| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Czopek, Marcin Kołaczkowski, Adam Bucki, Hanna Byrtus, Maciej Pawłowski, Grzegorz Kazek, Andrzej J Bojarski, Agata Piaskowska, Justyna Kalinowska-Tłuścik, Anna Partyka, Anna Wesołowsk. Novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent. Bioorganic & medicinal chemistry. vol 23. issue 13. 2016-02-26. PMID:25936259. |
a series of novel spirohydantoin derivatives with arylpiperazinylbutyl moiety were synthesized and evaluated for serotonin 5-ht1a, 5-ht2a, 5-ht7 and dopamine d2 receptors. |
2016-02-26 |
2023-08-13 |
mouse |
| Hanne D Hansen, Valdemar L Andersen, Szabolcs Lehel, Janus H Magnussen, Agnete Dyssegaard, Nikolas Stroth, Jesper L Kristensen, Gitte M Knudsen, Matthias M Hert. Labeling and preliminary in vivo evaluation of the 5-HT(7) receptor selective agonist [(11)C]E-55888. Bioorganic & medicinal chemistry letters. vol 25. issue 9. 2016-02-19. PMID:25857944. |
e-55888 has been identified as a selective serotonin 7 (5-ht7) receptor agonist. |
2016-02-19 |
2023-08-13 |
Not clear |
| Agnieszka Nikiforuk, Małgorzata Hołuj, Agnieszka Potasiewicz, Piotr Popi. Effects of the selective 5-HT7 receptor antagonist SB-269970 on premature responding in the five-choice serial reaction time test in rats. Behavioural brain research. vol 289. 2016-02-05. PMID:25930219. |
the antagonists of serotonin 5-ht7 receptors have been demonstrated to ameliorate cognitive impairments in pharmacological animal models of schizophrenia that involve blockade of n-methyl-d-aspartate receptors (nmdars). |
2016-02-05 |
2023-08-13 |
rat |
| Mostafa El Mansari, Maurice Lecours, Pierre Blie. Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Psychopharmacology. vol 232. issue 13. 2016-02-02. PMID:25665528. |
vortioxetine is a novel multimodal antidepressant that is a 5-ht1b receptor partial agonist, a 5-ht1a receptor agonist, an inhibitor of the serotonin (5-ht) transporter, and a 5-ht1d, 5-ht3, and 5-ht7 receptor antagonist in vitro. |
2016-02-02 |
2023-08-13 |
rat |
| Emmanuel Deau, Elodie Robin, Raluca Voinea, Nathalie Percina, Grzegorz Satała, Adriana-Luminita Finaru, Agnès Chartier, Gilles Tamagnan, David Alagille, Andrzej J Bojarski, Séverine Morisset-Lopez, Franck Suzenet, Gérald Guillaume. Rational Design, Pharmacomodulation, and Synthesis of Dual 5-Hydroxytryptamine 7 (5-HT7)/5-Hydroxytryptamine 2A (5-HT2A) Receptor Antagonists and Evaluation by [(18)F]-PET Imaging in a Primate Brain. Journal of medicinal chemistry. vol 58. issue 20. 2016-02-02. PMID:26348247. |
rational design, pharmacomodulation, and synthesis of dual 5-hydroxytryptamine 7 (5-ht7)/5-hydroxytryptamine 2a (5-ht2a) receptor antagonists and evaluation by [(18)f]-pet imaging in a primate brain. |
2016-02-02 |
2023-08-13 |
Not clear |
| Paweł Żmudzki, Grażyna Chłoń-Rzepa, Andrzej J Bojarski, Małgorzata Zygmunt, Grzegorz Kazek, Barbara Mordyl, Maciej Pawłowsk. Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773578. |
in order to examine the influence of the substituent in the position 8 of the purine moiety on the affinity for the serotonin 5-ht1a , 5-ht2a , and 5-ht7 receptors, a series of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl (thiq) derivatives of 8-amino-1,3-dimethyl-1h-purine-2,6(3h,7h)-dione were synthesized. |
2016-01-21 |
2023-08-13 |
Not clear |
| Paweł Żmudzki, Grażyna Chłoń-Rzepa, Andrzej J Bojarski, Małgorzata Zygmunt, Grzegorz Kazek, Barbara Mordyl, Maciej Pawłowsk. Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773578. |
all the final compounds were investigated in in vitro competition binding experiments for serotonin 5-ht1a , 5-ht2a , and 5-ht7 receptors. |
2016-01-21 |
2023-08-13 |
Not clear |
| Grażyna Chłoń-Rzepa, Agnieszka Zagórska, Adam Bucki, Marcin Kołaczkowski, Maciej Pawłowski, Grzegorz Satała, Andrzej J Bojarski, Anna Partyka, Anna Wesołowska, Elżbieta Pękala, Karolina Słoczyńsk. New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773907. |
to obtain potential antidepressants and/or antipsychotics, a series of new long-chain arylpiperazine derivatives of 8-alkoxy-purine-2,6-dione (10-24) and dihydro[1,3]oxazolo[2,3-f]purinedione (30-34) were synthesized and their serotonin (5-ht1a , 5-ht2a , 5-ht6 , 5-ht7 ) and dopamine (d2 ) receptor affinities were determined. |
2016-01-21 |
2023-08-13 |
mouse |
| Ichiro Kusumi, Shuken Boku, Yoshito Takahash. Psychopharmacology of atypical antipsychotic drugs: From the receptor binding profile to neuroprotection and neurogenesis. Psychiatry and clinical neurosciences. vol 69. issue 5. 2016-01-18. PMID:25296946. |
a variety of serotonin (5-ht) receptors, such as 5-ht2a / 2c , 5-ht1a , 5-ht6 and 5-ht7 receptors, may contribute to the mechanisms of action of 'atypicality'. |
2016-01-18 |
2023-08-13 |
Not clear |
| Antony Loebel, Leslie Citrom. Lurasidone: a novel antipsychotic agent for the treatment of schizophrenia and bipolar depression. BJPsych bulletin. vol 39. issue 5. 2016-01-12. PMID:26755968. |
in addition to full antagonist activity at dopamine d2 (k i(d2) = 1 nm) and serotonin 5-ht2a (k i(5-ht2a) = 0.5 nm) receptors, the pharmacodynamic profile of lurasidone is notable for its high affinity for serotonin 5-ht7 receptors (k i(5-ht7) = 0.5 nm) and its partial agonist activity at 5-ht1a receptors (k i(5-ht1a) = 6.4 nm). |
2016-01-12 |
2023-08-13 |
Not clear |
| Cécile Bétry, Adeline Etiévant, Alan Pehrson, Connie Sánchez, Nasser Haddjer. Effect of the multimodal acting antidepressant vortioxetine on rat hippocampal plasticity and recognition memory. Progress in neuro-psychopharmacology & biological psychiatry. vol 58. 2016-01-05. PMID:25524057. |
vortioxetine is a multimodal acting antidepressant that functions as a 5-ht3 and 5-ht7 and 5-ht1d receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and inhibitor of the 5-ht transporter. |
2016-01-05 |
2023-08-13 |
human |
| Maria N Modica, Sebastiano Intagliata, Valeria Pittalà, Loredana Salerno, Maria A Siracusa, Alfredo Cagnotto, Mario Salmona, Giuseppe Rome. Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands. Bioorganic & medicinal chemistry letters. vol 25. issue 7. 2015-12-21. PMID:25759032. |
new long-chain 4-substituted piperazines linked to a thienopyrimidine or a quinazoline system were synthesized and tested for their binding properties on human cloned 5-ht1a and 5-ht7 serotonin receptors. |
2015-12-21 |
2023-08-13 |
human |
| Takeshi Chiba, Soichiro Kimura, Katsuo Takahashi, Yasunori Morimoto, Tomoji Maeda, Atsushi Sanbe, Hideo Ueda, Kenzo Kud. Serotonin regulates β-casein expression via 5-HT7 receptors in human mammary epithelial MCF-12A cells. Biological & pharmaceutical bulletin. vol 38. issue 3. 2015-11-30. PMID:25757927. |
serotonin regulates β-casein expression via 5-ht7 receptors in human mammary epithelial mcf-12a cells. |
2015-11-30 |
2023-08-13 |
human |
| Katarzyna Panczyk, Sylwia Golda, Anna Waszkielewicz, Dorota Zelaszczyk, Agnieszka Gunia-Krzyzak, Henryk Maron. Serotonergic system and its role in epilepsy and neuropathic pain treatment: a review based on receptor ligands. Current pharmaceutical design. vol 21. issue 13. 2015-11-23. PMID:25412650. |
so far, participation in the epileptogenesis and maintenance of epilepsy was proved for 5-ht1a, 5-ht2c, 5-ht3, 5-ht4 and 5-ht7 receptors as well as 5-htt serotonin transporter. |
2015-11-23 |
2023-08-13 |
Not clear |
| Katarzyna Panczyk, Sylwia Golda, Anna Waszkielewicz, Dorota Zelaszczyk, Agnieszka Gunia-Krzyzak, Henryk Maron. Serotonergic system and its role in epilepsy and neuropathic pain treatment: a review based on receptor ligands. Current pharmaceutical design. vol 21. issue 13. 2015-11-23. PMID:25412650. |
according to the available data, neuropathic pain mechanisms involve 5-ht1a/1b/1d, 5-ht2a/2b/2c, 5-ht3, 5-ht4, 5-ht6, 5-ht7 receptors and 5-htt serotonin transporter. |
2015-11-23 |
2023-08-13 |
Not clear |
| Clinton E Canal, Daniel E Felsing, Yue Liu, Wanying Zhu, JodiAnne T Wood, Charles K Perry, Rajender Vemula, Raymond G Boot. Correction to an orally active phenylaminotetralin-chemotype serotonin 5-HT7 and 5-HT1A receptor partial agonist that corrects motor stereotypy in mouse models. ACS chemical neuroscience. vol 6. issue 8. 2015-10-27. PMID:26225542. |
correction to an orally active phenylaminotetralin-chemotype serotonin 5-ht7 and 5-ht1a receptor partial agonist that corrects motor stereotypy in mouse models. |
2015-10-27 |
2023-08-13 |
mouse |
| Virginia E Hawkins, Joanna M Hawryluk, Ana C Takakura, Anastasios V Tzingounis, Thiago S Moreira, Daniel K Mulke. HCN channels contribute to serotonergic modulation of ventral surface chemosensitive neurons and respiratory activity. Journal of neurophysiology. vol 113. issue 4. 2015-10-23. PMID:25429115. |
these results suggest that hcn channels contribute to resting chemoreceptor activity and that serotonin activates rtn chemoreceptors and breathing in part by a 5-ht7 receptor-dependent mechanism and downstream activation of ih. |
2015-10-23 |
2023-08-13 |
rat |
| Anna Partyka, Grażyna Chłoń-Rzepa, Anna Wasik, Magdalena Jastrzębska-Więsek, Adam Bucki, Marcin Kołaczkowski, Grzegorz Satała, Andrzej J Bojarski, Anna Wesołowsk. Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT₁A receptor functional profile. Bioorganic & medicinal chemistry. vol 23. issue 1. 2015-10-22. PMID:25435254. |
continuing our earlier study in a group of purine-2,6-dione derivatives of long chain arylpiperazines (lcaps), a series of 8-unsubstituted 7-phenylpiperazin-4-yl-alkyl (4-14) and 7-tetrahydroisoquinolinyl-alkyl (15-17) analogues were synthesized and their serotonin 5-ht1a, 5-ht2a, 5-ht6, 5-ht7 and dopamine d2 receptor affinities were determined. |
2015-10-22 |
2023-08-13 |
mouse |
| Vaibhav P Pai, Laura L Hernandez, Malinda A Stull, Nelson D Horsema. The type 7 serotonin receptor, 5-HT 7 , is essential in the mammary gland for regulation of mammary epithelial structure and function. BioMed research international. vol 2015. 2015-10-12. PMID:25664318. |
published studies suggested that the 5-ht7 receptor type was important for mediating several effects of 5-ht in the mammary epithelium. |
2015-10-12 |
2023-08-13 |
mouse |
| Vaibhav P Pai, Laura L Hernandez, Malinda A Stull, Nelson D Horsema. The type 7 serotonin receptor, 5-HT 7 , is essential in the mammary gland for regulation of mammary epithelial structure and function. BioMed research international. vol 2015. 2015-10-12. PMID:25664318. |
here, using 5-ht7 receptor-null (ht7ko) mice we attempt to understand the role of this receptor in mediating 5-ht actions within the mammary gland. |
2015-10-12 |
2023-08-13 |
mouse |