| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Nakano, A C Hirko, A D Smith, M Oka, R Dawson, J Peris, N Terada, E M Meye. Presynaptic dopaminergic properties of differentiated mouse embryonic stem cells. Neurochemistry international. vol 45. issue 7. 2004-11-09. PMID:15337306. |
these and other important dopaminergic genes found expressed in these cultures by rt-pcr included nurr1, vesicular monoamine transporter 2 (vmat2), th, dopamine transporter (dat), and glial cell line-derived neurotrophic factor (gdnf) receptors c-ret and gfralpha1. |
2004-11-09 |
2023-08-12 |
mouse |
| Manuela Contin, Paolo Martinelli, Mirella Mochi, Fiorenzo Albani, Roberto Riva, Cesa Scaglione, Maurizio Dondi, Stefano Fanti, Cinzia Pettinato, Agostino Baruzz. Dopamine transporter gene polymorphism, spect imaging, and levodopa response in patients with Parkinson disease. Clinical neuropharmacology. vol 27. issue 3. 2004-09-27. PMID:15190232. |
to assess the potential association between dopamine transporter (dat) genotype, single photon emission ct (spect) measures using [123i]-n-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl)nortropane ([123i]-fp-cit) of striatal dopaminergic function, and oral levodopa response pattern in a cohort of patients with parkinson disease. |
2004-09-27 |
2023-08-12 |
Not clear |
| Chuantao Jiang, Xinhua Wan, Joseph Jankovic, Samuel T Christian, Zdenek B Pristupa, Hyman B Niznik, John S Sundsmo, Weidong L. Dopaminergic properties and experimental anti-parkinsonian effects of IPX750 in rodent models of Parkinson disease. Clinical neuropharmacology. vol 27. issue 2. 2004-09-09. PMID:15252266. |
one member of this new class, ipx-750, is a pro-drug dopamine-gluconamine designed to retain stereospecificity of binding at: glucose transporters (glut 1/glut 3 and intestinal na/glucose co-transporters sglt1), dopamine transporter (dat); and, dopaminergic receptors of the d1/d2 families. |
2004-09-09 |
2023-08-12 |
mouse |
| Manuel Miranda, Tatiana Sorkina, Tom N Grammatopoulos, W Michael Zawada, Alexander Sorki. Multiple molecular determinants in the carboxyl terminus regulate dopamine transporter export from endoplasmic reticulum. The Journal of biological chemistry. vol 279. issue 29. 2004-08-17. PMID:15128747. |
the plasma membrane dopamine transporter (dat) has an essential role in terminating dopaminergic neurotransmission by reuptake of dopamine into the presynaptic neurons. |
2004-08-17 |
2023-08-12 |
rat |
| Ki-Hwan Lee, Mi-Young Kim, Dong-Hwan Kim, Yong-Sung Le. Syntaxin 1A and receptor for activated C kinase interact with the N-terminal region of human dopamine transporter. Neurochemical research. vol 29. issue 7. 2004-08-10. PMID:15202772. |
the dopamine transporter (dat) regulates the extent and duration of dopamine receptor activation through sodium-dependant reuptake of dopamine into presynaptic neurons, resulting in termination of dopaminergic neurotransmission. |
2004-08-10 |
2023-08-12 |
human |
| Michael R Kilbourn, Elyse S Kemmerer, Timothy J Desmond, Philip S Sherman, Kirk A Fre. Differential effects of scopolamine on in vivo binding of dopamine transporter and vesicular monoamine transporter radioligands in rat brain. Experimental neurology. vol 188. issue 2. 2004-08-10. PMID:15246838. |
cholinergic drugs thus differentially affect in vivo specific binding of dat and vmat2 radioligands, suggesting this should be a consideration in selection of in vivo markers for imaging studies of dopaminergic terminals in the brain of animals and humans. |
2004-08-10 |
2023-08-12 |
rat |
| Kristopher M Kahlig, Jonathan A Javitch, Aurelio Gall. Amphetamine regulation of dopamine transport. Combined measurements of transporter currents and transporter imaging support the endocytosis of an active carrier. The Journal of biological chemistry. vol 279. issue 10. 2004-07-06. PMID:14699142. |
dopaminergic neurotransmission is fine-tuned by the rate of removal of dopamine (da) from the extracellular space via the na(+)/cl(-)-dependent da transporter (dat). |
2004-07-06 |
2023-08-12 |
human |
| Deborah Pareto, Albert Cot, Javier Pavía, Carles Falcón, Ignacio Juvells, Francisco Lomeña, Domènec Ro. Iterative reconstruction with correction of the spatially variant fan-beam collimator response in neurotransmission SPET imaging. European journal of nuclear medicine and molecular imaging. vol 30. issue 10. 2004-07-02. PMID:12845485. |
although visual inspection is often sufficient to assess dat imaging, quantification could improve the diagnostic accuracy of single-photon emission tomography (spet) studies of the dopaminergic system. |
2004-07-02 |
2023-08-12 |
Not clear |
| Michael W Jakowec, Kerry Nixon, Elizabeth Hogg, Tom McNeill, Giselle M Petzinge. Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. Journal of neuroscience research. vol 76. issue 4. 2004-06-21. PMID:15114626. |
these results suggest that th and dat may differ in their time course of expression in surviving dopaminergic neurons and may play a role in mediating the return of striatal dopamine. |
2004-06-21 |
2023-08-12 |
mouse |
| Ruth Reeves, Mona Thiruchelvam, Eric K Richfield, Deborah A Cory-Slecht. Behavioral sensitization and long-term neurochemical alterations associated with the fungicide triadimefon. Pharmacology, biochemistry, and behavior. vol 76. issue 2. 2004-06-18. PMID:14592684. |
tdf induction/expression of behavioral sensitization was associated with long-term, perhaps permanent modulation of dopaminergic function that included increases in striatal dihydroxyphenylacetic acid (dopac) and da turnover, increases in medial prefrontal cortex (mpfc) dopamine transporter (dat) binding, as well as decreases in da d1 and increases in da d2 and dat receptor binding that appeared to target the nucleus accumbens shell (nas) subregion. |
2004-06-18 |
2023-08-12 |
mouse |
| Anthony J Baucum, Kristi S Rau, Evan L Riddle, Glen R Hanson, Annette E Fleckenstei. Methamphetamine increases dopamine transporter higher molecular weight complex formation via a dopamine- and hyperthermia-associated mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 13. 2004-06-18. PMID:15056723. |
multiple high-dose administrations of methamphetamine (meth) both rapidly (within hours) decrease plasmalemmal dopamine (da) uptake and cause long-term deficits in da transporter (dat) levels and other dopaminergic parameters persisting weeks to months in rat striatum. |
2004-06-18 |
2023-08-12 |
rat |
| Anthony J Baucum, Kristi S Rau, Evan L Riddle, Glen R Hanson, Annette E Fleckenstei. Methamphetamine increases dopamine transporter higher molecular weight complex formation via a dopamine- and hyperthermia-associated mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 13. 2004-06-18. PMID:15056723. |
the long-term dopaminergic deficits caused by meth have been suggested, in part, to involve the dat. |
2004-06-18 |
2023-08-12 |
rat |
| Steven P Presgraves, Tariq Ahmed, Sabine Borwege, Jeffrey N Joyc. Terminally differentiated SH-SY5Y cells provide a model system for studying neuroprotective effects of dopamine agonists. Neurotoxicity research. vol 5. issue 8. 2004-05-25. PMID:15111235. |
we characterized undifferentiated (un) and three differentiation conditions of the sh-sy5y neuroblastoma cell line for phenotypic markers of dopaminergic cells, sensitivity to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinium ion (mpp+), the requirement to utilize the dopamine (da) transporter (dat) for mpp+ toxicity, and the neuroprotective effects of pramipexole. |
2004-05-25 |
2023-08-12 |
mouse |
| Alexander Storch, Yu-I Hwang, Debra A Gearhart, J Warren Beach, Edward J Neafsey, Michael A Collins, Johannes Schwar. Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake. Journal of neurochemistry. vol 89. issue 3. 2004-05-19. PMID:15086525. |
we addressed the importance of the dopamine transporter (dat) for selective dopaminergic toxicity by testing the differential cytotoxicity and cellular uptake of 12 betacs in human embryonic kidney hek-293 cells ectopically expressing the dat gene. |
2004-05-19 |
2023-08-12 |
human |
| Jeffrey N Joyce, Lynn Renish, Tracy Osredkar, Jon M Walro, Jan Kucera, Dean E Dluze. Methamphetamine-induced loss of striatal dopamine innervation in BDNF heterozygote mice does not further reduce D3 receptor concentrations. Synapse (New York, N.Y.). vol 52. issue 1. 2004-05-07. PMID:14755628. |
we assessed selective markers of the dopaminergic system including caudate-putamen da concentrations and quantitative autoradiographic measurement of tyrosine hydroxylase (th) levels, da transporter (dat), and da d(3) receptor binding between vehicle and methamphetamine-treated bdnf +/- and their wildtype (wt) littermate control mice. |
2004-05-07 |
2023-08-12 |
mouse |
| Keun-Ah Cheon, Young-Hoon Ryu, Kee Namkoong, Chan-Hyung Kim, Jae-Jin Kim, Jong Doo Le. Dopamine transporter density of the basal ganglia assessed with [123I]IPT SPECT in drug-naive children with Tourette's disorder. Psychiatry research. vol 130. issue 1. 2004-05-04. PMID:14972371. |
there is evidence that abnormalities in the dopaminergic system involving the dopamine transporter (dat) are involved in the pathophysiology of tourette's disorder (td) from previous studies using [(123)i]2beta-carbomethoxy-3-(4-iodophenyl)tropane ([(123)i]beta-cit) and single photon emission tomography (spect). |
2004-05-04 |
2023-08-12 |
Not clear |
| Vicky Marshall, Donald Grosse. Role of dopamine transporter imaging in routine clinical practice. Movement disorders : official journal of the Movement Disorder Society. vol 18. issue 12. 2004-04-28. PMID:14673877. |
functional imaging of the dopamine transporter (dat) defines integrity of the dopaminergic system and has its main clinical application in patients with mild, incomplete, or uncertain parkinsonism. |
2004-04-28 |
2023-08-12 |
Not clear |
| Mei-Chun Hsiao, Kun-Ju Lin, Chia-Yih Liu, Kai-Yuan Tzen, Tzu-Chen Ye. Dopamine transporter change in drug-naive schizophrenia: an imaging study with 99mTc-TRODAT-1. Schizophrenia research. vol 65. issue 1. 2004-04-06. PMID:14623373. |
the aim of this study was to use a specific dopamine transporter (dat) ligand, 99mtc-trodat-1 with single photon emission computed tomography (spect) to investigate the densities of dat in the striatal dopaminergic system in patients with schizophrenia. |
2004-04-06 |
2023-08-12 |
human |
| Paola P Piccin. Dopamine transporter: basic aspects and neuroimaging. Movement disorders : official journal of the Movement Disorder Society. vol 18 Suppl 7. 2004-03-29. PMID:14531039. |
positron emission tomography (pet) and single-photon emission computed tomography (spect) represent unique techniques for assessing in vivo dat distribution in humans and offer reliable methods for studying nigrostriatal dopaminergic function in health and disease. |
2004-03-29 |
2023-08-12 |
Not clear |
| Paola P Piccin. Dopamine transporter: basic aspects and neuroimaging. Movement disorders : official journal of the Movement Disorder Society. vol 18 Suppl 7. 2004-03-29. PMID:14531039. |
the characteristics of different dat radiotracers, the modifying influences of factors such as age, gender, smoking habit, and dopaminergic drugs on dat transporters as well as their implication in evaluation of neuroimaging studies are discussed. |
2004-03-29 |
2023-08-12 |
Not clear |