| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vaibhav P Pai, Laura L Hernandez, Malinda A Stull, Nelson D Horsema. The type 7 serotonin receptor, 5-HT 7 , is essential in the mammary gland for regulation of mammary epithelial structure and function. BioMed research international. vol 2015. 2015-10-12. PMID:25664318. |
our results show that 5-ht7 is required for multiple actions of 5-ht in the mammary glands including core functions that contribute to changes in cell shape and cell turnover, as well as specialized secretory functions. |
2015-10-12 |
2023-08-13 |
mouse |
| L Samalin, M Ben Gharbia, M Garnier, P-M Llorc. [Short-term efficacy and safety of lurasidone in the treatment of schizophrenia]. L'Encephale. vol 40. issue 6. 2015-09-21. PMID:25453735. |
lurasidone is the second-generation antipsychotic with the greatest affinity for 5ht7 receptors and has a low affinity for α1 and α2c-adrenergic and 5ht2c serotonin receptors, and no affinity for histaminergic h1 or muscarinic m1 receptors. |
2015-09-21 |
2023-08-13 |
Not clear |
| Stephen M Stah. Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): enhancing serotonin release by combining serotonin (5HT) transporter inhibition with actions at 5HT receptors (5HT1A, 5HT1B, 5HT1D, 5HT7 receptors). CNS spectrums. vol 20. issue 2. 2015-09-15. PMID:25831967. |
modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (mma): enhancing serotonin release by combining serotonin (5ht) transporter inhibition with actions at 5ht receptors (5ht1a, 5ht1b, 5ht1d, 5ht7 receptors). |
2015-09-15 |
2023-08-13 |
Not clear |
| Hai Lin, Bong Ha Heo, Woong Mo Kim, Yong Chul Kim, Myung Ha Yoo. Antiallodynic effect of tianeptine via modulation of the 5-HT7 receptor of GABAergic interneurons in the spinal cord of neuropathic rats. Neuroscience letters. vol 598. 2015-09-14. PMID:25982324. |
we examined the antiallodynic effect of intrathecal tianeptine in neuropathic pain rats and determined the involvement of 5-hydroxytryptamine type 7 (5-ht7) receptor of the gabaergic interneurons in the spinal cord. |
2015-09-14 |
2023-08-13 |
rat |
| Magdalena Kusek, Joanna Sowa, Katarzyna Kamińska, Krystyna Gołembiowska, Krzysztof Tokarski, Grzegorz Hes. 5-HT7 receptor modulates GABAergic transmission in the rat dorsal raphe nucleus and controls cortical release of serotonin. Frontiers in cellular neuroscience. vol 9. 2015-09-08. PMID:26347612. |
5-ht7 receptor modulates gabaergic transmission in the rat dorsal raphe nucleus and controls cortical release of serotonin. |
2015-09-08 |
2023-08-13 |
rat |
| Magdalena Kusek, Joanna Sowa, Katarzyna Kamińska, Krystyna Gołembiowska, Krzysztof Tokarski, Grzegorz Hes. 5-HT7 receptor modulates GABAergic transmission in the rat dorsal raphe nucleus and controls cortical release of serotonin. Frontiers in cellular neuroscience. vol 9. 2015-09-08. PMID:26347612. |
the 5-ht7 receptor is one of the several serotonin (5-ht) receptor subtypes that are expressed in the dorsal raphe nucleus (drn). |
2015-09-08 |
2023-08-13 |
rat |
| Magdalena Kusek, Joanna Sowa, Katarzyna Kamińska, Krystyna Gołembiowska, Krzysztof Tokarski, Grzegorz Hes. 5-HT7 receptor modulates GABAergic transmission in the rat dorsal raphe nucleus and controls cortical release of serotonin. Frontiers in cellular neuroscience. vol 9. 2015-09-08. PMID:26347612. |
some earlier findings suggested that 5-ht7 receptors in the drn were localized on gabaergic interneurons modulating the activity of 5-ht projection neurons. |
2015-09-08 |
2023-08-13 |
rat |
| Magdalena Kusek, Joanna Sowa, Katarzyna Kamińska, Krystyna Gołembiowska, Krzysztof Tokarski, Grzegorz Hes. 5-HT7 receptor modulates GABAergic transmission in the rat dorsal raphe nucleus and controls cortical release of serotonin. Frontiers in cellular neuroscience. vol 9. 2015-09-08. PMID:26347612. |
the aim of the present study was to find out how the 5-ht7 receptor modulates the gabaergic synaptic input to putative 5-ht drn neurons, and whether blockade of the 5-ht7 receptor would affect the release of 5-ht in the target structure. |
2015-09-08 |
2023-08-13 |
rat |
| Magdalena Kusek, Joanna Sowa, Katarzyna Kamińska, Krystyna Gołembiowska, Krzysztof Tokarski, Grzegorz Hes. 5-HT7 receptor modulates GABAergic transmission in the rat dorsal raphe nucleus and controls cortical release of serotonin. Frontiers in cellular neuroscience. vol 9. 2015-09-08. PMID:26347612. |
male wistar rats with microdialysis probes implanted in the prefrontal cortex (pfc) received injections of the 5-ht7 receptor antagonist (2r)-1-[(3-hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine hydrochloride (sb 269970), which induced an increase in the levels of 5-ht and its metabolite, 5-hydroxyindoleacetic acid (5-hiaa) in the pfc. |
2015-09-08 |
2023-08-13 |
rat |
| Asres Berhan, Alex Barke. Vortioxetine in the treatment of adult patients with major depressive disorder: a meta-analysis of randomized double-blind controlled trials. BMC psychiatry. vol 14. 2015-09-02. PMID:25260373. |
it is a selective serotonin (5-ht) 3a and 5-ht7 receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and inhibitor of serotonin transporters. |
2015-09-02 |
2023-08-13 |
Not clear |
| Connie Sanchez, Karen E Asin, Francesc Artiga. Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data. Pharmacology & therapeutics. vol 145. 2015-08-31. PMID:25016186. |
vortioxetine, a novel antidepressant for the treatment of major depressive disorder (mdd), is a 5-ht3, 5-ht7 and 5-ht1d receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and serotonin (5-ht) transporter (sert) inhibitor. |
2015-08-31 |
2023-08-13 |
Not clear |
| Shu-Fa Li, Yuan-Yuan Zhang, You-Yan Li, Song Wen, Zhi Xia. Antihyperalgesic effect of 5-HT7 receptor activation on the midbrain periaqueductal gray in a rat model of neuropathic pain. Pharmacology, biochemistry, and behavior. vol 127. 2015-08-28. PMID:25450118. |
the 5-ht7 receptor is the most recently discovered receptor for 5-hydroxytryptamine (5-ht), and only little is known about the analgesic potential of this receptor. |
2015-08-28 |
2023-08-13 |
rat |
| Przemysław Bieńkowski, Dominika Dudek, Jerzy Samochowie. [Towards better non-selectivity: the role of 5-HT7 receptors in therapeutic efficacy of a second-generation antipsychotic - lurasidone]. Psychiatria polska. vol 49. issue 2. 2015-08-27. PMID:26093589. |
the primary aim of this mini-review is to summarize available evidence supporting the role of serotonin receptors, especially 5-ht7 receptors, in therapeutic effects of a second-generation antipsychotic drug, lurasidone. |
2015-08-27 |
2023-08-13 |
Not clear |
| A Meneses, G Perez-Garcia, G Liy-Salmeron, T Ponce-López, E Lacivita, M Leopold. 5-HT7 receptor activation: procognitive and antiamnesic effects. Psychopharmacology. vol 232. issue 3. 2015-08-11. PMID:25074446. |
the serotonin (5-hydroxytryptamine (5-ht)) 5-ht7 receptor is localized in brain areas mediating memory; however, the role of this receptor on memory remains little explored. |
2015-08-11 |
2023-08-13 |
Not clear |
| Alfredo Menese. Serotonin, neural markers, and memory. Frontiers in pharmacology. vol 6. 2015-08-10. PMID:26257650. |
5-ht1a, 5-ht4, 5-ht5, 5-ht6, and 5-ht7 receptors as well as sert (serotonin transporter) seem to be useful neural markers and/or therapeutic targets. |
2015-08-10 |
2023-08-13 |
Not clear |
| Milt Teitler, Katharine Herrick-Davi. Determining the oligomer number of native GPCR using florescence correlation spectroscopy and drug-induced inactivation-reactivation. Current pharmaceutical biotechnology. vol 15. issue 10. 2015-08-06. PMID:25213307. |
studies of the 5-ht7 and 5-ht2a serotonin receptors have revealed that binding of a pseudo-irreversible antagonist ("inactivator") to one of the orthosteric sites of a homodimer abolishes all receptor activity, and subsequent binding of a competitive antagonist to the orthosteric site of the second protomer releases the inactivator, allowing the receptor to return to an active state. |
2015-08-06 |
2023-08-13 |
rat |
| Yunpeng Du, Megan Cramer, Chieh Allen Lee, Jie Tang, Arivalagan Muthusamy, David A Antonetti, Hui Jin, Krzysztof Palczewski, Timothy S Ker. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 5. 2015-07-30. PMID:25667222. |
this response was reduced or ablated by pharmacologic inhibition of the α1-ar (a gq-coupled receptor) or gs-coupled serotonin (5-ht2, 5-ht4, 5-ht6, and 5-ht7) receptors or by activation of the gi-coupled α2-ar. |
2015-07-30 |
2023-08-13 |
mouse |
| Ligia Westrich, Nasser Haddjeri, Ouria Dkhissi-Benyahya, Connie Sánche. Involvement of 5-HT₇ receptors in vortioxetine's modulation of circadian rhythms and episodic memory in rodents. Neuropharmacology. vol 89. 2015-07-15. PMID:25446573. |
vortioxetine is a multimodal antidepressant that inhibits 5-ht1d, 5-ht3, 5-ht7 receptor activity, 5-ht reuptake, and enhances the activity of 5-ht1a and 5-ht1b receptors. |
2015-07-15 |
2023-08-13 |
mouse |
| Stephanie W Watt. Serotonin and sensory nerves: meeting in the cardiovascular system. Vascular pharmacology. vol 63. issue 1. 2015-07-02. PMID:25181552. |
the work by cuesta et al., in this issue of vascular pharmacology adds another layer of complexity by providing sound in vivo data that 5-ht, through the 5-ht7 receptor, can inhibit the vasodepressor actions of the sensory nervous system and thereby promote blood pressure maintenance. |
2015-07-02 |
2023-08-13 |
Not clear |
| Laurent Tritschler, Daniela Felice, Romain Colle, Jean-Philippe Guilloux, Emmanuelle Corruble, Alain Michel Gardier, Denis Joseph Davi. Vortioxetine for the treatment of major depressive disorder. Expert review of clinical pharmacology. vol 7. issue 6. 2015-06-15. PMID:25166025. |
vortioxetine (brintellix(®), 1-[2-(2,4-dimethylphenyl-sulfanyl)-phenyl]-piperazine) is a multimodal antidepressant targeting the 5-ht1a, 5-ht1b, 5-ht1d, 5-ht3, 5-ht7 receptors and the serotonin (5-ht) transporter (5-htt). |
2015-06-15 |
2023-08-13 |
Not clear |