| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephanie J Adams, Richard J P Crook, Michael Deture, Suzanne J Randle, Amy E Innes, Xin Z Yu, Wen-Lang Lin, Brittany N Dugger, Melinda McBride, Mike Hutton, Dennis W Dickson, Eileen McGowa. Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration. The American journal of pathology. vol 175. issue 4. 2009-12-09. PMID:19717642. |
in contrast, older mice show a decrease in tau pathology levels, which may represent hippocampal neuronal loss occurring in this wild-type model. |
2009-12-09 |
2023-08-12 |
mouse |
| J Vogel, V S Anand, B Ludwig, S Nawoschik, J Dunlop, S P Braithwait. The JNK pathway amplifies and drives subcellular changes in tau phosphorylation. Neuropharmacology. vol 57. issue 5-6. 2009-12-04. PMID:19628001. |
to model this pathology, okadaic acid (oa) has been used in primary cultured hippocampal neurons to investigate effects on tau, and the role of the jnk pathway in tau phosphorylation. |
2009-12-04 |
2023-08-12 |
Not clear |
| L Serenó, M Coma, M Rodríguez, P Sánchez-Ferrer, M B Sánchez, I Gich, J M Agulló, M Pérez, J Avila, C Guardia-Laguarta, J Clarimón, A Lleó, T Gómez-Isl. A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo. Neurobiology of disease. vol 35. issue 3. 2009-12-03. PMID:19523516. |
treatment with this thiadiazolidinone compound resulted in lower levels of tau phosphorylation, decreased amyloid deposition and plaque-associated astrocytic proliferation, protection of neurons in the entorhinal cortex and ca1 hippocampal subfield against cell death, and prevention of memory deficits in this transgenic mouse model. |
2009-12-03 |
2023-08-12 |
mouse |
| Pu Chen, Aiguo Shen, Wei Zhao, Seong-Joon Baek, Hua Yuan, Jiming H. Raman signature from brain hippocampus could aid Alzheimer's disease diagnosis. Applied optics. vol 48. issue 24. 2009-11-04. PMID:19696863. |
the biochemical changes of brain hippocampus tissue including the deposit of beta-amyloid (abeta) protein, the increase of cholesterol, and hyperphosphorylated tau are observed through mrs when ad occurs. |
2009-11-04 |
2023-08-12 |
rat |
| Estelle Leclerc, Emmanuel Sturchler, Stefan W Vetter, Claus W Heizman. Crosstalk between calcium, amyloid beta and the receptor for advanced glycation endproducts in Alzheimer's disease. Reviews in the neurosciences. vol 20. issue 2. 2009-10-20. PMID:19774788. |
hallmarks of alzheimer's disease (ad) include the accumulation of amyloid beta peptide (abeta), hyperphosphorylation of tau protein, and increased inflammatory activity in the hippocampus and cerebral cortex. |
2009-10-20 |
2023-08-12 |
Not clear |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19251758. |
6-12 months, with mri in the large multicentre setting of the alzheimer's disease neuroimaging initiative (adni); (ii) to determine the extent to which the polymorphism of the apolipoprotein e (apoe) gene modulates hippocampal change; and (iii) to determine if rates of hippocampal loss correlate with cerebrospinal fluid (csf) biomarkers of alzheimer's disease, such as the beta-amyloid (abeta(1-42)) and tau proteins (tau). |
2009-10-01 |
2023-08-12 |
Not clear |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19251758. |
moreover, increased rates of hippocampal loss were associated with presence of the apoe allele epsilon4 gene in alzheimer's disease and lower csf abeta(1-42) in mild cognitive impairment, irrespective of apoe genotype, whereas relations with tau were only trends. |
2009-10-01 |
2023-08-12 |
Not clear |
| Irina Tint, Daphney Jean, Peter W Baas, Mark M Blac. Doublecortin associates with microtubules preferentially in regions of the axon displaying actin-rich protrusive structures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 35. 2009-09-21. PMID:19726658. |
in hippocampal neurons but not sympathetic neurons, discrete focal patches of microtubules rich in dcx and deficient in tau are present along the axonal shaft. |
2009-09-21 |
2023-08-12 |
Not clear |
| Henrik Viber. Exposure to polybrominated diphenyl ethers 203 and 206 during the neonatal brain growth spurt affects proteins important for normal neurodevelopment in mice. Toxicological sciences : an official journal of the Society of Toxicology. vol 109. issue 2. 2009-09-03. PMID:19380496. |
furthermore, there were no significant changes in the levels of gap-43 and tau in the cerebral cortex or hippocampus after neonatal exposure to pbde 203 or 206. |
2009-09-03 |
2023-08-12 |
mouse |
| Marta Barrachina, Isidre Ferre. DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain. Journal of neuropathology and experimental neurology. vol 68. issue 8. 2009-09-01. PMID:19606065. |
dna methylation was analyzed in selected regions of mapt, app, and psen1 in the frontal cortex and hippocampus of controls (n=26) and those with alzheimer disease at stages i to ii (n=17); alzheimer disease at stages iii to iv (n=15); alzheimer disease at stages v to vi (n=12); argyrophilic grain disease (n=10); frontotemporal lobar degeneration linked to tau mutations (n=6); frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions (n=4); frontotemporal lobar degeneration with motor neuron disease (n=3); pick disease (n=3); parkinson disease (n=8); dementia with lewy bodies, pure form (n=5); and dementia with lewy bodies, common form (n=15). |
2009-09-01 |
2023-08-12 |
human |
| Peter Filipcik, Martin Cente, Gabriela Krajciova, Ivo Vanicky, Michal Nova. Cortical and hippocampal neurons from truncated tau transgenic rat express multiple markers of neurodegeneration. Cellular and molecular neurobiology. vol 29. issue 6-7. 2009-08-19. PMID:19263214. |
cortical and hippocampal neurons from truncated tau transgenic rat express multiple markers of neurodegeneration. |
2009-08-19 |
2023-08-12 |
human |
| Elaine Cristina Pereira, Daniel Luna Lucetti, José Maria Barbosa-Filho, Eliane Magalhães de Brito, Valdécio Silvano Monteiro, Manoel Cláudio Azevedo Patrocínio, Rebeca Ribeiro de Moura, Luzia Kalyne Almeida Moreira Leal, Danielle Silveira Macedo, Francisca Cléa Florenço de Sousa, Glauce Socorro de Barros Viana, Silvânia Maria Mendes Vasconcelo. Coumarin effects on amino acid levels in mice prefrontal cortex and hippocampus. Neuroscience letters. vol 454. issue 2. 2009-08-17. PMID:19429071. |
the present work evaluated the effect of coumarin administration on the levels of gamma-aminobutyric acid (gaba), glutamate (glu), glycine (gly) and taurine (tau) in the prefrontal cortex and hippocampus of mice. |
2009-08-17 |
2023-08-12 |
mouse |
| Elaine Cristina Pereira, Daniel Luna Lucetti, José Maria Barbosa-Filho, Eliane Magalhães de Brito, Valdécio Silvano Monteiro, Manoel Cláudio Azevedo Patrocínio, Rebeca Ribeiro de Moura, Luzia Kalyne Almeida Moreira Leal, Danielle Silveira Macedo, Francisca Cléa Florenço de Sousa, Glauce Socorro de Barros Viana, Silvânia Maria Mendes Vasconcelo. Coumarin effects on amino acid levels in mice prefrontal cortex and hippocampus. Neuroscience letters. vol 454. issue 2. 2009-08-17. PMID:19429071. |
in the hippocampus, only glutamate had its levels decreased after coumarin treatment, while diazepam increased the levels of gaba and tau and decreased the levels of glu in this brain region. |
2009-08-17 |
2023-08-12 |
mouse |
| Xi Kuang, Jun-Rong Du, Ya-Shu Chen, Jing Wang, Yan-Nan Wan. Protective effect of Z-ligustilide against amyloid beta-induced neurotoxicity is associated with decreased pro-inflammatory markers in rat brains. Pharmacology, biochemistry, and behavior. vol 92. issue 4. 2009-08-14. PMID:19324070. |
compared to the sham-operated rats, abeta(25-35) injection significantly prolonged the mean escape latency in vehicle-treated rats in the morris water maze test (p < 0.01) and increased both ad-related neuropathological signs (i.e., abeta, amyloid precursor protein, and phosphorylated tau immunoreactivity) and pro-inflammatory mediators (i.e., tnf-alpha and activated nf-kappab) in the prefrontal cortex and ca1 subregion of the hippocampus. |
2009-08-14 |
2023-08-12 |
rat |
| Henrik Viber. Neonatal ontogeny and neurotoxic effect of decabrominated diphenyl ether (PBDE 209) on levels of synaptophysin and tau. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 27. issue 5. 2009-08-12. PMID:19465108. |
the animals were euthanized 7 days after exposure to pbde 209 and levels of synaptophysin and tau were analyzed in the hippocampus and cerebral cortex. |
2009-08-12 |
2023-08-12 |
mouse |
| Henrik Viber. Neonatal ontogeny and neurotoxic effect of decabrominated diphenyl ether (PBDE 209) on levels of synaptophysin and tau. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 27. issue 5. 2009-08-12. PMID:19465108. |
the analysis of protein levels showed no changes in tau in the hippocampus or cerebral cortex 7 days after exposure to pbde 209 on postnatal day 3. |
2009-08-12 |
2023-08-12 |
mouse |
| Qiu-Lan Ma, Fusheng Yang, Emily R Rosario, Oliver J Ubeda, Walter Beech, Dana J Gant, Ping Ping Chen, Beverly Hudspeth, Cory Chen, Yongle Zhao, Harry V Vinters, Sally A Frautschy, Greg M Col. Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 28. 2009-08-03. PMID:19605645. |
here, we report abeta oligomers significantly increased active jnk and phosphorylation of irs-1 (ser616) and tau (ser422) in cultured hippocampal neurons, whereas jnk inhibition blocked these responses. |
2009-08-03 |
2023-08-12 |
mouse |
| Qiu-Lan Ma, Fusheng Yang, Emily R Rosario, Oliver J Ubeda, Walter Beech, Dana J Gant, Ping Ping Chen, Beverly Hudspeth, Cory Chen, Yongle Zhao, Harry V Vinters, Sally A Frautschy, Greg M Col. Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 28. 2009-08-03. PMID:19605645. |
the omega-3 fatty acid docosahexaenoic acid (dha) similarly inhibited jnk and the phosphorylation of irs-1 and tau in cultured hippocampal neurons. |
2009-08-03 |
2023-08-12 |
mouse |
| C Reitz, L Honig, J P Vonsattel, M-X Tang, R Mayeu. Memory performance is related to amyloid and tau pathology in the hippocampus. Journal of neurology, neurosurgery, and psychiatry. vol 80. issue 7. 2009-07-29. PMID:19258354. |
memory performance is related to amyloid and tau pathology in the hippocampus. |
2009-07-29 |
2023-08-12 |
Not clear |
| Charles Duyckaerts, Benoît Delatour, Marie-Claude Potie. Classification and basic pathology of Alzheimer disease. Acta neuropathologica. vol 118. issue 1. 2009-07-29. PMID:19381658. |
the progression of tau pathology is stepwise and stereotyped from the entorhinal cortex, through the hippocampus, to the isocortex. |
2009-07-29 |
2023-08-12 |
Not clear |