| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniele Vigli, Laura Rusconi, Daniela Valenti, Paolo La Montanara, Livia Cosentino, Enza Lacivita, Marcello Leopoldo, Elena Amendola, Cornelius Gross, Nicoletta Landsberger, Giovanni Laviola, Charlotte Kilstrup-Nielsen, Rosa A Vacca, Bianca De Filippi. Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder. Neuropharmacology. vol 144. 2019-03-04. PMID:30326240. |
this study provides the first characterization of the neurobehavioural phenotype of 1 year old cdkl5-null mice and demonstrates that stimulation of the serotonin receptor 7 (5-ht |
2019-03-04 |
2023-08-13 |
mouse |
| Luis D Arreola-Peralta, Frida Altamirano-Reyna, Deni M Galindo-González, Jessica G Solis-Anguiano, Enza Lacivita, Marcello Leopoldo, José A Terró. Potentiation of capsaicin-induced neurogenic inflammation by 5-HT7 receptors in the rat hind paw: Involvement of calcitonin gen-related peptide. Peptides. vol 105. 2019-02-25. PMID:29730242. |
a decrease in the activation threshold of primary sensory neurons to transient receptor potential v1 (trpv1) stimulation by serotonin 5-ht7 receptors has been reported but no confirmation if this might translate into facilitation of neurogenic inflammation has been provided. |
2019-02-25 |
2023-08-13 |
rat |
| Anna Rita Zuena, Daniela Maftei, Giovanni Sebastiano Alemà, Francesca Dal Moro, Roberta Lattanzi, Paola Casolini, Ferdinando Nicolett. Multimodal antidepressant vortioxetine causes analgesia in a mouse model of chronic neuropathic pain. Molecular pain. vol 14. 2019-02-20. PMID:30289053. |
vortioxetine is a multimodal antidepressant that potently antagonizes 5-ht3 serotonin receptors, inhibits the high-affinity serotonin transporter, activates 5-ht1a and 5-ht1b receptors, and antagonizes 5-ht1d and 5-ht7 receptors. |
2019-02-20 |
2023-08-13 |
mouse |
| Hyung Gon Lee, Ji A Song, Dong Soo Han, Kyeong Wan Woo, Myung Ha Yoo. Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats. Pharmacology. vol 102. issue 5-6. 2018-12-19. PMID:30304725. |
the involvement of 5-ht and α2-adrenergic receptors in antiallodynia was determined using antagonists with the following receptor specificities: nonselective 5-ht (dihydroergocristine), 5-ht7 (sb269970), nonselective α2-adrenoceptor (yohimbine), α-2a (brl 44408), α-2b (arc 239), and α-2c (jp 1302). |
2018-12-19 |
2023-08-13 |
rat |
| Denise Vizziano-Cantonnet, André Lasalle, Santiago Di Landro, Christophe Klopp, Clémence Gentho. De novo transcriptome analysis to search for sex-differentiation genes in the Siberian sturgeon. General and comparative endocrinology. vol 268. 2018-12-11. PMID:30081002. |
genes related to sex-specific nerve cell developments were: the neurofilament medium polypeptides, the gene coding for serotonin receptor 7, 5-hydroxytryptamine receptor 7; neurotensin, isoform cra-a, the neuron-specific transmembrane protein delta/notch-like epidermal growth factor-related receptor; and insulinoma-associated protein 1. |
2018-12-11 |
2023-08-13 |
Not clear |
| Miriam A Snider, David L Harmon, James L Klot. Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations. Journal of animal science. vol 96. issue 4. 2018-10-09. PMID:29471490. |
to determine what 5-ht receptors are involved in vasoconstriction of gut vasculature, contractility of ruminal and mesenteric arteries and veins collected from cattle was evaluated in the presence of agonists selective for 5-ht1b (cp 93129), 5-ht1d (l-694, 247), 5-ht2a (tcb-2), 5-ht2b (bw 723c86), 5-ht4 (bimu-8), and 5-ht7 (lp 44) receptors. |
2018-10-09 |
2023-08-13 |
cattle |
| Jose Luis Cortes-Altamirano, Adriana Olmos-Hernandez, Herlinda Bonilla Jaime, Paul Carrillo-Mora, Cindy Bandala, Samuel Reyes-Long, Alfonso Alfaro-Rodrígue. Review: 5-HT1, 5-HT2, 5-HT3 and 5-HT7 Receptors and their Role in the Modulation of Pain Response in the Central Nervous System. Current neuropharmacology. vol 16. issue 2. 2018-10-01. PMID:28901281. |
on the other hand, several researches reported that serotonin modulates nociceptive response through 5-ht1, 5-ht2, 5-ht3, and 5-ht7 receptors in the central nervous system (cns). |
2018-10-01 |
2023-08-13 |
Not clear |
| Xiaozhen Yang, Genyong Huang, Minjie Xu, Cong Zhang, Yongxu Chen. Molecular cloning and functional expression of the 5-HT Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 226. 2018-10-01. PMID:30110659. |
to our knowledge, this is the first study to isolate and characterize the serotonin receptor 7 (5-ht |
2018-10-01 |
2023-08-13 |
Not clear |
| Hongyan Zhao, Yang Lin, Shurui Chen, Xin Li, Hongliang Hu. 5-HT3 Receptors: A Potential Therapeutic Target for Epilepsy. Current neuropharmacology. vol 16. issue 1. 2018-07-26. PMID:28486926. |
5-ht subtype have been divided into seven sub-groups from 5-ht1 to 5ht7. |
2018-07-26 |
2023-08-13 |
human |
| Mona K Tawfik, Samy Makar. 5-HT7 receptor antagonism (SB-269970) attenuates bleomycin-induced pulmonary fibrosis in rats via downregulating oxidative burden and inflammatory cascades and ameliorating collagen deposition: Comparison to terguride. European journal of pharmacology. vol 814. 2018-06-01. PMID:28821451. |
5-hydroxytryptamine 5-ht7 receptor antagonist showed more benefits than 5-ht2a/b receptor antagonist on the deleterious effects accompanied blm instillation. |
2018-06-01 |
2023-08-13 |
rat |
| Lauren Hatherall, Connie Sánchez, David A Morila. Chronic Vortioxetine Treatment Reduces Exaggerated Expression of Conditioned Fear Memory and Restores Active Coping Behavior in Chronically Stressed Rats. The international journal of neuropsychopharmacology. vol 20. issue 4. 2018-05-18. PMID:27927740. |
vortioxetine, a novel multimodal antidepressant, is a serotonin transporter inhibitor; 5-ht3, 5-ht7, and 5-ht1d receptor antagonist; 5-ht1b partial agonist; and 5-ht1a agonist. |
2018-05-18 |
2023-08-13 |
rat |
| Anna Czopek, Agnieszka Zagorska, Marcin Kolaczkowski, Adam Bucki, Beata Gryzlo, Joanna Rychtyk, Maciej Pawlowsk, Agata Siwek, Grzegorz Satala, Andrzej Bojarski, Monika Kubacka, Barbara Filipe. NEW SPIROHYDANTOIN DERIVATIVES - SYNTHESIS, PHARMACOLOGICAL EVALUATION, AND MOLECULAR MODELING STUDY. Acta poloniae pharmaceutica. vol 73. issue 6. 2018-05-03. PMID:29634109. |
a series of new arylpiperazinylpropyl derivatives of 8/6-phenyl-1,3-diazaspiro[4.5]decan-2,4-dione and spiro[imidazolidine-4,1'-indene/naphthalene]-2,5-dione was synthesized and their affinity was evaluated toward serotonin 5-htia, 5-ht2a, 5-ht7 receptors, dopaminergic d2, d3 receptors, adrenergic ox, receptors, and serotonin transporter (sert). |
2018-05-03 |
2023-08-13 |
Not clear |
| Anna Czopek, Agnieszka Zagorska, Marcin Kolaczkowski, Adam Bucki, Beata Gryzlo, Joanna Rychtyk, Maciej Pawlowsk, Agata Siwek, Grzegorz Satala, Andrzej Bojarski, Monika Kubacka, Barbara Filipe. NEW SPIROHYDANTOIN DERIVATIVES - SYNTHESIS, PHARMACOLOGICAL EVALUATION, AND MOLECULAR MODELING STUDY. Acta poloniae pharmaceutica. vol 73. issue 6. 2018-05-03. PMID:29634109. |
a binding mode of representative molecule 19, which behaved as a 5-ht1a agonist and weak 5-ht7 antagonist in the site of 5-ht 1a/7, was also analyzed in computational stud- ies. |
2018-05-03 |
2023-08-13 |
Not clear |
| Andrea Rague, Kevin Tidgewel. Pharmacophore Comparison and Development of Recently Discovered Long Chain Arylpiperazine and Sulfonamide Based 5-HT7 Ligands. Mini reviews in medicinal chemistry. vol 18. issue 7. 2018-04-26. PMID:28901854. |
of the 14 serotonin receptors, the 5-ht7 receptor is the most recently discovered. |
2018-04-26 |
2023-08-13 |
Not clear |
| Monika Bijata, Josephine Labus, Daria Guseva, Michał Stawarski, Malte Butzlaff, Joanna Dzwonek, Jenny Schneeberg, Katrin Böhm, Piotr Michaluk, Dmitri A Rusakov, Alexander Dityatev, Grzegorz Wilczyński, Jakub Wlodarczyk, Evgeni Ponimaski. Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix. Cell reports. vol 19. issue 9. 2018-03-05. PMID:28564597. |
here, we mechanistically link these processes by uncovering a signaling pathway involving the serotonin 5-ht7 receptor (5-ht7r), matrix metalloproteinase 9 (mmp-9), the hyaluronan receptor cd44, and the small gtpase cdc42. |
2018-03-05 |
2023-08-13 |
Not clear |
| G Beaudet, E Paizanis, F Zoratto, E Lacivita, M Leopoldo, T Freret, G Laviola, M Boulouard, W Adrian. LP-211, a selective 5-HT Synapse (New York, N.Y.). vol 71. issue 12. 2018-03-01. PMID:28752923. |
the present study aimed to investigate the effect of 5-ht7 receptor (5-ht |
2018-03-01 |
2023-08-13 |
Not clear |
| Laura Orsolini, Carmine Tomasetti, Alessandro Valchera, Felice Iasevoli, Elisabetta Filomena Buonaguro, Michele Fornaro, Annastasia L C Fiengo, Giovanni Martinotti, Federica Vellante, Ilaria Matarazzo, Roberta Vecchiotti, Giampaolo Perna, Marco Di Nicola, Alessandro Carano, Andrea Di Bartolomeis, Massimo De Giannantonio, Domenico De Berardi. Current and Future Perspectives on the Major Depressive Disorder: Focus on the New Multimodal Antidepressant Vortioxetine. CNS & neurological disorders drug targets. vol 16. issue 1. 2018-02-09. PMID:27781949. |
vortioxetine (vrx) is a multimodal antidepressant that acts as serotonin (5ht) transporter inhibitor as well as 5ht3a and 5ht7 receptors antagonist, 5ht1a and 5ht1b receptors partial agonist. |
2018-02-09 |
2023-08-13 |
Not clear |
| Alfredo Menese. Neural activity, memory, and dementias: serotonergic markers. Behavioural pharmacology. vol 28. issue 2 and 3-Spec Issue. 2018-01-11. PMID:27926574. |
in addition, at least, 5-ht1a, 5-ht4, 5-ht6, and 5-ht7 receptors as well as serotonin transporter seem to be useful neural markers and therapeutic targets. |
2018-01-11 |
2023-08-13 |
Not clear |
| R Forcén, E Latorre, J Pardo, A I Alcalde, M D Murillo, L Gras. Toll-like receptors 2 and 4 exert opposite effects on the contractile response induced by serotonin in mouse colon: role of serotonin receptors. Experimental physiology. vol 101. issue 8. 2018-01-01. PMID:27282784. |
in wt, tlr2(-/-) and tlr2/4 dko mice, 5-ht2 , 5-ht3 , 5-ht4 and 5-ht7 receptor antagonists reduced or blocked the contractile response evoked by 5-ht. |
2018-01-01 |
2023-08-13 |
mouse |
| José Ángel García-Pedraza, Mónica García, María Luisa Martín, Nélida Eleno, Asunción Morá. Chronic Sarpogrelate Treatment Reveals 5-HT7 Receptor in the Serotonergic Inhibition of the Rat Vagal Bradycardia. Journal of cardiovascular pharmacology. vol 69. issue 1. 2017-11-27. PMID:27676327. |
the iv administration of 5-ht (10-200 μg/kg) dose dependently decreased the vagally induced bradycardia, and agonists 5-ct (5-ht1/7), 8-oh-dpat (5-ht1a), or as-19 (5-ht7) (50 μg/kg each) mimicked the 5-ht-induced inhibitory effect. |
2017-11-27 |
2023-08-13 |
rat |