Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Fabio Fumagalli, Raffaella Molteni, Mila Roceri, Francesco Bedogni, Raffaella Santero, Claudia Fossati, Massimo Gennarelli, Giorgio Racagni, Marco Andrea Riv. Effect of antipsychotic drugs on brain-derived neurotrophic factor expression under reduced N-methyl-D-aspartate receptor activity. Journal of neuroscience research. vol 72. issue 5. 2003-07-16. PMID:12749027. |
mk-801 reduces the hippocampal expression of the neurotrophin; this effect was exacerbated by haloperidol, but it was normalized by olanzapine. |
2003-07-16 |
2023-08-12 |
Not clear |
Ratna Sirca. Postnatal phencyclidine-induced deficit in adult water maze performance is associated with N-methyl-D-aspartate receptor upregulation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 21. issue 3. 2003-07-01. PMID:12711354. |
separate groups of adult male and female postnatal pcp-treated and saline-treated rats were sacrificed and saturation [3h]mk-801 binding experiments were carried out in their hippocampi and frontal cortices; hippocampus and frontal cortex have high densities of nmda receptors and both regions are important in spatial learning and memory. |
2003-07-01 |
2023-08-12 |
rat |
Ratna Sirca. Postnatal phencyclidine-induced deficit in adult water maze performance is associated with N-methyl-D-aspartate receptor upregulation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 21. issue 3. 2003-07-01. PMID:12711354. |
adult male and female rats treated postnatally with pcp had increased maximal [3h]mk-801 binding in the hippocampus and frontal cortex compared to same-sex saline-treated controls. |
2003-07-01 |
2023-08-12 |
rat |
Ratna Sirca. Postnatal phencyclidine-induced deficit in adult water maze performance is associated with N-methyl-D-aspartate receptor upregulation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 21. issue 3. 2003-07-01. PMID:12711354. |
taken together, repeated postnatal pcp (rpp) administration impaired the acquisition of spatial learning in adolescent and adult male and female rats, and this cognitive deficit was associated with increased [3h]mk-801 labeled nmda receptor in the hippocampus and frontal cortex. |
2003-07-01 |
2023-08-12 |
rat |
Jin-Koo Lee, Seong-Soo Choi, Han-Kyu Lee, Ki-Jung Han, Eun-Jung Han, Hong-Won Su. Effects of MK-801 and CNQX on various neurotoxic responses induced by kainic acid in mice. Molecules and cells. vol 14. issue 3. 2003-06-13. PMID:12521295. |
both mk-801 and cnqx blocked the pyramidal cell death in ca3 hippocampal region induced by ka. |
2003-06-13 |
2023-08-12 |
mouse |
Jin-Koo Lee, Seong-Soo Choi, Han-Kyu Lee, Ki-Jung Han, Eun-Jung Han, Hong-Won Su. Effects of MK-801 and CNQX on various neurotoxic responses induced by kainic acid in mice. Molecules and cells. vol 14. issue 3. 2003-06-13. PMID:12521295. |
in addition, both mk-801 and cnqx partially reduced the increased c-fos and c-jun protein expression in hippocampus induced by ka. |
2003-06-13 |
2023-08-12 |
mouse |
Mark E Bardgett, Ryan Boeckman, Daniel Krochmal, Hiran Fernando, Rebecca Ahrens, John G Csernansk. NMDA receptor blockade and hippocampal neuronal loss impair fear conditioning and position habit reversal in C57Bl/6 mice. Brain research bulletin. vol 60. issue 1-2. 2003-06-06. PMID:12725901. |
this research assessed the effects of different doses of the nmda receptor antagonist, mk-801, or different-sized hippocampal lesions on several behavioral parameters in adult male c57bl/6 mice. |
2003-06-06 |
2023-08-12 |
mouse |
Leslie L Devaud, Gabriel Bartoo, Gaurangi Malthanka. Altered responses to dizocilpine maleate administration in ethanol-withdrawn male and female rats. Alcohol (Fayetteville, N.Y.). vol 28. issue 2. 2003-04-08. PMID:12457939. |
[3h]mk-801 binding analysis ruled out changes in cerebral cortex or hippocampus receptor density or affinity as having a primary role in these differential responses. |
2003-04-08 |
2023-08-12 |
rat |
Christopher D Toscano, Hossein Hashemzadeh-Gargari, Jennifer L McGlothan, Tomás R Guilart. Developmental Pb2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brain. Brain research. Developmental brain research. vol 139. issue 2. 2003-04-02. PMID:12480136. |
ifenprodil inhibition of [3h]mk-801 binding to the nmdar channel in cortical and hippocampal neuronal membranes expressed high and low affinity components. |
2003-04-02 |
2023-08-12 |
rat |
Mark A Prendergast, D Trent Rogers, Patrick J Mulholland, John M Littleton, Lincoln H Wilkins, Rachel L Self, Avindra Nat. Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor. Brain research. vol 954. issue 2. 2003-01-28. PMID:12414113. |
the present studies examined the ability of hiv-1 tat1-72 protein (10 pm-1.0 microm) to displace [3h]mk-801 binding and to attenuate spermidine-induced potentiation of this binding in rat brain homogenate comprised of cerebellum, hippocampus, and cerebral cortex. |
2003-01-28 |
2023-08-12 |
human |
Mark A Prendergast, D Trent Rogers, Patrick J Mulholland, John M Littleton, Lincoln H Wilkins, Rachel L Self, Avindra Nat. Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor. Brain research. vol 954. issue 2. 2003-01-28. PMID:12414113. |
in hippocampal explants, tat produced neurotoxicity in the ca3 and ca1 pyramidal cell layers, as well as in the dentate gyrus, that was significantly reduced by co-exposure to mk-801 (20 microm) and the nmdar polyamine-site antagonist arcaine (10 microm). |
2003-01-28 |
2023-08-12 |
human |
b' Jasenka Mrsi\\xc4\\x87-Pelci\\xc4\\x87, Gordana Zupan, Dusica Maysinger, Goran Pelci\\xc4\\x87, Dinko Vitezi\\xc4\\x87, Ante Simoni\\xc4\\x8. The influence of MK-801 on the hippocampal free arachidonic acid level and Na+,K+-ATPase activity in global cerebral ischemia-exposed rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 7-8. 2003-01-27. PMID:12502020.' |
the influence of mk-801 on the hippocampal free arachidonic acid level and na+,k+-atpase activity in global cerebral ischemia-exposed rats. |
2003-01-27 |
2023-08-12 |
rat |
b' Jasenka Mrsi\\xc4\\x87-Pelci\\xc4\\x87, Gordana Zupan, Dusica Maysinger, Goran Pelci\\xc4\\x87, Dinko Vitezi\\xc4\\x87, Ante Simoni\\xc4\\x8. The influence of MK-801 on the hippocampal free arachidonic acid level and Na+,K+-ATPase activity in global cerebral ischemia-exposed rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 7-8. 2003-01-27. PMID:12502020.' |
treatment with 3.0 mg/kg of mk-801 significantly prevented the faa accumulation immediately and 0.5 h after ischemic insult while application of 5.0 mg/kg of mk-801 exerted a protective effect during the first 24 h. global cerebral ischemia induces the significant decline in the na+,k+-atpase activity in the hippocampus starting from 1 to 168 h of reperfusion. |
2003-01-27 |
2023-08-12 |
rat |
Ivaldo J L Oliveira, Simone Molz, Diogo O Souza, Carla I Tasc. Neuroprotective effect of GMP in hippocampal slices submitted to an in vitro model of ischemia. Cellular and molecular neurobiology. vol 22. issue 3. 2003-01-08. PMID:12469874. |
ka or n-methyl-d-aspartate (nmda) receptor antagonists, gamma-d-glutamylamino-methylsulfonate (gams) or (+)-5-methyl-10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5,10-imine maleate (mk-801, 20 microm) also prevented toxicity in hippocampal slices under ischemic conditions, respectively. |
2003-01-08 |
2023-08-12 |
rat |
Sveta Mayer, Barton R Harris, D Alex Gibson, John A Blanchard, Mark A Prendergast, Robert C Holley, John Littleto. Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus. Alcoholism, clinical and experimental research. vol 26. issue 10. 2002-12-27. PMID:12394279. |
acamprosate, mk-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus. |
2002-12-27 |
2023-08-12 |
rat |
B J Van Sickle, A S Cox, K Schak, L John Greenfield, E I Tiet. Chronic benzodiazepine administration alters hippocampal CA1 neuron excitability: NMDA receptor function and expression(1). Neuropharmacology. vol 43. issue 4. 2002-12-24. PMID:12367605. |
however, total hippocampal nmdar number, as assessed by autoradiography with the nmdar antagonist, [(3)h]mk-801, was unchanged by fzp treatment. |
2002-12-24 |
2023-08-12 |
rat |
Yong Min Ahn, Ung Gu Kang, Joo-Bae Park, Yong Sik Ki. Effects of MK-801 and electroconvulsive shock on c-Fos expression in the rat hippocampus and frontal cortex. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 3. 2002-11-05. PMID:11999902. |
effects of mk-801 and electroconvulsive shock on c-fos expression in the rat hippocampus and frontal cortex. |
2002-11-05 |
2023-08-12 |
rat |
Yong Min Ahn, Ung Gu Kang, Joo-Bae Park, Yong Sik Ki. Effects of MK-801 and electroconvulsive shock on c-Fos expression in the rat hippocampus and frontal cortex. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 3. 2002-11-05. PMID:11999902. |
to understand the mode of action of these treatments, the authors examined the effect of mk-801 and the interaction between mk-801 and ecs on the induction of c-fos in the rat hippocampus and frontal cortex. |
2002-11-05 |
2023-08-12 |
rat |
Yoshiaki Miyamoto, Toshitaka Nabeshim. [Analysis of neuronal functions in mice lacking the NMDA receptor epsilon 1 subunit]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 119. issue 6. 2002-07-26. PMID:12089904. |
mice lacking the glur epsilon 1 subunit exhibited a malfunction of nmda receptors, as evidenced by reduction of nmda receptor channel current, hippocampal long-term potentiation, [3h]mk-801 binding, and nmda-stimulated 45ca2+ uptake. |
2002-07-26 |
2023-08-12 |
mouse |
B Szewczyk, R Kata, G Nowa. Rise in zinc affinity for the NMDA receptor evoked by chronic imipramine is species-specific. Polish journal of pharmacology. vol 53. issue 6. 2002-07-19. PMID:11985339. |
the present study examined the effect of tricyclic antidepressant, imipramine, on the potency of zinc and magnesium to inhibit [3h]mk-801 binding in the mouse and rat cerebral cortex and hippocampus. |
2002-07-19 |
2023-08-12 |
mouse |