| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Y Chang, S H Lee, J H Kim, K H Lee, Y S Kim, H Son, Y S Le. Protein kinase C-mediated functional regulation of dopamine transporter is not achieved by direct phosphorylation of the dopamine transporter protein. Journal of neurochemistry. vol 77. issue 3. 2001-06-28. PMID:11331404. |
dopaminergic neurotransmission is terminated by the action of the presynaptic dopamine transporter (dat). |
2001-06-28 |
2023-08-12 |
Not clear |
| E Isovich, M Engelmann, R Landgraf, E Fuch. Social isolation after a single defeat reduces striatal dopamine transporter binding in rats. The European journal of neuroscience. vol 13. issue 6. 2001-06-21. PMID:11285023. |
because the dopaminergic system is thought to be altered in depressive illness, we investigated the impact of individual and group housing on the temporal development of changes of dopamine transporter (dat) binding in male rats after a single social defeat. |
2001-06-21 |
2023-08-12 |
rat |
| M Stamenkovic, S D Schindler, S Asenbaum, A Neumeister, M Willeit, U Willinger, M de Zwaan, F Riederer, H N Aschauer, S Kaspe. No change in striatal dopamine re-uptake site density in psychotropic drug naive and in currently treated Tourette's disorder patients: a [(123)I]-beta-CIT SPECt-study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 11. issue 1. 2001-05-31. PMID:11226814. |
there is evidence that tourette's disorder (td) is associated with abnormalities in the dopaminergic system involving the dopamine transporter (dat). |
2001-05-31 |
2023-08-12 |
Not clear |
| G E Torres, W D Yao, A R Mohn, H Quan, K M Kim, A I Levey, J Staudinger, M G Caro. Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. Neuron. vol 30. issue 1. 2001-05-31. PMID:11343649. |
in dopaminergic neurons, pick1 colocalizes with the dopamine transporter (dat) and forms a stable protein complex. |
2001-05-31 |
2023-08-12 |
Not clear |
| M Ho, M Segr. Individual and combined effects of ethanol and cocaine on the human dopamine transporter in neuronal cell lines. Neuroscience letters. vol 299. issue 3. 2001-05-21. PMID:11165777. |
these data support the hypothesis that the dat may be a common neural substrate for cocaine and ethanol in dopaminergic neurons and it may be involved in the psychological effects of both addictions. |
2001-05-21 |
2023-08-12 |
mouse |
| F J Lee, F Liu, Z B Pristupa, H B Nizni. Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 15. issue 6. 2001-05-10. PMID:11292651. |
since the selective vulnerability of dopaminergic neurons in pd has been ascribed in part to oxidative stress as a result of the cellular overaccumulation of dopamine or dopamine-like molecules by the presynaptic dat, these data provide mechanistic insight into the mode by which the activity of these two proteins may give rise to this process. |
2001-05-10 |
2023-08-12 |
human |
| Y Ouchi, T Kanno, H Okada, E Yoshikawa, M Futatsubashi, S Nobezawa, T Torizuka, K Tanak. Changes in dopamine availability in the nigrostriatal and mesocortical dopaminergic systems by gait in Parkinson's disease. Brain : a journal of neurology. vol 124. issue Pt 4. 2001-05-03. PMID:11287377. |
this was done by comparing dat radioligand uptake in the dopaminergic projection areas after gait with that under the resting condition using a dat probe, 11c-labelled 2-beta-carbomethoxy-3beta-(4-fluorophenyl) tropane ([11c]cft) and pet. |
2001-05-03 |
2023-08-12 |
human |
| G Page, M Peeters, M Najimi, J M Maloteaux, E Herman. Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes. Journal of neurochemistry. vol 76. issue 5. 2001-04-05. PMID:11238713. |
based on the close relationship between glutamatergic and dopaminergic systems in the striatum, we investigated the modulation of the dat activity by metabotropic glutamate receptors (mglurs). |
2001-04-05 |
2023-08-12 |
rat |
| S Doolen, N R Zahnise. Protein tyrosine kinase inhibitors alter human dopamine transporter activity in Xenopus oocytes. The Journal of pharmacology and experimental therapeutics. vol 296. issue 3. 2001-03-15. PMID:11181926. |
the dopamine (da) transporter (dat) regulates dopaminergic synaptic transmission by controlling extracellular levels of da. |
2001-03-15 |
2023-08-12 |
human |
| S Doolen, N R Zahnise. Protein tyrosine kinase inhibitors alter human dopamine transporter activity in Xenopus oocytes. The Journal of pharmacology and experimental therapeutics. vol 296. issue 3. 2001-03-15. PMID:11181926. |
thus, understanding signaling mechanisms that alter dat function is critical for understanding dopaminergic neurotransmission. |
2001-03-15 |
2023-08-12 |
human |
| S Dresel, J Krause, K H Krause, C LaFougere, K Brinkbäumer, H F Kung, K Hahn, K Tatsc. Attention deficit hyperactivity disorder: binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment. European journal of nuclear medicine. vol 27. issue 10. 2001-03-01. PMID:11083541. |
involvement of the dopaminergic system has been suggested in patients suffering from attention deficit hyperactivity disorder (adhd) since the symptoms can be successfully treated with methylphenidate, a potent blocker of the dopamine transporter (dat). |
2001-03-01 |
2023-08-12 |
human |
| J W Kim, D H Kim, S H Kim, J K Ch. Association of the dopamine transporter gene with Parkinson's disease in Korean patients. Journal of Korean medical science. vol 15. issue 4. 2001-01-25. PMID:10983695. |
dopamine transporters (dat) uptake neurotoxic substances such as 1-methyl-4-phenylpyridinium (mpp+) in the dopaminergic nerve terminals and may confer susceptibility to cytotoxic effects of neurotoxic substance. |
2001-01-25 |
2023-08-12 |
human |
| L Zimmer, E Kodas, D Guilloteau, L Garreau, J Besnard, S Chalo. Microdialysis as a tool for in vivo study of dopamine transporter function in rat brains. Journal of neuroscience methods. vol 103. issue 2. 2001-01-04. PMID:11084205. |
we measured the cellular extraction of [3h]-mpp+, which is known to accumulate in the dopaminergic neurones through the dat in the rat striatum, using [14c]-mannitol as reference substance characterized by absence of cellular accumulation. |
2001-01-04 |
2023-08-12 |
rat |
| T Zigova, L F Barroso, A E Willing, S Saporta, M P McGrogan, T B Freeman, P R Sanber. Dopaminergic phenotype of hNT cells in vitro. Brain research. Developmental brain research. vol 122. issue 1. 2000-09-26. PMID:10915908. |
furthermore, numerous th-positive hnt cells were also immunoreactive to dopamine transporter (dat), dopamine receptor (d2) and aldehyde dehydrogenase (ahd-2), an enzyme exclusively expressed by dopaminergic (da) ventral mesencephalic (vm) precursors. |
2000-09-26 |
2023-08-12 |
Not clear |
| F Grünhage, T G Schulze, D J Müller, M Lanczik, E Franzek, M Albus, M Borrmann-Hassenbach, M Knapp, S Cichon, W Maier, M Rietschel, P Propping, M M Nöthe. Systematic screening for DNA sequence variation in the coding region of the human dopamine transporter gene (DAT1). Molecular psychiatry. vol 5. issue 3. 2000-09-12. PMID:10889530. |
the dopamine transporter (dat) plays a central role in dopaminergic neurotransmission in the human brain. |
2000-09-12 |
2023-08-12 |
human |
| D J Vandenbergh, M D Thompson, E H Cook, E Bendahhou, T Nguyen, M D Krasowski, D Zarrabian, D Comings, E M Sellers, R F Tyndale, S R George, B F O'Dowd, G R Uh. Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations. Molecular psychiatry. vol 5. issue 3. 2000-09-12. PMID:10889531. |
associations between dat gene polymorphisms and human disorders with possible links to dopaminergic neurotransmission, including attention-deficit/hyperactivity disorder (adhd) and consequences of cocaine and alcohol administration, have been reported. |
2000-09-12 |
2023-08-12 |
human |
| R H Mach, M A Nader, R L Ehrenkaufer, H D Gage, S R Childers, L M Hodges, M M Hodges, H M Davie. Fluorine-18-labeled tropane analogs for PET imaging studies of the dopamine transporter. Synapse (New York, N.Y.). vol 37. issue 2. 2000-08-24. PMID:10881032. |
both compounds possessed a high affinity and selectivity for the dopamine transporter and had a higher accumulation in the basal ganglia, a brain region having a high density of the dopamine transporter (dat) than the cerebellum, a reference region devoid of dopaminergic terminals. |
2000-08-24 |
2023-08-12 |
Not clear |
| T C Yen, C S Lu, K Y Tzen, S P Wey, Y H Chou, Y H Weng, P F Kao, G Tin. Decreased dopamine transporter binding in Machado-Joseph disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 41. issue 6. 2000-07-07. PMID:10855623. |
the aim of this study was to use 99mtc-trodat-1 brain spect for investigation of the binding of dopamine transporter (dat) in the nigrostriatal dopaminergic pathway of symptomatic machado-joseph disease (mjd) and to compare the results with the abnormal cytidylate, adenylate, and guanylate (cag) expansion in the mjd1 gene and other clinical factors. |
2000-07-07 |
2023-08-12 |
Not clear |
| D M Donovan, L L Miner, M P Perry, R S Revay, L G Sharpe, S Przedborski, V Kostic, R M Philpot, C L Kirstein, R B Rothman, C W Schindler, G R Uh. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581396. |
the dopamine transporter (dat; slc6a3) is densely expressed by the dopaminergic midbrain neurons that play central roles in drug reward and is believed to be a primary site of action for cocaine reward. |
2000-02-14 |
2023-08-12 |
mouse |
| L Chen, D M Segal, C T Moraes, D C Mas. Dopamine transporter mRNA in autopsy studies of chronic cocaine users. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581411. |
the effects of chronic cocaine abuse on transcriptional regulation of human dopamine transporter (dat) mrna in midbrain dopaminergic neurons was assessed by reverse transcription-polymerase chain reaction (rt-pcr). |
2000-02-14 |
2023-08-12 |
human |