| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Sierra-Paredes, G Sierra-Marcuñ. Effects of NMDA antagonists on seizure thresholds induced by intrahippocampal microdialysis of picrotoxin in freely moving rats. Neuroscience letters. vol 218. issue 1. 1997-03-14. PMID:8939481. |
the role of n-methyl-d-aspartate (nmda) receptors on individual variations in animal seizure threshold induced by picrotoxin microperfusion in the hippocampus of freely moving rats was analyzed by testing the effects of nmda receptor antagonists 2-amino 5-phosphonovalerate (ap-5) and dizocilpine (mk-801) on individual seizure thresholds. |
1997-03-14 |
2023-08-12 |
rat |
| P Pichiule, J C Chávez, J Boero, A Arregu. Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain. Neuroscience letters. vol 218. issue 2. 1997-03-14. PMID:8945733. |
this study examined [3h]mk-801 binding to the n-methyl-d-aspartate (nmda) receptor in membranes prepared from cerebral cortex, hippocampus and corpus striatum of 3 week old rats exposed to 10 weeks of intermittent hypobaric hypoxia (4300 m; 450 torr) and compared results with those of normoxic controls. |
1997-03-14 |
2023-08-12 |
rat |
| A Barth, L Barth, R S Morrison, D W Newel. bFGF enhances the protective effects of MK-801 against ischemic neuronal injury in vitro. Neuroreport. vol 7. issue 9. 1997-03-06. PMID:8856698. |
the neuroprotective activity of basic fibroblast growth factor (bfgf) in combination with the n-methyl-d-aspartate (nmda) receptor antagonist mk-801 was evaluated in organotypic hippocampal slice cultures. |
1997-03-06 |
2023-08-12 |
Not clear |
| W Musleh, S Alvarez, M Baudry, R L Alkan. Effects of ethanol and temperature on NMDA receptor function in different mouse genotypes. Alcoholism, clinical and experimental research. vol 20. issue 7. 1997-03-03. PMID:8904985. |
we accomplished this by determining the effects of ethanol on three different mouse genotypes (c57, ls, and ss) on two types of nmda receptor-mediated responses at 30 degrees and 35 degrees c: (i) extracellularly recorded synaptic potentials elicited in the ca1 region of the in vitro hippocampal slice preparation by stimulation of the schaffer-commisural pathway in the presence of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor blocker, 6,7-dinitroquinoxaline-2,3-dione, and low magnesium concentration; and (ii) increase in [3h]mk-801 binding elicited by glutamate in telencephalic membrane preparations. |
1997-03-03 |
2023-08-12 |
mouse |
| H Nakanishi, A Kawachi, M Okada, M Fujiwara, K Yamamot. Protective effect of MK-801 on the anoxia-aglycemia induced damage in the fluorocitrate-treated hippocampal slice of the rat. Brain research. vol 732. issue 1-2. 1997-02-06. PMID:8891289. |
protective effect of mk-801 on the anoxia-aglycemia induced damage in the fluorocitrate-treated hippocampal slice of the rat. |
1997-02-06 |
2023-08-12 |
rat |
| K Nishida, S P Marke. Nicardipine and MK-801 attenuate platelet-activating factor increases following cerebral ischemia-reperfusion in gerbils. Brain research. vol 733. issue 2. 1997-02-06. PMID:8891303. |
mk-801 (10 mg/kg) reduces the accumulation of paf, the remaining increases in hippocampus, cortex and thalamus being 152%, 147% and 144% of the controls, respectively. |
1997-02-06 |
2023-08-12 |
Not clear |
| P Pérez, A Flores, A Santamaría, C Ríos, S Galván-Arzat. Changes in transition metal contents in rat brain regions after in vivo quinolinate intrastriatal administration. Archives of medical research. vol 27. issue 4. 1997-01-30. PMID:8987176. |
quin-induced increases in regional copper content were partially prevented in hippocampus, midbrain and striatum (17, 57, and 23% vs. control, respectively) by pretreatment of rats with an nmda receptor antagonist, dizocilpine (mk-801, 10 mg/kg, i.p. |
1997-01-30 |
2023-08-12 |
rat |
| D J Healy, J H Meador-Woodruf. Dopamine receptor gene expression in hippocampus is differentially regulated by the NMDA receptor antagonist MK-801. European journal of pharmacology. vol 306. issue 1-3. 1996-12-18. PMID:8813639. |
dopamine receptor gene expression in hippocampus is differentially regulated by the nmda receptor antagonist mk-801. |
1996-12-18 |
2023-08-12 |
rat |
| D J Healy, J H Meador-Woodruf. Dopamine receptor gene expression in hippocampus is differentially regulated by the NMDA receptor antagonist MK-801. European journal of pharmacology. vol 306. issue 1-3. 1996-12-18. PMID:8813639. |
glutamate agonists have been shown to stimulate the release of dopamine in the striatum, while the nmda receptor antagonist mk-801 has been shown to cause an increase in extracellular dopamine in the hippocampus. |
1996-12-18 |
2023-08-12 |
rat |
| D J Healy, J H Meador-Woodruf. Dopamine receptor gene expression in hippocampus is differentially regulated by the NMDA receptor antagonist MK-801. European journal of pharmacology. vol 306. issue 1-3. 1996-12-18. PMID:8813639. |
the effects of mk-801 treatment on dopamine receptor gene expression in the hippocampus are largely unknown. |
1996-12-18 |
2023-08-12 |
rat |
| D J Healy, J H Meador-Woodruf. Dopamine receptor gene expression in hippocampus is differentially regulated by the NMDA receptor antagonist MK-801. European journal of pharmacology. vol 306. issue 1-3. 1996-12-18. PMID:8813639. |
to begin to address this question, we treated rats with 0.3, 1.0, and 3.0 mg/kg of mk-801 daily for 1 week, and measured the mrnas encoding all five of the dopamine receptors in the hippocampus. |
1996-12-18 |
2023-08-12 |
rat |
| D J Healy, J H Meador-Woodruf. Dopamine receptor gene expression in hippocampus is differentially regulated by the NMDA receptor antagonist MK-801. European journal of pharmacology. vol 306. issue 1-3. 1996-12-18. PMID:8813639. |
mk-801 caused changes in dopamine d1, d2, d3, and d4 receptor gene expression in a complex manner that suggests that dopamine receptor gene expression in the hippocampus may be differentially regulated by glutamate, via the nmda receptor. |
1996-12-18 |
2023-08-12 |
rat |
| J A Dzubay, C E Jah. Kinetics of NMDA channel opening. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 13. 1996-12-13. PMID:8753874. |
the period required for nmda channels to open for the first time after agonist binding (the first latency) was estimated in outside-out patch recordings from rat hippocampal neurons using fast-application techniques and the open channel blocker mk-801. |
1996-12-13 |
2023-08-12 |
rat |
| C Wang, F E Jense. Age dependence of NMDA receptor involvement in epileptiform activity in rat hippocampal slices. Epilepsy research. vol 23. issue 2. 1996-12-04. PMID:8964271. |
bath application of the nmda receptor antagonist d,l-2-amino-5-phosphonovaleric acid (dl-apv, 20 microm) converted ictal activity to interictal activity in the hippocampal slices from immature rats. |
1996-12-04 |
2023-08-12 |
rat |
| M Misztal, J Skangiel-Kramska, G Niewiadomska, W Danys. Subchronic intraventricular infusion of quinolinic acid produces working memory impairment--a model of progressive excitotoxicity. Neuropharmacology. vol 35. issue 4. 1996-12-03. PMID:8793907. |
surprisingly no change was observed in [3h]mk-801 binding to nmda receptor channels in the hippocampus and cortex. |
1996-12-03 |
2023-08-12 |
Not clear |
| A Barth, L Barth, D W Newel. Combination therapy with MK-801 and alpha-phenyl-tert-butyl-nitrone enhances protection against ischemic neuronal damage in organotypic hippocampal slice cultures. Experimental neurology. vol 141. issue 2. 1996-11-27. PMID:8812169. |
combination therapy with mk-801 and alpha-phenyl-tert-butyl-nitrone enhances protection against ischemic neuronal damage in organotypic hippocampal slice cultures. |
1996-11-27 |
2023-08-12 |
rat |
| M Makimura, H Sugimoto, K Shinomiya, Y Kabasawa, H Fukud. Inhibitory effect of the NMDA receptor antagonist, dizocilpine (MK-801), on the development of morphine dependence. The Journal of toxicological sciences. vol 21. issue 2. 1996-11-12. PMID:8780997. |
we investigated the effect of a noncompetitive n-methyl-d-aspartate (nmda) receptor antagonist, (+)-5-methyl-10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5,10-imin ehydrogen maleate (dizocilpine, mk-801), on hippocampal norepinephrine release in morphine-treated rats in order to clarify the relationship between nmda receptors and the development of morphine dependence. |
1996-11-12 |
2023-08-12 |
rat |
| X Zhang, A A Boulton, P H Y. Expression of heat shock protein-70 and limbic seizure-induced neuronal death in the rat brain. The European journal of neuroscience. vol 8. issue 7. 1996-11-06. PMID:8758950. |
the effect of mk-801, a non-competitive n-methyl-d-aspartate (nmda) antagonist, on the kainic acid-induced expression of the inducible heat shock protein 70 kda (hsp70) and on neuronal death in the rat hippocampus was investigated. |
1996-11-06 |
2023-08-12 |
rat |
| P H Hutson, J E Hog. Effects of and interactions between antagonists for different sites on the NMDA receptor complex on hippocampal and striatal acetylcholine efflux in vivo. European journal of pharmacology. vol 295. issue 1. 1996-10-29. PMID:8925873. |
intraperitoneal administration of the non-competitive nmda receptor antagonists (5r,10s)-(+)-5-methyl-10,11-dihydro-5h-dibenzo[a,d] cyclohepten-5,10-imine (mk-801, 0.25 and 0.5 mg/kg) and 1-(1-phenylcyclohexyl)piperidine (pcp, 5 and 10 mg/kg) increased the extracellular concentration of acetylcholine in rat hippocampus but not striatum. |
1996-10-29 |
2023-08-12 |
rat |
| P H Hutson, J E Hog. Effects of and interactions between antagonists for different sites on the NMDA receptor complex on hippocampal and striatal acetylcholine efflux in vivo. European journal of pharmacology. vol 295. issue 1. 1996-10-29. PMID:8925873. |
pretreatment with r(+)-ha-966 (60 mg/kg) or (+/-)cpp (10 mg/kg) attenuated the increase of hippocampal acetylcholine efflux by mk-801 (0.5 mg/kg). |
1996-10-29 |
2023-08-12 |
rat |