| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S L Peterson, L E Boehnk. Anticonvulsant effects of MK-801 and glycine on hippocampal afterdischarge. Experimental neurology. vol 104. issue 2. 1989-06-06. PMID:2651137. |
the effects of glycine and mk-801 on hippocampal seizure threshold and afterdischarge (ad) were determined in freely moving rats implanted with intracranial electrodes. |
1989-06-06 |
2023-08-11 |
rat |
| S L Peterson, L E Boehnk. Anticonvulsant effects of MK-801 and glycine on hippocampal afterdischarge. Experimental neurology. vol 104. issue 2. 1989-06-06. PMID:2651137. |
the 0.25 mg/kg (ip) dose of mk-801 significantly reduced the primary hippocampal and cortical ad but induced neurological deficit in 4 of 16 rats. |
1989-06-06 |
2023-08-11 |
rat |
| S L Peterson, L E Boehnk. Anticonvulsant effects of MK-801 and glycine on hippocampal afterdischarge. Experimental neurology. vol 104. issue 2. 1989-06-06. PMID:2651137. |
these results demonstrate the differential effects of mk-801 and glycine on primary and rebound hippocampal ad, respectively, which further establishes the independence of the hippocampal seizure ad parameters. |
1989-06-06 |
2023-08-11 |
rat |
| R F Halliwell, J A Peters, J J Lamber. The mechanism of action and pharmacological specificity of the anticonvulsant NMDA antagonist MK-801: a voltage clamp study on neuronal cells in culture. British journal of pharmacology. vol 96. issue 2. 1989-05-05. PMID:2647206. |
some possible molecular mechanisms of action of the anxiolytic, anticonvulsant and neuroprotective agent mk-801 have been examined in 'whole-cell' voltage clamp recordings performed on rat hippocampal and cortical neurones, bovine adrenomedullary chromaffin cells and n1e-115 neuroblastoma cells maintained in cell culture. |
1989-05-05 |
2023-08-11 |
rat |
| R F Halliwell, J A Peters, J J Lamber. The mechanism of action and pharmacological specificity of the anticonvulsant NMDA antagonist MK-801: a voltage clamp study on neuronal cells in culture. British journal of pharmacology. vol 96. issue 2. 1989-05-05. PMID:2647206. |
transmembrane currents recorded from rat hippocampal and cortical neurones in response to locally applied n-methyl-d-aspartate (nmda) were antagonized by mk-801 (0.1-3.0 microm). |
1989-05-05 |
2023-08-11 |
rat |
| R F Halliwell, J A Peters, J J Lamber. The mechanism of action and pharmacological specificity of the anticonvulsant NMDA antagonist MK-801: a voltage clamp study on neuronal cells in culture. British journal of pharmacology. vol 96. issue 2. 1989-05-05. PMID:2647206. |
mk-801 (100 microm) had no effect on currents evoked by gaba on hippocampal neurones. |
1989-05-05 |
2023-08-11 |
rat |
| I S Kass, G Chambers, J E Cottrel. The N-methyl-D-aspartate antagonists aminophosphonovaleric acid and MK-801 reduce anoxic damage to dentate granule and CA1 pyramidal cells in the rat hippocampal slice. Experimental neurology. vol 103. issue 2. 1989-03-03. PMID:2563246. |
the n-methyl-d-aspartate antagonists aminophosphonovaleric acid and mk-801 reduce anoxic damage to dentate granule and ca1 pyramidal cells in the rat hippocampal slice. |
1989-03-03 |
2023-08-11 |
rat |
| I S Kass, G Chambers, J E Cottrel. The N-methyl-D-aspartate antagonists aminophosphonovaleric acid and MK-801 reduce anoxic damage to dentate granule and CA1 pyramidal cells in the rat hippocampal slice. Experimental neurology. vol 103. issue 2. 1989-03-03. PMID:2563246. |
the effect of the n-methyl-d-aspartate antagonists, aminophosphonovaleric acid and mk-801, on irreversible transmission loss subsequent to anoxia was examined using the hippocampal slice preparation. |
1989-03-03 |
2023-08-11 |
rat |
| C J Schmidt, V L Taylo. Release of [3H]norepinephrine from rat hippocampal slices by N-methyl-D-aspartate: comparison of the inhibitory effects of Mg2+ and MK-801. European journal of pharmacology. vol 156. issue 1. 1989-02-21. PMID:2850205. |
release of [3h]norepinephrine from rat hippocampal slices by n-methyl-d-aspartate: comparison of the inhibitory effects of mg2+ and mk-801. |
1989-02-21 |
2023-08-11 |
rat |
| A C Foster, R Gill, G N Woodruf. Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 12. 1989-01-26. PMID:2904493. |
the ability of the noncompetitive n-methyl-d-aspartate (nmda) receptor antagonist mk-801 to prevent neuronal degeneration in the rat striatum and hippocampus caused by intracerebral injection of excitotoxins has been examined. |
1989-01-26 |
2023-08-11 |
rat |
| A C Foster, R Gill, G N Woodruf. Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 12. 1989-01-26. PMID:2904493. |
in the rat hippocampus, administration of 10 mg/kg mk-801 i.p. |
1989-01-26 |
2023-08-11 |
rat |
| K Sato, K Morimoto, M Okamot. Anticonvulsant action of a non-competitive antagonist of NMDA receptors (MK-801) in the kindling model of epilepsy. Brain research. vol 463. issue 1. 1989-01-25. PMID:2848606. |
(2) the mk-801 also showed significant anticonvulsant effects on kindled seizures from the frontal cortex and the ventral and dorsal hippocampus. |
1989-01-25 |
2023-08-11 |
rat |
| M E Gilber. The NMDA-receptor antagonist, MK-801, suppresses limbic kindling and kindled seizures. Brain research. vol 463. issue 1. 1989-01-25. PMID:2848609. |
a second experiment evaluated the anticonvulsant properties of mk-801 in rats kindled in the hippocampus and amygdala, and contrasted its efficacy with the antiepileptic agents, diazepam, phenobarbital and phenytoin, and the dissociative anesthetics phencyclidine and ketamine. |
1989-01-25 |
2023-08-11 |
rat |
| M E Gilber. The NMDA-receptor antagonist, MK-801, suppresses limbic kindling and kindled seizures. Brain research. vol 463. issue 1. 1989-01-25. PMID:2848609. |
mk-801 blocked motor seizures induced by stimulation of hippocampal or amygdala kindled foci, but was more effective in reducing seizure severity and ad duration resulting from stimulation of the hippocampal focus. |
1989-01-25 |
2023-08-11 |
rat |
| D Ashton, R Willems, E De Prins, A Wauquie. Selective inhibition of synaptic versus non-synaptic epileptogenesis by NMDA antagonists in the in vitro hippocampus. Epilepsy research. vol 2. issue 3. 1989-01-17. PMID:2848699. |
three nmda antagonists (2-amino-7-phosphonoheptanoic acid (aph), mk-801, and ketamine) were tested for their ability to antagonize epileptogenic responses in a synaptic and a non-synaptic model of epileptogenesis in the ca1 region of the hippocampal slice. |
1989-01-17 |
2023-08-11 |
Not clear |
| M Lalies, D N Middlemiss, R Ranso. Stereoselective antagonism of NMDA-stimulated noradrenaline release from rat hippocampal slices by MK-801. Neuroscience letters. vol 91. issue 3. 1988-11-30. PMID:2847087. |
stereoselective antagonism of nmda-stimulated noradrenaline release from rat hippocampal slices by mk-801. |
1988-11-30 |
2023-08-11 |
rat |
| M Lalies, D N Middlemiss, R Ranso. Stereoselective antagonism of NMDA-stimulated noradrenaline release from rat hippocampal slices by MK-801. Neuroscience letters. vol 91. issue 3. 1988-11-30. PMID:2847087. |
n-methyl-d-aspartate (nmda)-stimulated [3h]noradrenaline release from rat hippocampal slices was blocked stereospecifically and non-competitively by mk-801 with the (+)-isomer achieving 50% blockade of 100 microm nmda at 16 nm. |
1988-11-30 |
2023-08-11 |
rat |
| R Gill, A C Foster, G N Woodruf. MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period. Neuroscience. vol 25. issue 3. 1988-09-22. PMID:3043254. |
the neuroprotective effects of the non-competitive n-methyl-d-aspartate receptor antagonist (+)-5-methyl-10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5,10-imine maleate (mk-801) have been evaluated in the gerbil hippocampus when the drug was administered i.p. |
1988-09-22 |
2023-08-11 |
Not clear |
| R Gill, A C Foster, G N Woodruf. MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period. Neuroscience. vol 25. issue 3. 1988-09-22. PMID:3043254. |
these results indicate that mk-801 can protect hippocampal neurons from ischaemia-induced neuronal degeneration when it is administered up to 24 h after the insult. |
1988-09-22 |
2023-08-11 |
Not clear |
| S Rothma. Noncompetitive N-methyl-D-aspartate antagonists affect multiple ionic currents. The Journal of pharmacology and experimental therapeutics. vol 246. issue 1. 1988-08-17. PMID:2455788. |
in view of previous reports that phencyclidine interacts with potassium channels in a variety of excitable cells, the author investigated the ability of phencyclidine, ketamine and mk-801 to block voltage-gated potassium currents in cultured rat hippocampal neurons. |
1988-08-17 |
2023-08-11 |
rat |