| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shinji Sato, Jiqing Xu, Satoshi Okuyama, Lindsey B Martinez, Shannon M Walsh, Michael T Jacobsen, Russell J Swan, Joshua D Schlautman, Pawel Ciborowski, Tsuneya Ikez. Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 53. 2009-04-09. PMID:19118186. |
ttbk1-tg mice show significant age-dependent memory impairment as determined by radial arm water maze test, which is associated with enhancement of tau and neurofilament phosphorylation, increased levels of p25 and p35, both activators of cyclin-dependent protein kinase 5 (cdk5), enhanced calpain i activity, and reduced levels of hippocampal nmda receptor types 2b (nr2b) and d. enhanced cdk5/p35 complex formation is strongly correlated with dissociation of f-actin from p35, suggesting the inhibitory mechanism of cdk5/p35 complex formation by f-actin. |
2009-04-09 |
2023-08-12 |
mouse |
| Yasumasa Yoshiyam. [Neurodegeneration and inflammation: analysis of a FTDP-17 model mouse]. Rinsho shinkeigaku = Clinical neurology. vol 48. issue 11. 2009-04-08. PMID:19198115. |
filamentous tau lesions developed in ps19 mice at 6-months of age, and progressively accumulated in association with striking neuron loss as well as hippocampal and entorhinal cortical atrophy by 9-12 months of age. |
2009-04-08 |
2023-08-12 |
mouse |
| Yasumasa Yoshiyam. [Neurodegeneration and inflammation: analysis of a FTDP-17 model mouse]. Rinsho shinkeigaku = Clinical neurology. vol 48. issue 11. 2009-04-08. PMID:19198115. |
remarkably, hippocampal synapse loss and impaired synaptic function were detected in 3 month old ps19 mice before fibrillary tau tangles emerged. |
2009-04-08 |
2023-08-12 |
mouse |
| Yasser A El-faramawy, Mohamed H El-banouby, Pavel Sergeev, Ahmed K Mortagy, Motassem S Amer, Ahmed M Abdel-tawa. Changes in glutamate decarboxylase enzyme activity and tau-protein phosphorylation in the hippocampus of old rats exposed to chronic mild stress: reversal with the neuronal nitric oxide synthase inhibitor 7-nitroindazole. Pharmacology, biochemistry, and behavior. vol 91. issue 3. 2009-04-02. PMID:18755209. |
hippocampal glutamate levels and glutamate decarboxylase (gad) activity were determined and tau protein phosphorylation was assessed. |
2009-04-02 |
2023-08-12 |
rat |
| Masashi Kitazawa, David Cheng, Frank M Laferl. Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD. Journal of neurochemistry. vol 108. issue 6. 2009-04-02. PMID:19183260. |
furthermore, tau pathology within hippocampal neurons was exacerbated in copper-exposed 3xtg-ad group. |
2009-04-02 |
2023-08-12 |
mouse |
| Jia-Yu Zhang, Caixia Peng, Hairong Shi, Shaohui Wang, Qun Wang, Jian-Zhi Wan. Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain. Journal of Alzheimer's disease : JAD. vol 16. issue 1. 2009-03-27. PMID:19158420. |
here, we infused chloroquine, 3-methyladenine or rapamycin into rat hippocampus or the lateral ventricle to manipulate the autophagic activity and measured the levels of tau protein by western blotting. |
2009-03-27 |
2023-08-12 |
rat |
| Ana-María Simón, Lucio Schiapparelli, Pablo Salazar-Colocho, Mar Cuadrado-Tejedor, Luis Escribano, Rakel López de Maturana, Joaquín Del Río, Alberto Pérez-Mediavilla, Diana Frechill. Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels. Neurobiology of disease. vol 33. issue 3. 2009-03-10. PMID:19101630. |
a tau pathology with an early increase in the levels of phosphorylated tau in the hippocampus, a likely consequence of enhanced erk1/2 activation, was also observed. |
2009-03-10 |
2023-08-12 |
mouse |
| Rosa Guerrero, Paloma Navarro, Eva Gallego, Ana M Garcia-Cabrero, Jesus Avila, Marina P Sanche. Hyperphosphorylated tau aggregates in the cortex and hippocampus of transgenic mice with mutant human FTDP-17 Tau and lacking the PARK2 gene. Acta neuropathologica. vol 117. issue 2. 2009-02-23. PMID:19057915. |
hyperphosphorylated tau aggregates in the cortex and hippocampus of transgenic mice with mutant human ftdp-17 tau and lacking the park2 gene. |
2009-02-23 |
2023-08-12 |
mouse |
| Rosa Guerrero, Paloma Navarro, Eva Gallego, Ana M Garcia-Cabrero, Jesus Avila, Marina P Sanche. Hyperphosphorylated tau aggregates in the cortex and hippocampus of transgenic mice with mutant human FTDP-17 Tau and lacking the PARK2 gene. Acta neuropathologica. vol 117. issue 2. 2009-02-23. PMID:19057915. |
here, we show that cortical and hippocampal neurons of double mutant mice develop argyrophilic gallyas-braak aggregates of phosphorylated tau from 3 months of age. |
2009-02-23 |
2023-08-12 |
mouse |
| Henny Wati, Takeshi Kawarabayashi, Etsuro Matsubara, Ayumi Kasai, Takae Hirasawa, Takeo Kubota, Yasuo Harigaya, Mikio Shoji, Shuichiro Maed. Transthyretin accelerates vascular Abeta deposition in a mouse model of Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 19. issue 1. 2009-02-19. PMID:18429966. |
it was reported that the lack of neurodegeneration in a transgenic mouse model of alzheimer's disease (ad) (tg2576 mouse) was associated with increased ttr level in the hippocampus, and that chronic infusion of anti-ttr antibody into the hippocampus of tg2576 mice led to increased local abeta deposits, tau hyperphosphorylation and apoptosis. |
2009-02-19 |
2023-08-12 |
mouse |
| Natasha Deters, Lars M Ittner, Jürgen Göt. Substrate-specific reduction of PP2A activity exaggerates tau pathology. Biochemical and biophysical research communications. vol 379. issue 2. 2009-02-13. PMID:19126401. |
double-transgenic dom5/pr5 mice showed 7-fold increased numbers of hippocampal neurons that specifically phosphorylated the pathological s422 epitope of tau. |
2009-02-13 |
2023-08-12 |
mouse |
| Chang-E Zhang, Qing Tian, Wei Wei, Jun-Hua Peng, Gong-Ping Liu, Xin-Wen Zhou, Qun Wang, Dao-Wen Wang, Jian-Zhi Wan. Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiology of aging. vol 29. issue 11. 2009-01-23. PMID:17537547. |
homocysteine induces tau phosphorylation by inactivating protein phosphatase 2a in rat hippocampus. |
2009-01-23 |
2023-08-12 |
rat |
| Chang-E Zhang, Qing Tian, Wei Wei, Jun-Hua Peng, Gong-Ping Liu, Xin-Wen Zhou, Qun Wang, Dao-Wen Wang, Jian-Zhi Wan. Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiology of aging. vol 29. issue 11. 2009-01-23. PMID:17537547. |
here, we found that high plasma homocysteine induced by vena caudalis injection for 2 weeks could induce ad-like tau hyperphosphorylation at multiple sites in rat brain hippocampus. |
2009-01-23 |
2023-08-12 |
rat |
| Chang-E Zhang, Qing Tian, Wei Wei, Jun-Hua Peng, Gong-Ping Liu, Xin-Wen Zhou, Qun Wang, Dao-Wen Wang, Jian-Zhi Wan. Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiology of aging. vol 29. issue 11. 2009-01-23. PMID:17537547. |
in hippocampal slices of the homocysteine injected-rats and of the ad patients, the demethylated but not the methylated pp2a(c) was co-localized with the hyperphosphorylated tau. |
2009-01-23 |
2023-08-12 |
rat |
| V Corsetti, G Amadoro, A Gentile, S Capsoni, M T Ciotti, M T Cencioni, A Atlante, N Canu, T T Rohn, A Cattaneo, P Calissan. Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease models. Molecular and cellular neurosciences. vol 38. issue 3. 2008-12-09. PMID:18511295. |
in addition this nh2-terminally cleaved tau fragment, whose expression correlates with a significant up-regulation of caspase(s) activity, is also specifically detected in vivo in the hippocampus of 15 month-old ad11 transgenic mice, a model in which a progressive ad-like neurodegeneration is induced by the expression of transgenic anti-ngf antibodies. |
2008-12-09 |
2023-08-12 |
mouse |
| Charles Duyckaerts, Claire Perruchini, Thibaud Lebouvier, Marie-Claude Potie. [The lesions of Alzheimer's disease: which therapeutic perspectives?]. Bulletin de l'Academie nationale de medecine. vol 192. issue 2. 2008-11-14. PMID:18819685. |
the abeta deposits first involve the neocortex, while the tau pathology is initially found in the hippocampal region. |
2008-11-14 |
2023-08-12 |
mouse |
| Charles Duyckaerts, Claire Perruchini, Thibaud Lebouvier, Marie-Claude Potie. [The lesions of Alzheimer's disease: which therapeutic perspectives?]. Bulletin de l'Academie nationale de medecine. vol 192. issue 2. 2008-11-14. PMID:18819685. |
abeta deposits first occur in the neocortex, while intracellular tau accumulation mainly affect the hippocampal region. |
2008-11-14 |
2023-08-12 |
mouse |
| Charles Duyckaerts, Claire Perruchini, Thibaud Lebouvier, Marie-Claude Potie. [The lesions of Alzheimer's disease: which therapeutic perspectives?]. Bulletin de l'Academie nationale de medecine. vol 192. issue 2. 2008-11-14. PMID:18819685. |
tau lesions successively involve the hippocampal regions, multi- and uni-modal areas and finally the primary cortices in stereotyped stages. |
2008-11-14 |
2023-08-12 |
mouse |
| Jose A Rodríguez-Navarro, Ana Gómez, Izaskun Rodal, Juan Perucho, Armando Martinez, Vicente Furió, Israel Ampuero, María J Casarejos, Rosa M Solano, Justo García de Yébenes, Maria A Men. Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice. Human molecular genetics. vol 17. issue 20. 2008-11-12. PMID:18640988. |
pk(-/-)/tau(vlw) mice have abnormal behaviour and severe drop out of dopamine neurons in the ventral midbrain, up to 70%, at 12 months and abundant phosphorylated tau positive neuritic plaques, neuro-fibrillary tangles, astrogliosis, microgliosis and plaques of murine beta-amyloid in the hippocampus. |
2008-11-12 |
2023-08-12 |
mouse |
| Yue Wang, Jun-Xia Zhang, Xiao-Xia Du, Li Zhao, Qing Tian, Ling-Qiang Zhu, Shao-Hui Wang, Jian-Zhi Wan. Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3. Journal of neurochemistry. vol 106. issue 6. 2008-11-07. PMID:18643871. |
we observed that the severe memory deficit occurred at 24 and 48 h, and simultaneously, gsk-3 activation, tau hyperphosphorylation at thr231, ser396, and ser404 and decline of ach in hippocampus were detected, and these changes were mostly recovered at 72 and 96 h after the injection of wt/gfx. |
2008-11-07 |
2023-08-12 |
rat |