| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N M Richtand, J R Kelsoe, D S Segal, R Kuczensk. Regional quantification of dopamine transporter mRNA in rat brain using a ribonuclease protection assay. Neuroscience letters. vol 200. issue 2. 1996-06-06. PMID:8614566. |
dat mrna level varied widely between brain regions, and was detected only in cell body regions of the major dopaminergic pathways. |
1996-06-06 |
2023-08-12 |
rat |
| M J Nirenberg, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 2. 1996-02-22. PMID:8551328. |
dat also can transport dopamine neurotoxins and has been implicated in the selective vulnerability of nigrostriatal dopaminergic neurons in major models of parkinson's disease. |
1996-02-22 |
2023-08-12 |
rat |
| M J Nirenberg, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 2. 1996-02-22. PMID:8551328. |
these findings support the proposed topological model for dat and suggest that this transporter is strategically located to facilitate uptake of dopamine and neurotoxins into distal dendritic and axonal processes of nigrostriatal dopaminergic neurons. |
1996-02-22 |
2023-08-12 |
rat |
| D M Donovan, D J Vandenbergh, M P Perry, G S Bird, R Ingersoll, E Nanthakumar, G R Uh. Human and mouse dopamine transporter genes: conservation of 5'-flanking sequence elements and gene structures. Brain research. Molecular brain research. vol 30. issue 2. 1995-09-13. PMID:7637582. |
several dat features, including its exclusive expression in dopaminergic neurons, implication in cocaine action, and prominent role in the mechanisms of parkinsonism-inducing neurotoxins, make understanding of the dat gene of interest. |
1995-09-13 |
2023-08-12 |
mouse |
| T Himi, M Cao, N Mor. Reduced expression of the molecular markers of dopaminergic neuronal atrophy in the aging rat brain. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 50. issue 4. 1995-08-18. PMID:7614230. |
expression of mrnas encoding the dopamine transporter (dat) and tyrosine hydroxylase (th) in dopaminergic neurons of the substantia nigra (sn) was examined in young and aged fischer 344 rats by in situ hybridization. |
1995-08-18 |
2023-08-12 |
rat |
| B J Ciliax, C Heilman, L L Demchyshyn, Z B Pristupa, E Ince, S M Hersch, H B Niznik, A I Leve. The dopamine transporter: immunochemical characterization and localization in brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 3 Pt 1. 1995-04-20. PMID:7534339. |
dat immunocytochemistry with these antibodies were also sensitive to preabsorption with fusion protein and to lesions of dopaminergic mesostriatal and mesocorticolimbic pathways. |
1995-04-20 |
2023-08-12 |
human |
| B J Ciliax, C Heilman, L L Demchyshyn, Z B Pristupa, E Ince, S M Hersch, H B Niznik, A I Leve. The dopamine transporter: immunochemical characterization and localization in brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 3 Pt 1. 1995-04-20. PMID:7534339. |
regional distribution of dat coincided with established dopaminergic innervation of several regions, including ventral mesencephalon, medial forebrain bundle, and dorsal and ventral striatum. |
1995-04-20 |
2023-08-12 |
human |
| B J Ciliax, C Heilman, L L Demchyshyn, Z B Pristupa, E Ince, S M Hersch, H B Niznik, A I Leve. The dopamine transporter: immunochemical characterization and localization in brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 3 Pt 1. 1995-04-20. PMID:7534339. |
however, certain mismatches between immunocytochemical distributions of dat and tyrosine hydroxylase were apparent, indicating that dopaminergic systems are heterogeneous and may use independent mechanisms for the regulation of dopamine levels in brain. |
1995-04-20 |
2023-08-12 |
human |
| B J Ciliax, C Heilman, L L Demchyshyn, Z B Pristupa, E Ince, S M Hersch, H B Niznik, A I Leve. The dopamine transporter: immunochemical characterization and localization in brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 3 Pt 1. 1995-04-20. PMID:7534339. |
the generation of specific dat antibodies will permit further characterization of the cellular and subcellular localization of dat protein, and of dopaminergic circuits in neurological and psychiatric disorders. |
1995-04-20 |
2023-08-12 |
human |
| M K Sanghera, K F Manaye, C L Liang, A M Lacopino, M J Bannon, D C Germa. Low dopamine transporter mRNA levels in midbrain regions containing calbindin. Neuroreport. vol 5. issue 13. 1995-02-10. PMID:7819538. |
the dopamine transporter (dat) is the site at which the neurotoxic metabolite of mptp gains access to midbrain dopaminergic (da) neurons. |
1995-02-10 |
2023-08-12 |
mouse |
| C A Leslie, M W Robertson, A B Jung, J Liebermann, J P Bennet. Effects of prenatal cocaine exposure upon postnatal development of neostriatal dopaminergic function. Synapse (New York, N.Y.). vol 17. issue 3. 1994-11-29. PMID:7974205. |
brains from offspring were examined with quantitative receptor autoradiography [d1 receptor (d1r), d2 receptor (d2r) and dopamine transporter (dat)] and quantitative in situ hybridization [d1r mrna, d2r mrna, preproenkephalin (ppe) mrna] for markers of neostriatal dopaminergic function. |
1994-11-29 |
2023-08-12 |
rat |
| C Perrone-Capano, A Tino, U di Porzi. Target cells modulate dopamine transporter gene expression during brain development. Neuroreport. vol 5. issue 9. 1994-10-11. PMID:7521683. |
we have analysed the expression of the dopamine transporter (dat) gene and compared it with that of tyrosine hydroxylase, neuronal gaba transporter and synaptic vesicle monoamine transporter genes during pre- and post-natal development of rat mesencephalic dopaminergic (da) neurones. |
1994-10-11 |
2023-08-12 |
rat |
| D Lorang, S G Amara, R B Simerl. Cell-type-specific expression of catecholamine transporters in the rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 8. 1994-08-30. PMID:8046459. |
all dopaminergic cell groups of the mesencephalon contained high levels of dat mrna but only the a12 and a13 dopaminergic cell groups of the diencephalon appear to express detectable levels of dat. |
1994-08-30 |
2023-08-12 |
rat |
| S Kitayama, J B Wang, G R Uh. Dopamine transporter mutants selectively enhance MPP+ transport. Synapse (New York, N.Y.). vol 15. issue 1. 1994-03-17. PMID:8310426. |
mpp+ (1-methyl-4-phenylpyridinium), a dopaminergic neurotoxin that provides the best available experimental model of parkinson's disease, is selectively concentrated in dopamine neurons by the dopamine transporter (dat). |
1994-03-17 |
2023-08-12 |
Not clear |
| B Meister, R Eld. Dopamine transporter mRNA in neurons of the rat hypothalamus. Neuroendocrinology. vol 58. issue 4. 1994-02-16. PMID:8284024. |
the membrane-bound dopamine transporter (dat) protein terminates dopaminergic neurotransmission by rapid reaccumulation of dopamine into presynaptic nerve endings. |
1994-02-16 |
2023-08-12 |
rat |
| A M Persico, C W Schindler, M T Brannock, A M Gonzalez, C K Surratt, G R Uh. Dopaminergic gene expression during amphetamine withdrawal. Neuroreport. vol 4. issue 1. 1993-04-16. PMID:8095821. |
amphetamine withdrawal could involve the dopaminergic systems that are thought to underlie psychostimulant rewarding effects, and may thus conceivably alter expression of key genes for dopaminergic transmission, including those encoding tyrosine hydroxylase (th), the membrane dopamine transporter (dat) and the synaptic vesicle amine transporter (svat). |
1993-04-16 |
2023-08-12 |
rat |
| J L Cumming. The dementias of Parkinson's disease: prevalence, characteristics, neurobiology, and comparison with dementia of the Alzheimer type. European neurology. vol 28 Suppl 1. 1988-07-15. PMID:3288478. |
the dopaminergic deficit of pd is complicated in some patients by a cholinergic deficit and in others by dat. |
1988-07-15 |
2023-08-11 |
Not clear |