| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexandre V Ivachtchenko, Elena S Golovina, Madina G Kadieva, Angela G Koryakova, Sergiy M Kovalenko, Oleg D Mitkin, Ilya M Okun, Irina M Ravnyeyko, Sergey E Tkachenko, Oleg V Zaremb. Synthesis and biological study of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines as potent and selective serotonin 5-HT6 receptor antagonists. Bioorganic & medicinal chemistry. vol 18. issue 14. 2010-11-23. PMID:20541425. |
a number of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines were prepared and their 5-ht6 receptor binding affinity and ability to inhibit the functional cellular responses to serotonin were evaluated. |
2010-11-23 |
2023-08-12 |
Not clear |
| Beatriz Marcos, Maria Cabero, Maite Solas, Bárbara Aisa, Maria J Ramire. Signalling pathways associated with 5-HT6 receptors: relevance for cognitive effects. The international journal of neuropsychopharmacology. vol 13. issue 6. 2010-09-29. PMID:19737440. |
a growing body of evidence supports the use of serotonin 5-ht6 receptor antagonists as a promising mechanism for treating cognitive dysfunction. |
2010-09-29 |
2023-08-12 |
rat |
| B K Sharma, P Singh, K Sarbhai, Y S Prabhaka. A quantitative structure-activity relationship study on serotonin 5-HT6) receptor ligands: indolyl and piperidinyl sulphonamides. SAR and QSAR in environmental research. vol 21. issue 3-4. 2010-09-15. PMID:20544556. |
a quantitative structure-activity relationship study on serotonin 5-ht6) receptor ligands: indolyl and piperidinyl sulphonamides. |
2010-09-15 |
2023-08-12 |
Not clear |
| Yasuhisa Fukuo, Taro Kishi, Reiji Yoshimura, Tsuyoshi Kitajima, Tomo Okochi, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Hiroshi Naitoh, Wakako Umene-Nakano, Toshiya Inada, Hiroshi Kunugi, Tadafumi Kato, Takeo Yoshikawa, Hiroshi Ujike, Jun Nakamura, Norio Ozaki, Nakao Iwat. Serotonin 6 receptor gene and mood disorders: case-control study and meta-analysis. Neuroscience research. vol 67. issue 3. 2010-09-13. PMID:20394784. |
several evidence suggests that alterations in serotonin 6 (5-ht6) receptors might be associated with the pathophysiology of mood disorders. |
2010-09-13 |
2023-08-12 |
Not clear |
| Alexandre V Ivachtchenko, Dmitri E Dmitriev, Elena S Golovina, Madina G Kadieva, Angela G Koryakova, Volodymyr M Kysil, Oleg D Mitkin, Ilya M Okun, Sergey E Tkachenko, Anton A Vorobie. (3-Phenylsulfonylcycloalkano[e and d]pyrazolo[1,5-a]pyrimidin-2-yl)amines: potent and selective antagonists of the serotonin 5-HT6 receptor. Journal of medicinal chemistry. vol 53. issue 14. 2010-08-25. PMID:20560595. |
(3-phenylsulfonylcycloalkano[e and d]pyrazolo[1,5-a]pyrimidin-2-yl)amines: potent and selective antagonists of the serotonin 5-ht6 receptor. |
2010-08-25 |
2023-08-12 |
Not clear |
| Sabina Cevoli, Nadia Marzocchi, Sabina Capellari, Chiara Scapoli, Giulia Pierangeli, Daniela Grimaldi, Federica Naldi, L Alberto Pini, Pasquale Montagna, Pietro Cortell. Lack of association between five serotonin metabolism-related genes and medication overuse headache. The journal of headache and pain. vol 11. issue 1. 2010-03-25. PMID:19936617. |
we performed a genetic association study using polymorphisms of five serotonin metabolism-related genes: serotonin transporter (5htt), serotonin receptor 1a(5-ht1a), serotonin receptor 1b (5-ht1b), serotonin receptor 2a (5-ht2a) and serotonin receptor 6 (5ht6)genes. |
2010-03-25 |
2023-08-12 |
Not clear |
| Sabina Cevoli, Nadia Marzocchi, Sabina Capellari, Chiara Scapoli, Giulia Pierangeli, Daniela Grimaldi, Federica Naldi, L Alberto Pini, Pasquale Montagna, Pietro Cortell. Lack of association between five serotonin metabolism-related genes and medication overuse headache. The journal of headache and pain. vol 11. issue 1. 2010-03-25. PMID:19936617. |
in conclusion, our studydoes not provide evidence that the 5htt, 5-ht1a, 5ht1b,5ht2a and 5ht6 gene polymorphisms play a role in the genetic predisposition to moh. |
2010-03-25 |
2023-08-12 |
Not clear |
| Tania de la Fuente, Mar Martín-Fontecha, Jessica Sallander, Bellinda Benhamú, Mercedes Campillo, Rocío A Medina, Lucie P Pellissier, Sylvie Claeysen, Aline Dumuis, Leonardo Pardo, María L López-Rodrígue. Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation. Journal of medicinal chemistry. vol 53. issue 3. 2010-03-12. PMID:20078106. |
benzimidazole derivatives as new serotonin 5-ht6 receptor antagonists. |
2010-03-12 |
2023-08-12 |
human |
| Werner J Geldenhuys, Cornelis J Van der Schy. The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's disease. Expert review of neurotherapeutics. vol 9. issue 7. 2009-09-21. PMID:19589055. |
the serotonin 5-ht6 receptor: a viable drug target for treating cognitive deficits in alzheimer's disease. |
2009-09-21 |
2023-08-12 |
Not clear |
| O Riccio, G Potter, C Walzer, P Vallet, G Szabó, L Vutskits, J Z Kiss, A G Daye. Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6. Molecular psychiatry. vol 14. issue 3. 2009-06-03. PMID:18663366. |
excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6. |
2009-06-03 |
2023-08-12 |
mouse |
| O Riccio, G Potter, C Walzer, P Vallet, G Szabó, L Vutskits, J Z Kiss, A G Daye. Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6. Molecular psychiatry. vol 14. issue 3. 2009-06-03. PMID:18663366. |
we next found that 5-ht6 receptors were expressed in cortical interneurons and that 5-ht6 receptor activation decreased interneuron migration, whereas 5-ht6 receptor blockade prevented the migratory effects induced by 5-ht. |
2009-06-03 |
2023-08-12 |
mouse |
| Andrea Frassetto, Jiaping Zhang, Julie Z Lao, Amanda White, Joseph M Metzger, Tung M Fong, Richard Z Che. Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor. Brain research. vol 1236. 2009-04-16. PMID:18755168. |
given the documented role of the serotonin systems in human feeding, our results provide an interesting piece of evidence supporting the development of 5-ht6 receptor antagonists for treating obesity. |
2009-04-16 |
2023-08-12 |
mouse |
| M Shahid, G B Walker, S H Zorn, E H F Won. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. Journal of psychopharmacology (Oxford, England). vol 23. issue 1. 2009-04-03. PMID:18308814. |
in comparison with the antipsychotics, asenapine showed high affinity and a different rank order of binding affinities (pki) for serotonin receptors (5-ht1a [8.6], 5-ht1b [8.4], 5-ht2a [10.2], 5-ht2b [9.8], 5-ht2c [10.5], 5-ht5 [8.8], 5-ht6 [9.6] and 5-ht7 [9.9]), adrenoceptors (alpha1 [8.9], alpha2a [8.9], alpha2b [9.5] and alpha2c [8.9]), dopamine receptors (d1 [8.9], d2 [8.9], d3 [9.4] and d4 [9.0]) and histamine receptors (h1 [9.0] and h2 [8.2]). |
2009-04-03 |
2023-08-12 |
human |
| Andrew Holme. Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease. Neuroscience and biobehavioral reviews. vol 32. issue 7. 2009-02-19. PMID:18439676. |
serotonergic modulation of the acute response to stress and the adaptation to chronic stress is mediated by a myriad of molecules controlling serotonin neuron development (pet-1), synthesis (tryptophan hydroxylase 1 and 2 isozymes), packaging (vesicular monoamine transporter 2), actions at presynaptic and postsynaptic receptors (5-ht1a, 5-ht1b, 5-ht2a, 5-ht2c, 5-ht3a, 5-ht4, 5-ht5a, 5-ht6, 5-ht7), reuptake (serotonin transporter), and degradation (monoamine oxidase a). |
2009-02-19 |
2023-08-12 |
mouse |
| Madeleine V King, Charles A Marsden, Kevin C F Fon. A role for the 5-HT(1A), 5-HT4 and 5-HT6 receptors in learning and memory. Trends in pharmacological sciences. vol 29. issue 9. 2009-01-30. PMID:19086256. |
a role for the 5-ht(1a), 5-ht4 and 5-ht6 receptors in learning and memory. |
2009-01-30 |
2023-08-12 |
mouse |
| Madeleine V King, Charles A Marsden, Kevin C F Fon. A role for the 5-HT(1A), 5-HT4 and 5-HT6 receptors in learning and memory. Trends in pharmacological sciences. vol 29. issue 9. 2009-01-30. PMID:19086256. |
5-ht(1a), 5-ht4 and 5-ht6 receptors are densely expressed in brain regions innervated by serotonergic projections from the raphe nuclei and are associated with learning and memory. |
2009-01-30 |
2023-08-12 |
mouse |
| Andrew G Ramage, Carlos M Villaló. 5-hydroxytryptamine and cardiovascular regulation. Trends in pharmacological sciences. vol 29. issue 9. 2009-01-30. PMID:19086344. |
all 5-hydroxytryptamine (5-ht; serotonin) receptors, except the 5-ht6 type, have been shown to be involved in cardiovascular regulation. |
2009-01-30 |
2023-08-12 |
Not clear |
| b' Ermitas Alcalde, Neus Mesquida, Jordi Frigola, Sara L\\xc3\\xb3pez-P\\xc3\\xa9rez, Ramon Merc\\xc3\\xa. Indene-based scaffolds. Design and synthesis of novel serotonin 5-HT6 receptor ligands. Organic & biomolecular chemistry. vol 6. issue 20. 2008-12-01. PMID:18843410.' |
design and synthesis of novel serotonin 5-ht6 receptor ligands. |
2008-12-01 |
2023-08-12 |
Not clear |
| Werner J Geldenhuys, Cornelis J Van der Schy. Serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 8. issue 12. 2008-10-27. PMID:18691131. |
serotonin 5-ht6 receptor antagonists for the treatment of alzheimer's disease. |
2008-10-27 |
2023-08-12 |
Not clear |
| Christopher N Johnson, Mahmood Ahmed, Neil D Mille. 5-HT6 receptor antagonists: prospects for the treatment of cognitive disorders including dementia. Current opinion in drug discovery & development. vol 11. issue 5. 2008-10-03. PMID:18729016. |
a growing body of preclinical evidence has supported the use of serotonin 5-ht6 receptor antagonism as a promising mechanism for treating cognitive dysfunction. |
2008-10-03 |
2023-08-12 |
Not clear |