| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M R Rod, I Q Whishaw, R N Aue. The relationship of structural ischemic brain damage to neurobehavioural deficit: the effect of postischemic MK-801. Canadian journal of psychology. vol 44. issue 2. 1990-09-20. PMID:2200595. |
previous studies have shown (a) a detectable neurobehavioural deficit due to ischemic brain damage limited to half of the ca1 sector of the hippocampus and (b) a reduction of ischemic neuronal necrosis with the noncompetitive n-methyl-d-aspartate (nmda) antagonist mk-801. |
1990-09-20 |
2023-08-11 |
rat |
| M R Rod, I Q Whishaw, R N Aue. The relationship of structural ischemic brain damage to neurobehavioural deficit: the effect of postischemic MK-801. Canadian journal of psychology. vol 44. issue 2. 1990-09-20. PMID:2200595. |
in the hippocampus, mk-801 treated animals showed hippocampal damage limited to the vulnerable portion of the pyramidal cell band comprising 48.8% of the ca1 pyramidal cells, as opposed to 72.4% in untreated controls. |
1990-09-20 |
2023-08-11 |
rat |
| M Yuzaki, A Miyawaki, K Akita, Y Kudo, A Ogura, H Ino, K Mikoshib. Mode of blockade by MK-801 of N-methyl-D-aspartate-induced increase in intracellular Ca2+ in cultured mouse hippocampal neurons. Brain research. vol 517. issue 1-2. 1990-09-05. PMID:2165437. |
mode of blockade by mk-801 of n-methyl-d-aspartate-induced increase in intracellular ca2+ in cultured mouse hippocampal neurons. |
1990-09-05 |
2023-08-11 |
mouse |
| M Yuzaki, A Miyawaki, K Akita, Y Kudo, A Ogura, H Ino, K Mikoshib. Mode of blockade by MK-801 of N-methyl-D-aspartate-induced increase in intracellular Ca2+ in cultured mouse hippocampal neurons. Brain research. vol 517. issue 1-2. 1990-09-05. PMID:2165437. |
microfluorometry with fura-2 was applied to study the action of the anticonvulsant (+)-5-methyl-10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5,10-imine maleate (mk-801) on n-methyl-d-aspartate (nmda)-induced increase in intracellular ca2+ concentration ([ca2+]i) in cultured mouse hippocampal neurons. |
1990-09-05 |
2023-08-11 |
mouse |
| A S Ramoa, M Alkondon, Y Aracava, J Irons, G G Lunt, S S Deshpande, S Wonnacott, R S Aronstam, E X Albuquerqu. The anticonvulsant MK-801 interacts with peripheral and central nicotinic acetylcholine receptor ion channels. The Journal of pharmacology and experimental therapeutics. vol 254. issue 1. 1990-08-13. PMID:1694895. |
mk-801 (10-25 microm) depressed (-)nicotine-evoked gamma-amino[2,3-3h]butyric acid release from rat hippocampal synaptosomes; however, it failed to affect the binding of [3h](-)nicotine to brain membranes and also failed to interfere with the binding of [125i]alpha-bungarotoxin to either frog muscle or torpedo membranes. |
1990-08-13 |
2023-08-11 |
rat |
| W Dimpfel, M Spüle. Dizocilpine (MK-801), ketamine and phencyclidine: low doses affect brain field potentials in the freely moving rat in the same way as activation of dopaminergic transmission. Psychopharmacology. vol 101. issue 3. 1990-08-08. PMID:2163537. |
mk-801 produced strongly dose-dependent effects which could be followed quantitatively over a time of 4 h. during this time spectral analysis of the field potentials continuously recorded from frontal cortex, hippocampus, striatum, and reticular formation revealed a particular pattern of changes which was very stable over time, and after low doses of 0.05 and 0.1 mg/kg, matched that produced by phencyclidine (2 and 4 mg/kg) or ketamine chloride (10 and 20 mg/kg). |
1990-08-08 |
2023-08-11 |
rat |
| D Corbett, S Evans, C Thomas, D Wang, R A Jona. MK-801 reduced cerebral ischemic injury by inducing hypothermia. Brain research. vol 514. issue 2. 1990-08-01. PMID:2162711. |
in gerbils made ischemic, but maintained at normal body temperature, a dose of 3.0 mg/kg of mk-801 provided no protection against hippocampal cell loss or spatial memory impairment. |
1990-08-01 |
2023-08-11 |
Not clear |
| J W Bekenstein, J P Bennett, G F Wooten, E W Lothma. Autoradiographic evidence that NMDA receptor-coupled channels are located postsynaptically and not presynaptically in the perforant path-dentate granule cell system of the rat hippocampal formation. Brain research. vol 514. issue 2. 1990-08-01. PMID:2162712. |
[3h]mk-801 binding did not change in other hippocampal subregions as a consequence of colchicine injection. |
1990-08-01 |
2023-08-11 |
rat |
| D G Nehls, C K Park, A G MacCormack, J McCulloc. The effects of N-methyl-D-aspartate receptor blockade with MK-801 upon the relationship between cerebral blood flow and glucose utilisation. Brain research. vol 511. issue 2. 1990-06-14. PMID:2159360. |
glucose utilisation was significantly and markedly elevated with mk-801 in some limbic structures (particularly the hippocampus, posterior cingulate and entorhinal cortices), the inferior colliculus and most of the neocortex displayed moderate reductions in gu after mk-801 treatment. |
1990-06-14 |
2023-08-11 |
rat |
| B C Rogers, H A Tilso. Kainate-induced functional deficits are not blocked by MK-801. Neuroscience letters. vol 109. issue 3. 1990-05-31. PMID:2158640. |
however, higher doses (1.0 and 10.0 mg/kg) of mk-801 reduced the amount of kainate-induced granule cell and to some extent ca1 pyramidal cell damage in the hippocampus. |
1990-05-31 |
2023-08-11 |
rat |
| J J Grigg, E G Anderso. Competitive and noncompetitive N-methyl-D-aspartate antagonists modify hypoxia-induced membrane potential changes and protect rat hippocampal slices from functional failure: a quantitative comparison. The Journal of pharmacology and experimental therapeutics. vol 253. issue 1. 1990-05-30. PMID:1970359. |
thus, in contrast to their higher affinities for the nmda receptor mk-801 and phencyclidine were not significantly more potent than dl-ap5 in protecting hippocampal slices from hypoxia, and isobolographic analysis revealed dose-additive interactions. |
1990-05-30 |
2023-08-11 |
rat |
| R Gill, G N Woodruf. The neuroprotective actions of kynurenic acid and MK-801 in gerbils are synergistic and not related to hypothermia. European journal of pharmacology. vol 176. issue 2. 1990-04-26. PMID:2178948. |
neither kynurenic acid (200 or 400 mg/kg) nor mk-801 (0.3 mg/kg) was neuroprotective when administered by itself 30 min post-ischaemically, but when co-administered significant protection of the ca1 pyramidal neurones of the hippocampus was seen. |
1990-04-26 |
2023-08-11 |
Not clear |
| M Alkondon, A C Costa, V Radhakrishnan, R S Aronstam, E X Albuquerqu. Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead. FEBS letters. vol 261. issue 1. 1990-04-06. PMID:1689669. |
pb2+ also inhibited the [3h]mk-801 binding to rat hippocampal membranes in vitro. |
1990-04-06 |
2023-08-11 |
rat |
| R L Michaels, S M Rothma. Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 10. issue 1. 1990-03-06. PMID:1967639. |
interestingly, kainate was very toxic to the hippocampal neurons, but this toxicity was markedly attenuated by mk-801. |
1990-03-06 |
2023-08-11 |
rat |
| A Buchan, W A Pulsinell. Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 10. issue 1. 1990-03-06. PMID:2405111. |
in adult female gerbils, single doses of mk-801 injected 1 hr prior to ischemia significantly (p less than 0.01) reduced damage to ca1 hippocampal neurons. |
1990-03-06 |
2023-08-11 |
Not clear |
| A Buchan, W A Pulsinell. Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 10. issue 1. 1990-03-06. PMID:2405111. |
in subsequent experiments, animals pretreated with mk-801 and maintained normothermic during and after forebrain ischemia demonstrated no amelioration of hippocampal damage. |
1990-03-06 |
2023-08-11 |
Not clear |
| K Morimot. Seizure-triggering mechanisms in the kindling model of epilepsy: collapse of GABA-mediated inhibition and activation of NMDA receptors. Neuroscience and biobehavioral reviews. vol 13. issue 4. 1990-02-14. PMID:2558330. |
the excitatory role of nmda receptors in kindling were also investigated by examining the effects of a noncompetitive antagonist of nmda receptors (mk-801) on amygdala kindling and hippocampal long-term potentiation (ltp). |
1990-02-14 |
2023-08-11 |
Not clear |
| R A Keith, T J Mangano, A I Salam. Inhibition of N-methyl-D-aspartate- and kainic acid-induced neurotransmitter release by omega-conotoxin GVIA. British journal of pharmacology. vol 98. issue 3. 1990-01-25. PMID:2574063. |
selective antagonists of the nmda receptor ionophore complex, mg2+, cpp and mk-801, inhibited nmda- but not ka-evoked release of [3h]-noradrenaline from hippocampal and cortical brain slices. |
1990-01-25 |
2023-08-11 |
rat |
| A Kurumaji, J McCulloc. Effects of MK-801 upon local cerebral glucose utilisation in conscious rats and in rats anaesthetised with halothane. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 9. issue 6. 1989-12-29. PMID:2684992. |
pronounced increases in glucose use were observed after mk-801 in the olfactory areas and in a number of brain areas in the limbic system (e.g., hippocampus molecular layer, dentate gyrus, subicular complex, posterior cingulate cortex, and mammillary body). |
1989-12-29 |
2023-08-11 |
rat |
| A Kurumaji, J McCulloc. Effects of MK-801 upon local cerebral glucose utilisation in conscious rats and in rats anaesthetised with halothane. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 9. issue 6. 1989-12-29. PMID:2684992. |
in halothane-anaesthetised rats, mk-801 failed to change the rates of glucose use in the olfactory areas, the hippocampus molecular layer, and the dentate gyrus. |
1989-12-29 |
2023-08-11 |
rat |