| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José Ángel García-Pedraza, Mónica García, María Luisa Martín, Nélida Eleno, Asunción Morá. Chronic Sarpogrelate Treatment Reveals 5-HT7 Receptor in the Serotonergic Inhibition of the Rat Vagal Bradycardia. Journal of cardiovascular pharmacology. vol 69. issue 1. 2017-11-27. PMID:27676327. |
moreover, sb-258719 (5-ht7 antagonist) abolished the 5-ht-, 5-ct-, 8-oh-dpat-, and as-19-induced bradycardia inhibition; 5-ht or as-19 did not modify the bradycardia induced by iv acetylcholine; and 5-ht7 receptor was expressed in both the vagus nerve and the right atrium. |
2017-11-27 |
2023-08-13 |
rat |
| José Ángel García-Pedraza, Mónica García, María Luisa Martín, Nélida Eleno, Asunción Morá. Chronic Sarpogrelate Treatment Reveals 5-HT7 Receptor in the Serotonergic Inhibition of the Rat Vagal Bradycardia. Journal of cardiovascular pharmacology. vol 69. issue 1. 2017-11-27. PMID:27676327. |
our outcomes suggest that blocking chronically 5-ht2 receptors modifies the serotonergic influence on cardiac vagal neurotransmission exhibiting 5-ht as an exclusively inhibitory agent via prejunctional 5-ht7 receptor. |
2017-11-27 |
2023-08-13 |
rat |
| Andrea de Bartolomeis, Andrea Fagiolini, Giuseppe Main. [Vortioxetine in the treatment of major depression]. Rivista di psichiatria. vol 51. issue 6. 2017-11-20. PMID:27996982. |
vortioxetine is a multi-modal antidepressant that functions both as serotonin transporter (sert) inhibitor and as 5-ht3, 5-ht7 and 5-ht1d receptors antagonist, 5-ht1a receptor agonist and 5-ht1b receptor partial agonist. |
2017-11-20 |
2023-08-13 |
Not clear |
| Kangjian Xiang, Xuefei Zhao, Youjun Li, Liang Zheng, Jue Wang, Yan-Hai L. Selective 5-HT7 Receptor Activation May Enhance Synaptic Plasticity Through N-methyl-D-aspartate (NMDA) Receptor Activity in the Visual Cortex. Current neurovascular research. vol 13. issue 4. 2017-10-19. PMID:27558200. |
similar results were obtained by exogenously applied 5-ct or 8-oh-dpat (the 5-ht<sub>1a</sub> and 5-ht7 receptor agonist). |
2017-10-19 |
2023-08-13 |
rat |
| Luisa Speranza, Josephine Labus, Floriana Volpicelli, Daria Guseva, Enza Lacivita, Marcello Leopoldo, Gian Carlo Bellenchi, Umberto di Porzio, Monika Bijata, Carla Perrone-Capano, Evgeni Ponimaski. Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons. Journal of neurochemistry. vol 141. issue 5. 2017-08-17. PMID:28122114. |
serotonin 5-ht7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons. |
2017-08-17 |
2023-08-13 |
mouse |
| Luisa Speranza, Josephine Labus, Floriana Volpicelli, Daria Guseva, Enza Lacivita, Marcello Leopoldo, Gian Carlo Bellenchi, Umberto di Porzio, Monika Bijata, Carla Perrone-Capano, Evgeni Ponimaski. Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons. Journal of neurochemistry. vol 141. issue 5. 2017-08-17. PMID:28122114. |
here, we report that prolonged activation of the serotonin 5-ht7 receptor (5-ht7r) with selective agonist lp-211 promotes formation of dendritic spines and facilitates synaptogenesis in postnatal cortical and striatal neurons. |
2017-08-17 |
2023-08-13 |
mouse |
| Sebastiano Intagliata, Maria N Modica, Valeria Pittalà, Loredana Salerno, Maria A Siracusa, Alfredo Cagnotto, Mario Salmona, Giuseppe Rome. Design and synthesis of new homo and hetero bis-piperazinyl-1-propanone derivatives as 5-HT7R selective ligands over 5-HT1AR. Bioorganic & medicinal chemistry letters. vol 26. issue 16. 2017-07-26. PMID:27396505. |
these newly synthesized compounds possess a 4-arylpiperazine linked through an acyl spacer to another substituted piperazine system and were tested for their binding properties on human cloned 5-ht1a and 5-ht7 serotonin receptors. |
2017-07-26 |
2023-08-13 |
human |
| Ling Na Han, Li Zhang, Yi Na Sun, Cheng Xue Du, Yu Ming Zhang, Tao Wang, Jin Zhang, Jian Li. Serotonin7 receptors in the lateral habenular nucleus regulate depressive-like behaviors in the hemiparkinsonian rats. Brain research. vol 1644. 2017-06-29. PMID:27178363. |
these findings suggest that activation or blockade of 5-ht7 receptors in the lhb may change the activity of lhb glutamate neurons, and then decreases or increases dopamine and 5-ht levels in the limbic and limbic-related brain regions, which are involved in the regulation of depressive-like behaviors. |
2017-06-29 |
2023-08-13 |
rat |
| Laura Orsolini, Carmine Tomasetti, Alessandro Valchera, Felice Iasevoli, Elisabetta Filomena Buonaguro, Federica Vellante, Michele Fornaro, Annastasia Fiengo, Monica Mazza, Roberta Vecchiotti, Giampaolo Perna, Andrea de Bartolomeis, Giovanni Martinotti, Massimo Di Giannantonio, Domenico De Berardi. New advances in the treatment of generalized anxiety disorder: the multimodal antidepressant vortioxetine. Expert review of neurotherapeutics. vol 16. issue 5. 2017-06-27. PMID:27050932. |
vortioxetine (vrx) is a multimodal antidepressant with a unique mechanism of action, by acting as 5-ht3a, 5-ht1d and 5-ht7 receptor antagonist, partial agonist at the 5-ht1a and 5-ht1b receptors and inhibitor at the 5-ht transporter. |
2017-06-27 |
2023-08-13 |
Not clear |
| Dioneia Araldi, Luiz F Ferrari, Jon D Levin. Gi-protein-coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming. Pain. vol 157. issue 8. 2017-03-13. PMID:27075428. |
the prolongation of pge2 hyperalgesia induced by sumatriptan was partially prevented by coinjection of antagonists for the 5-ht1b and 5-ht1d, but not 5-ht7, serotonin receptors and completely prevented by coadministration of a combination of the 5-ht1b and 5-ht1d antagonists. |
2017-03-13 |
2023-08-13 |
rat |
| Enza Lacivita, Sabina Podlewska, Luisa Speranza, Mauro Niso, Grzegorz Satała, Roberto Perrone, Carla Perrone-Capano, Andrzej J Bojarski, Marcello Leopold. Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. European journal of medicinal chemistry. vol 120. 2017-02-13. PMID:27318552. |
structural modifications of the serotonin 5-ht7 receptor agonist n-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (lp-211) to improve in vitro microsomal stability: a case study. |
2017-02-13 |
2023-08-13 |
mouse |
| Gennady N Smagin, Dekun Song, David P Budac, Jessica A Waller, Yan Li, Alan L Pehrson, Connie Sánche. Histamine may contribute to vortioxetine's procognitive effects; possibly through an orexigenic mechanism. Progress in neuro-psychopharmacology & biological psychiatry. vol 68. 2017-01-02. PMID:26945513. |
vortioxetine is a novel multimodal antidepressant that acts as a serotonin (5-ht)3, 5-ht7, and 5-ht1d receptor antagonist; 5-ht1b receptor partial agonist; 5-ht1a receptor agonist; and 5-ht transporter inhibitor in vitro. |
2017-01-02 |
2023-08-13 |
rat |
| J A García-Pedraza, M García, M L Martín, A Rodríguez-Barbero, A Morá. 5-HT2 receptor blockade exhibits 5-HT vasodilator effects via nitric oxide, prostacyclin and ATP-sensitive potassium channels in rat renal vasculature. Vascular pharmacology. vol 79. 2016-12-13. PMID:26586311. |
agonists 5-ct (5-ht1/7), cgs-12066b (5-ht1b), l-694,247 (5-ht1d) or as-19 (5-ht7) mimicked renal 5-ht vasodilator effect. |
2016-12-13 |
2023-08-13 |
rat |
| J A García-Pedraza, M García, M L Martín, A Rodríguez-Barbero, A Morá. 5-HT2 receptor blockade exhibits 5-HT vasodilator effects via nitric oxide, prostacyclin and ATP-sensitive potassium channels in rat renal vasculature. Vascular pharmacology. vol 79. 2016-12-13. PMID:26586311. |
our data suggest that 5-ht exerts renal vasodilator effect in the in situ autoperfused sarpogrelate-treated rat kidney, mediated by 5-ht1d, 5-ht1b and 5-ht7 receptors, involving cyclooxygenase-derived prostacyclin, nitric oxide synthesis/release and atp-sensitive k+ channels, respectively. |
2016-12-13 |
2023-08-13 |
rat |
| Jessica A Waller, Fenghua Chen, Connie Sánche. Vortioxetine promotes maturation of dendritic spines in vitro: A comparative study in hippocampal cultures. Neuropharmacology. vol 103. 2016-12-13. PMID:26702943. |
the multimodal-acting antidepressant vortioxetine is an antagonist at 5-ht3, 5-ht7, and 5-ht1d receptors, a partial agonist at 5-ht1b receptors, an agonist at 5-ht1a receptors, and an inhibitor of the serotonin (5-ht) transporter (sert) and has pro-cognitive properties. |
2016-12-13 |
2023-08-13 |
Not clear |
| D J David, L Tritschler, J-P Guilloux, A M Gardier, C Sanchez, R Gaillar. [Pharmacological properties of vortioxetine and its pre-clinical consequences]. L'Encephale. vol 42. issue 1 Suppl 1. 2016-12-13. PMID:26879252. |
compared to the ssris, vortioxetine is defined as a multimodal antidepressant drug since it is not only a serotonin reuptake inhibitor, but also a 5-ht1d, 5-ht3, 5-ht7 receptor antagonist, 5-ht1b receptor partial agonist and 5-ht1a receptor agonist. |
2016-12-13 |
2023-08-13 |
Not clear |
| Katarzyna Kucwaj-Brysz, Dawid Warszycki, Sabina Podlewska, Jagna Witek, Karolina Witek, Andrea González Izquierdo, Grzegorz Satała, María I Loza, Annamaria Lubelska, Gniewomir Latacz, Andrzej J Bojarski, Marián Castro, Katarzyna Kieć-Kononowicz, Jadwiga Handzli. Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation. European journal of medicinal chemistry. vol 112. 2016-11-07. PMID:26900658. |
a series of novel arylpiperazine 5-(4-fluorophenyl)-5-methylhydantoins with 2-hydroxypropyl linker (2-15) was synthesized and evaluated on their affinity towards serotonin 5-ht7 receptor (5-ht7r) in comparison to other closely related gpcrs: serotonin 5-ht1a, and dopamine d2 receptors. |
2016-11-07 |
2023-08-13 |
human |
| Sarwat Fatima, Xiaoke Shi, Zesi Lin, Guo-qing Chen, Xiao-hua Pan, Justin Che-Yuen Wu, John W Ho, Nikki P Lee, Hengjun Gao, Ge Zhang, Aiping Lu, Zhao Xiang Bia. 5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin. Molecular oncology. vol 10. issue 2. 2016-10-28. PMID:26474915. |
increased wnt/β-catenin activity was attenuated by antagonist of receptor 5-ht7 (sb-258719) in hcc cell lines and patient-derived primary tumour tissues in the presence of 5-ht. |
2016-10-28 |
2023-08-13 |
Not clear |
| Nicholas V Cozzi, Paul F Dale. Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines. Bioorganic & medicinal chemistry letters. vol 26. issue 3. 2016-10-13. PMID:26739781. |
five of the dalt compounds had affinity in the 50-400 nm range for serotonin 5-ht1d, 5-ht6, and 5-ht7 receptors; again, it was the unsubstituted dalt that had the weakest affinity at all three subtypes. |
2016-10-13 |
2023-08-13 |
Not clear |
| Danielle A Diniz, Júlia Alvarenga Petrocchi, Larissa Caldeira Navarro, Tâmara Cristina Souza, Marina G M Castor, Andrea C Perez, Igor D G Duarte, Thiago R L Romer. Serotonin induces peripheral mechanical antihyperalgesic effects in mice. European journal of pharmacology. vol 767. 2016-10-05. PMID:26460149. |
we used selective antagonists of serotonin receptors (isamoltan 5-ht1b, brl 15572 5-ht1d, ketanserin 5-ht2a, ondansetron 5-ht3 and sb-269970 5-ht7). |
2016-10-05 |
2023-08-13 |
mouse |