| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariana Angoa-Pérez, Michael J Kane, Denise I Briggs, Nieves Herrera-Mundo, Catherine E Sykes, Dina M Francescutti, Donald M Kuh. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25089765. |
tryptophan hydroxylase 2 (tph2) is the initial and rate-limiting enzyme in the biosynthetic pathway of 5ht in the cns, and losses in its catalytic activity lead to reductions in 5ht production and release. |
2015-11-02 |
2023-08-13 |
mouse |
| Mariana Angoa-Pérez, Michael J Kane, Denise I Briggs, Nieves Herrera-Mundo, Catherine E Sykes, Dina M Francescutti, Donald M Kuh. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25089765. |
mice lacking the gene for tph2 are genetically depleted of brain 5ht and were tested for a depression-like behavioral phenotype using a battery of valid tests for affective-like disorders in animals. |
2015-11-02 |
2023-08-13 |
mouse |
| Mariana Angoa-Pérez, Michael J Kane, Denise I Briggs, Nieves Herrera-Mundo, Catherine E Sykes, Dina M Francescutti, Donald M Kuh. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25089765. |
the behavioral phenotype of the tph2(-/-) mouse questions the role of 5ht in depression. |
2015-11-02 |
2023-08-13 |
mouse |
| Mariana Angoa-Pérez, Michael J Kane, Denise I Briggs, Nieves Herrera-Mundo, Catherine E Sykes, Dina M Francescutti, Donald M Kuh. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25089765. |
furthermore, the tph2(-/-) mouse may serve as a useful model in the search for new medications that have therapeutic targets for depression that are outside of the 5ht neuronal system. |
2015-11-02 |
2023-08-13 |
mouse |
| C L Bethea, K Coleman, K Phu, A P Reddy, A Ph. Relationships between androgens, serotonin gene expression and innervation in male macaques. Neuroscience. vol 274. 2015-10-15. PMID:24909896. |
this study reports the expression of serotonin-related genes: tryptophan hydroxylase 2 (tph2), serotonin reuptake transporter (sert) and the serotonin 1a autoreceptor (5ht1a) using digoxigenin-ish and image analysis. |
2015-10-15 |
2023-08-13 |
monkey |
| C L Bethea, K Coleman, K Phu, A P Reddy, A Ph. Relationships between androgens, serotonin gene expression and innervation in male macaques. Neuroscience. vol 274. 2015-10-15. PMID:24909896. |
comparatively, t- and dht + atd-treated groups had elevated tph2 and sert gene expression, but the dht + atd group had markedly suppressed serotonin axon density relative to the t-treated group. |
2015-10-15 |
2023-08-13 |
monkey |
| C L Bethea, K Coleman, K Phu, A P Reddy, A Ph. Relationships between androgens, serotonin gene expression and innervation in male macaques. Neuroscience. vol 274. 2015-10-15. PMID:24909896. |
this suggested that androgen activity increased tph2 and sert gene expression but, aromatase activity, and neural production of estradiol (e), may subserve axonal serotonin and determination of the compartment acted upon by fenfluramine. |
2015-10-15 |
2023-08-13 |
monkey |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Guangzhi Zeng, Zhigang Zeng, Hongbiao Chu, Hui Wang, Zhi Xia, Renle W. The effects of Acorus tatarinowii Schott on 5-HT concentrations, TPH2 and 5-HT1B expression in the dorsal raphe of exercised rats. Journal of ethnopharmacology. vol 158 Pt A. 2015-09-25. PMID:25456438. |
the effects of acorus tatarinowii schott on 5-ht concentrations, tph2 and 5-ht1b expression in the dorsal raphe of exercised rats. |
2015-09-25 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Guangzhi Zeng, Zhigang Zeng, Hongbiao Chu, Hui Wang, Zhi Xia, Renle W. The effects of Acorus tatarinowii Schott on 5-HT concentrations, TPH2 and 5-HT1B expression in the dorsal raphe of exercised rats. Journal of ethnopharmacology. vol 158 Pt A. 2015-09-25. PMID:25456438. |
in this study, the effects of acorus tatarinowii schott on treadmill running endurance, 5-ht concentrations, tph2, 5-ht1b expression in the dorsal raphe of exercised rats were investigated. |
2015-09-25 |
2023-08-13 |
rat |
| Nozomi Asaoka, Kazuki Nagayasu, Naoya Nishitani, Mayumi Yamashiro, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kanek. Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures. Neuroscience letters. vol 593. 2015-09-08. PMID:25796177. |
sustained treatment with tsa (1μm) for 2 or 4 days significantly increased the 5-ht tissue content and tryptophan hydroxylase 2 (tph2) expression, which were accompanied by hyper-acetylation of histone h3 in the promoter region of the tph2 gene. |
2015-09-08 |
2023-08-13 |
Not clear |
| Darya V Bazovkina, Daria V Lichman, Alexander V Kuliko. The C1473G polymorphism in the Tryptophan hydroxylase-2 gene: involvement in ethanol-related behavior in mice. Neuroscience letters. vol 589. 2015-08-27. PMID:25603476. |
tryptophan hydroxylase-2 (tph2) is the rate limiting enzyme of serotonin synthesis in the brain. |
2015-08-27 |
2023-08-13 |
mouse |
| Kelli Lehto, Mariliis Vaht, Jarek Mäestu, Toomas Veidebaum, Jaanus Harr. Effect of tryptophan hydroxylase-2 gene polymorphism G-703 T on personality in a population representative sample. Progress in neuro-psychopharmacology & biological psychiatry. vol 57. 2015-08-13. PMID:25455586. |
the tryptophan hydroxylase-2 gene (tph2) is coding for the key enzyme of serotonin (5-ht) synthesis in the brain and has been associated with a number of psychiatric conditions. |
2015-08-13 |
2023-08-13 |
human |
| Kelli Lehto, Mariliis Vaht, Jarek Mäestu, Toomas Veidebaum, Jaanus Harr. Effect of tryptophan hydroxylase-2 gene polymorphism G-703 T on personality in a population representative sample. Progress in neuro-psychopharmacology & biological psychiatry. vol 57. 2015-08-13. PMID:25455586. |
we have examined the association of the tph2 g-703t polymorphism with ffm personality traits, and the possible modulation by the functional variation in the serotonin transporter gene (5-httlpr) in a large longitudinal population representative sample. |
2015-08-13 |
2023-08-13 |
human |
| Robert Brommage, Jeff Liu, Deon Doree, Wangsheng Yu, David R Powell, Qi Melissa Yan. Adult Tph2 knockout mice without brain serotonin have moderately elevated spine trabecular bone but moderately low cortical bone thickness. BoneKEy reports. vol 4. 2015-08-03. PMID:26229596. |
adult tph2 knockout mice without brain serotonin have moderately elevated spine trabecular bone but moderately low cortical bone thickness. |
2015-08-03 |
2023-08-13 |
mouse |
| Robert Brommage, Jeff Liu, Deon Doree, Wangsheng Yu, David R Powell, Qi Melissa Yan. Adult Tph2 knockout mice without brain serotonin have moderately elevated spine trabecular bone but moderately low cortical bone thickness. BoneKEy reports. vol 4. 2015-08-03. PMID:26229596. |
disruption of serotonin synthesis in neurons and the periphery by knockout (ko) of mouse genes for tryptophan hydroxylases (peripheral tph1 and neuronal tph2) has been claimed to decrease (tph2 ko) and increase (tph1 ko) bone mass. |
2015-08-03 |
2023-08-13 |
mouse |
| Shiqing Chen, Xiaoye Huang, Tao Yu, Xin Li, Yanfei Cao, Xingwang Li, Fei Xu, Fengping Yang, Forrest Fabian Jesse, Mingqing Xu, Weidong Li, Lin He, Guang H. Association study of TPH2 polymorphisms and bipolar disorder in the Han Chinese population. Progress in neuro-psychopharmacology & biological psychiatry. vol 56. 2015-07-31. PMID:25152196. |
tryptophan hydroxylase isoform-2 (tph2), which controls the synthesis of serotonin in the brain, has been suggested as a candidate gene for bdp. |
2015-07-31 |
2023-08-13 |
Not clear |
| Sandra Van der Auwera, Deborah Janowitz, Andrea Schulz, Georg Homuth, Matthias Nauck, Henry Völzke, Matthias Rose, Henriette Meyer zu Schwabedissen, Harald Jürgen Freyberger, Hans Jörgen Grab. Interaction among childhood trauma and functional polymorphisms in the serotonin pathway moderate the risk of depressive disorders. European archives of psychiatry and clinical neuroscience. vol 264 Suppl 1. 2015-06-08. PMID:25214390. |
as a rate-limiting enzyme of serotonin synthesis in the brain, tryptophan hydroxylase 2 (tph2) represents a plausible candidate gene. |
2015-06-08 |
2023-08-13 |
human |
| M Angoa-Pérez, M J Kane, C E Sykes, S A Perrine, M W Church, D M Kuh. Brain serotonin determines maternal behavior and offspring survival. Genes, brain, and behavior. vol 13. issue 7. 2015-05-22. PMID:25077934. |
to evaluate the contribution of serotonin to maternal care, we used mice with a null mutation in the gene for tryptophan hydroxylase-2 (tph2), which results in a genetic depletion of brain serotonin, and tested them in a wide range of maternal behavior paradigms. |
2015-05-22 |
2023-08-13 |
mouse |
| M Angoa-Pérez, M J Kane, C E Sykes, S A Perrine, M W Church, D M Kuh. Brain serotonin determines maternal behavior and offspring survival. Genes, brain, and behavior. vol 13. issue 7. 2015-05-22. PMID:25077934. |
these findings illustrate a profound influence of brain serotonin on virtually all elements of maternal behavior and establish that tph2(-/-) pups can engender maladaptive mothering in dams of both genotypes. |
2015-05-22 |
2023-08-13 |
mouse |
| Peiyan Wong, Ying Sze, Laura Jane Gray, Cecilia Chin Roei Chang, Shiwei Cai, Xiaodong Zhan. Early life environmental and pharmacological stressors result in persistent dysregulations of the serotonergic system. Frontiers in behavioral neuroscience. vol 9. 2015-05-12. PMID:25964750. |
we showed that chronic mild stress applied in adulthood did not affect the behaviors and serotonin levels of wt and tph2 knock-in (ki) mice. |
2015-05-12 |
2023-08-13 |
mouse |