| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Wedzony, M Maćkowiak, A Czyrak, K Fijał, B Michalsk. Single doses of MK-801, a non-competitive antagonist of NMDA receptors, increase the number of 5-HT1A serotonin receptors in the rat brain. Brain research. vol 756. issue 1-2. 1997-08-15. PMID:9187317. |
in saturation binding studies, an increase in the bmax value in the rat hippocampus was found after mk-801 (0.4 mg/kg) while no changes being noted in the kd value. |
1997-08-15 |
2023-08-12 |
rat |
| K Wedzony, M Maćkowiak, A Czyrak, K Fijał, B Michalsk. Single doses of MK-801, a non-competitive antagonist of NMDA receptors, increase the number of 5-HT1A serotonin receptors in the rat brain. Brain research. vol 756. issue 1-2. 1997-08-15. PMID:9187317. |
mk-801 (0.4 mg/kg) increased the concentration of the serotonin metabolite 5-hiaa in the prefrontal cortex and hippocampus, respectively, at 2 and 3 or 3 h after administration, being without effect on the level of serotonin. |
1997-08-15 |
2023-08-12 |
rat |
| E Bozas, N Tritos, H Phillipidis, F Stylianopoulo. At least three neurotransmitter systems mediate a stress-induced increase in c-fos mRNA in different rat brain areas. Cellular and molecular neurobiology. vol 17. issue 2. 1997-07-29. PMID:9140695. |
in both the cerebral cortex and the hippocampus the stress-induced increase in c-fos mrna was inhibited by mk-801, suggesting that it is mediated via nmda receptors. |
1997-07-29 |
2023-08-12 |
rat |
| E Bozas, N Tritos, H Phillipidis, F Stylianopoulo. At least three neurotransmitter systems mediate a stress-induced increase in c-fos mRNA in different rat brain areas. Cellular and molecular neurobiology. vol 17. issue 2. 1997-07-29. PMID:9140695. |
furthermore, administration of mk-801 resulted in an increase in c-fos mrna in the hippocampus of the nonstressed animals. |
1997-07-29 |
2023-08-12 |
rat |
| Y Nomura, Y Kitamura, T Ohnuki, T Arima, Y Yamanaka, K Sasaki, Y Oomur. Alterations in acetylcholine, NMDA, benzodiazepine receptors and protein kinase C in the brain of the senescence-accelerated mouse: an animal model useful for studies on cognitive enhancers. Behavioural brain research. vol 83. issue 1-2. 1997-07-09. PMID:9062660. |
in the hippocampus of samp8 at 12 months, bindings of [3h]pirenzepine, [3h]mk-801, [3h]flunitrazepam, [3h]8-oh-dpat and [3h]pdbu were significantly lower than those in samr1. |
1997-07-09 |
2023-08-12 |
mouse |
| Y Matsuoka, Y Kitamura, R Fukunaga, S Shimohama, T Nabeshima, I Tooyama, H Kimura, T Taniguch. In vivo hypoxia-induced neuronal damage in dentate gyrus of rat hippocampus: changes in NMDA receptors and the effect of MK-801. Neurochemistry international. vol 30. issue 6. 1997-07-07. PMID:9152994. |
in vivo hypoxia-induced neuronal damage in dentate gyrus of rat hippocampus: changes in nmda receptors and the effect of mk-801. |
1997-07-07 |
2023-08-12 |
rat |
| D W Newell, A Barth, T N Ricciardi, A T Malou. Glycine causes increased excitability and neurotoxicity by activation of NMDA receptors in the hippocampus. Experimental neurology. vol 145. issue 1. 1997-06-27. PMID:9184125. |
the nmda antagonists mk-801 (10 microm) and apv (100 microm) significantly reduced glycine-induced neuronal damage in all hippocampal subfields (p < 0.01). |
1997-06-27 |
2023-08-12 |
Not clear |
| A A Mathé, S Gruber, P A Jiménez, E Theodorsson, C Stenfor. Effects of electroconvulsive stimuli and MK-801 on neuropeptide Y, neurokinin A, and calcitonin gene-related peptide in rat brain. Neurochemical research. vol 22. issue 5. 1997-06-20. PMID:9131643. |
although the higher mk-801 dose reduced seizure duration by 50%, the ecs induced npy-li increase in striatum, occipital cortex and hippocampus, and nka-li in occipital cortex was not diminished. |
1997-06-20 |
2023-08-12 |
rat |
| L T Thompson, J F Disterhof. N-methyl-D-aspartate receptors in associative eyeblink conditioning: both MK-801 and phencyclidine produce task- and dose-dependent impairments. The Journal of pharmacology and experimental therapeutics. vol 281. issue 2. 1997-06-12. PMID:9152403. |
additionally, even low doses of mk-801 (10 micrograms/kg) or of pcp (0.1 mg/kg) severely altered conditioned response timing in trace but not in delay conditioning, resembling effects observed after hippocampal lesions. |
1997-06-12 |
2023-08-12 |
rabbit |
| K Thompson, C Wasterlai. Partial protection of hippocampal neurons by MK-801 during perforant path stimulation in the immature brain. Brain research. vol 751. issue 1. 1997-06-09. PMID:9098572. |
partial protection of hippocampal neurons by mk-801 during perforant path stimulation in the immature brain. |
1997-06-09 |
2023-08-12 |
rat |
| K Thompson, C Wasterlai. Partial protection of hippocampal neurons by MK-801 during perforant path stimulation in the immature brain. Brain research. vol 751. issue 1. 1997-06-09. PMID:9098572. |
a high dose of mk-801 reduced the number of injured hilar interneurons in the stimulated hippocampus from 30.0 +/- 5.2 in unmedicated rats to 12.2 +/- 9.6 in mk-801 treated animals (p < 0.05). |
1997-06-09 |
2023-08-12 |
rat |
| M G Lee, J Y Chou, K H Lee, B J Choi, S K Kim, C Y Ki. MK-801 augments pilocarpine-induced electrographic seizure but protects against brain damage in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 21. issue 2. 1997-06-05. PMID:9061777. |
pentobarbital, scopolamine and mk-801 protected the brain damage by pilocarpine, though in the mk-801-treated group, the pyramidal cells of hippocampus appeared darker than normal. |
1997-06-05 |
2023-08-12 |
rat |
| M A Castro-Alamancos, B W Connor. Distinct forms of short-term plasticity at excitatory synapses of hippocampus and neocortex. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 8. 1997-05-22. PMID:9108122. |
the effects of the irreversible open-channel blocker of n-methyl-d-aspartate receptors, mk-801, implied that synapses in the neocortical pathway have a relatively high probability of transmitter release as compared with synapses in the hippocampal pathway. |
1997-05-22 |
2023-08-12 |
Not clear |
| I Matsumoto, M Davidson, M Otsuki, P A Wilc. Decreased severity of ethanol withdrawal behaviors in kainic acid-treated rats. Pharmacology, biochemistry, and behavior. vol 55. issue 3. 1997-05-08. PMID:8951978. |
there was severe neuronal degeneration in the hippocampal ca region and the piriform cortex of the ka/saline-treated animals that was reduced by mk-801 treatment. |
1997-05-08 |
2023-08-12 |
rat |
| H Wei, G Fiskum, R E Rosenthal, D C Perr. Global cerebral ischemia and reperfusion alters NMDA receptor binding in canine brain. Molecular and chemical neuropathology. vol 30. issue 1-2. 1997-05-06. PMID:9138427. |
modest decreases in [3h]glutamate and [3h]mk-801 binding were seen in several regions of hippocampus, and parietal and temporal cortex at early times after reperfusion, with values returning toward control by 24 h. in the striatum, a different pattern was seen: [3h]glutamate and [3h]mk-801 binding increased 50-200% at 0.5-4 h after the start of reperfusion, returning toward control levels by 24 h. these increases correlate with findings of increased sensitivity to nmda-stimulated release of dopamine from striatal tissue in the same model (werling et al., 1993), and suggest that changes in tissue receptors may contribute to the selective vulnerability to ischemic damage during the first hours following reperfusion. |
1997-05-06 |
2023-08-12 |
Not clear |
| H N Bhargava, S Kuma. Modification of the binding of [3H]MK-801 to brain regions and spinal cord of rats treated chronically with U-50,488H, a kappa-opioid receptor agonist. Brain research. vol 749. issue 2. 1997-05-06. PMID:9138737. |
in tolerant rats, the binding of [3h]mk-801 was increased in pons and medulla and corpus striatum but decreased in midbrain and hippocampus and was due to changes in bmax values. |
1997-05-06 |
2023-08-12 |
rat |
| H N Bhargava, S Kuma. Modification of the binding of [3H]MK-801 to brain regions and spinal cord of rats treated chronically with U-50,488H, a kappa-opioid receptor agonist. Brain research. vol 749. issue 2. 1997-05-06. PMID:9138737. |
in u-50,488h-abstinent rats, the binding of [3h]mk-801 was increased in pons and medulla and hippocampus, and decreased in midbrain and amygdala. |
1997-05-06 |
2023-08-12 |
rat |
| H N Bhargava, S Kuma. Modification of the binding of [3H]MK-801 to brain regions and spinal cord of rats treated chronically with U-50,488H, a kappa-opioid receptor agonist. Brain research. vol 749. issue 2. 1997-05-06. PMID:9138737. |
in hippocampus, the bmax of [3h]mk-801 was increased but the kd was decreased whereas in amygdala and pons and medulla, the changes were due to alterations in the bmax values. |
1997-05-06 |
2023-08-12 |
rat |
| T Gloveli, C Iserhot, D Schmitz, E Castrén, J Behr, U Heineman. Systemic administration of the phencyclidine compound MK-801 affects stimulus-induced field potentials selectively in layer III of rat medial entorhinal cortex. Neuroscience letters. vol 221. issue 2-3. 1997-04-18. PMID:9121708. |
since the principal cells of layer iii project directly to area ca1 and the subiculum, the selective effects of mk-801 may have implications for the transfer of information to the hippocampus. |
1997-04-18 |
2023-08-12 |
rat |
| G J Lees, W Leon. Interactions between excitotoxins and the Na+/K+-ATPase inhibitor ouabain in causing neuronal lesions in the rat hippocampus. Brain research. vol 714. issue 1-2. 1997-03-19. PMID:8861619. |
the selective glutamate receptor antagonists, dizocilpine (mk-801) and nbqx (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline), in doses which blocked the direct toxicity of glutamate receptor agonists acting on either the nmda and non-nmda classes of glutamate receptor, failed to provide more than a minor protection against ouabain-induced neuronal death in the rat dorsal hippocampus. |
1997-03-19 |
2023-08-12 |
rat |