(4) or 5-ht(7) receptor blockade, the facilitatory effect induced by ro-04-6790 involved specifically 5-ht6 receptors. |
2003-10-22 |
2023-08-12 |
mouse |