| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204909. |
the dopamine transporter (dat) plays an important role in the plasmalemmal reuptake of dopamine and, thus, in the termination of normal dopaminergic neurotransmission. |
1997-07-21 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204909. |
dat is also a major binding site for cocaine and other stimulants, the psychoactive effects of which are associated primarily with the inhibition of dopamine reuptake within mesocorticolimbic dopaminergic neurons. |
1997-07-21 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204909. |
we used electron microscopy with an anti-peptide antiserum directed against the n-terminal domain of dat to determine the subcellular localization of this transporter in the rat ventral tegmental area (vta), the region that contains the cell bodies and dendrites of these dopaminergic neurons. |
1997-07-21 |
2023-08-12 |
rat |
| V Planté-Bordeneuve, D Taussig, F Thomas, G Said, N W Wood, C D Marsden, A E Hardin. Evaluation of four candidate genes encoding proteins of the dopamine pathway in familial and sporadic Parkinson's disease: evidence for association of a DRD2 allele. Neurology. vol 48. issue 6. 1997-07-10. PMID:9191771. |
we assessed the role of four candidate genes encoding proteins involved in dopaminergic transmission, the dopamine transporter (dat), the dopamine receptor d2 (drd2), and the main catabolic enzymes of dopamine, monoamine oxidase a (maoa) and b (maob), through allelic association studies in a population of familial and sporadic parkinson's disease (pd). |
1997-07-10 |
2023-08-12 |
human |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 11. 1997-06-10. PMID:9151720. |
the dopamine transporter (dat) plays an important role in the plasmalemmal reuptake of dopamine and, thus, in the termination of normal dopaminergic neurotransmission. |
1997-06-10 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 11. 1997-06-10. PMID:9151720. |
dat is also a major binding site for cocaine and other stimulants, the psychoactive effects of which are associated primarily with the inhibition of dopamine reuptake within mesocorticolimbic dopaminergic neurons. |
1997-06-10 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 11. 1997-06-10. PMID:9151720. |
we used electron microscopy with an anti-peptide antiserum directed against the n-terminal domain of dat to determine the subcellular localization of this transporter in the rat ventral tegmental area (vta), the region that contains the cell bodies and dendrites of these dopaminergic neurons. |
1997-06-10 |
2023-08-12 |
rat |
| P Szot, C E Reigel, S S White, R C Veit. Alterations in mRNA expression of systems that regulate neurotransmitter synaptic content in seizure-naive genetically epilepsy-prone rat (GEPR): transporter proteins and rate-limiting synthesizing enzymes for norepinephrine, dopamine and serotonin. Brain research. Molecular brain research. vol 43. issue 1-2. 1997-05-29. PMID:9037538. |
th and da transporter (dat) mrna was measured in the dopaminergic neurons of the substantia nigra pars compacta (snpc), ventral tegmental area (vta) and zona incerta (zi), dat mrna level was significantly reduced in all dopaminergic neurons in the gepr-3 compared to sd rats and gepr-9, while th mrna level was significantly elevated in the snpc/vta equally in gepr-3 and gepr-9 compared to sd rats. |
1997-05-29 |
2023-08-12 |
rat |
| P Szot, C E Reigel, S S White, R C Veit. Alterations in mRNA expression of systems that regulate neurotransmitter synaptic content in seizure-naive genetically epilepsy-prone rat (GEPR): transporter proteins and rate-limiting synthesizing enzymes for norepinephrine, dopamine and serotonin. Brain research. Molecular brain research. vol 43. issue 1-2. 1997-05-29. PMID:9037538. |
in contrast, presynaptic da tissue content which was unaltered in both strains of gepr, shows an alteration in th and dat mrna level compared to sd rats in all dopaminergic neurons examined. |
1997-05-29 |
2023-08-12 |
rat |
| C Adelbrecht, Y Agid, R Raisman-Vozar. Effect of the weaver mutation on the expression of dopamine membrane transporter, tyrosine hydroxylase and vesicular monoamine transporter in dopaminergic neurons of the substantia nigra and the ventral tegmental area. Brain research. Molecular brain research. vol 43. issue 1-2. 1997-05-29. PMID:9037545. |
quantitative in situ hybridization of three different dopaminergic markers: dopamine membrane transporter (dat), tyrosine hydroxylase (th), and vesicular monoamine transporter (vmat2) was performed on individual dopaminergic cells of the substantia nigra pars compacta (snc) and the ventral tegmental area (vta) in 2-month-old wv/wv mice, in order to investigate the metabolic state of remaining dopaminergic cell bodies and gain further insight into modifications observed on dopaminergic nerve terminals in the striatum and the nucleus accumbens. |
1997-05-29 |
2023-08-12 |
mouse |
| C Adelbrecht, Y Agid, R Raisman-Vozar. Effect of the weaver mutation on the expression of dopamine membrane transporter, tyrosine hydroxylase and vesicular monoamine transporter in dopaminergic neurons of the substantia nigra and the ventral tegmental area. Brain research. Molecular brain research. vol 43. issue 1-2. 1997-05-29. PMID:9037545. |
cellular expression of dat mrna in remaining dopaminergic cells of both the snc and the vta was decreased in the wv/wv mice compared to the wild-type mice (+/+). |
1997-05-29 |
2023-08-12 |
mouse |
| C Adelbrecht, Y Agid, R Raisman-Vozar. Effect of the weaver mutation on the expression of dopamine membrane transporter, tyrosine hydroxylase and vesicular monoamine transporter in dopaminergic neurons of the substantia nigra and the ventral tegmental area. Brain research. Molecular brain research. vol 43. issue 1-2. 1997-05-29. PMID:9037545. |
dat mrna levels were reduced in dopaminergic neurons in both the snc and vta. |
1997-05-29 |
2023-08-12 |
mouse |
| G W Miller, J K Staley, C J Heilman, J T Perez, D C Mash, D B Rye, A I Leve. Immunochemical analysis of dopamine transporter protein in Parkinson's disease. Annals of neurology. vol 41. issue 4. 1997-04-24. PMID:9124811. |
the plasma membrane dopamine transporter (dat) is considered to be a reliable marker of presynaptic dopaminergic terminal loss. |
1997-04-24 |
2023-08-12 |
human |
| G W Miller, J K Staley, C J Heilman, J T Perez, D C Mash, D B Rye, A I Leve. Immunochemical analysis of dopamine transporter protein in Parkinson's disease. Annals of neurology. vol 41. issue 4. 1997-04-24. PMID:9124811. |
thus, immunological analysis of dat protein provides novel and sensitive means for localizing and quantifying dat protein in pd and other neurological disorders involving dopaminergic systems. |
1997-04-24 |
2023-08-12 |
human |
| J R Kelsoe, A D Sadovnick, H Kristbjarnarson, P Bergesch, Z Mroczkowski-Parker, M Drennan, M H Rapaport, P Flodman, M A Spence, R A Remic. Possible locus for bipolar disorder near the dopamine transporter on chromosome 5. American journal of medical genetics. vol 67. issue 6. 1997-03-11. PMID:8950410. |
the dopamine transporter (dat) plays a key role in the regulation of dopaminergic neurotransmission by mediating the active reuptake of synaptic dopamine. |
1997-03-11 |
2023-08-12 |
Not clear |
| J Gelernter, D Vandenbergh, S D Kruger, D L Pauls, R Kurlan, A J Pakstis, K K Kidd, G Uh. The dopamine transporter protein gene (SLC6A3): primary linkage mapping and linkage studies in Tourette syndrome. Genomics. vol 30. issue 3. 1997-02-06. PMID:8825631. |
the protein's actions and dat's specific localization to dopaminergic neurons make it a candidate gene for several psychiatric illnesses. |
1997-02-06 |
2023-08-12 |
Not clear |
| M Fujita, H Nishino, M Kumazaki, S Shimada, M Tohyama, T Nishimur. Expression of dopamine transporter mRNA and its binding site in fetal nigral cells transplanted into the striatum of 6-OHDA lesioned rat. Brain research. Molecular brain research. vol 39. issue 1-2. 1996-12-03. PMID:8804721. |
these results indicated that transplanted fetal dopaminergic cells maturated in cpu of host animals and extended nerve terminals where high density of dat binding sites were found. |
1996-12-03 |
2023-08-12 |
rat |
| F Thibaut, J M Vaugeois, M Peti. [The dopamine transporter: characterization and physiopathologic implications]. L'Encephale. vol 21. issue 6. 1996-08-09. PMID:8674469. |
thus, this marker does not provide any evidence for the dopaminergic hypothesis, but an impairment of the dat itself could possibly be involved in the etiology of schizophrenia. |
1996-08-09 |
2023-08-12 |
Not clear |
| J M Wilson, S J Kis. The vesicular monoamine transporter, in contrast to the dopamine transporter, is not altered by chronic cocaine self-administration in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 10. 1996-06-21. PMID:8627383. |
although much evidence suggests that the brain dopamine transporter (dat) is susceptible to dopaminergic regulation, only limited information is available for the vesicular monoamine transporter (vmat2). |
1996-06-21 |
2023-08-12 |
rat |
| J M Wilson, S J Kis. The vesicular monoamine transporter, in contrast to the dopamine transporter, is not altered by chronic cocaine self-administration in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 10. 1996-06-21. PMID:8627383. |
these data provide additional evidence that vmat2, unlike dat, is resistant to dopaminergic regulation. |
1996-06-21 |
2023-08-12 |
rat |