| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenxue Liu, Min Jia, Keyin Zhang, Jiang Chen, Xiyu Zhu, Ruisha Li, Zhenjun Xu, Yanyu Zang, Yapeng Wang, Jun Pan, Daqing Ma, Jianjun Yang, Dongjin Wan. Increased A1 astrocyte activation-driven hippocampal neural network abnormality mediates delirium-like behavior in aged mice undergoing cardiac surgery. Aging cell. 2023-12-29. PMID:38155547. |
increased a1 astrocyte activation-driven hippocampal neural network abnormality mediates delirium-like behavior in aged mice undergoing cardiac surgery. |
2023-12-29 |
2023-12-31 |
mouse |
| Wenxue Liu, Min Jia, Keyin Zhang, Jiang Chen, Xiyu Zhu, Ruisha Li, Zhenjun Xu, Yanyu Zang, Yapeng Wang, Jun Pan, Daqing Ma, Jianjun Yang, Dongjin Wan. Increased A1 astrocyte activation-driven hippocampal neural network abnormality mediates delirium-like behavior in aged mice undergoing cardiac surgery. Aging cell. 2023-12-29. PMID:38155547. |
the results showed that surgery significantly increased hippocampal a1 astrocyte activation in aged compared to young mice. |
2023-12-29 |
2023-12-31 |
mouse |
| Wenxue Liu, Min Jia, Keyin Zhang, Jiang Chen, Xiyu Zhu, Ruisha Li, Zhenjun Xu, Yanyu Zang, Yapeng Wang, Jun Pan, Daqing Ma, Jianjun Yang, Dongjin Wan. Increased A1 astrocyte activation-driven hippocampal neural network abnormality mediates delirium-like behavior in aged mice undergoing cardiac surgery. Aging cell. 2023-12-29. PMID:38155547. |
therefore, our study suggested that cardiac surgery increased a1 astrocyte activation which subsequently impaired the hippocampal neural networks and triggered delirium development. |
2023-12-29 |
2023-12-31 |
mouse |
| Jimcy Platholi, Roberta Marongiu, Laibaik Park, Fangmin Yu, Garrett Sommer, Rena Weinberger, William Tower, Teresa A Milner, Michael J Glas. Hippocampal glial inflammatory markers are differentially altered in a novel mouse model of perimenopausal cerebral amyloid angiopathy. Frontiers in aging neuroscience. vol 15. 2023-11-30. PMID:38035277. |
we found that peri-aof swdi mice showed increased astrocyte activation accompanied by elevated aβ in select regions of the hippocampus, a brain system involved in learning and memory that is severely impacted during dementia. |
2023-11-30 |
2023-12-10 |
mouse |
| Gabriel Henrique Schirmbeck, Marina Seady, Fernanda Telles Fróes, Jéssica Taday, Carollina Da Ré, Jéssica Maria Souza, Carlos Alberto Gonçalves, Marina Concli Leit. Long-term LPS systemic administration leads to memory impairment and disturbance in astrocytic homeostasis. Neurotoxicology. 2023-11-25. PMID:38006911. |
our present work demonstrates that long-term repeated systemic inflammation can lead to memory impairment and hippocampal metabolic disorders, especially regarding astrocyte function. |
2023-11-25 |
2023-11-28 |
rat |
| Zhen Mei, Jiaqi Liu, Jason P Schroeder, David Weinshenker, Duc M Duong, Nicholas T Seyfried, Yujing Li, Peng Jin, Aliza P Wingo, Thomas S Wing. Lowering Hippocampal miR-29a Expression Slows Cognitive Decline and Reduces Beta-Amyloid Deposition in 5×FAD Mice. Molecular neurobiology. 2023-11-22. PMID:37989983. |
mir-29a sponge significantly reduced hippocampal beta-amyloid deposition in 5×fad mice and lowered astrocyte and microglia activation in both 5×fad and wt mice. |
2023-11-22 |
2023-11-29 |
mouse |
| Adriana Fernanda K Vizuete, Fernanda Fróes, Marina Seady, Fernanda Hansen, Rodrigo Ligabue-Braun, Carlos-Alberto Gonçalves, Diogo O Souz. A Mechanism of Action of Metformin in the Brain: Prevention of Methylglyoxal-Induced Glutamatergic Impairment in Acute Hippocampal Slices. Molecular neurobiology. 2023-11-18. PMID:37980327. |
both mg and metformin also influenced astrocyte function in hippocampal slices. |
2023-11-18 |
2023-11-20 |
Not clear |
| Amir-Hossein Bayat, Neda Eskandari, Mojtaba Sani, Farid Fotouhi, Zahra Shenasandeh, Sara Saeidikhoo, Razieh Rohani, Mohammadamin Sabbagh Alvani, Mohammadreza Mafi Balani, Mahdi Eskandarian Boroujeni, Mohammad-Amin Abdollahifar, Faezeh Tajari, Abbas Aliaghaei, Meysam Hassani Moghadda. Anti-inflammatory and antioxidative effects of elderberry diet in the rat model of seizure: a behavioral and histological investigation on the hippocampus. Toxicology research. vol 12. issue 5. 2023-11-02. PMID:37915479. |
the results in the seizure + eb group showed an improvement in the behavioral aspects of the study, a reduction in astrogliosis, astrocyte process length, number of branches, and intersections distal to the soma in the hippocampus of rats compared to controls. |
2023-11-02 |
2023-11-08 |
rat |
| Jonathan C Vincent, Colleen N Garnett, James B Watson, Emma K Higgins, Teresa Macheda, Lydia Sanders, Kelly N Roberts, Ryan K Shahidehpour, Eric M Blalock, Ning Qaun, Adam D Bachstette. IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury. Journal of neuroinflammation. vol 20. issue 1. 2023-10-26. PMID:37884959. |
we found that il-1r1 gko attenuated behavioral impairments 14 weeks post-injury and reduced reactive microglia and astrocyte staining in the neocortex, corpus callosum, and hippocampus. |
2023-10-26 |
2023-11-08 |
mouse |
| Hangbing Cao, Bing Li, Min Mu, Shanshan Li, Haoming Chen, Huihui Tao, Wenyang Wang, Yuanjie Zou, Yehong Zhao, Yang Liu, Xinrong Ta. Nicotine suppresses crystalline silica-induced astrocyte activation and neuronal death by inhibiting NF-κB in the mouse hippocampus. CNS neuroscience & therapeutics. 2023-10-21. PMID:37864452. |
nicotine suppresses crystalline silica-induced astrocyte activation and neuronal death by inhibiting nf-κb in the mouse hippocampus. |
2023-10-21 |
2023-11-08 |
mouse |
| Chiara Orciani, Sonia Do Carmo, Morgan K Foret, Helene Hall, Quentin Bonomo, Agustina Lavagna, Chunwei Huang, A Claudio Cuell. Early treatment with an M1 and sigma-1 receptor agonist prevents cognitive decline in a transgenic rat model displaying Alzheimer-like amyloid pathology. Neurobiology of aging. vol 132. 2023-10-21. PMID:37864952. |
af710b treatment also reduced microglia and astrocyte recruitment toward ca1 hippocampal aβ-burdened neurons compared to vehicle-treated mcgill-r-thy1-app rats, also altering the inflammatory cytokines profile. |
2023-10-21 |
2023-11-08 |
rat |
| Franco Díaz, Freddy Aguilar, Mario Wellmann, Andrés Martorell, Camila González-Arancibia, Lorena Chacana-Véliz, Ignacio Negrón-Oyarzo, Andrés E Chávez, Marco Fuenzalida, Francisco Nualart, Ramón Sotomayor-Zárate, Christian Bonansc. Enhanced Astrocyte Activity and Excitatory Synaptic Function in the Hippocampus of Pentylenetetrazole Kindling Model of Epilepsy. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37833953. |
enhanced astrocyte activity and excitatory synaptic function in the hippocampus of pentylenetetrazole kindling model of epilepsy. |
2023-10-14 |
2023-10-15 |
mouse |
| Noriko Itoh, Yuichiro Itoh, Cassandra E Meyer, Timothy Takazo Suen, Diego Cortez-Delgado, Michelle Rivera Lomeli, Sophia Wendin, Sri Sanjana Somepalli, Lisa C Golden, Allan MacKenzie-Graham, Rhonda R Voskuh. Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice. Nature communications. vol 14. issue 1. 2023-09-27. PMID:37758709. |
here, we identify a sex hormone by age interaction whereby loss of ovarian hormones in female mice at midlife, but not young age, induced hippocampal-dependent cognitive impairment, dorsal hippocampal atrophy, and astrocyte and microglia activation with synaptic loss. |
2023-09-27 |
2023-10-07 |
mouse |
| Dandan Xu, Yayun Xu, Xinran Gao, Mengyu Yan, Chen Zhang, Xian Wu, Qingrong Xia, Jinfang G. Potential value of Interleukin-6 as a diagnostic biomarker in human MDD and the antidepressant effect of its receptor antagonist tocilizumab in lipopolysaccharide-challenged rats. International immunopharmacology. vol 124. issue Pt B. 2023-09-17. PMID:37717319. |
moreover, tocilizumab could alleviate the "inflammatory storm" and impaired hippocampal synaptic plasticity in lps-challenged depression rats, inhibiting the hyperactivation of astrocyte and microglia, decreasing the peripheral and central abundance of il-6, crp, and tnf-α, and balancing the hippocampal expression levels of synaptic plasticity-associated proteins and key molecular in wnt/β-catenin signaling pathway. |
2023-09-17 |
2023-10-07 |
human |
| Blessing A Obafemi, Isaac A Adedara, Joao B T Roch. Neurotoxicity of ochratoxin A: Molecular mechanisms and neurotherapeutic strategies. Toxicology. 2023-09-14. PMID:37709162. |
specifically, the neurotoxic mechanisms associated with ochratoxin a exposure were unequivocally unraveled in vitro using human neuroblastoma sh-sy5y cells, mouse hippocampal ht22 cells, human astrocyte (nha-sv40lt) cells and microglia cells as well as in vivo using mammalian and non-mammalian models. |
2023-09-14 |
2023-10-07 |
mouse |
| James G McLarno. Glial-derived neuroinflammation induced with amyloid-beta-peptide plus fibrinogen injection in rat hippocampus. Current Alzheimer research. 2023-09-13. PMID:37702232. |
the present study has examined microglial and astrocyte activation in association with neuronal degeneration in an animal model using an injection of amyloid-beta peptide aβ1-42 (aβ42) plus fibrinogen into rat hippocampus. |
2023-09-13 |
2023-10-07 |
rat |
| Haylee L Hamilton, Noah A Kinscherf, Garrett Balmer, Mariana Bresque, Shahriar M Salamat, Marcelo R Vargas, Mariana Peha. FABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer's disease. GeroScience. 2023-09-09. PMID:37688656. |
we observed that treatment of primary hippocampal astrocyte cultures with amyloid β fragment 25-35 (aβ |
2023-09-09 |
2023-10-07 |
human |
| Natallia Makarava, Olga Mychko, Kara Molesworth, Jennifer Chen-Yu Chang, Rebecca J Henry, Natalya Tsymbalyuk, Volodymyr Gerzanich, J Marc Simard, David J Loane, Ilia V Baskako. Region-Specific Homeostatic Identity of Astrocytes Is Essential for Defining Their Response to Pathological Insults. Cells. vol 12. issue 17. 2023-09-08. PMID:37681904. |
to address this question, region-specific gene expression profiling was performed for four brain regions (cortex, hippocampus, thalamus, and hypothalamus) in mice using a custom nanostring panel consisting of selected sets of genes associated with astrocyte functions and their reactivity for five conditions: prion disease, traumatic brain injury, brain ischemia, 5xfad alzheimer's disease model and normal aging. |
2023-09-08 |
2023-10-07 |
mouse |
| Zhen Mei, Jiaqi Liu, Jason P Schroeder, David Weinshenker, Duc M Duong, Nicholas T Seyfried, Yujing Li, Peng Jin, Aliza P Wingo, Thomas S Wing. Lowering hippocampal miR-29a expression slows cognitive decline and reduces beta-amyloid deposition in 5xFAD mice. Research square. 2023-08-30. PMID:37645711. |
mir-29a sponge expression significantly reduced hippocampal beta-amyloid deposition in 5xfad mice and lowered astrocyte and microglia activation in both 5xfad and wt mice. |
2023-08-30 |
2023-09-07 |
mouse |
| Guadalupe Herrera, M Jazmín Silvero C, M Cecilia Becerra, Mercedes Lasaga, Teresa Scimonell. Modulatory role of α-MSH in hippocampal-dependent memory impairment, synaptic plasticity changes, oxidative stress, and astrocyte reactivity induced by short-term high-fat diet intake. Neuropharmacology. 2023-08-17. PMID:37591460. |
in this study, we used male wistar rats to evaluate the effect of short-term hfd intake (5 days) plus a mild immune challenge, lipopolysaccharide (lps 10 μg/kg) on contextual fear, changes in structural plasticity, oxidative stress, and astrocyte reactivation in the hippocampus. |
2023-08-17 |
2023-09-07 |
rat |