| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Marcaida, M D Miñana, M Burgal, S Grisolía, V Felip. Ammonia prevents activation of NMDA receptors by glutamate in rat cerebellar neuronal cultures. The European journal of neuroscience. vol 7. issue 12. 1996-10-22. PMID:8845943. |
it is shown that chronic hyperammonaemia in rats decreases the binding of [3h]mk-801 to synaptosomal membranes from the hippocampus but not the amount of nmdar1 receptor protein as determined by immunoblotting. |
1996-10-22 |
2023-08-12 |
rat |
| K P Gudehithlu, H N Bhargav. Differential binding of [3H]MK-801 to brain regions and spinal cord of mice treated chronically with morphine. General pharmacology. vol 27. issue 1. 1996-10-10. PMID:8742501. |
the binding of [3h]mk-801 to membranes prepared from spinal cord and brain regions (cortex, pons-medulla, hypothalamus, hippocampus, amygdala, striatum, and midbrain) was determined by using a 5 nm concentration of the ligand in the presence of 30 microm glycine and 50 microm of glutamate. |
1996-10-10 |
2023-08-12 |
mouse |
| K P Gudehithlu, H N Bhargav. Differential binding of [3H]MK-801 to brain regions and spinal cord of mice treated chronically with morphine. General pharmacology. vol 27. issue 1. 1996-10-10. PMID:8742501. |
the binding of [3h]mk-801 was increased in the hippocampus of morphine-abstinent mice. |
1996-10-10 |
2023-08-12 |
mouse |
| S A Thornberg, S R Sakla. A review of NMDA receptors and the phencyclidine model of schizophrenia. Pharmacotherapy. vol 16. issue 1. 1996-09-04. PMID:8700797. |
by decreasing glutamatergic neurotransmission, phencyclidine decreases gamma-aminobutyric acid release from the nucleus accumbens, striatum, and hippocampus (manifested by mk-801); may inhibit tonic release of dopamine from the nucleus accumbens and striatum, resulting in increased dopamine phasic reactivity; and decreases long-term potentiation. |
1996-09-04 |
2023-08-12 |
Not clear |
| T Frankiewicz, B Potier, Z I Bashir, G L Collingridge, C G Parson. Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices. British journal of pharmacology. vol 117. issue 4. 1996-07-24. PMID:8646415. |
effects of memantine and mk-801 on nmda-induced currents in cultured neurones and on synaptic transmission and ltp in area ca1 of rat hippocampal slices. |
1996-07-24 |
2023-08-12 |
rat |
| T Frankiewicz, B Potier, Z I Bashir, G L Collingridge, C G Parson. Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices. British journal of pharmacology. vol 117. issue 4. 1996-07-24. PMID:8646415. |
the effects of the uncompetitive n-methyl-d-aspartate (nmda) receptor antagonists, memantine (1-amino-3,5-dimethyladamantane) and mk-801 ((+)-5-methyl-10,11-dihydro-5h-dibenzocyclo-hepten-5,10-imin e maleate) were compared on synaptic transmission and long-term potentiation (ltp) in hippocampal slices and on nmda-induced currents in cultured superior collicular neurones. |
1996-07-24 |
2023-08-12 |
rat |
| L D Pozzo Miller, J J Petrozzino, J A Conno. G protein-coupled receptors mediate a fast excitatory postsynaptic current in CA3 pyramidal neurons in hippocampal slices. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 12. 1996-06-06. PMID:8613765. |
synaptic activation in the presence of competitive (d,l-apv,cnqx) and noncompetitive (mk-801,gyki-52466) ionotropic glutamate receptor antagonists induced fast (10-90% rise time of 15-30 msec) postsynaptic responses in ca3 pyramidal neurons from acute and cultured hippocampal slices. |
1996-06-06 |
2023-08-12 |
Not clear |
| K Nishida, S P Markey, Y Kustova, H C Morse, P Skolnick, A S Basile, Y Se. Increased brain levels of platelet-activating factor in a murine acquired immune deficiency syndrome are NMDA receptor-mediated. Journal of neurochemistry. vol 66. issue 1. 1996-01-24. PMID:8522986. |
administration of the nmda antagonist mk-801 significantly reduced the increased paf levels in the cerebral cortex and hippocampus of lp-bm5 mulv-infected mice. |
1996-01-24 |
2023-08-12 |
mouse |
| B Woodside, B Robinson, S Ami. Induction of Fos protein in a model of closed head injury in rats. Brain research. vol 690. issue 1. 1996-01-18. PMID:7496806. |
pretreatment with the nmda receptor blocker mk-801 eliminated closed head injury induced fos expression in the pyriform cortex and attenuated that seen in the hippocampus. |
1996-01-18 |
2023-08-12 |
rat |
| A Schurr, R S Payne, B M Rigo. Protection by MK-801 against hypoxia-, excitotoxin-, and depolarization-induced neuronal damage in vitro. Neurochemistry international. vol 26. issue 5. 1996-01-11. PMID:7492949. |
considering (1) the ability of mk-801 to antagonize hypoxic neuronal damage in the absence or the presence of nmda, kainate or ampa; (2) the antihypoxic effect of mk-801 in the presence of apv + 7-chlorokynurenate, a pairing that supposedly blocks mk-801 binding to the nmda receptor; (3) the ability of mk-801 to protect hippocampal slices against brain damage induced by depolarization + excitotoxin (50 mm kcl + mm glutamate for 60 min); and (4) the ability of diltiazem, an l-type calcium channel blocker, to protect hippocampal slices against hypoxic neuronal damage, we conclude that the mode of action of mk-801 cannot be explained by its nmda receptor antagonistic properties alone. |
1996-01-11 |
2023-08-12 |
rat |
| D W Newell, A Barth, V Papermaster, A T Malou. Glutamate and non-glutamate receptor mediated toxicity caused by oxygen and glucose deprivation in organotypic hippocampal cultures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 11. 1995-12-26. PMID:7472521. |
we found that nmda receptor blockade using dizocilpine (mk-801), dl-2-amino-5-phosphonovaleric acid (apv), or cgs 19755, was highly effective in reducing ca1 injury in organotypic hippocampal cultures, caused by complete oxygen and glucose deprivation. |
1995-12-26 |
2023-08-12 |
Not clear |
| W D Dietrich, B Lin, M Y Globus, E J Green, M D Ginsberg, R Bust. Effect of delayed MK-801 (dizocilpine) treatment with or without immediate postischemic hypothermia on chronic neuronal survival after global forebrain ischemia in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 15. issue 6. 1995-12-13. PMID:7593357. |
postischemic hypothermia alone or mk-801 treatment alone failed to protect the ca1 hippocampus chronically. |
1995-12-13 |
2023-08-12 |
rat |
| R P Kesner, M Daki. Phencyclidine injections into the dorsal hippocampus disrupt long- but not short-term memory within a spatial learning task. Psychopharmacology. vol 120. issue 2. 1995-12-07. PMID:7480553. |
since the hippocampus is likely to be a major site of phencyclidine (pcp) action, the effects of various doses of pcp (1.8, 18 or 36 nm) as well as 3.6 nm mk-801 or saline injected directly into the dentate gyrus of the hippocampus was tested for acquisition of a spatial navigation task (dry land version of a water maze) using a paradigm that assesses short term memory based on learning within a day and long term memory based on learning between days. |
1995-12-07 |
2023-08-12 |
rat |
| A Schurr, R S Payne, B M Rigo. Synergism between diltiazem and MK-801 but not APV in protecting hippocampal slices against hypoxic damage. Brain research. vol 684. issue 2. 1995-11-24. PMID:7583230. |
synergism between diltiazem and mk-801 but not apv in protecting hippocampal slices against hypoxic damage. |
1995-11-24 |
2023-08-12 |
rat |
| M Ohno, S Watanab. Intrahippocampal administration of (+)-SKF 10,047, a sigma ligand, reverses MK-801-induced impairment of working memory in rats. Brain research. vol 684. issue 2. 1995-11-24. PMID:7583231. |
mk-801, a potent noncompetitive nmda antagonist with high affinity for the pcp site, significantly increased the number of working memory errors (attempts to pass through two incorrect panels of the three panel-gates at four choice points), when injected bilaterally at 0.1 and 0.18 microgram/side into the dorsal hippocampus. |
1995-11-24 |
2023-08-12 |
rat |
| R Näkki, G Wong, E R Korp. [3H]MK-801 binding in various brain regions of rat lines selected for differential alcohol sensitivity. Alcohol (Fayetteville, N.Y.). vol 12. issue 4. 1995-11-09. PMID:7546329. |
saturation analyses of [3h]mk-801 binding to cerebrocortical, hippocampal, and cerebellar synaptosomal membranes revealed no statistically significant differences in either the affinity constant (kd) or binding site density (bmax) between the rat lines. |
1995-11-09 |
2023-08-12 |
rat |
| M Pitkänen, J Sirviö, A Ylinen, E Koivisto, P Riekkine. Effects of NMDA receptor modulation on hippocampal type 2 theta activity in rats. General pharmacology. vol 26. issue 5. 1995-10-24. PMID:7557252. |
using adult wistar rats, which had recording electrodes implanted unilaterally into the hilus of dentate gyrus, we recorded five 4 sec epochs of awake-immobility-related hippocampal eeg activity bands (1-20 hz) 40 min after d-cycloserine and 2 hr after administration of mk-801. |
1995-10-24 |
2023-08-12 |
rat |
| M Pitkänen, J Sirviö, A Ylinen, E Koivisto, P Riekkine. Effects of NMDA receptor modulation on hippocampal type 2 theta activity in rats. General pharmacology. vol 26. issue 5. 1995-10-24. PMID:7557252. |
in line with the previous findings, 0.1 mg/kg mk-801 decreased both the frequency at the maximal theta power as well as the spectral power of hippocampal type 2 eeg activity. |
1995-10-24 |
2023-08-12 |
rat |
| J P Apland, F J Can. Anticonvulsant effects of memantine and MK-801 in guinea pig hippocampal slices. Brain research bulletin. vol 37. issue 3. 1995-09-07. PMID:7627576. |
anticonvulsant effects of memantine and mk-801 in guinea pig hippocampal slices. |
1995-09-07 |
2023-08-12 |
Not clear |
| J P Apland, F J Can. Anticonvulsant effects of memantine and MK-801 in guinea pig hippocampal slices. Brain research bulletin. vol 37. issue 3. 1995-09-07. PMID:7627576. |
thus, in the guinea pig hippocampal slice preparation, mem appeared to have anticonvulsant properties qualitatively similar to those of mk-801, but was 10-100 fold less potent. |
1995-09-07 |
2023-08-12 |
Not clear |