| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helene Bach, Victoria Arango, Suham A Kassir, Tea Tsaava, Andrew J Dwork, J John Mann, Mark D Underwoo. Alcoholics have more tryptophan hydroxylase 2 mRNA and protein in the dorsal and median raphe nuclei. Alcoholism, clinical and experimental research. vol 38. issue 7. 2015-04-14. PMID:24942188. |
chronic alcohol use depletes brain serotonin (5-hydroxytryptamine [5-ht]), yet we previously found more tryptophan hydroxylase 2 (tph2), the rate-limiting biosynthetic enzyme for 5-ht, in the dorsal raphe nucleus (drn) of alcoholics. |
2015-04-14 |
2023-08-13 |
Not clear |
| Justin D Crane, Rengasamy Palanivel, Emilio P Mottillo, Adam L Bujak, Huaqing Wang, Rebecca J Ford, Andrew Collins, Regje M Blümer, Morgan D Fullerton, Julian M Yabut, Janice J Kim, Jean-Eric Ghia, Shereen M Hamza, Katherine M Morrison, Jonathan D Schertzer, Jason R B Dyck, Waliul I Khan, Gregory R Steinber. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nature medicine. vol 21. issue 2. 2015-04-09. PMID:25485911. |
serotonin (5-hydroxytryptamine, 5-ht) is a highly conserved biogenic amine that resides in non-neuronal and neuronal tissues that are specifically regulated via tryptophan hydroxylase 1 (tph1) and tph2, respectively. |
2015-04-09 |
2023-08-13 |
mouse |
| Valentina Mosienko, Susann Matthes, Natalie Hirth, Daniel Beis, Michael Flinders, Michael Bader, Anita C Hansson, Natalia Alenin. Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology. vol 85. 2015-03-30. PMID:24863038. |
adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced tph2 activity. |
2015-03-30 |
2023-08-13 |
mouse |
| Valentina Mosienko, Susann Matthes, Natalie Hirth, Daniel Beis, Michael Flinders, Michael Bader, Anita C Hansson, Natalia Alenin. Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology. vol 85. 2015-03-30. PMID:24863038. |
polymorphisms in the tph2 gene coding for the serotonin synthesizing enzyme in the brain are considered as risk factors associated with depression and anxiety in humans. |
2015-03-30 |
2023-08-13 |
mouse |
| Valentina Mosienko, Susann Matthes, Natalie Hirth, Daniel Beis, Michael Flinders, Michael Bader, Anita C Hansson, Natalia Alenin. Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology. vol 85. 2015-03-30. PMID:24863038. |
however, whether a certain variation in the tph2 gene leads to decreased brain serotonin production and development of psychological abnormalities remains unresolved. |
2015-03-30 |
2023-08-13 |
mouse |
| Valentina Mosienko, Susann Matthes, Natalie Hirth, Daniel Beis, Michael Flinders, Michael Bader, Anita C Hansson, Natalia Alenin. Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology. vol 85. 2015-03-30. PMID:24863038. |
progressive reduction in tph2 activity had no effect on emotional behavior, and only slightly affected brain serotonin levels. |
2015-03-30 |
2023-08-13 |
mouse |
| Valentina Mosienko, Susann Matthes, Natalie Hirth, Daniel Beis, Michael Flinders, Michael Bader, Anita C Hansson, Natalia Alenin. Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology. vol 85. 2015-03-30. PMID:24863038. |
however, serotonin degradation rate was drastically decreased in mice with reduced tph2 activity, thereby compensating for the lowered rate of serotonin production in these mice. |
2015-03-30 |
2023-08-13 |
mouse |
| J W Lunden, L G Kirb. Opiate exposure and withdrawal dynamically regulate mRNA expression in the serotonergic dorsal raphe nucleus. Neuroscience. vol 254. 2015-02-23. PMID:24055683. |
gene expression for brain-derived neurotrophic factor (bdnf), tyrosine kinase receptor b (trkb), corticotrophin releasing-factor (crf)-r1, crf-r2, alpha 1 subunit of the gabaa receptor (gabaa-α1), μ-opioid receptor (mor), 5-ht1a receptor, tryptophan hydroxylase2 (tph2) and the 5-ht transporter was then measured using quantitative real-time polymerase chain reaction at multiple time-points across the model of morphine exposure, withdrawal and post withdrawal stress. |
2015-02-23 |
2023-08-12 |
rat |
| Aki Takahashi, Isabel M Quadros, Rosa M M de Almeida, Klaus A Micze. Behavioral and pharmacogenetics of aggressive behavior. Current topics in behavioral neurosciences. vol 12. 2015-01-20. PMID:22297576. |
studies of aggression in genetically modified mice identified several molecules that affect the 5-ht system directly (e.g., tph2, 5-ht1b, 5-ht transporter, pet1, maoa) or indirectly[e.g., bdnf, neuronal nitric oxide (nnos), acamkii, neuropeptide y].the future agenda delineates specific receptor subpopulations for gaba, glutamate and neuropeptides as they modulate the canonical aminergic neurotransmitters in brainstem, limbic and cortical regions with the ultimate outcome of attenuating or escalating aggressive behavior. |
2015-01-20 |
2023-08-12 |
mouse |
| Jonas Waider, Florian Proft, Georg Langlhofer, Esther Asan, Klaus-Peter Lesch, Lise Gutknech. GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice. Histochemistry and cell biology. vol 139. issue 2. 2014-12-17. PMID:23052836. |
gaba concentration and gabaergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in tph2 knockout mice. |
2014-12-17 |
2023-08-12 |
mouse |
| Jonas Waider, Florian Proft, Georg Langlhofer, Esther Asan, Klaus-Peter Lesch, Lise Gutknech. GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice. Histochemistry and cell biology. vol 139. issue 2. 2014-12-17. PMID:23052836. |
while tryptophan hydroxylase-2 (tph2) null mutant (tph2(-/-)) mice are completely deficient in brain serotonin (5-ht) synthesis, the formation of serotonergic neurons and pathfinding of their projections are not impaired. |
2014-12-17 |
2023-08-12 |
mouse |
| Jonas Waider, Florian Proft, Georg Langlhofer, Esther Asan, Klaus-Peter Lesch, Lise Gutknech. GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice. Histochemistry and cell biology. vol 139. issue 2. 2014-12-17. PMID:23052836. |
to assess the influence of 5-ht deficiency on γ-amino butyric acid (gaba) systems, we carried out measurements of gaba concentrations in limbic brain regions of adult male wildtype (wt), heterozygous (tph2(+/-)) and tph2(-/-) mice. |
2014-12-17 |
2023-08-12 |
mouse |
| Thomas Del'Guidice, Francis Lemay, Morgane Lemasson, Jean Levasseur-Moreau, Stella Manta, Adeline Etievant, Guy Escoffier, François Y Doré, François S Roman, Jean-Martin Beaulie. Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 5. 2014-12-01. PMID:24196946. |
polymorphisms in the gene encoding the serotonin synthesis enzyme tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and adhd. |
2014-12-01 |
2023-08-12 |
mouse |
| Thomas Del'Guidice, Francis Lemay, Morgane Lemasson, Jean Levasseur-Moreau, Stella Manta, Adeline Etievant, Guy Escoffier, François Y Doré, François S Roman, Jean-Martin Beaulie. Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 5. 2014-12-01. PMID:24196946. |
furthermore, identification of a role for a 5-ht(2) receptor agonist as a cognition-enhancing agent in mutant mice suggests a potential avenue to explore for the personalized treatment of cognitive symptoms in humans with reduced 5-ht synthesis and tph2 polymorphisms. |
2014-12-01 |
2023-08-12 |
mouse |
| Sören Enge, Monika Fleischhauer, Klaus-Peter Lesch, Andreas Reif, Alexander Strobe. Variation in key genes of serotonin and norepinephrine function predicts gamma-band activity during goal-directed attention. Cerebral cortex (New York, N.Y. : 1991). vol 24. issue 5. 2014-11-28. PMID:23258345. |
to investigate this link, 130 volunteers were genotyped for the 5-ht transporter gene-linked polymorphic region (5-httlpr) and for a variation (tph2-703 g/t) of the tph2 gene coding for the rate-limiting enzyme of 5-ht synthesis in the brain. |
2014-11-28 |
2023-08-12 |
human |
| Takuya Yokoyama, Yamaguchi-Yamada Misuzu, Yoshio Yamamot. Immunohistochemical localization of tryptophan hydroxylase and serotonin transporter in the carotid body of the rat. Histochemistry and cell biology. vol 140. issue 2. 2014-11-24. PMID:23266900. |
in the present study, we investigated mrna expression and immunohistochemical localization of the 5-ht synthetic enzyme isoforms, tryptophan hydroxylase 1 (tph1) and tph2, and the 5-ht plasma membrane transport protein, 5-ht transporter (sert), in the cb of the rat. |
2014-11-24 |
2023-08-12 |
rat |
| X M Xu, M Ding, H Pang, B J Wan. TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese. Genetics and molecular research : GMR. vol 13. issue 1. 2014-11-04. PMID:24668623. |
the rate-limiting enzyme of 5-ht synthesis is tryptophan hydroxylase 2 (tph2). |
2014-11-04 |
2023-08-12 |
Not clear |
| X M Xu, M Ding, H Pang, B J Wan. TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese. Genetics and molecular research : GMR. vol 13. issue 1. 2014-11-04. PMID:24668623. |
single nucleotide polymorphisms (snps) in the regulatory regions of tph2 gene may affect gene expression and biosynthesis of 5-ht triggering to various neuropsychiatric disorders related to 5-ht dysfunction. |
2014-11-04 |
2023-08-12 |
Not clear |
| Nurgul Carkaci-Salli, Ugur Salli, Izel Tekin, Jeremy A Hengst, Moe K Zhao, T Lee Gilman, Anne M Andrews, Kent E Vran. Functional characterization of the S41Y (C2755A) polymorphism of tryptophan hydroxylase 2. Journal of neurochemistry. vol 130. issue 6. 2014-10-30. PMID:24899127. |
human tph2 (htph2) catalyzes the rate-limiting step in cns serotonin biosynthesis. |
2014-10-30 |
2023-08-13 |
human |
| Stephen Hickner, Najaah Hussain, Mariana Angoa-Perez, Dina M Francescutti, Donald M Kuhn, Jason H Mateik. Ventilatory long-term facilitation is evident after initial and repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin. Journal of applied physiology (Bethesda, Md. : 1985). vol 116. issue 3. 2014-10-18. PMID:24336886. |
nineteen tryptophan hydroxylase 2-deficient (tph2(-/-)) mice, devoid of serotonin in the cns, and their wild-type counterparts (tph2(+/+)) were exposed to intermittent hypoxia each day for 10 consecutive days. |
2014-10-18 |
2023-08-12 |
mouse |