| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Nellgård, I Gustafson, T Wieloc. Lack of protection by the N-methyl-D-aspartate receptor blocker dizocilpine (MK-801) after transient severe cerebral ischemia in the rat. Anesthesiology. vol 75. issue 2. 1991-08-23. PMID:1859015. |
we investigated the effect of the noncompetitive nmda receptor antagonist dizocipiline (mk-801) on neuronal damage in the ca1 region of the rat hippocampus, using two models of reversible cerebral ischemia: 10 or 15 min of bilateral common carotid occlusion combined with hypotension, or 6-8.5 min of cardiac arrest. |
1991-08-23 |
2023-08-11 |
rat |
| S Liljequist, K Ossowska, M Grabowska-Andén, N E Andé. Effect of the NMDA receptor antagonist, MK-801, on locomotor activity and on the metabolism of dopamine in various brain areas of mice. European journal of pharmacology. vol 195. issue 1. 1991-08-15. PMID:1829683. |
mk-801, 0.2 mg/kg i.p., a dose which produced marked locomotor stimulation, increased the rate of disappearance of dopamine in the striatum and in the limbic forebrain of the animals, whereas the rate of disappearance of noradrenaline remained unchanged in the limbic forebrain and in the hippocampus. |
1991-08-15 |
2023-08-11 |
mouse |
| R Pohorecki, G L Becker, P J Reilly, D F Lander. Ketamine, MK-801 or calmidazolium protects rat hippocampal energy status during in vitro ischemia. Annals of the New York Academy of Sciences. vol 625. 1991-08-01. PMID:2058937. |
ketamine, mk-801 or calmidazolium protects rat hippocampal energy status during in vitro ischemia. |
1991-08-01 |
2023-08-11 |
rat |
| D W Clow, S J Lee, R P Hamme. Competitive (AP7) and non-competitive (MK-801) NMDA receptor antagonists differentially alter glucose utilization in rat cortex. Synapse (New York, N.Y.). vol 7. issue 4. 1991-07-08. PMID:1828310. |
in contrast, mk-801 (0.1 or 1.0 mg/kg) resulted in a dose-dependent decrease of metabolic activity in sensory cortices, and an increase in limbic regions such as the hippocampal stratum lacunosum moleculare and entorhinal cortex. |
1991-07-08 |
2023-08-11 |
rat |
| T S Nowa. Localization of 70 kDa stress protein mRNA induction in gerbil brain after ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 11. issue 3. 1991-05-17. PMID:2016350. |
pretreatment with a single injection of mk-801 (10 mg/kg) considerably attenuated the induction of hsp70 mrna in hippocampus at 6 h of recirculation, an effect apparently mediated by persistent drug-induced hypothermia. |
1991-05-17 |
2023-08-11 |
Not clear |
| A Buchan, H Li, W A Pulsinell. The N-methyl-D-aspartate antagonist, MK-801, fails to protect against neuronal damage caused by transient, severe forebrain ischemia in adult rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 11. issue 4. 1991-05-09. PMID:2010804. |
multidose treatment with mk-801 (1 mg/kg) given 1 hr prior to 5 min of ischemia (n = 60) and again at approximately 8 and 16 hr after recirculation failed to attenuate hippocampal injury. |
1991-05-09 |
2023-08-11 |
rat |
| A J Gunn, M Dragunow, R L Faull, P D Gluckma. Effects of hypoxia-ischemia and seizures on neuronal and glial-like c-fos protein levels in the infant rat. Brain research. vol 531. issue 1-2. 1991-04-01. PMID:2126969. |
mk-801 or carbamazepine, which prevented hypoxia-ischemia-induced seizures, also prevented c-fos induction in the non-ligated hemisphere while mk-801 was associated with increased c-fos induction in hippocampal neurones from the ligated side, as well as in glial-like and ependymal cells. |
1991-04-01 |
2023-08-11 |
rat |
| M T Low. MK-801 antagonizes methamphetamine-induced decreases in hippocampal and striatal corticosteroid receptors. Brain research. vol 533. issue 2. 1991-04-01. PMID:2289150. |
mk-801 antagonizes methamphetamine-induced decreases in hippocampal and striatal corticosteroid receptors. |
1991-04-01 |
2023-08-11 |
rat |
| M T Low. MK-801 antagonizes methamphetamine-induced decreases in hippocampal and striatal corticosteroid receptors. Brain research. vol 533. issue 2. 1991-04-01. PMID:2289150. |
pretreatment with mk-801, a non-competitive antagonist of n-methyl-d-aspartate receptors, antagonized the methamphetamine-induced decrease in hippocampal and striatal corticosteroid receptors. |
1991-04-01 |
2023-08-11 |
rat |
| S Subramaniam, P McGonigl. Quantitative autoradiographic characterization of the binding of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5, 10-imine ([3H]MK-801) in rat brain: regional effects of polyamines. The Journal of pharmacology and experimental therapeutics. vol 256. issue 2. 1991-03-21. PMID:1671602. |
scatchard plots based upon densitometric measurements of [3h]mk-801 binding in serial sections of rat brain were also linear, with dissociation constant values ranging from 5.0 to 8.4 nm in different regions at the level of the hippocampus. |
1991-03-21 |
2023-08-11 |
rat |
| T Dalkara, E Tan, G Erdemli, R Onur, T Zilel. Electrophysiological evidence for activation of NMDA receptors and its antagonism by MK-801 in cerebral ischemia. Brain research. vol 532. issue 1-2. 1991-03-21. PMID:1980849. |
we studied the effects of iontophoretically administered mk-801 (50-150 na) on ischemic changes on the ca1 hippocampal field potential. |
1991-03-21 |
2023-08-11 |
rat |
| T Dalkara, E Tan, G Erdemli, R Onur, T Zilel. Electrophysiological evidence for activation of NMDA receptors and its antagonism by MK-801 in cerebral ischemia. Brain research. vol 532. issue 1-2. 1991-03-21. PMID:1980849. |
mk-801 was applied after the appearance of ischemic changes and partly restored the deteriorated hippocampal field potential in 16 of 34 penetrations. |
1991-03-21 |
2023-08-11 |
rat |
| K Morimoto, K Katayama, K Sato, M Ohnishi, M Okamoto, S Otsuk. The role of NMDA receptors in epilepsy: II. Effects of NMDA receptor antagonists (CPP and MK-801) on hippocampal long-term potentiation in anesthetized rats. The Japanese journal of psychiatry and neurology. vol 44. issue 2. 1991-01-25. PMID:2175367. |
effects of nmda receptor antagonists (cpp and mk-801) on hippocampal long-term potentiation in anesthetized rats. |
1991-01-25 |
2023-08-11 |
rat |
| J W McDonald, F S Silverstein, M V Johnsto. MK-801 pretreatment enhances N-methyl-D-aspartate-mediated brain injury and increases brain N-methyl-D-aspartate recognition site binding in rats. Neuroscience. vol 38. issue 1. 1991-01-24. PMID:2255390. |
a 2 h mk-801 pretreatment produced a 30-50% increase in [3h]glutamate binding at n-methyl-d-aspartate preferring recognition sites in all four brain regions examined (areas ca1 and ca3 of the hippocampus, corpus striatum, cingulate cortex) in comparison with saline-treated controls (p less than 0.05, anova). |
1991-01-24 |
2023-08-11 |
rat |
| J W McDonald, F S Silverstein, D Cardona, C Hudson, R Chen, M V Johnsto. Systemic administration of MK-801 protects against N-methyl-D-aspartate- and quisqualate-mediated neurotoxicity in perinatal rats. Neuroscience. vol 36. issue 3. 1990-12-06. PMID:2234402. |
intraperitoneal administration of mk-801 (0.1-1.0 mg/kg) 30 min before n-methyl-d-aspartate injection had a prominent dose-dependent neuroprotective effects as assessed morphometrically by comparison of bilateral striatal, hippocampal and cerebral hemisphere cross-sectional areas five days later. |
1990-12-06 |
2023-08-11 |
rat |
| P Valverius, J C Crabbe, P L Hoffman, B Tabakof. NMDA receptors in mice bred to be prone or resistant to ethanol withdrawal seizures. European journal of pharmacology. vol 184. issue 1. 1990-11-21. PMID:2145177. |
ethanol-naive wsp mice inherently have a greater number of hippocampal binding sites for the nmda receptor-gated ion channel blocker, mk-801, than ethanol-naive wsr mice. |
1990-11-21 |
2023-08-11 |
mouse |
| P Valverius, J C Crabbe, P L Hoffman, B Tabakof. NMDA receptors in mice bred to be prone or resistant to ethanol withdrawal seizures. European journal of pharmacology. vol 184. issue 1. 1990-11-21. PMID:2145177. |
after chronic ethanol ingestion, hippocampal (but not cerebral cortical) mk-801 binding sites increase in both lines of mice. |
1990-11-21 |
2023-08-11 |
mouse |
| P Valverius, J C Crabbe, P L Hoffman, B Tabakof. NMDA receptors in mice bred to be prone or resistant to ethanol withdrawal seizures. European journal of pharmacology. vol 184. issue 1. 1990-11-21. PMID:2145177. |
at the time of ethanol withdrawal, the number of hippocampal mk-801 binding sites in each line of wsp mice is 50-70% higher than the number of such sites in wsr mice. |
1990-11-21 |
2023-08-11 |
mouse |
| E Kohmura, K Yamada, T Hayakawa, A Kinoshita, K Matsumoto, H Mogam. Hippocampal neurons become more vulnerable to glutamate after subcritical hypoxia: an in vitro study. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 10. issue 6. 1990-11-20. PMID:2211881. |
administration of mk-801, a selective noncompetitive antagonist of the n-methyl-d-aspartate (nmda) receptor, could in part reverse this increased susceptibility to low-dose glutamate after hypoxia, although mk-801 could not protect hippocampal neurons from high-dose glutamate. |
1990-11-20 |
2023-08-11 |
rat |
| A Kurumaji, J McCulloc. Effects of unilateral intrahippocampal injection of MK-801 upon local cerebral glucose utilisation in conscious rats. Brain research. vol 518. issue 1-2. 1990-10-04. PMID:2202490. |
the intrahippocampal injection of mk-801 (10 nmol) induced significant marked increases in glucose use in the ipsilateral hippocampus molecular layer and dentate gyrus (by 31 and 44%, respectively). |
1990-10-04 |
2023-08-11 |
rat |