| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Kurosaki, Y Muramatsu, H Watanabe, M Michimata, M Matsubara, Y Imai, T Arak. Role of dopamine transporter against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice. Metabolic brain disease. vol 18. issue 2. 2003-07-24. PMID:12822832. |
the present results provide further evidence that the functional damage of dat may precede dopaminergic neuronal death after mptp treatment, although the decrease in the number of th-immunopositive neurons was more pronounced than that in the number of dat-immunopositive neurons. |
2003-07-24 |
2023-08-12 |
mouse |
| R Kurosaki, Y Muramatsu, H Watanabe, M Michimata, M Matsubara, Y Imai, T Arak. Role of dopamine transporter against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice. Metabolic brain disease. vol 18. issue 2. 2003-07-24. PMID:12822832. |
furthermore, our findings demonstrate that mptp can selectively injure the dopaminergic neurons which dat proteins are predominantly distributed on the striatum and substantia nigra. |
2003-07-24 |
2023-08-12 |
mouse |
| Brian Dean, Robyn Bradbury, David Leon Copolo. Cannabis-sensitive dopaminergic markers in postmortem central nervous system: changes in schizophrenia. Biological psychiatry. vol 53. issue 7. 2003-07-11. PMID:12679236. |
this study investigated if changes in pre-synaptic markers on dopaminergic neurons (dopamine transporter [dat], tyrosine hydroxylase [th]) were present in the caudate from subjects with schizophrenia who had delta(9)(-)tetrahydrocannabinol (thc) in their blood at autopsy. |
2003-07-11 |
2023-08-12 |
human |
| Zhicheng Lin, Ping-Wu Zhang, Xuguang Zhu, Jean-Marc Melgari, Robin Huff, Rachel L Spieldoch, George R Uh. Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. The Journal of biological chemistry. vol 278. issue 22. 2003-07-10. PMID:12660249. |
selective dat expression by dopaminergic neurons has led to use of cocaine analog dat radioligands to assess rates of progression of dopamine neuronal degeneration in parkinson's disease. |
2003-07-10 |
2023-08-12 |
Not clear |
| Zhicheng Lin, Ping-Wu Zhang, Xuguang Zhu, Jean-Marc Melgari, Robin Huff, Rachel L Spieldoch, George R Uh. Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. The Journal of biological chemistry. vol 278. issue 22. 2003-07-10. PMID:12660249. |
these results have a number of implications for dat regulation and mandate caution in using dat radioligand binding to infer changes in dopaminergic neuronal integrity after treatments that alter activities of these kinase pathways. |
2003-07-10 |
2023-08-12 |
Not clear |
| Jos L Venero, Mati Revuelta, Leila Atiki, Marti Santiago, Mayka C Toms-Camardiel, Josefina Cano, Alberto Machad. Evidence for dopamine-derived hydroxyl radical formation in the nigrostriatal system in response to axotomy. Free radical biology & medicine. vol 34. issue 1. 2003-07-07. PMID:12498986. |
we anticipate a key regulatory role of the dat to maximally optimize dopaminergic transmission in the synaptic cleft under conditions of degeneration. |
2003-07-07 |
2023-08-12 |
Not clear |
| J V Trinh, D L Nehrenberg, J P R Jacobsen, M G Caron, W C Wetse. Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice. Neuroscience. vol 118. issue 2. 2003-06-16. PMID:12699766. |
since the dat gene is disrupted in the ko mouse, these findings suggest that dopaminergic mechanisms may mediate the wt responses, whereas non-dopaminergic systems predominate in the mutant. |
2003-06-16 |
2023-08-12 |
mouse |
| Philip Gorwood, Frédéric Limosin, Philippe Batel, Michel Hamon, Jean Adès, Claudette Bon. The A9 allele of the dopamine transporter gene is associated with delirium tremens and alcohol-withdrawal seizure. Biological psychiatry. vol 53. issue 1. 2003-04-22. PMID:12513948. |
the dopamine transporter (dat) plays a key role in homeostatic regulation of dopaminergic neurotransmission and could thus be involved in the variability of two severe alcohol-withdrawal symptoms, alcohol-withdrawal seizure (aws) and delirium tremens (dt). |
2003-04-22 |
2023-08-12 |
Not clear |
| A Antonini, R M Moresco, C Gobbo, R De Notaris, A Panzacchi, P Barone, V Bonifati, G Pezzoli, F Fazi. Striatal dopaminergic denervation in early and late onset Parkinson's disease assessed by PET and the tracer [11C]FECIT: preliminary findings in one patient with autosomal recessive parkinsonism (Park2). Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 23 Suppl 2. 2003-03-28. PMID:12548339. |
neuroimaging studies of striatal dopamine transporters (dat) have shown that this measurement is a specific marker of dopaminergic degeneration in patients with parkinson's disease. |
2003-03-28 |
2023-08-12 |
human |
| Gonzalo E Torres, Ana Carneiro, Katie Seamans, Chiara Fiorentini, Ava Sweeney, Wei-Dong Yao, Marc G Caro. Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter. The Journal of biological chemistry. vol 278. issue 4. 2003-03-04. PMID:12429746. |
the dopamine transporter (dat) is a presynaptic plasma membrane protein responsible for the termination of dopaminergic neurotransmission in the central nervous system. |
2003-03-04 |
2023-08-12 |
human |
| Hideo Saji, Yasuhiko Iida, Hidekazu Kawashima, Mikako Ogawa, Youji Kitamura, Takahiro Mukai, Seiichiro Shimazu, Fumiro Yoned. In vivo imaging of brain dopaminergic neurotransmission system in small animals with high-resolution single photon emission computed tomography. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. vol 19. issue 1. 2003-02-13. PMID:12558026. |
thus, we applied the high-resolution spect to in vivo imaging of the brain dopaminergic neurotransmission system in common marmosets using two radiolabeled ligands, [123i]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane (beta-cit) as a dopamine transporter (dat) ligand and [123i]iodobenzamide (ibzm) as a dopamine d2 receptor (d2r) ligand. |
2003-02-13 |
2023-08-12 |
Not clear |
| Tianhong Pan, Jian Fei, Xiaoda Zhou, Joseph Jankovic, Weidong L. Effects of green tea polyphenols on dopamine uptake and on MPP+ -induced dopamine neuron injury. Life sciences. vol 72. issue 9. 2003-02-05. PMID:12495785. |
our studies have demonstrated that polyphenols extracted from green tea (gt) can inhibit the uptake of 3h-dopamine (3h-da) and 1-methyl-4-phenylpyridinium (mpp(+)) by da transporters (dat) and partially protect embryonic rat mesencephalic dopaminergic (daergic) neurons from mpp(+)-induced injury. |
2003-02-05 |
2023-08-12 |
mouse |
| Chien-Nan Lin, Hsiu-Chih Liu, Shih-Jen Tsai, Tsung-Yun Liu, Chen-Jee Hon. Association study for Parkinson's disease and a dopamine transporter gene polymorphism (1215A/G). European neurology. vol 48. issue 4. 2003-01-28. PMID:12422069. |
the dopamine transporter (dat) may play a role in the pathogenesis of parkinson's disease (pd) because dopamine-specific neurotoxins are taken into dopaminergic nerve terminals via the dat. |
2003-01-28 |
2023-08-12 |
Not clear |
| Christoph Scherfler, Eveline Donnemiller, Michael Schocke, Katja Dierkes, Clemens Decristoforo, Michael Oberladstätter, Christian Kolbitsch, Fritz Zschiegner, Georg Riccabona, Werner Poewe, Gregor Wennin. Evaluation of striatal dopamine transporter function in rats by in vivo beta-[123I]CIT pinhole SPECT. NeuroImage. vol 17. issue 1. 2003-01-14. PMID:12482072. |
following estimation of the in vivo binding equilibrium of beta-[123i]cit in the healthy rat striatum, we evaluated the 6-hydroxydopamine-induced loss of striatal dat function using beta-[123i]cit spect and mri coregistration and correlated these findings with dopaminergic cell counts in the substantia nigra pars compacta using th immunohistochemistry. |
2003-01-14 |
2023-08-12 |
rat |
| Christoph Scherfler, Eveline Donnemiller, Michael Schocke, Katja Dierkes, Clemens Decristoforo, Michael Oberladstätter, Christian Kolbitsch, Fritz Zschiegner, Georg Riccabona, Werner Poewe, Gregor Wennin. Evaluation of striatal dopamine transporter function in rats by in vivo beta-[123I]CIT pinhole SPECT. NeuroImage. vol 17. issue 1. 2003-01-14. PMID:12482072. |
a subtotal unilateral dat deficit was detected by beta-[123i]cit spect in all animals which correlated significantly with the cell counting of the remaining dopaminergic neurons. |
2003-01-14 |
2023-08-12 |
rat |
| b' Marko Huotari, Miklos Santha, Louis R Lucas, Maria Karayiorgou, Joseph A Gogos, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice. The Journal of pharmacology and experimental therapeutics. vol 303. issue 3. 2002-12-24. PMID:12438556.' |
for dopaminergic neurons, uptake by the high-affinity dopamine transporter (dat) is the most effective mechanism, and the contribution of glial comt remains secondary under normal conditions. |
2002-12-24 |
2023-08-12 |
mouse |
| Chin-Chang Huang, Tzu-Chen Yen, Yi-Hsin Weng, Chin-Song L. Normal dopamine transporter binding in dopa responsive dystonia. Journal of neurology. vol 249. issue 8. 2002-12-23. PMID:12195447. |
a normal dat uptake was found in drd suggesting a normal presynaptic nigrostriatal dopaminergic terminal. |
2002-12-23 |
2023-08-12 |
Not clear |
| Chin-Chang Huang, Tzu-Chen Yen, Yi-Hsin Weng, Chin-Song L. Normal dopamine transporter binding in dopa responsive dystonia. Journal of neurology. vol 249. issue 8. 2002-12-23. PMID:12195447. |
in addition, dat with (99m)tc-trodat-1 is a reliable and convenient tool to study the function of the presynaptic dopaminergic axonal terminals. |
2002-12-23 |
2023-08-12 |
Not clear |
| Maria Antonietta Casu, Dinuccio Dinucci, Giancarlo Colombo, Gian Luigi Gessa, Luca Pan. Reduced DAT- and DBH-immunostaining in the limbic system of Sardinian alcohol-preferring rats. Brain research. vol 948. issue 1-2. 2002-10-30. PMID:12383975. |
to this aim, we carried out the present immunohistochemistry study using two antibodies raised against dopamine beta-hydroxylase (dbh), the enzyme responsible for the conversion of dopamine into noradrenaline, and against the dopamine transporter (dat), as markers for noradrenergic and dopaminergic fibers, respectively. |
2002-10-30 |
2023-08-12 |
rat |
| Virginia M Pickel, Miguel Garzón, Elisa Mengua. Electron microscopic immunolabeling of transporters and receptors identifies transmitter-specific functional sites envisioned in Cajal's neuron. Progress in brain research. vol 136. 2002-09-19. PMID:12143378. |
dopamine terminals in the striatum and ventral pallidum, as well as dendrites of midbrain dopaminergic neurons in the ventral tegmental area and substantia nigra express the plasmalemmal dopamine transporter (dat) and the vesicular monoamine transporter (vmat2). |
2002-09-19 |
2023-08-12 |
Not clear |