| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Florence Clavaguera, Tristan Bolmont, R Anthony Crowther, Dorothee Abramowski, Stephan Frank, Alphonse Probst, Graham Fraser, Anna K Stalder, Martin Beibel, Matthias Staufenbiel, Mathias Jucker, Michel Goedert, Markus Tolna. Transmission and spreading of tauopathy in transgenic mouse brain. Nature cell biology. vol 11. issue 7. 2009-07-20. PMID:19503072. |
cognitive impairment becomes manifest when inclusions reach the hippocampus, with abundant neocortical tau inclusions and extracellular beta-amyloid deposits being the defining pathological hallmarks of alzheimer's disease. |
2009-07-20 |
2023-08-12 |
mouse |
| Yu-Hua Xie, Xiao-Chun Chen, Jing Zhang, Tian-Wen Huang, Jin-Qiu Song, Ya-Xiu Fang, Xiao-Dong Pan, Zhi-Ying Li. [Ginsenoside Rb1 attenuates beta-amyloid peptide(25-35) -induced hyperphosphorylation of tau protein through CDK5 signal pathway]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 42. issue 8. 2009-07-16. PMID:17944229. |
western blotting and/or immunocytochemical staining were used to detect the levels of phosphorylation of tau protein at the sites of thr205, ser396, ser404 in hippocampal neurons, cdk5 and p25/p35. |
2009-07-16 |
2023-08-12 |
Not clear |
| Evan Elliott, Offir Laufer, Irith Ginzbur. BAG-1M is up-regulated in hippocampus of Alzheimer's disease patients and associates with tau and APP proteins. Journal of neurochemistry. vol 109. issue 4. 2009-07-16. PMID:19317853. |
bag-1m is up-regulated in hippocampus of alzheimer's disease patients and associates with tau and app proteins. |
2009-07-16 |
2023-08-12 |
human |
| Evan Elliott, Offir Laufer, Irith Ginzbur. BAG-1M is up-regulated in hippocampus of Alzheimer's disease patients and associates with tau and APP proteins. Journal of neurochemistry. vol 109. issue 4. 2009-07-16. PMID:19317853. |
in addition, bag-1 binds to both tau and amyloid precursor protein physically, and is found highly expressed in the same neurons that contain intracellular tau or amyloid in hippocampal sections from ad patients. |
2009-07-16 |
2023-08-12 |
human |
| G Lace, G M Savva, G Forster, R de Silva, C Brayne, F E Matthews, J J Barclay, L Dakin, P G Ince, S B Wharto. Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. Brain : a journal of neurology. vol 132. issue Pt 5. 2009-06-24. PMID:19321462. |
hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. |
2009-06-24 |
2023-08-12 |
Not clear |
| G Lace, G M Savva, G Forster, R de Silva, C Brayne, F E Matthews, J J Barclay, L Dakin, P G Ince, S B Wharto. Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. Brain : a journal of neurology. vol 132. issue Pt 5. 2009-06-24. PMID:19321462. |
we aimed to determine the extent and pattern of spread of tau pathology in the hippocampus, a susceptible region important in dementia and milder states of memory impairment, using hippocampal samples from the elderly population-based medical research council cognitive function and ageing study neuropathology cohort. |
2009-06-24 |
2023-08-12 |
Not clear |
| G Lace, G M Savva, G Forster, R de Silva, C Brayne, F E Matthews, J J Barclay, L Dakin, P G Ince, S B Wharto. Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. Brain : a journal of neurology. vol 132. issue Pt 5. 2009-06-24. PMID:19321462. |
tau deposition was assessed in hippocampal anatomical sub-regions using the at8 antibody to phosphorylated tau and isoform-specific antibodies to 3 and 4-repeat tau (rd3 and rd4). |
2009-06-24 |
2023-08-12 |
Not clear |
| G Lace, G M Savva, G Forster, R de Silva, C Brayne, F E Matthews, J J Barclay, L Dakin, P G Ince, S B Wharto. Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. Brain : a journal of neurology. vol 132. issue Pt 5. 2009-06-24. PMID:19321462. |
six hippocampal tau anatomical stages were defined, each linking projectionally to their adjacent stages, suggesting spread of tau malfunction through neuroanatomical pathways in hippocampal ageing. |
2009-06-24 |
2023-08-12 |
Not clear |
| Wolfgang Härtig, Andreas Reichenbach, Cornelia Voigt, Johannes Boltze, Larysa Bulavina, Martin U Schuhmann, Johannes Seeger, Gerald F Schusser, Christiane Freytag, Jens Grosch. Triple fluorescence labelling of neuronal, glial and vascular markers revealing pathological alterations in various animal models. Journal of chemical neuroanatomy. vol 37. issue 2. 2009-06-22. PMID:19028564. |
moreover, the versatility of the method is verified by its application to sections from old triple transgenic mice with age-dependent beta-amyloidosis and tau hyperphosphorylation in the hippocampus, modelling neuropathological alterations in alzheimer's disease. |
2009-06-22 |
2023-08-12 |
mouse |
| Karim Belarbi, Katharina Schindowski, Sylvie Burnouf, Raphaëlle Caillierez, Marie-Eve Grosjean, Dominique Demeyer, Malika Hamdane, Nicolas Sergeant, David Blum, Luc Bué. Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease. Current Alzheimer research. vol 6. issue 2. 2009-06-22. PMID:19355850. |
interestingly, early tau pathology was observed in both hippocampus and basal forebrain. |
2009-06-22 |
2023-08-12 |
mouse |
| Niclas Johansson, Per Eriksson, Henrik Viber. Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brain. Toxicological sciences : an official journal of the Society of Toxicology. vol 108. issue 2. 2009-06-15. PMID:19211617. |
both compounds significantly increased the levels of synaptophysin and tau in cerebral cortex, and pfoa also increased the levels of tau in hippocampus. |
2009-06-15 |
2023-08-12 |
mouse |
| Alexandra M Nicholson, Adriana Ferreir. Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 14. 2009-05-06. PMID:19357288. |
increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity. |
2009-05-06 |
2023-08-12 |
Not clear |
| Alexandra M Nicholson, Adriana Ferreir. Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 14. 2009-05-06. PMID:19357288. |
we have recently described that, in addition to increasing tau phosphorylation, abeta enhanced calpain activity leading to the generation of a toxic 17 kda tau fragment in cultured hippocampal neurons. |
2009-05-06 |
2023-08-12 |
Not clear |
| Alexandra M Nicholson, Adriana Ferreir. Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 14. 2009-05-06. PMID:19357288. |
in this study, we assessed the susceptibility of cultured hippocampal neurons to abeta-dependent 17 kda tau production at different developmental stages. |
2009-05-06 |
2023-08-12 |
Not clear |
| Karunya K Kandimalla, Olenych G Scott, Smita Fulzele, Michael W Davidson, Joseph F Podusl. Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta protein. PloS one. vol 4. issue 2. 2009-04-27. PMID:19247480. |
alzheimer's disease (ad) is characterized by significant neurodegeneration in the cortex and hippocampus; intraneuronal tangles of hyperphosphorylated tau protein; and accumulation of beta-amyloid (abeta) proteins 40 and 42 in the brain parenchyma as well as in the cerebral vasculature. |
2009-04-27 |
2023-08-12 |
mouse |
| M E Kalaitzakis, L M Christian, L B Moran, M B Graeber, R K B Pearce, S M Gentlema. Dementia and visual hallucinations associated with limbic pathology in Parkinson's disease. Parkinsonism & related disorders. vol 15. issue 3. 2009-04-20. PMID:18602855. |
the extent of alpha-synuclein (alphasyn), tau and amyloid beta peptide (abeta) deposition was then examined in the ca2 sector of the hippocampus and in neocortical and subcortical areas known to subserve cognitive function. |
2009-04-20 |
2023-08-12 |
Not clear |
| M E Kalaitzakis, L M Christian, L B Moran, M B Graeber, R K B Pearce, S M Gentlema. Dementia and visual hallucinations associated with limbic pathology in Parkinson's disease. Parkinsonism & related disorders. vol 15. issue 3. 2009-04-20. PMID:18602855. |
abeta in the anterior cingulate gyrus, entorhinal cortex, amygdaloid complex and nucleus basalis of meynert is also associated with dementia as is tau in the ca2 sector of the hippocampus. |
2009-04-20 |
2023-08-12 |
Not clear |
| T Engel, P Goñi-Oliver, P Gomez-Ramos, M A Morán, J J Lucas, J Avila, F Hernánde. Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta. Neuroscience. vol 157. issue 4. 2009-04-15. PMID:18951953. |
hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta. |
2009-04-15 |
2023-08-12 |
mouse |
| T Engel, P Goñi-Oliver, P Gomez-Ramos, M A Morán, J J Lucas, J Avila, F Hernánde. Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta. Neuroscience. vol 157. issue 4. 2009-04-15. PMID:18951953. |
these studies also allow us to propose a model of spreading of pathology through the hippocampus as a consequence of gsk-3 and tau dysregulation. |
2009-04-15 |
2023-08-12 |
mouse |
| P Navarro, R Guerrero, E Gallego, J Avila, R Luquin, P J Garcia Ruiz, M P Sanche. Motor alterations are reduced in mice lacking the PARK2 gene in the presence of a human FTDP-17 mutant form of four-repeat tau. Journal of the neurological sciences. vol 275. issue 1-2. 2009-04-09. PMID:18817929. |
however, the presence of both mutations in a parkin-deficient and htauvlw double mutant mouse causes a tau neuropathology, reactive astrocytosis, and neuronal loss in the cortex and hippocampus, as well as lesions in nigrostriatal and motor neurons. |
2009-04-09 |
2023-08-12 |
mouse |