| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J A Gorter, M Veerman, M Mirmira. Hippocampal neuronal responsiveness to NMDA agonists and antagonists in the adult rat neonatally treated with MK-801. Brain research. vol 572. issue 1-2. 1992-07-24. PMID:1351784. |
hippocampal neuronal responsiveness to nmda agonists and antagonists in the adult rat neonatally treated with mk-801. |
1992-07-24 |
2023-08-11 |
rat |
| G B Robinson, G D Ree. Effect of MK-801 on the induction and subsequent decay of long-term potentiation in the unanesthetized rabbit hippocampal dentate gyrus. Brain research. vol 569. issue 1. 1992-07-24. PMID:1611480. |
effect of mk-801 on the induction and subsequent decay of long-term potentiation in the unanesthetized rabbit hippocampal dentate gyrus. |
1992-07-24 |
2023-08-11 |
rabbit |
| J A Gorter, M Titulaer, N P Bos, E Huisma. Chronic neonatal MK-801 administration leads to a long-lasting increase in seizure sensitivity during the early stages of hippocampal kindling. Neuroscience letters. vol 134. issue 1. 1992-06-24. PMID:1840001. |
chronic neonatal mk-801 administration leads to a long-lasting increase in seizure sensitivity during the early stages of hippocampal kindling. |
1992-06-24 |
2023-08-11 |
rat |
| K Inoue, K Morimoto, K Sato, N Yamada, S Otsuk. Mechanisms in the development of limbic status epilepticus and hippocampal neuron loss: an experimental study in a model of status epilepticus induced by kindling-like electrical stimulation of the deep prepyriform cortex in rats. Acta medica Okayama. vol 46. issue 2. 1992-06-04. PMID:1533485. |
pretreatment with mk-801, a non-competitive n-methyl-d-aspartate (nmda) receptor antagonist (0.25 or 1 mg/kg), also prevented hippocampal cell loss, although it did not block se generation completely, which suggests dissociation of the mechanisms underlying the development of se and hippocampal damage. |
1992-06-04 |
2023-08-11 |
rat |
| K Suyam. Changes of neuronal transmission in the hippocampus after transient ischemia in spontaneously hypertensive rats and the protective effects of MK-801. Stroke. vol 23. issue 2. 1992-05-11. PMID:1313997. |
changes of neuronal transmission in the hippocampus after transient ischemia in spontaneously hypertensive rats and the protective effects of mk-801. |
1992-05-11 |
2023-08-11 |
rat |
| H Nakanishi, O Kamata, K Ukai, K Yamamot. Inhibitory effects of NMDA receptor antagonists on hypoxia-induced seizures in dietary Mg(2+)-deficient mice. European journal of pharmacology. vol 204. issue 1. 1992-05-06. PMID:1839534. |
the effects of the non-competitive n-methyl-d-aspartate (nmda) antagonists, (+)-mk-801 hydrogen maleate (mk-801) and phencyclidine hydrochloride (pcp), were tested against hypoxia-induced tonic convulsions and hippocampal epileptiform discharges. |
1992-05-06 |
2023-08-11 |
mouse |
| G B Robinso. Kindling-induced potentiation of excitatory and inhibitory inputs to hippocampal dentate granule cells. II. Effects of the NMDA antagonist MK-801. Brain research. vol 562. issue 1. 1992-04-21. PMID:1799870. |
the effect of the non-competitive n-methyl-d-aspartate antagonist mk-801 on the early development of kindling-induced potentiation was examined in the rabbit hippocampal dentate gyrus. |
1992-04-21 |
2023-08-11 |
rabbit |
| G B Robinso. Kindling-induced potentiation of excitatory and inhibitory inputs to hippocampal dentate granule cells. II. Effects of the NMDA antagonist MK-801. Brain research. vol 562. issue 1. 1992-04-21. PMID:1799870. |
these results suggest that mk-801 differentially affects kindling-induced potentiation of excitatory and inhibitory circuits within the rabbit hippocampal dentate gyrus. |
1992-04-21 |
2023-08-11 |
rabbit |
| P S Whitton, C S Biggs, B R Pearce, L J Fowle. MK-801 increases extracellular 5-hydroxytryptamine in rat hippocampus and striatum in vivo. Journal of neurochemistry. vol 58. issue 4. 1992-04-17. PMID:1372346. |
mk-801 increases extracellular 5-hydroxytryptamine in rat hippocampus and striatum in vivo. |
1992-04-17 |
2023-08-11 |
rat |
| P S Whitton, C S Biggs, B R Pearce, L J Fowle. MK-801 increases extracellular 5-hydroxytryptamine in rat hippocampus and striatum in vivo. Journal of neurochemistry. vol 58. issue 4. 1992-04-17. PMID:1372346. |
the effect of mk-801 (0.25 or 0.5 mg/kg) on the extracellular concentration of 5-hydroxytryptamine (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) in rat hippocampus and striatum was studied using intracerebral dialysis. |
1992-04-17 |
2023-08-11 |
rat |
| C E Jah. High probability opening of NMDA receptor channels by L-glutamate. Science (New York, N.Y.). vol 255. issue 5043. 1992-03-04. PMID:1346477. |
short applications of l-glutamate to outside-out patches from hippocampal neurons in the presence and absence of mk-801 revealed that about 30 percent of l-glutamate-bound channels are open at the peak of the current. |
1992-03-04 |
2023-08-11 |
Not clear |
| S Holemans, F Javoy, Y Agid, E C Laterre, J M Maloteau. [3H]MK-801 binding to NMDA glutamatergic receptors in Parkinson's disease and progressive supranuclear palsy. Brain research. vol 565. issue 1. 1992-02-28. PMID:1837752. |
the binding of [3h]dizocilpine maleate (mk-801) to glutamate receptors of the n-methyl-d-aspartate (nmda)-subtype was characterized in temporal and frontal cortex, in hippocampus and in subcortical areas (caudate nucleus and putamen) from controls and patients with parkinson's disease or progressive supranuclear palsy. |
1992-02-28 |
2023-08-11 |
Not clear |
| Y Yoneda, K Ogit. Heterogeneity of the N-methyl-D-aspartate receptor ionophore complex in rat brain, as revealed by ligand binding techniques. The Journal of pharmacology and experimental therapeutics. vol 259. issue 1. 1991-11-21. PMID:1681092. |
the polyamine spermidine markedly potentiated the binding of (+)-[3h]5-methyl-10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5,10-imi ne (mk-801) to open ion channels associated with an n-methyl-d-aspartate (nmda)-sensitive subclass of brain excitatory amino acid receptors, in the presence of a maximally effective concentration of l-glutamic acid (glu) and glycine (gly), in triton-treated preparations of synaptic membranes from the cerebral cortex as well as hippocampus of rat brain, without significantly affecting that in cerebellar synaptic membranes. |
1991-11-21 |
2023-08-11 |
rat |
| Y Yoneda, K Ogit. Heterogeneity of the N-methyl-D-aspartate receptor ionophore complex in rat brain, as revealed by ligand binding techniques. The Journal of pharmacology and experimental therapeutics. vol 259. issue 1. 1991-11-21. PMID:1681092. |
among several ligands for the binding sites of [3h]mk-801, the binding was most potently displaced by (+)-mk-801, followed by n-[1-(2-thienyl)cyclohexyl]piperidine, (-)-mk-801, phencyclidine, cyclazocine, ketamine, ketocyclazocine, n-allylnormetazocine and pentazocine, in a rank order of decreasing potency, in hippocampal synaptic membranes. |
1991-11-21 |
2023-08-11 |
rat |
| Y Yoneda, K Ogit. Heterogeneity of the N-methyl-D-aspartate receptor ionophore complex in rat brain, as revealed by ligand binding techniques. The Journal of pharmacology and experimental therapeutics. vol 259. issue 1. 1991-11-21. PMID:1681092. |
competitive nmda antagonists induced a much more potent inhibition of [3h] mk-801 binding in the hippocampus than in the cerebellum, whereas competitive gly antagonists elicited a similarly potent inhibition of the binding in both structures. |
1991-11-21 |
2023-08-11 |
rat |
| b' G Keilhoff, G Wolf, F Stastn\\xc3\\xb. Effects of MK-801, ketamine and alaptide on quinolinate models in the maturing hippocampus. Neuroscience. vol 42. issue 2. 1991-10-21. PMID:1832751.' |
effects of mk-801, ketamine and alaptide on quinolinate models in the maturing hippocampus. |
1991-10-21 |
2023-08-11 |
rat |
| J F MacDonald, M C Bartlett, I Mody, P Pahapill, J N Reynolds, M W Salter, J H Schneiderman, P S Pennefathe. Actions of ketamine, phencyclidine and MK-801 on NMDA receptor currents in cultured mouse hippocampal neurones. The Journal of physiology. vol 432. 1991-10-04. PMID:1832184. |
actions of ketamine, phencyclidine and mk-801 on nmda receptor currents in cultured mouse hippocampal neurones. |
1991-10-04 |
2023-08-11 |
mouse |
| J F MacDonald, M C Bartlett, I Mody, P Pahapill, J N Reynolds, M W Salter, J H Schneiderman, P S Pennefathe. Actions of ketamine, phencyclidine and MK-801 on NMDA receptor currents in cultured mouse hippocampal neurones. The Journal of physiology. vol 432. 1991-10-04. PMID:1832184. |
we have characterized the voltage- and use-dependent blockade of the currents by three dissociative anaesthetics: ketamine, phencyclidine (pcp) and mk-801 in mouse hippocampal neurones grown in dissociated tissue culture. |
1991-10-04 |
2023-08-11 |
mouse |
| K Gulya, K A Grant, P Valverius, P L Hoffman, B Tabakof. Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal. Brain research. vol 547. issue 1. 1991-09-05. PMID:1830510. |
previous work, using membrane receptor binding techniques, demonstrated an increase in hippocampal mk-801 binding sites in mice after chronic ethanol ingestion. |
1991-09-05 |
2023-08-11 |
mouse |
| K Gulya, K A Grant, P Valverius, P L Hoffman, B Tabakof. Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal. Brain research. vol 547. issue 1. 1991-09-05. PMID:1830510. |
the current studies, using quantitative autoradiography, demonstrate that chronic ethanol ingestion also produces increases in mk-801 binding in cerebral cortex, striatum and thalamus, as well as in hippocampus. |
1991-09-05 |
2023-08-11 |
mouse |