All Relations between (2R)-amino-5-phosphonovaleric acid (AP5) and hippocampus

Publication Sentence Publish Date Extraction Date Species
Fabio Fumagalli, Raffaella Molteni, Mila Roceri, Francesco Bedogni, Raffaella Santero, Claudia Fossati, Massimo Gennarelli, Giorgio Racagni, Marco Andrea Riv. Effect of antipsychotic drugs on brain-derived neurotrophic factor expression under reduced N-methyl-D-aspartate receptor activity. Journal of neuroscience research. vol 72. issue 5. 2003-07-16. PMID:12749027. mk-801 reduces the hippocampal expression of the neurotrophin; this effect was exacerbated by haloperidol, but it was normalized by olanzapine. 2003-07-16 2023-08-12 Not clear
Ratna Sirca. Postnatal phencyclidine-induced deficit in adult water maze performance is associated with N-methyl-D-aspartate receptor upregulation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 21. issue 3. 2003-07-01. PMID:12711354. separate groups of adult male and female postnatal pcp-treated and saline-treated rats were sacrificed and saturation [3h]mk-801 binding experiments were carried out in their hippocampi and frontal cortices; hippocampus and frontal cortex have high densities of nmda receptors and both regions are important in spatial learning and memory. 2003-07-01 2023-08-12 rat
Ratna Sirca. Postnatal phencyclidine-induced deficit in adult water maze performance is associated with N-methyl-D-aspartate receptor upregulation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 21. issue 3. 2003-07-01. PMID:12711354. adult male and female rats treated postnatally with pcp had increased maximal [3h]mk-801 binding in the hippocampus and frontal cortex compared to same-sex saline-treated controls. 2003-07-01 2023-08-12 rat
Ratna Sirca. Postnatal phencyclidine-induced deficit in adult water maze performance is associated with N-methyl-D-aspartate receptor upregulation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 21. issue 3. 2003-07-01. PMID:12711354. taken together, repeated postnatal pcp (rpp) administration impaired the acquisition of spatial learning in adolescent and adult male and female rats, and this cognitive deficit was associated with increased [3h]mk-801 labeled nmda receptor in the hippocampus and frontal cortex. 2003-07-01 2023-08-12 rat
Jin-Koo Lee, Seong-Soo Choi, Han-Kyu Lee, Ki-Jung Han, Eun-Jung Han, Hong-Won Su. Effects of MK-801 and CNQX on various neurotoxic responses induced by kainic acid in mice. Molecules and cells. vol 14. issue 3. 2003-06-13. PMID:12521295. both mk-801 and cnqx blocked the pyramidal cell death in ca3 hippocampal region induced by ka. 2003-06-13 2023-08-12 mouse
Jin-Koo Lee, Seong-Soo Choi, Han-Kyu Lee, Ki-Jung Han, Eun-Jung Han, Hong-Won Su. Effects of MK-801 and CNQX on various neurotoxic responses induced by kainic acid in mice. Molecules and cells. vol 14. issue 3. 2003-06-13. PMID:12521295. in addition, both mk-801 and cnqx partially reduced the increased c-fos and c-jun protein expression in hippocampus induced by ka. 2003-06-13 2023-08-12 mouse
Mark E Bardgett, Ryan Boeckman, Daniel Krochmal, Hiran Fernando, Rebecca Ahrens, John G Csernansk. NMDA receptor blockade and hippocampal neuronal loss impair fear conditioning and position habit reversal in C57Bl/6 mice. Brain research bulletin. vol 60. issue 1-2. 2003-06-06. PMID:12725901. this research assessed the effects of different doses of the nmda receptor antagonist, mk-801, or different-sized hippocampal lesions on several behavioral parameters in adult male c57bl/6 mice. 2003-06-06 2023-08-12 mouse
Leslie L Devaud, Gabriel Bartoo, Gaurangi Malthanka. Altered responses to dizocilpine maleate administration in ethanol-withdrawn male and female rats. Alcohol (Fayetteville, N.Y.). vol 28. issue 2. 2003-04-08. PMID:12457939. [3h]mk-801 binding analysis ruled out changes in cerebral cortex or hippocampus receptor density or affinity as having a primary role in these differential responses. 2003-04-08 2023-08-12 rat
Christopher D Toscano, Hossein Hashemzadeh-Gargari, Jennifer L McGlothan, Tomás R Guilart. Developmental Pb2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brain. Brain research. Developmental brain research. vol 139. issue 2. 2003-04-02. PMID:12480136. ifenprodil inhibition of [3h]mk-801 binding to the nmdar channel in cortical and hippocampal neuronal membranes expressed high and low affinity components. 2003-04-02 2023-08-12 rat
Mark A Prendergast, D Trent Rogers, Patrick J Mulholland, John M Littleton, Lincoln H Wilkins, Rachel L Self, Avindra Nat. Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor. Brain research. vol 954. issue 2. 2003-01-28. PMID:12414113. the present studies examined the ability of hiv-1 tat1-72 protein (10 pm-1.0 microm) to displace [3h]mk-801 binding and to attenuate spermidine-induced potentiation of this binding in rat brain homogenate comprised of cerebellum, hippocampus, and cerebral cortex. 2003-01-28 2023-08-12 human
Mark A Prendergast, D Trent Rogers, Patrick J Mulholland, John M Littleton, Lincoln H Wilkins, Rachel L Self, Avindra Nat. Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor. Brain research. vol 954. issue 2. 2003-01-28. PMID:12414113. in hippocampal explants, tat produced neurotoxicity in the ca3 and ca1 pyramidal cell layers, as well as in the dentate gyrus, that was significantly reduced by co-exposure to mk-801 (20 microm) and the nmdar polyamine-site antagonist arcaine (10 microm). 2003-01-28 2023-08-12 human
b' Jasenka Mrsi\\xc4\\x87-Pelci\\xc4\\x87, Gordana Zupan, Dusica Maysinger, Goran Pelci\\xc4\\x87, Dinko Vitezi\\xc4\\x87, Ante Simoni\\xc4\\x8. The influence of MK-801 on the hippocampal free arachidonic acid level and Na+,K+-ATPase activity in global cerebral ischemia-exposed rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 7-8. 2003-01-27. PMID:12502020.' the influence of mk-801 on the hippocampal free arachidonic acid level and na+,k+-atpase activity in global cerebral ischemia-exposed rats. 2003-01-27 2023-08-12 rat
b' Jasenka Mrsi\\xc4\\x87-Pelci\\xc4\\x87, Gordana Zupan, Dusica Maysinger, Goran Pelci\\xc4\\x87, Dinko Vitezi\\xc4\\x87, Ante Simoni\\xc4\\x8. The influence of MK-801 on the hippocampal free arachidonic acid level and Na+,K+-ATPase activity in global cerebral ischemia-exposed rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 7-8. 2003-01-27. PMID:12502020.' treatment with 3.0 mg/kg of mk-801 significantly prevented the faa accumulation immediately and 0.5 h after ischemic insult while application of 5.0 mg/kg of mk-801 exerted a protective effect during the first 24 h. global cerebral ischemia induces the significant decline in the na+,k+-atpase activity in the hippocampus starting from 1 to 168 h of reperfusion. 2003-01-27 2023-08-12 rat
Ivaldo J L Oliveira, Simone Molz, Diogo O Souza, Carla I Tasc. Neuroprotective effect of GMP in hippocampal slices submitted to an in vitro model of ischemia. Cellular and molecular neurobiology. vol 22. issue 3. 2003-01-08. PMID:12469874. ka or n-methyl-d-aspartate (nmda) receptor antagonists, gamma-d-glutamylamino-methylsulfonate (gams) or (+)-5-methyl-10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5,10-imine maleate (mk-801, 20 microm) also prevented toxicity in hippocampal slices under ischemic conditions, respectively. 2003-01-08 2023-08-12 rat
Sveta Mayer, Barton R Harris, D Alex Gibson, John A Blanchard, Mark A Prendergast, Robert C Holley, John Littleto. Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus. Alcoholism, clinical and experimental research. vol 26. issue 10. 2002-12-27. PMID:12394279. acamprosate, mk-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus. 2002-12-27 2023-08-12 rat
B J Van Sickle, A S Cox, K Schak, L John Greenfield, E I Tiet. Chronic benzodiazepine administration alters hippocampal CA1 neuron excitability: NMDA receptor function and expression(1). Neuropharmacology. vol 43. issue 4. 2002-12-24. PMID:12367605. however, total hippocampal nmdar number, as assessed by autoradiography with the nmdar antagonist, [(3)h]mk-801, was unchanged by fzp treatment. 2002-12-24 2023-08-12 rat
Yong Min Ahn, Ung Gu Kang, Joo-Bae Park, Yong Sik Ki. Effects of MK-801 and electroconvulsive shock on c-Fos expression in the rat hippocampus and frontal cortex. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 3. 2002-11-05. PMID:11999902. effects of mk-801 and electroconvulsive shock on c-fos expression in the rat hippocampus and frontal cortex. 2002-11-05 2023-08-12 rat
Yong Min Ahn, Ung Gu Kang, Joo-Bae Park, Yong Sik Ki. Effects of MK-801 and electroconvulsive shock on c-Fos expression in the rat hippocampus and frontal cortex. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 3. 2002-11-05. PMID:11999902. to understand the mode of action of these treatments, the authors examined the effect of mk-801 and the interaction between mk-801 and ecs on the induction of c-fos in the rat hippocampus and frontal cortex. 2002-11-05 2023-08-12 rat
Yoshiaki Miyamoto, Toshitaka Nabeshim. [Analysis of neuronal functions in mice lacking the NMDA receptor epsilon 1 subunit]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 119. issue 6. 2002-07-26. PMID:12089904. mice lacking the glur epsilon 1 subunit exhibited a malfunction of nmda receptors, as evidenced by reduction of nmda receptor channel current, hippocampal long-term potentiation, [3h]mk-801 binding, and nmda-stimulated 45ca2+ uptake. 2002-07-26 2023-08-12 mouse
B Szewczyk, R Kata, G Nowa. Rise in zinc affinity for the NMDA receptor evoked by chronic imipramine is species-specific. Polish journal of pharmacology. vol 53. issue 6. 2002-07-19. PMID:11985339. the present study examined the effect of tricyclic antidepressant, imipramine, on the potency of zinc and magnesium to inhibit [3h]mk-801 binding in the mouse and rat cerebral cortex and hippocampus. 2002-07-19 2023-08-12 mouse