| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valentina Mosienko, Susann Matthes, Natalie Hirth, Daniel Beis, Michael Flinders, Michael Bader, Anita C Hansson, Natalia Alenin. Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology. vol 85. 2015-03-30. PMID:24863038. |
however, whether a certain variation in the tph2 gene leads to decreased brain serotonin production and development of psychological abnormalities remains unresolved. |
2015-03-30 |
2023-08-13 |
mouse |
| Valentina Mosienko, Susann Matthes, Natalie Hirth, Daniel Beis, Michael Flinders, Michael Bader, Anita C Hansson, Natalia Alenin. Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology. vol 85. 2015-03-30. PMID:24863038. |
progressive reduction in tph2 activity had no effect on emotional behavior, and only slightly affected brain serotonin levels. |
2015-03-30 |
2023-08-13 |
mouse |
| Valentina Mosienko, Susann Matthes, Natalie Hirth, Daniel Beis, Michael Flinders, Michael Bader, Anita C Hansson, Natalia Alenin. Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology. vol 85. 2015-03-30. PMID:24863038. |
however, serotonin degradation rate was drastically decreased in mice with reduced tph2 activity, thereby compensating for the lowered rate of serotonin production in these mice. |
2015-03-30 |
2023-08-13 |
mouse |
| J W Lunden, L G Kirb. Opiate exposure and withdrawal dynamically regulate mRNA expression in the serotonergic dorsal raphe nucleus. Neuroscience. vol 254. 2015-02-23. PMID:24055683. |
gene expression for brain-derived neurotrophic factor (bdnf), tyrosine kinase receptor b (trkb), corticotrophin releasing-factor (crf)-r1, crf-r2, alpha 1 subunit of the gabaa receptor (gabaa-α1), μ-opioid receptor (mor), 5-ht1a receptor, tryptophan hydroxylase2 (tph2) and the 5-ht transporter was then measured using quantitative real-time polymerase chain reaction at multiple time-points across the model of morphine exposure, withdrawal and post withdrawal stress. |
2015-02-23 |
2023-08-12 |
rat |
| Aki Takahashi, Isabel M Quadros, Rosa M M de Almeida, Klaus A Micze. Behavioral and pharmacogenetics of aggressive behavior. Current topics in behavioral neurosciences. vol 12. 2015-01-20. PMID:22297576. |
studies of aggression in genetically modified mice identified several molecules that affect the 5-ht system directly (e.g., tph2, 5-ht1b, 5-ht transporter, pet1, maoa) or indirectly[e.g., bdnf, neuronal nitric oxide (nnos), acamkii, neuropeptide y].the future agenda delineates specific receptor subpopulations for gaba, glutamate and neuropeptides as they modulate the canonical aminergic neurotransmitters in brainstem, limbic and cortical regions with the ultimate outcome of attenuating or escalating aggressive behavior. |
2015-01-20 |
2023-08-12 |
mouse |
| Jonas Waider, Florian Proft, Georg Langlhofer, Esther Asan, Klaus-Peter Lesch, Lise Gutknech. GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice. Histochemistry and cell biology. vol 139. issue 2. 2014-12-17. PMID:23052836. |
gaba concentration and gabaergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in tph2 knockout mice. |
2014-12-17 |
2023-08-12 |
mouse |
| Jonas Waider, Florian Proft, Georg Langlhofer, Esther Asan, Klaus-Peter Lesch, Lise Gutknech. GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice. Histochemistry and cell biology. vol 139. issue 2. 2014-12-17. PMID:23052836. |
while tryptophan hydroxylase-2 (tph2) null mutant (tph2(-/-)) mice are completely deficient in brain serotonin (5-ht) synthesis, the formation of serotonergic neurons and pathfinding of their projections are not impaired. |
2014-12-17 |
2023-08-12 |
mouse |
| Jonas Waider, Florian Proft, Georg Langlhofer, Esther Asan, Klaus-Peter Lesch, Lise Gutknech. GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice. Histochemistry and cell biology. vol 139. issue 2. 2014-12-17. PMID:23052836. |
to assess the influence of 5-ht deficiency on γ-amino butyric acid (gaba) systems, we carried out measurements of gaba concentrations in limbic brain regions of adult male wildtype (wt), heterozygous (tph2(+/-)) and tph2(-/-) mice. |
2014-12-17 |
2023-08-12 |
mouse |
| Thomas Del'Guidice, Francis Lemay, Morgane Lemasson, Jean Levasseur-Moreau, Stella Manta, Adeline Etievant, Guy Escoffier, François Y Doré, François S Roman, Jean-Martin Beaulie. Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 5. 2014-12-01. PMID:24196946. |
polymorphisms in the gene encoding the serotonin synthesis enzyme tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and adhd. |
2014-12-01 |
2023-08-12 |
mouse |
| Thomas Del'Guidice, Francis Lemay, Morgane Lemasson, Jean Levasseur-Moreau, Stella Manta, Adeline Etievant, Guy Escoffier, François Y Doré, François S Roman, Jean-Martin Beaulie. Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 5. 2014-12-01. PMID:24196946. |
furthermore, identification of a role for a 5-ht(2) receptor agonist as a cognition-enhancing agent in mutant mice suggests a potential avenue to explore for the personalized treatment of cognitive symptoms in humans with reduced 5-ht synthesis and tph2 polymorphisms. |
2014-12-01 |
2023-08-12 |
mouse |
| Sören Enge, Monika Fleischhauer, Klaus-Peter Lesch, Andreas Reif, Alexander Strobe. Variation in key genes of serotonin and norepinephrine function predicts gamma-band activity during goal-directed attention. Cerebral cortex (New York, N.Y. : 1991). vol 24. issue 5. 2014-11-28. PMID:23258345. |
to investigate this link, 130 volunteers were genotyped for the 5-ht transporter gene-linked polymorphic region (5-httlpr) and for a variation (tph2-703 g/t) of the tph2 gene coding for the rate-limiting enzyme of 5-ht synthesis in the brain. |
2014-11-28 |
2023-08-12 |
human |
| Takuya Yokoyama, Yamaguchi-Yamada Misuzu, Yoshio Yamamot. Immunohistochemical localization of tryptophan hydroxylase and serotonin transporter in the carotid body of the rat. Histochemistry and cell biology. vol 140. issue 2. 2014-11-24. PMID:23266900. |
in the present study, we investigated mrna expression and immunohistochemical localization of the 5-ht synthetic enzyme isoforms, tryptophan hydroxylase 1 (tph1) and tph2, and the 5-ht plasma membrane transport protein, 5-ht transporter (sert), in the cb of the rat. |
2014-11-24 |
2023-08-12 |
rat |
| X M Xu, M Ding, H Pang, B J Wan. TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese. Genetics and molecular research : GMR. vol 13. issue 1. 2014-11-04. PMID:24668623. |
the rate-limiting enzyme of 5-ht synthesis is tryptophan hydroxylase 2 (tph2). |
2014-11-04 |
2023-08-12 |
Not clear |
| X M Xu, M Ding, H Pang, B J Wan. TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese. Genetics and molecular research : GMR. vol 13. issue 1. 2014-11-04. PMID:24668623. |
single nucleotide polymorphisms (snps) in the regulatory regions of tph2 gene may affect gene expression and biosynthesis of 5-ht triggering to various neuropsychiatric disorders related to 5-ht dysfunction. |
2014-11-04 |
2023-08-12 |
Not clear |
| Nurgul Carkaci-Salli, Ugur Salli, Izel Tekin, Jeremy A Hengst, Moe K Zhao, T Lee Gilman, Anne M Andrews, Kent E Vran. Functional characterization of the S41Y (C2755A) polymorphism of tryptophan hydroxylase 2. Journal of neurochemistry. vol 130. issue 6. 2014-10-30. PMID:24899127. |
human tph2 (htph2) catalyzes the rate-limiting step in cns serotonin biosynthesis. |
2014-10-30 |
2023-08-13 |
human |
| Stephen Hickner, Najaah Hussain, Mariana Angoa-Perez, Dina M Francescutti, Donald M Kuhn, Jason H Mateik. Ventilatory long-term facilitation is evident after initial and repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin. Journal of applied physiology (Bethesda, Md. : 1985). vol 116. issue 3. 2014-10-18. PMID:24336886. |
nineteen tryptophan hydroxylase 2-deficient (tph2(-/-)) mice, devoid of serotonin in the cns, and their wild-type counterparts (tph2(+/+)) were exposed to intermittent hypoxia each day for 10 consecutive days. |
2014-10-18 |
2023-08-12 |
mouse |
| Yun-Fang Jia, Ning-Ning Song, Rong-Rong Mao, Jin-Nan Li, Qiong Zhang, Ying Huang, Lei Zhang, Hui-Li Han, Yu-Qiang Ding, Lin X. Abnormal anxiety- and depression-like behaviors in mice lacking both central serotonergic neurons and pancreatic islet cells. Frontiers in behavioral neuroscience. vol 8. 2014-10-08. PMID:25294992. |
mice lacking either 5-ht or central serotonergic neurons were generated by conditional deletion of tph2 or lmx1b respectively. |
2014-10-08 |
2023-08-13 |
mouse |
| Joon W Shim, Todd R Dodge, Max A Hammond, Joseph M Wallace, Feng C Zhou, Hiroki Yokot. Physical weight loading induces expression of tryptophan hydroxylase 2 in the brain stem. PloS one. vol 9. issue 1. 2014-09-02. PMID:24416346. |
focusing on serotonergic signaling, we addressed a question: does local mechanical loading to the skeleton elevate expression of tryptophan hydroxylase 2 (tph2) that is a rate-limiting enzyme for brain serotonin? |
2014-09-02 |
2023-08-12 |
mouse |
| C M Ragan, J S Lonstei. Differential postpartum sensitivity to the anxiety-modulating effects of offspring contact is associated with innate anxiety and brainstem levels of dopamine beta-hydroxylase in female laboratory rats. Neuroscience. vol 256. 2014-08-27. PMID:24161285. |
levels of dopamine β-hydroxylase (dbh, norepinephrine synthesizing enzyme) and tryptophan hydroxylase-2 (tph2, serotonin synthesizing enzyme) were measured in the brainstem and dorsal raphe, respectively. |
2014-08-27 |
2023-08-12 |
rat |
| Yuwei Wu, Qisheng Tu, Paloma Valverde, Jin Zhang, Dana Murray, Lily Q Dong, Jessica Cheng, Hua Jiang, Maribel Rios, Elise Morgan, Zhihui Tang, Jake Che. Central adiponectin administration reveals new regulatory mechanisms of bone metabolism in mice. American journal of physiology. Endocrinology and metabolism. vol 306. issue 12. 2014-08-20. PMID:24780611. |
in addition, centrally administered apn increased hypothalamic tryptophan hydroxylase 2 (tph2), cocaine- and amphetamine-regulated transcript (cart), and 5-hydroxytryptamine (serotonin) receptor 2c (htr2c) expressions but decreased hypothalamic cannabinoid receptor-1 expression. |
2014-08-20 |
2023-08-13 |
mouse |