| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tillmann Weber, Miriam A Vogt, Sarah E Gartside, Stefan M Berger, Rafael Lujan, Thorsten Lau, Elke Herrmann, Rolf Sprengel, Dusan Bartsch, Peter Gas. Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25547714. |
increased anxiety-related behavior was associated with significant decreases in tryptophan hydroxylase 2 (tph2) expression and activity, and subsequent reductions in tissue levels of 5-ht, its metabolite 5-hydroxyindoleacetic acid (5-hiaa), and norepinephrine in the raphe nuclei. |
2016-03-29 |
2023-08-13 |
mouse |
| Tillmann Weber, Miriam A Vogt, Sarah E Gartside, Stefan M Berger, Rafael Lujan, Thorsten Lau, Elke Herrmann, Rolf Sprengel, Dusan Bartsch, Peter Gas. Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25547714. |
however, tph2 expression and activity as well as monoamine levels were unchanged in the projection areas of 5-ht neurons. |
2016-03-29 |
2023-08-13 |
mouse |
| Yuqi Zhang, Zaohuo Chang, Jionghua Chen, Yang Ling, Xiaowei Liu, Zhang Feng, Caixia Chen, Minghua Xia, Xingfu Zhao, Wang Ying, Xu Qing, Guilin Li, Changsong Zhan. Methylation of the tryptophan hydroxylase‑2 gene is associated with mRNA expression in patients with major depression with suicide attempts. Molecular medicine reports. vol 12. issue 2. 2016-03-01. PMID:25955598. |
tryptophan hydroxylase-2 (tph2) contributes to alterations in the function of neuronal serotonin (5-ht), which are associated with various psychopathologies, including major depressive disorder (mdd) or suicidal behavior. |
2016-03-01 |
2023-08-13 |
Not clear |
| Andras David Nagy, Ayaka Iwamoto, Misato Kawai, Ryosei Goda, Haruka Matsuo, Tsuyoshi Otsuka, Mao Nagasawa, Mitsuhiro Furuse, Shinobu Yasu. Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder. Chronobiology international. vol 32. issue 4. 2016-02-16. PMID:25515595. |
melatonin treatments altered the expression of genes of serotonergic neurotransmission in the dorsal raphe (tph2, sert, vmat2 and 5ht1a) and serotonin contents in the amygdala. |
2016-02-16 |
2023-08-13 |
mouse |
| Mirjana Carli, Chrysaugi Kostoula, Giuseppina Sacchetti, Pierangela Mainolfi, Alessia Anastasia, Claudia Villani, Roberto William Invernizz. Tph2 gene deletion enhances amphetamine-induced hypermotility: effect of 5-HT restoration and role of striatal noradrenaline release. Journal of neurochemistry. vol 135. issue 4. 2016-02-16. PMID:26259827. |
tph2 gene deletion enhances amphetamine-induced hypermotility: effect of 5-ht restoration and role of striatal noradrenaline release. |
2016-02-16 |
2023-08-13 |
mouse |
| Mirjana Carli, Chrysaugi Kostoula, Giuseppina Sacchetti, Pierangela Mainolfi, Alessia Anastasia, Claudia Villani, Roberto William Invernizz. Tph2 gene deletion enhances amphetamine-induced hypermotility: effect of 5-HT restoration and role of striatal noradrenaline release. Journal of neurochemistry. vol 135. issue 4. 2016-02-16. PMID:26259827. |
variants of tryptophan hydroxylase-2 (tph2), the gene encoding enzyme responsible for the synthesis of brain serotonin (5-ht), have been associated with neuropsychiatric disorders, substance abuse and addiction. |
2016-02-16 |
2023-08-13 |
mouse |
| Mirjana Carli, Chrysaugi Kostoula, Giuseppina Sacchetti, Pierangela Mainolfi, Alessia Anastasia, Claudia Villani, Roberto William Invernizz. Tph2 gene deletion enhances amphetamine-induced hypermotility: effect of 5-HT restoration and role of striatal noradrenaline release. Journal of neurochemistry. vol 135. issue 4. 2016-02-16. PMID:26259827. |
the role of endogenous 5-ht in enhancing the effect of amphetamine was confirmed showing that treatment with the 5-ht precursor 5-hydroxytryptophan (10 mg/kg) restored tissue and extracellular levels of brain 5-ht and the effects of amphetamine on striatal na release and motor activity in tph2(-/-) mice. |
2016-02-16 |
2023-08-13 |
mouse |
| Mirjana Carli, Chrysaugi Kostoula, Giuseppina Sacchetti, Pierangela Mainolfi, Alessia Anastasia, Claudia Villani, Roberto William Invernizz. Tph2 gene deletion enhances amphetamine-induced hypermotility: effect of 5-HT restoration and role of striatal noradrenaline release. Journal of neurochemistry. vol 135. issue 4. 2016-02-16. PMID:26259827. |
here, we show that deletion of tph2, the gene responsible for brain 5-ht synthesis, enhances the motor effect of amphetamine in mice through the inhibition of striatal na release. |
2016-02-16 |
2023-08-13 |
mouse |
| Lise Gutknecht, Sandy Popp, Jonas Waider, Frank M J Sommerlandt, Corinna Göppner, Antonia Post, Andreas Reif, Daniel van den Hove, Tatyana Strekalova, Angelika Schmitt, Maria B N Colaςo, Claudia Sommer, Rupert Palme, Klaus-Peter Lesc. Interaction of brain 5-HT synthesis deficiency, chronic stress and sex differentially impact emotional behavior in Tph2 knockout mice. Psychopharmacology. vol 232. issue 14. 2016-01-19. PMID:25716307. |
interaction of brain 5-ht synthesis deficiency, chronic stress and sex differentially impact emotional behavior in tph2 knockout mice. |
2016-01-19 |
2023-08-13 |
mouse |
| Mark Pitzer, Jordan Lueras, Anna Warden, Sydney Weber, Jodi McBrid. Viral vector mediated expression of mutant huntingtin in the dorsal raphe produces disease-related neuropathology but not depressive-like behaviors in wildtype mice. Brain research. vol 1608. 2015-12-24. PMID:25732261. |
moreover, n171-82q injected mice showed a 75% reduction in cells that stained positive for the serotonin synthesis enzyme, tryptophan hydroxylase-2 (tph2) compared to controls (p<0.05). |
2015-12-24 |
2023-08-13 |
mouse |
| Mariana Angoa-Pérez, Nieves Herrera-Mundo, Michael J Kane, Catherine E Sykes, John H Anneken, Dina M Francescutti, Donald M Kuh. Brain serotonin signaling does not determine sexual preference in male mice. PloS one. vol 10. issue 2. 2015-12-03. PMID:25706994. |
presently, mice with a null mutation in the gene for tryptophan hydroxylase 2 (tph2), which are depleted of brain 5-ht, were tested for sexual preference. |
2015-12-03 |
2023-08-13 |
mouse |
| D A Nielsen, M J Harding, S C Hamon, W Huang, T R Koste. Modifying the role of serotonergic 5-HTTLPR and TPH2 variants on disulfiram treatment of cocaine addiction: a preliminary study. Genes, brain, and behavior. vol 11. issue 8. 2015-11-30. PMID:22925276. |
disulfiram is a cocaine pharmacotherapy that may act through increasing serotonin, benefiting patients with genetically low serotonin transporter levels (5-httlpr, s' allele carriers) and low serotonin synthesis (tph2, a allele carriers). |
2015-11-30 |
2023-08-12 |
Not clear |
| Barbara Pelosi, Sara Migliarini, Giulia Pacini, Marta Pratelli, Massimo Pasqualett. Generation of Pet1210-Cre transgenic mouse line reveals non-serotonergic expression domains of Pet1 both in CNS and periphery. PloS one. vol 9. issue 8. 2015-11-30. PMID:25098329. |
in the mouse, pet1 mrna expression appears between 10 and 11 days post coitum (dpc) in serotonergic post-mitotic precursors and persists in serotonergic neurons up to adulthood, where it promotes the expression of genes defining the mature serotonergic phenotype such as tryptophan hydroxylase 2 (tph2) and serotonin transporter (sert). |
2015-11-30 |
2023-08-13 |
mouse |
| Pei Jiang, Li-Hong Zhang, Hua-Lin Cai, Huan-De Li, Yi-Ping Liu, Mi-Mi Tang, Rui-Li Dang, Wen-Ye Zhu, Ying Xue, Xin H. Neurochemical effects of chronic administration of calcitriol in rats. Nutrients. vol 6. issue 12. 2015-11-25. PMID:25533012. |
additionally, calcitriol treatment promoted tyrosine hydroxylase (th) and tryptophan hydroxylase 2 (tph2) expression without changing dopamine and serotonin status. |
2015-11-25 |
2023-08-13 |
rat |
| Ichiro Kaneko, Marya S Sabir, Christopher M Dussik, G Kerr Whitfield, Amitis Karrys, Jui-Cheng Hsieh, Mark R Haussler, Mark B Meyer, J Wesley Pike, Peter W Jurutk. 1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 9. 2015-11-25. PMID:26071405. |
brain tph2 mrna, encoding the rate-limiting enzyme in serotonin synthesis, was induced 2.2-fold by 10 nm 1,25d in human u87 glioblastoma cells and 47.8-fold in rat serotonergic rn46a-b14 cells. |
2015-11-25 |
2023-08-13 |
mouse |
| D Beis, K Holzwarth, M Flinders, M Bader, M Wöhr, N Alenin. Brain serotonin deficiency leads to social communication deficits in mice. Biology letters. vol 11. issue 3. 2015-11-10. PMID:25808003. |
we challenged this hypothesis in mice with a brain-specific serotonin depletion caused by a tryptophan hydroxylase 2 (tph2) deficiency. |
2015-11-10 |
2023-08-13 |
mouse |
| Mariana Angoa-Pérez, Michael J Kane, Denise I Briggs, Nieves Herrera-Mundo, Catherine E Sykes, Dina M Francescutti, Donald M Kuh. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25089765. |
tryptophan hydroxylase 2 (tph2) is the initial and rate-limiting enzyme in the biosynthetic pathway of 5ht in the cns, and losses in its catalytic activity lead to reductions in 5ht production and release. |
2015-11-02 |
2023-08-13 |
mouse |
| Mariana Angoa-Pérez, Michael J Kane, Denise I Briggs, Nieves Herrera-Mundo, Catherine E Sykes, Dina M Francescutti, Donald M Kuh. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25089765. |
mice lacking the gene for tph2 are genetically depleted of brain 5ht and were tested for a depression-like behavioral phenotype using a battery of valid tests for affective-like disorders in animals. |
2015-11-02 |
2023-08-13 |
mouse |
| Mariana Angoa-Pérez, Michael J Kane, Denise I Briggs, Nieves Herrera-Mundo, Catherine E Sykes, Dina M Francescutti, Donald M Kuh. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25089765. |
the behavioral phenotype of the tph2(-/-) mouse questions the role of 5ht in depression. |
2015-11-02 |
2023-08-13 |
mouse |
| Mariana Angoa-Pérez, Michael J Kane, Denise I Briggs, Nieves Herrera-Mundo, Catherine E Sykes, Dina M Francescutti, Donald M Kuh. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25089765. |
furthermore, the tph2(-/-) mouse may serve as a useful model in the search for new medications that have therapeutic targets for depression that are outside of the 5ht neuronal system. |
2015-11-02 |
2023-08-13 |
mouse |