| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Hui Wang, Hongbiao Chu, Chonglin Zhan. Central anti-fatigue activity of verbascoside. Neuroscience letters. vol 616. 2016-08-04. PMID:26827721. |
in this study, the effects of verbascoside on treadmill exercise endurance, 5-hydroxytryptamine (5-ht) concentrations, the second isoforms of tryptophan hydroxylase (tph2) and serotonergic type 1b inhibitory autoreceptors (5-ht1b) protein expression in the caudate putamen of exercised rats were investigated. |
2016-08-04 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Hui Wang, Hongbiao Chu, Chonglin Zhan. Central anti-fatigue activity of verbascoside. Neuroscience letters. vol 616. 2016-08-04. PMID:26827721. |
we found that verbascoside could prolong the time to exhaustion in treadmill exercise and suppress the exercise-induced increase of 5-ht synthesis and tph2 protein expression, and prevent the exercise-induced decrease of 5-ht1b protein expression in the caudate putamen. |
2016-08-04 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Hui Wang, Hongbiao Chu, Chonglin Zhan. Central anti-fatigue activity of verbascoside. Neuroscience letters. vol 616. 2016-08-04. PMID:26827721. |
the mechanism of verbascoside' s anti-fatigue activity might be related to the inhibition of the exercise-induced synthesis of 5-ht and tph2 expression, and to the increase of the 5-ht1b expression in the caudate putamen of exercised rats. |
2016-08-04 |
2023-08-13 |
rat |
| Moina Hasni Ebou, Amrit Singh-Estivalet, Jean-Marie Launay, Jacques Callebert, François Tronche, Pascal Ferré, Jean-François Gautier, Ghislaine Guillemain, Bernadette Bréant, Bertrand Blondeau, Jean-Pierre Rivelin. Glucocorticoids Inhibit Basal and Hormone-Induced Serotonin Synthesis in Pancreatic Beta Cells. PloS one. vol 11. issue 2. 2016-07-18. PMID:26901633. |
we showed in isolated islets and min6 cells that gcs decreased expression and activity of the two key enzymes of serotonin synthesis, tryptophan hydroxylase 1 (tph1) and 2 (tph2), leading to reduced serotonin contents. |
2016-07-18 |
2023-08-13 |
mouse |
| Moina Hasni Ebou, Amrit Singh-Estivalet, Jean-Marie Launay, Jacques Callebert, François Tronche, Pascal Ferré, Jean-François Gautier, Ghislaine Guillemain, Bernadette Bréant, Bertrand Blondeau, Jean-Pierre Rivelin. Glucocorticoids Inhibit Basal and Hormone-Induced Serotonin Synthesis in Pancreatic Beta Cells. PloS one. vol 11. issue 2. 2016-07-18. PMID:26901633. |
finally, islets from mice deleted for the gr in the pancreas displayed an increased expression of tph1 and tph2 and a strong increased serotonin content per islet. |
2016-07-18 |
2023-08-13 |
mouse |
| Isabelle E Bauer, David P Graham, Jair C Soares, David A Nielse. Serotonergic gene variation in substance use pharmacotherapy: a systematic review. Pharmacogenomics. vol 16. issue 11. 2016-06-29. PMID:26265436. |
current evidence suggests that genetic variability of the serotonergic biosynthesis enzyme tryptophan hydroxylase 2 (tph2) and the serotonin transporter (slc6a4) genes mediates the efficacy of several addiction treatments, such as ondansetron and disulfiram, and the antidepressants bupropion, nortriptyline and sertraline. |
2016-06-29 |
2023-08-13 |
Not clear |
| Qiang Shen, Meijun Teo, Eyal Winter, Einav Hart, Soo H Chew, Richard P Ebstei. To Cheat or Not To Cheat: Tryptophan Hydroxylase 2 SNP Variants Contribute to Dishonest Behavior. Frontiers in behavioral neuroscience. vol 10. 2016-05-20. PMID:27199691. |
the results of this exploratory study provide provisional evidence that snp variants across the tryptophan hydroxylase 2 (tph2) gene, that encodes the rate-limiting enzyme in the biosynthesis of brain serotonin, contribute to individual differences in deceptive behavior. |
2016-05-20 |
2023-08-13 |
Not clear |
| Barbara Pelosi, Marta Pratelli, Sara Migliarini, Giulia Pacini, Massimo Pasqualett. Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin. PloS one. vol 10. issue 8. 2016-05-13. PMID:26291320. |
generation of a tph2 conditional knockout mouse line for time- and tissue-specific depletion of brain serotonin. |
2016-05-13 |
2023-08-13 |
mouse |
| Barbara Pelosi, Marta Pratelli, Sara Migliarini, Giulia Pacini, Massimo Pasqualett. Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin. PloS one. vol 10. issue 8. 2016-05-13. PMID:26291320. |
serotonin synthesis is a 2-step process, the first step of which is mediated by the rate-limiting activity of tph enzymes, belonging to the family of aromatic amino acid hydroxylases and existing in two isoforms, tph1 and tph2, responsible for the production of peripheral and brain serotonin, respectively. |
2016-05-13 |
2023-08-13 |
mouse |
| Barbara Pelosi, Marta Pratelli, Sara Migliarini, Giulia Pacini, Massimo Pasqualett. Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin. PloS one. vol 10. issue 8. 2016-05-13. PMID:26291320. |
we demonstrated that the cre-mediated excision of the third exon of tph2 gene results in the production of a tph2null allele in which we observed the near-complete loss of brain serotonin, as well as the growth defects and perinatal lethality observed in serotonin conventional knockouts. |
2016-05-13 |
2023-08-13 |
mouse |
| D L A Van den Hove, N K Leibold, E Strackx, M Martinez-Claros, K P Lesch, H W M Steinbusch, K R J Schruers, J Prickaert. Prenatal stress and subsequent exposure to chronic mild stress in rats; interdependent effects on emotional behavior and the serotonergic system. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 4. 2016-05-06. PMID:24139910. |
at the neurochemical level, both ps and cms induced various sex-specific alterations in serotonin (5-ht) and tryptophan hydroxylase 2 (tph2) immunoreactivity in the dorsal raphe nucleus, hippocampus and prefrontal cortex with, in line with the behavioral observations, more profound effects in male offspring. |
2016-05-06 |
2023-08-12 |
rat |
| D L A Van den Hove, N K Leibold, E Strackx, M Martinez-Claros, K P Lesch, H W M Steinbusch, K R J Schruers, J Prickaert. Prenatal stress and subsequent exposure to chronic mild stress in rats; interdependent effects on emotional behavior and the serotonergic system. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 4. 2016-05-06. PMID:24139910. |
in conclusion, these findings show that prenatal maternal stress in sprague-dawley rats induces various anxiety- and depression-related behavioral and neuroendocrine changes, as well as alterations in central 5-ht and tph2 function, predominantly in male offspring. |
2016-05-06 |
2023-08-12 |
rat |
| Cynthia L Bethea, Kenny Phu, Yelena Belikova, Sarah C Bethe. Localization and regulation of reproductive steroid receptors in the raphe serotonin system of male macaques. Journal of chemical neuroanatomy. vol 66-67. 2016-05-05. PMID:25908331. |
we previously showed that tryptophan hydroxylase 2 (tph2) and serotonin reuptake transporter (sert) mrnas are increased by the androgens, testosterone (t) and dihydrotestosterone (dht) in serotonin neurons of male macaques. |
2016-05-05 |
2023-08-13 |
monkey |
| Cynthia L Bethea, Kenny Phu, Yelena Belikova, Sarah C Bethe. Localization and regulation of reproductive steroid receptors in the raphe serotonin system of male macaques. Journal of chemical neuroanatomy. vol 66-67. 2016-05-05. PMID:25908331. |
double-label of raphe neurons for each receptor plus tph2 determined whether the receptors were localized in serotonin neurons. |
2016-05-05 |
2023-08-13 |
monkey |
| Cynthia L Bethea, Kenny Phu, Yelena Belikova, Sarah C Bethe. Localization and regulation of reproductive steroid receptors in the raphe serotonin system of male macaques. Journal of chemical neuroanatomy. vol 66-67. 2016-05-05. PMID:25908331. |
however, approximately 40% of dorsal raphe serotonin neurons contained erα or erβ⋅ in conclusion, the stimulatory effect of androgens on tph2 and sert mrna expression is mediated indirectly by neighboring neurons contain ar. |
2016-05-05 |
2023-08-13 |
monkey |
| Steven C Wyler, Lauren J Donovan, Mia Yeager, Evan Deneri. Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25642596. |
coordinated serotonin (5-ht) synthesis and reuptake depends on coexpression of tph2, aadc (ddc), and sert (slc6a4) in brain 5-ht neurons. |
2016-04-19 |
2023-08-13 |
Not clear |
| Steven C Wyler, Lauren J Donovan, Mia Yeager, Evan Deneri. Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25642596. |
our previous studies showed that pet-1 is a critical transcription factor in a regulatory program that controls coexpression of tph2, aadc, and sert in 5-ht neurons. |
2016-04-19 |
2023-08-13 |
Not clear |
| Steven C Wyler, Lauren J Donovan, Mia Yeager, Evan Deneri. Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25642596. |
thus, pet-1 coordinates expression of all rate-limiting enzymatic (tph2, gch1) and post-translational regulatory (gchfr) steps that determine the level of mammalian brain 5-ht synthesis. |
2016-04-19 |
2023-08-13 |
Not clear |
| Francis Lemay, François Y Doré, Jean-Martin Beaulie. Increased ethanol consumption despite taste aversion in mice with a human tryptophan hydroxylase 2 loss of function mutation. Neuroscience letters. vol 609. 2016-04-15. PMID:26497913. |
polymorphisms in the gene encoding the brain serotonin synthesis enzyme tph2 have been identified in mental illnesses, with co-morbidity of substance use disorder. |
2016-04-15 |
2023-08-13 |
mouse |
| Karina Villalba, Jessy G Dévieux, Rhonda Rosenberg, Jean Lud Cade. Serotonin-Related Gene Polymorphisms and Asymptomatic Neurocognitive Impairment in HIV-Infected Alcohol Abusers. Genetics research international. vol 2016. 2016-04-12. PMID:27069689. |
single nucleotide polymorphisms in the slc6a4, tph2, and galm genes may affect the activity of serotonin and increase the risk of hand. |
2016-04-12 |
2023-08-13 |
Not clear |