| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Kurumaji, D G Nehls, C K Park, J McCulloc. Effects of NMDA antagonists, MK-801 and CPP, upon local cerebral glucose use. Brain research. vol 496. issue 1-2. 1989-12-21. PMID:2553203. |
pronounced dose-related increases in glucose use were observed after mk-801 in the subicular complex, hippocampus molecular layer, dentate gyrus, limbic system (posterior cingulate cortex; mamillary body; anteroventral thalamic nucleus), olfactory areas and substantia nigra (pars reticulata). |
1989-12-21 |
2023-08-11 |
rat |
| K Sato, K Morimoto, M Hiramatsu, A Mori, S Otsuk. Effect of a noncompetitive antagonist (MK-801) of NMDA receptors on convulsions and brain amino acid level in E1 mice. Neurochemical research. vol 14. issue 8. 1989-12-18. PMID:2554174. |
following the administration of a fully anticonvulsant dose of mk-801 (1 mg/kg), amino acid analysis revealed a significantly elevated level of glycine in the hippocampus. |
1989-12-18 |
2023-08-11 |
mouse |
| L M Ford, P R Sanberg, A B Norman, M H Fogelso. MK-801 prevents hippocampal neurodegeneration in neonatal hypoxic-ischemic rats. Archives of neurology. vol 46. issue 10. 1989-11-09. PMID:2552968. |
mk-801 prevents hippocampal neurodegeneration in neonatal hypoxic-ischemic rats. |
1989-11-09 |
2023-08-11 |
rat |
| L M Ford, P R Sanberg, A B Norman, M H Fogelso. MK-801 prevents hippocampal neurodegeneration in neonatal hypoxic-ischemic rats. Archives of neurology. vol 46. issue 10. 1989-11-09. PMID:2552968. |
the neuroprotective potential of the novel, potent nmda receptor antagonist mk-801 was assessed by evaluating hippocampal behavioral and histologic outcomes in an experimental rat model of neonatal hypoxia/ischemia. |
1989-11-09 |
2023-08-11 |
rat |
| L M Ford, P R Sanberg, A B Norman, M H Fogelso. MK-801 prevents hippocampal neurodegeneration in neonatal hypoxic-ischemic rats. Archives of neurology. vol 46. issue 10. 1989-11-09. PMID:2552968. |
hippocampal neuronal damage in the ca1 and ca3 regions was prevented in animals pretreated with mk-801 vs saline-treated controls. |
1989-11-09 |
2023-08-11 |
rat |
| L M Ford, P R Sanberg, A B Norman, M H Fogelso. MK-801 prevents hippocampal neurodegeneration in neonatal hypoxic-ischemic rats. Archives of neurology. vol 46. issue 10. 1989-11-09. PMID:2552968. |
therefore, while saline-treated rats with hippocampal lesions showed defective memory and hippocampal neuronal destruction, pretreatment with mk-801 protected rats. |
1989-11-09 |
2023-08-11 |
rat |
| L M Ford, P R Sanberg, A B Norman, M H Fogelso. MK-801 prevents hippocampal neurodegeneration in neonatal hypoxic-ischemic rats. Archives of neurology. vol 46. issue 10. 1989-11-09. PMID:2552968. |
thus, mk-801 appears to protect hippocampal neurons from hypoxia/ischemia and may be potentially beneficial in preventing neonatal asphyxial brain damage. |
1989-11-09 |
2023-08-11 |
rat |
| B C Rogers, M I Barnes, C L Mitchell, H A Tilso. Functional deficits after sustained stimulation of the perforant path. Brain research. vol 493. issue 1. 1989-10-25. PMID:2776009. |
the learning and memory deficits were associated with a loss of ca1 and ca3 pyramidal cells and pretreatment with the n-methyl-d-aspartate antagonist mk-801 reduced this cell loss, particularly in the ca1 region of the hippocampus. |
1989-10-25 |
2023-08-11 |
Not clear |
| S F Stasheff, W W Anderson, S Clark, W A Wilso. NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. Science (New York, N.Y.). vol 245. issue 4918. 1989-09-12. PMID:2569762. |
in an electrographic model of seizures in the hippocampal slice, both of the n-methyl-d-aspartate (nmda) antagonists 2-amino-5-phosphonovaleric acid and 5-methyl-10,11-dihydro-5h-dibenzo(a,d)cyclohepten-5,10-imine maleate (mk-801) prevented the progressive development of seizures but did not block previously induced seizures. |
1989-09-12 |
2023-08-11 |
Not clear |
| J Kornhuber, F Mack-Burkhardt, P Riederer, G F Hebenstreit, G P Reynolds, H B Andrews, H Beckman. [3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients. Journal of neural transmission. vol 77. issue 2-3. 1989-09-11. PMID:2547892. |
[3h]mk-801 binding was used as a marker for the nmda receptorion channel complex in postmortem brain samples from the frontal cortex, hippocampus, putamen, entorhinal region, and amygdala of schizophrenic patients and controls. |
1989-09-11 |
2023-08-11 |
Not clear |
| B C Rogers, H A Tilso. MK-801 prevents cognitive and behavioral deficits produced by NMDA receptor overstimulation in the rat hippocampus. Toxicology and applied pharmacology. vol 99. issue 3. 1989-08-18. PMID:2546291. |
mk-801 prevents cognitive and behavioral deficits produced by nmda receptor overstimulation in the rat hippocampus. |
1989-08-18 |
2023-08-11 |
rat |
| B C Rogers, H A Tilso. MK-801 prevents cognitive and behavioral deficits produced by NMDA receptor overstimulation in the rat hippocampus. Toxicology and applied pharmacology. vol 99. issue 3. 1989-08-18. PMID:2546291. |
we report here that the functional deficits and histological damage mediated by the overactivation of nmda receptors in the fischer 344 rat hippocampus can be blocked effectively by systemic administration of the noncompetitive nmda antagonist, mk-801. |
1989-08-18 |
2023-08-11 |
rat |
| B C Rogers, H A Tilso. MK-801 prevents cognitive and behavioral deficits produced by NMDA receptor overstimulation in the rat hippocampus. Toxicology and applied pharmacology. vol 99. issue 3. 1989-08-18. PMID:2546291. |
these results suggest that mk-801 may be effective clinically in attenuating memory loss and hippocampal damage in disorders associated with the overstimulation of nmda receptors. |
1989-08-18 |
2023-08-11 |
rat |
| J Kornhuber, F Mack-Burkhardt, P Riedere. Regional distribution of [3H]MK-801 binding sites in the human brain. Brain research. vol 489. issue 2. 1989-08-11. PMID:2663114. |
specific [3h]mk-801 binding was measured under equilibrium conditions in 8 brain regions (frontal cortex, area entorhinalis, hippocampus, amygdala, putamen, thalamus, substantia nigra and nucleus dentatus) in the right hemisphere of the human brain (n = 4). |
1989-08-11 |
2023-08-11 |
human |
| J Kornhuber, F Mack-Burkhardt, P Riedere. Regional distribution of [3H]MK-801 binding sites in the human brain. Brain research. vol 489. issue 2. 1989-08-11. PMID:2663114. |
high [3h]mk-801 binding levels occurred in the area entorhinalis, frontal cortex, hippocampus and amygdala, medium levels were observed in the putamen and thalamus and low levels were found in the substantia nigra and nucleus dentatus. |
1989-08-11 |
2023-08-11 |
human |
| H S Swartzwelder, C Ferrari, W W Anderson, W A Wilso. The drug MK-801 attenuates the development, but not the expression, of long-term potentiation and stimulus train-induced bursting in hippocampal slices. Neuropharmacology. vol 28. issue 5. 1989-07-11. PMID:2657480. |
the drug mk-801 attenuates the development, but not the expression, of long-term potentiation and stimulus train-induced bursting in hippocampal slices. |
1989-07-11 |
2023-08-11 |
rat |
| J D Michenfelder, W L Lanier, B W Scheithauer, W J Perkins, G T Shearman, J H Mild. Evaluation of the glutamate antagonist dizocilipine maleate (MK-801) on neurologic outcome in a canine model of complete cerebral ischemia: correlation with hippocampal histopathology. Brain research. vol 481. issue 2. 1989-06-30. PMID:2655824. |
evaluation of the glutamate antagonist dizocilipine maleate (mk-801) on neurologic outcome in a canine model of complete cerebral ischemia: correlation with hippocampal histopathology. |
1989-06-30 |
2023-08-11 |
Not clear |
| J D Michenfelder, W L Lanier, B W Scheithauer, W J Perkins, G T Shearman, J H Mild. Evaluation of the glutamate antagonist dizocilipine maleate (MK-801) on neurologic outcome in a canine model of complete cerebral ischemia: correlation with hippocampal histopathology. Brain research. vol 481. issue 2. 1989-06-30. PMID:2655824. |
this study was designed to determine if dizocilipine maleate (mk-801), administered following 11 min of complete ischemia in dogs, could favorably alter neurologic outcome and hippocampal damage. |
1989-06-30 |
2023-08-11 |
Not clear |
| H Hattori, A M Morin, P H Schwartz, D G Fujikawa, C G Wasterlai. Posthypoxic treatment with MK-801 reduces hypoxic-ischemic damage in the neonatal rat. Neurology. vol 39. issue 5. 1989-06-07. PMID:2651970. |
mk-801, given 0.5 hr before and immediately after the insult, reduced striatal damage and, given 0.5 hr before, attenuated neuronal necrosis in hippocampal regions. |
1989-06-07 |
2023-08-11 |
rat |
| S L Peterson, L E Boehnk. Anticonvulsant effects of MK-801 and glycine on hippocampal afterdischarge. Experimental neurology. vol 104. issue 2. 1989-06-06. PMID:2651137. |
anticonvulsant effects of mk-801 and glycine on hippocampal afterdischarge. |
1989-06-06 |
2023-08-11 |
rat |