| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lee E Schechter, Qian Lin, Deborah L Smith, Guoming Zhang, Qin Shan, Brian Platt, Michael R Brandt, Lee A Dawson, Derek Cole, Ron Bernotas, Albert Robichaud, Sharon Rosenzweig-Lipson, Chad E Beye. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 6. 2008-08-07. PMID:17625499. |
one of the most recently identified serotonin (5-hydroxytryptamine (5-ht)) receptor subtypes is the 5-ht6 receptor. |
2008-08-07 |
2023-08-12 |
human |
| Anna Wesołowsk. The anxiolytic-like effect of the selective 5-HT6 receptor antagonist SB-399885: the impact of benzodiazepine receptors. European journal of pharmacology. vol 580. issue 3. 2008-05-30. PMID:18096153. |
the effect of lesion of 5-hydroxytryptamine (5-ht) neurons, produced by p-chloroamphetamine (p-ca; 2 x 10 mg/kg), and the influence of the benzodiazepine receptor antagonist flumazenil (10 mg/kg) on the anticonflict action of n-[3,5-dichloro-2-(methoxy)phenyl]-4-(methoxy)-3-(1-piperazinyl)benzenesulfonamide (sb-399885), a selective 5-ht6 receptor antagonist, were investigated in the vogel conflict drinking test in rats. |
2008-05-30 |
2023-08-12 |
rat |
| Anna Wesołowsk. The anxiolytic-like effect of the selective 5-HT6 receptor antagonist SB-399885: the impact of benzodiazepine receptors. European journal of pharmacology. vol 580. issue 3. 2008-05-30. PMID:18096153. |
the present results suggest that the anticonflict activity of sb-399885 is not conditioned by the integrity of 5-ht neurons, and that benzodiazepine receptors are indirectly involved in its effect, possibly due to a functional interaction between 5-ht6 receptors and the gamma-aminobutyric acid (gaba)/benzodiazepine system. |
2008-05-30 |
2023-08-12 |
rat |
| Małgorzata Dukat, Philip D Mosier, Renata Kolanos, Bryan L Roth, Richard A Glenno. Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. Journal of medicinal chemistry. vol 51. issue 3. 2008-05-05. PMID:18201064. |
binding of serotonin and n1-benzenesulfonyltryptamine-related analogs at human 5-ht6 serotonin receptors: receptor modeling studies. |
2008-05-05 |
2023-08-12 |
human |
| Małgorzata Dukat, Philip D Mosier, Renata Kolanos, Bryan L Roth, Richard A Glenno. Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. Journal of medicinal chemistry. vol 51. issue 3. 2008-05-05. PMID:18201064. |
the endogenous tryptamine-based agonist serotonin (5-ht; 1) and the benzenesulfonyl-containing tryptamine-derived 5-ht6 receptor antagonist ms-245 (4a) were automatically docked with each of the 100 receptor models using a genetic algorithm approach. |
2008-05-05 |
2023-08-12 |
human |
| Małgorzata Dukat, Philip D Mosier, Renata Kolanos, Bryan L Roth, Richard A Glenno. Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. Journal of medicinal chemistry. vol 51. issue 3. 2008-05-05. PMID:18201064. |
the results indicate that the presence or absence of an n1-benzenesulfonyl group is a major determinant of the manner in which tryptamine-related agents bind at 5-ht6 serotonin receptors. |
2008-05-05 |
2023-08-12 |
human |
| Hye-Jung Kim, Munikumar Reddy Doddareddy, Hyunah Choo, Yong Seo Cho, Kyoung Tai No, Woo-Kyu Park, Ae Nim Pa. New serotonin 5-HT(6) ligands from common feature pharmacophore hypotheses. Journal of chemical information and modeling. vol 48. issue 1. 2008-04-02. PMID:18044950. |
serotonin 5-ht6 receptor antagonists are thought to play an important role in the treatment of psychiatry, alzheimer's disease, and probably obesity. |
2008-04-02 |
2023-08-12 |
Not clear |
| F M Theisen, M Haberhausen, M A Firnges, P Gregory, J H Reinders, H Remschmidt, J Hebebrand, J Ante. No evidence for binding of clozapine, olanzapine and/or haloperidol to selected receptors involved in body weight regulation. The pharmacogenomics journal. vol 7. issue 4. 2007-09-27. PMID:16983399. |
with respect to other candidates from (neuro)transmitter systems already suggested to be involved in ap-induced weight gain, the binding profile of olanzapine resembled that of clozapine, with high affinity (ki<10 nm) for serotonin (5-ht) 5-ht2a, 5-ht2c and 5-ht6, muscarinic m1 and histamine h1 receptors. |
2007-09-27 |
2023-08-12 |
Not clear |
| Paola Bonsi, Dario Cuomo, Jun Ding, Giuseppe Sciamanna, Sasha Ulrich, Anne Tscherter, Giorgio Bernardi, D James Surmeier, Antonio Pisan. Endogenous serotonin excites striatal cholinergic interneurons via the activation of 5-HT 2C, 5-HT6, and 5-HT7 serotonin receptors: implications for extrapyramidal side effects of serotonin reuptake inhibitors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 8. 2007-09-26. PMID:17203014. |
endogenous serotonin excites striatal cholinergic interneurons via the activation of 5-ht 2c, 5-ht6, and 5-ht7 serotonin receptors: implications for extrapyramidal side effects of serotonin reuptake inhibitors. |
2007-09-26 |
2023-08-12 |
rat |
| Paola Bonsi, Dario Cuomo, Jun Ding, Giuseppe Sciamanna, Sasha Ulrich, Anne Tscherter, Giorgio Bernardi, D James Surmeier, Antonio Pisan. Endogenous serotonin excites striatal cholinergic interneurons via the activation of 5-HT 2C, 5-HT6, and 5-HT7 serotonin receptors: implications for extrapyramidal side effects of serotonin reuptake inhibitors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 8. 2007-09-26. PMID:17203014. |
the depolarizing response to 5-ht was also reduced by the selective 5-ht6 and 5-ht7 receptor antagonists sb258585 and sb269970, respectively, and mimicked by the 5-ht7 agonist, 5-ct. |
2007-09-26 |
2023-08-12 |
rat |
| Per Svenningsson, Eleni T Tzavara, Hongshi Qi, Robert Carruthers, Jeffrey M Witkin, George G Nomikos, Paul Greengar. Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 15. 2007-05-03. PMID:17428998. |
the present study examined whether 5-ht6 receptors might be involved in the antidepressant-like effects mediated by enhanced neurotransmission at 5-ht synapses. |
2007-05-03 |
2023-08-12 |
mouse |
| Per Svenningsson, Eleni T Tzavara, Hongshi Qi, Robert Carruthers, Jeffrey M Witkin, George G Nomikos, Paul Greengar. Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 15. 2007-05-03. PMID:17428998. |
our results indicate that 5-ht6 receptor stimulation may be a mechanism initiating some of the biochemical and behavioral outcomes of 5-ht reuptake inhibitors, such as fluoxetine. |
2007-05-03 |
2023-08-12 |
mouse |
| Orazio Prezzavento, Agata Campisi, Simone Ronsisvalle, Giovanni Li Volti, Agostino Marrazzo, Vincenzo Bramanti, Giuseppe Cannavò, Luca Vanella, Alfredo Cagnotto, Tiziana Mennini, Riccardo Ientile, Giuseppe Ronsisvall. Novel sigma receptor ligands: synthesis and biological profile. Journal of medicinal chemistry. vol 50. issue 5. 2007-04-23. PMID:17328523. |
binding affinity studies showed that 4b binding on n-methyl-d-aspartate (nmda), dopaminergic (d1, d2, d3), muscarinic, histaminergic h1, adrenergic (alpha1, alpha2), serotoninergic (5-ht2a, 5-ht2c, 5-ht3, 5-ht4, 5-ht6), da (dat), and 5-ht (sert) transporters was not significant. |
2007-04-23 |
2023-08-12 |
Not clear |
| Vincenzo Garzya, Ian T Forbes, Andrew D Gribble, Mike S Hadley, Andrew P Lightfoot, Andrew H Payne, Alexander B Smith, Sara E Douglas, David G Cooper, Ian G Stansfield, Malcom Meeson, Emma E Dodds, Declan N C Jones, Martyn Wood, Charlie Reavill, Carol A Scorer, Angela Worby, Graham Riley, Peter Eddershaw, Chris Ioannou, Daniele Donati, Jim J Hagan, Emiliangelo A Ratt. Studies towards the identification of a new generation of atypical antipsychotic agents. Bioorganic & medicinal chemistry letters. vol 17. issue 2. 2007-04-09. PMID:17084080. |
the lead optimisation programme led to the identification of sulfonamide (25), a molecule combining dopamine d2/d3 receptor antagonism with serotonin 5-ht2a, 5-ht2c, 5-ht6 receptor antagonism for an effective treatment of schizophrenia. |
2007-04-09 |
2023-08-12 |
Not clear |
| Zhu Li, Mei Huang, Adam J Prus, Jin Dai, Herbert Y Meltze. 5-HT6 receptor antagonist SB-399885 potentiates haloperidol and risperidone-induced dopamine efflux in the medial prefrontal cortex or hippocampus. Brain research. vol 1134. issue 1. 2007-04-05. PMID:17207474. |
many studies suggest that the 5-ht6 receptors are involved, along with other 5-ht receptors, in the pathophysiology and pharmacotherapy of schizophrenia. |
2007-04-05 |
2023-08-12 |
rat |
| A Papageorgiou, C Dene. Estradiol induces expression of 5-hydroxytryptamine (5-HT) 4, 5-HT5, and 5-HT6 receptor messenger ribonucleic acid in rat anterior pituitary cell aggregates and allows prolactin release via the 5-HT4 receptor. Endocrinology. vol 148. issue 3. 2007-04-04. PMID:17122082. |
estradiol induces expression of 5-hydroxytryptamine (5-ht) 4, 5-ht5, and 5-ht6 receptor messenger ribonucleic acid in rat anterior pituitary cell aggregates and allows prolactin release via the 5-ht4 receptor. |
2007-04-04 |
2023-08-12 |
rat |
| Gonzalo Romero, Elisabeth Sánchez, Marta Pujol, Pilar Pérez, Xavier Codony, Jörg Holenz, Helmut Buschmann, Petrus J Pauwel. Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways. British journal of pharmacology. vol 148. issue 8. 2006-12-05. PMID:16865095. |
5-ht (e(max), % over basal: 200), e-6801 (120) and e-6837 (23) induced camp formation at the rat 5-ht6 receptor. |
2006-12-05 |
2023-08-12 |
human |
| Gonzalo Romero, Elisabeth Sánchez, Marta Pujol, Pilar Pérez, Xavier Codony, Jörg Holenz, Helmut Buschmann, Petrus J Pauwel. Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways. British journal of pharmacology. vol 148. issue 8. 2006-12-05. PMID:16865095. |
intrinsic activity of these 5-ht6 receptor ligands at a constitutively active human s267k 5-ht6 receptor in cos-7 cells indicated similar efficacy (e(max), % over basal) for 5-ht (97), e-6801 (91) and e-6837 (100), while ro 04-6790 (-33) and sb-271046 (-39) were equi-efficacious inverse agonists. |
2006-12-05 |
2023-08-12 |
human |
| Anna M S Kindlundh-Högberg, Per Svenningsson, Helgi B Schiöt. Quantitative mapping shows that serotonin rather than dopamine receptor mRNA expressions are affected after repeated intermittent administration of MDMA in rat brain. Neuropharmacology. vol 51. issue 4. 2006-11-06. PMID:16820177. |
we used real-time rt-pcr to determine the gene expression of serotonin 5ht1a, 5ht1b, 5ht2a, 5ht2c, 5ht3, 5ht6 receptors and dopamine d1, d2, d3 receptors in seven brain nuclei. |
2006-11-06 |
2023-08-12 |
rat |
| Donald Sikazwe, Mikhail L Bondarev, Małgorzata Dukat, Jagadeesh B Rangisetty, Bryan L Roth, Richard A Glenno. Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. Journal of medicinal chemistry. vol 49. issue 17. 2006-10-03. PMID:16913710. |
binding of sulfonyl-containing arylalkylamines at human 5-ht6 serotonin receptors. |
2006-10-03 |
2023-08-12 |
human |