| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Chen, Akira Nakajima, Se Hoon Choi, Xiaoli Xiong, Ya-Ping Tan. Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouse. Journal of neuroscience research. vol 86. issue 7. 2008-07-08. PMID:18189321. |
in the present article, we show that conditional knockout of ps1 from the adult stage in the forebrain of mice with the ps2 null mutation triggers robust ad-like neurodegeneration including brain shrinkage, cortical and hippocampal atrophy,ventricular enlargement, severe neuronal loss, gliosis, tau hyperphosphorylation, neurofillament tangle-like structures, and intracellular filaments. |
2008-07-08 |
2023-08-12 |
mouse |
| Y-J Zhang, Y-F Xu, X-H Liu, D Li, J Yin, Y-H Liu, X-Q Chen, J-Z Wan. Carboxyl terminus of heat-shock cognate 70-interacting protein degrades tau regardless its phosphorylation status without affecting the spatial memory of the rats. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 3. 2008-07-01. PMID:18301957. |
here, we demonstrated that hippocampal transfection of chip plasmid in rats could reach a time-dependent elevated expression of chip mrna and protein in 24 h. concomitantly, expression of exogenous chip could promote the degradation of the hyperphosphorylated tau induced by overactivation of glycogen synthase kinase-3 (gsk-3) or inhibition of protein phosphatase-2a (pp-2a) in the rat brains and n2a cells. |
2008-07-01 |
2023-08-12 |
rat |
| Rosa Guerrero, Paloma Navarro, Eva Gallego, Jesus Avila, Justo G de Yebenes, Marina P Sanche. Park2-null/tau transgenic mice reveal a functional relationship between parkin and tau. Journal of Alzheimer's disease : JAD. vol 13. issue 2. 2008-06-10. PMID:18376058. |
aggregates of phosphorylated tau in neurons and reactive gliosis are quite abundant in cortex and hippocampus of these mice. |
2008-06-10 |
2023-08-12 |
mouse |
| Rosa Guerrero, Paloma Navarro, Eva Gallego, Jesus Avila, Justo G de Yebenes, Marina P Sanche. Park2-null/tau transgenic mice reveal a functional relationship between parkin and tau. Journal of Alzheimer's disease : JAD. vol 13. issue 2. 2008-06-10. PMID:18376058. |
the levels of phosphorylated tau and hsp70 are increased in the double-mutant mice, while chip expression in hippocampus is lower when the park-2 gene is deleted. |
2008-06-10 |
2023-08-12 |
mouse |
| B Dudas, M Rose, U Cornelli, A Pavlovich, I Hani. Neuroprotective properties of glycosaminoglycans: potential treatment for neurodegenerative disorders. Neuro-degenerative diseases. vol 5. issue 3-4. 2008-05-15. PMID:18322390. |
moreover, neuroparin reduced tau 2 immunoreactivity in the rat hippocampus, stimulated by intra-amygdaloid injection of abeta(25-35). |
2008-05-15 |
2023-08-12 |
rat |
| Abraham Fishe. M1 muscarinic agonists target major hallmarks of Alzheimer's disease--the pivotal role of brain M1 receptors. Neuro-degenerative diseases. vol 5. issue 3-4. 2008-05-15. PMID:18322400. |
in triple transgenic ad mice, af267b reduced cognitive deficits and decreased abeta(42) and tau pathologies in the cortex and hippocampus (not amygdala), via m1 machr activation of protein kinase c and a disintegrin and metalloproteinase domain 17 (adam17 or tace) and decreased beta-site amyloid precursor protein-cleaving enzyme 1 and glycogen synthase kinase 3beta, respectively. |
2008-05-15 |
2023-08-12 |
mouse |
| Dick Terwel, David Muyllaert, Ilse Dewachter, Peter Borghgraef, Sophie Croes, Herman Devijver, Fred Van Leuve. Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice. The American journal of pathology. vol 172. issue 3. 2008-05-09. PMID:18258852. |
extensive and remarkable parallels were observed between these strains including 1) aggravation of tauopathy with highly fibrillar tangles in the hippocampus and cortex; 2) prolonged survival correlated to alleviated brainstem tauopathy; 3) development of severe cognitive and behavioral defects in young adults before the onset of amyloid deposition or tauopathy; and 4) presence of pathological phospho-epitopes of tau, including the characteristic gsk-3beta motif at s396/s404. |
2008-05-09 |
2023-08-12 |
mouse |
| Lei Zhong, Jie Tan, Shi Ouyang, Jiang-ping X. [Effects of Saponin B from Anemarrhena asphodeloides Bunge on tau hyperphosphorylation induced by beta-amyloid peptide (25-35) in rats]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 26. issue 8. 2008-05-05. PMID:16939894. |
to investigate the changes in the expressions of p53, dkk (the inhibitor of wnt pathway) and phosphorylated tau in rat bilateral hippocampus after beta-amyloid peptide (beta-ap) (25-35) injection, and observe the effect of saponin b from anemarrhena asphodeloides bunge (saab) in this model. |
2008-05-05 |
2023-08-12 |
rat |
| Carla L Busceti, Francesca Biagioni, Barbara Riozzi, Giuseppe Battaglia, Marianna Storto, Carlo Cinque, Gemma Molinaro, Roberto Gradini, Andrea Caricasole, Anna Maria Canudas, Valeria Bruno, Ferdinando Nicoletti, Francesco Forna. Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy"). The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 12. 2008-04-25. PMID:18354027. |
enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("ecstasy"). |
2008-04-25 |
2023-08-12 |
mouse |
| Carla L Busceti, Francesca Biagioni, Barbara Riozzi, Giuseppe Battaglia, Marianna Storto, Carlo Cinque, Gemma Molinaro, Roberto Gradini, Andrea Caricasole, Anna Maria Canudas, Valeria Bruno, Ferdinando Nicoletti, Francesco Forna. Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy"). The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 12. 2008-04-25. PMID:18354027. |
an acute or 6 d treatment with mdma increased tau protein phosphorylation in the hippocampus, revealed by both anti-phospho(ser(404))-tau and paired helical filament-1 antibodies. |
2008-04-25 |
2023-08-12 |
mouse |
| Carla L Busceti, Francesca Biagioni, Barbara Riozzi, Giuseppe Battaglia, Marianna Storto, Carlo Cinque, Gemma Molinaro, Roberto Gradini, Andrea Caricasole, Anna Maria Canudas, Valeria Bruno, Ferdinando Nicoletti, Francesco Forna. Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy"). The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 12. 2008-04-25. PMID:18354027. |
we conclude that tau hyperphosphorylation in the hippocampus may contribute to the impairment of learning and memory associated with mdma abuse. |
2008-04-25 |
2023-08-12 |
mouse |
| Ina Hinners, Anika Hill, Ulrike Otto, Anke Michalsky, Till G A Mack, Frank Striggo. Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation. Molecular and cellular neurosciences. vol 37. issue 3. 2008-04-10. PMID:18201898. |
tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation. |
2008-04-10 |
2023-08-12 |
human |
| Ina Hinners, Anika Hill, Ulrike Otto, Anke Michalsky, Till G A Mack, Frank Striggo. Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation. Molecular and cellular neurosciences. vol 37. issue 3. 2008-04-10. PMID:18201898. |
human tau p301l, when expressed in pyramidal neurons of hippocampal slice cultures, was increasingly phosphorylated at several disease-relevant epitopes, leading to progressive neuronal dystrophy and formation of ripa-insoluble tau. |
2008-04-10 |
2023-08-12 |
human |
| Ina Hinners, Anika Hill, Ulrike Otto, Anke Michalsky, Till G A Mack, Frank Striggo. Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation. Molecular and cellular neurosciences. vol 37. issue 3. 2008-04-10. PMID:18201898. |
only srn-003-556 was able to protect hippocampal neurons from synaptic damage that was presumably caused by a toxic soluble tau fraction. |
2008-04-10 |
2023-08-12 |
human |
| Shinji Higashi, Eizo Iseki, Ryoko Yamamoto, Michiko Minegishi, Hiroaki Hino, Koshiro Fujisawa, Takashi Togo, Omi Katsuse, Hirotake Uchikado, Yoshiko Furukawa, Kenji Kosaka, Heii Ara. Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies. Brain research. vol 1184. 2008-04-08. PMID:17963732. |
the amygdala and hippocampus that were vulnerable to tau or alpha-synuclein pathology demonstrated more severe tdp-43 pathology in ad and dlb cases than in ftld-u cases. |
2008-04-08 |
2023-08-12 |
Not clear |
| Matthew Schrag, Sunita Sharma, Holly Brown-Borg, Othman Ghrib. Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels. Hippocampus. vol 18. issue 3. 2008-03-27. PMID:18000817. |
hippocampus of ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels. |
2008-03-27 |
2023-08-12 |
mouse |
| Abraham Fishe. M1 muscarinic agonists target major hallmarks of Alzheimer's disease--an update. Current Alzheimer research. vol 4. issue 5. 2008-03-21. PMID:18220527. |
in 3x transgenic-ad mice that recapitulate the major pathologies and cognitive deficits of ad, chronic af267b treatment rescued cognitive deficits and decreased abeta42 and tau pathologies in the cortex and hippocampus (not amygdala), via m1 machr-activation of adam17/tace and decreased bace1 steady state levels and inhibition of gsk3beta, extending findings from above. |
2008-03-21 |
2023-08-12 |
mouse |
| J Attems, M Preusser, M Grosinger-Quass, L Wagner, F Lintner, K Jellinge. Calcium-binding protein secretagogin-expressing neurones in the human hippocampus are largely resistant to neurodegeneration in Alzheimer's disease. Neuropathology and applied neurobiology. vol 34. issue 1. 2008-03-18. PMID:17961140. |
in this study we investigate the influence of hippocampal tau pathology on secretagogin expression in more details. |
2008-03-18 |
2023-08-12 |
human |
| J Attems, M Preusser, M Grosinger-Quass, L Wagner, F Lintner, K Jellinge. Calcium-binding protein secretagogin-expressing neurones in the human hippocampus are largely resistant to neurodegeneration in Alzheimer's disease. Neuropathology and applied neurobiology. vol 34. issue 1. 2008-03-18. PMID:17961140. |
no difference with respect to secretagogin immunoreactivity was observed in different stages of ad pathology, and similarly no significant associations were seen between the amount of secretagogin and tau immunoreactivity in the different hippocampal subfields. |
2008-03-18 |
2023-08-12 |
human |
| J Attems, M Preusser, M Grosinger-Quass, L Wagner, F Lintner, K Jellinge. Calcium-binding protein secretagogin-expressing neurones in the human hippocampus are largely resistant to neurodegeneration in Alzheimer's disease. Neuropathology and applied neurobiology. vol 34. issue 1. 2008-03-18. PMID:17961140. |
because there are no differences in the amount of hippocampal secretagogin expression between ad cases and controls (as we have shown previously), the lack of an association between the amount of secretagogin expression and tau burden together with the low frequency of colocalization of tau and secretagogin in the human hippocampus, suggest that secretagogin-expressing neurones are largely resistant to neurodegeneration in ad. |
2008-03-18 |
2023-08-12 |
human |