| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Walter Pirke. Correlation of dopamine transporter imaging with parkinsonian motor handicap: how close is it? Movement disorders : official journal of the Movement Disorder Society. vol 18 Suppl 7. 2004-03-29. PMID:14531046. |
by contrast, neither the severity of parkinsonian rest nor of action tremor is related to the degree of dopaminergic denervation as measured by dat imaging. |
2004-03-29 |
2023-08-12 |
Not clear |
| George R Uh. Dopamine transporter: basic science and human variation of a key molecule for dopaminergic function, locomotion, and parkinsonism. Movement disorders : official journal of the Movement Disorder Society. vol 18 Suppl 7. 2004-03-29. PMID:14531049. |
the localization of dat provides the best marker for the integrity of just the pre-synaptic dopaminergic systems that are most affected in pd. |
2004-03-29 |
2023-08-12 |
human |
| Elisa Mengual, Virginia M Picke. Regional and subcellular compartmentation of the dopamine transporter and tyrosine hydroxylase in the rat ventral pallidum. The Journal of comparative neurology. vol 468. issue 3. 2004-03-26. PMID:14681933. |
the vp catecholaminergic innervation is derived from midbrain dopaminergic neurons that differ in expression levels of the dopamine transporter (dat) and from brainstem noradrenergic neurons without dat. |
2004-03-26 |
2023-08-12 |
rat |
| Elisa Mengual, Virginia M Picke. Regional and subcellular compartmentation of the dopamine transporter and tyrosine hydroxylase in the rat ventral pallidum. The Journal of comparative neurology. vol 468. issue 3. 2004-03-26. PMID:14681933. |
the preferentially low level of dat in dopaminergic terminals in the prefrontal cortex and in striatal regions projecting more extensively to the vp medial (vpm) compared with vp lateral (vpl) compartment suggests possible region-specific differences in vp axonal distribution of dat. |
2004-03-26 |
2023-08-12 |
rat |
| Michael F Salvatore, Subbu Apparsundaram, Greg A Gerhard. Decreased plasma membrane expression of striatal dopamine transporter in aging. Neurobiology of aging. vol 24. issue 8. 2004-03-11. PMID:14643386. |
these data suggest that age-related decreases in striatal dat function and ligand binding are related to a decrease in plasma membrane expression of dat and not a decrease in the steady-state levels of dat protein or loss of dopaminergic neuropil. |
2004-03-11 |
2023-08-12 |
rat |
| Ki-Hwan Lee, Young-Don Kwak, Dong-Hwan Kim, Mi-Yoon Chang, Young-Seek Lee, Yong-Sung Le. Human zinc finger protein 161, a novel transcriptional activator of the dopamine transporter. Biochemical and biophysical research communications. vol 313. issue 4. 2004-03-05. PMID:14706637. |
the dopamine transporter (dat) terminates dopaminergic neurotransmission via reuptake of released dopamine into presynaptic neurons. |
2004-03-05 |
2023-08-12 |
human |
| Ramona M Rodriguiz, Richard Chu, Marc G Caron, William C Wetse. Aberrant responses in social interaction of dopamine transporter knockout mice. Behavioural brain research. vol 148. issue 1-2. 2004-03-01. PMID:14684259. |
the dopamine (da) transporter (dat) controls the temporal and spatial resolution of dopaminergic neurotransmission. |
2004-03-01 |
2023-08-12 |
mouse |
| Chin-Chang Huang, Yi-Hsin Weng, Chin-Song Lu, Nai-Shin Chu, Tzu-Chen Ye. Dopamine transporter binding in chronic manganese intoxication. Journal of neurology. vol 250. issue 11. 2004-01-16. PMID:14648150. |
(99m)tc-trodat-1 is a cocaine analogue that can bind to the dopamine transporter (dat) site reflecting the function of presynaptic dopaminergic terminals. |
2004-01-16 |
2023-08-12 |
human |
| Chin-Chang Huang, Yi-Hsin Weng, Chin-Song Lu, Nai-Shin Chu, Tzu-Chen Ye. Dopamine transporter binding in chronic manganese intoxication. Journal of neurology. vol 250. issue 11. 2004-01-16. PMID:14648150. |
the purpose of this study was to evaluate dat function using (99m)tc-trodat-1 to investigate the integrity of the presynaptic dopaminergic terminals in manganese-induced parkinsonism. |
2004-01-16 |
2023-08-12 |
human |
| Chin-Chang Huang, Yi-Hsin Weng, Chin-Song Lu, Nai-Shin Chu, Tzu-Chen Ye. Dopamine transporter binding in chronic manganese intoxication. Journal of neurology. vol 250. issue 11. 2004-01-16. PMID:14648150. |
although the dat shows a slight decrease in the putamen of manganism patients as compared with that of the normal controls, the data indicate that the presynaptic dopaminergic terminals are not the main target of chronic manganese intoxication. |
2004-01-16 |
2023-08-12 |
human |
| Klaus Henning Krause, Stefan H Dresel, Johanna Krause, Christian la Fougere, Manfred Ackenhei. The dopamine transporter and neuroimaging in attention deficit hyperactivity disorder. Neuroscience and biobehavioral reviews. vol 27. issue 7. 2004-01-15. PMID:14624805. |
for instance, dopaminergic psychostimulants, the drugs of first choice in adhd, interact directly with the dopamine transporter (dat). |
2004-01-15 |
2023-08-12 |
Not clear |
| D J Brooks, K A Frey, K L Marek, D Oakes, D Paty, R Prentice, C W Shults, A J Stoess. Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson's disease. Experimental neurology. vol 184 Suppl 1. 2004-01-08. PMID:14597329. |
one approach, which has been extensively explored, is neuroimaging with radiotracers that interact with processes central to dopaminergic neurotransmission in the nigrostriatal dopaminergic axons-conversion of levodopa to dopamine through aromatic amino acid decarboxylase (aadc), [(18)f]fluorodopa pet, storage of dopamine in synaptic vesicles via the vesicular monoamine transporter 2 (vmat2), (+)-[(11)c]dihydrotetrabenazine pet, and reuptake of dopamine into axons via the dopamine transporter (dat), [(123)i]beta-cit spect, and a number of other pet and spect ligands. |
2004-01-08 |
2023-08-12 |
human |
| Iwona E Misiuta, Lynn Anderson, Michael P McGrogan, Paul R Sanberg, Alison E Willing, Tanja Zigov. The transcription factor Nurr1 in human NT2 cells and hNT neurons. Brain research. Developmental brain research. vol 145. issue 1. 2003-12-16. PMID:14519498. |
our previous in vitro experiments showed that hnt cells possess immunocytochemically detectable markers typical of dopaminergic (da) ventral mesencephalic (vm) neurons, including tyrosine hydroxylase (th), dopamine transporter (dat), dopamine receptor (d2), and aldehyde dehydrogenase (ahd-2). |
2003-12-16 |
2023-08-12 |
human |
| John W Haycock, Laurence Becker, Lee Ang, Yoshiaki Furukawa, Oleh Hornykiewicz, Stephen J Kis. Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum. Journal of neurochemistry. vol 87. issue 3. 2003-11-24. PMID:14535941. |
because age-related changes in brain dopaminergic innervation are assumed to influence human disorders involving dopamine (da), we measured the levels of several presynpatic daergic markers [da, homovanillic acid, tyrosine hydroxylase (th), aromatic l-amino acid decarboxylase (aadc), vesicular monoamine transporter 2 (vmat2), and dopamine transporter (dat)] in post-mortem human striatum (caudate and putamen) from 56 neurologically normal subjects aged 1 day to 103 years. |
2003-11-24 |
2023-08-12 |
human |
| Chuen-Lin Huang, Nai-Kuei Huang, Song-Kun Shyue, Yijuang Cher. Hydrogen peroxide induces loss of dopamine transporter activity: a calcium-dependent oxidative mechanism. Journal of neurochemistry. vol 86. issue 5. 2003-11-12. PMID:12911632. |
collectively, our results indicate that the dat, one of the most important proteins controlling the dopaminergic system, is also a redox sensor. |
2003-11-12 |
2023-08-12 |
Not clear |
| Alberto Auricchio, Paul D Acton, Markus Hildinger, Jean-Pierre Louboutin, Karl Plössl, Erin O'Connor, Hank F Kung, James M Wilso. In vivo quantitative noninvasive imaging of gene transfer by single-photon emission computerized tomography. Human gene therapy. vol 14. issue 3. 2003-10-06. PMID:12639305. |
the dopamine transporter (dat) is normally expressed at high levels, mainly in the dopaminergic neurons of the central nervous system. |
2003-10-06 |
2023-08-12 |
human |
| Keun-Ah Cheon, Young Hoon Ryu, Young-Kee Kim, Kee Namkoong, Chan-Hyung Kim, Jong Doo Le. Dopamine transporter density in the basal ganglia assessed with [123I]IPT SPET in children with attention deficit hyperactivity disorder. European journal of nuclear medicine and molecular imaging. vol 30. issue 2. 2003-09-26. PMID:12552351. |
in this study, we investigated dopamine transporter (dat) density in children with adhd using iodine-123 labelled n-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane ([(123)i]ipt) single-photon emission tomography (spet) and postulated that an alteration in dat density in the basal ganglia is responsible for dopaminergic dysfunction in children with adhd. |
2003-09-26 |
2023-08-12 |
Not clear |
| Wen-Sheng Huang, Yung-Hsiao Chiang, Jiann-Chyun Lin, Yuan-Hwa Chou, Cheng-Yi Cheng, Ren-Shyan Li. Crossover study of (99m)Tc-TRODAT-1 SPECT and (18)F-FDOPA PET in Parkinson's disease patients. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 44. issue 7. 2003-09-04. PMID:12843212. |
99mtc-trodat-1 ([2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3,2,1]oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiolato(3-)-n2,n2',s2,s2']oxo-[1r-(exo-exo)]) is a potential agent for dopamine transporter (dat) spect, whereas 6-(18)f-fluoro-l-dopa ((18)f-fdopa) pet has been used for the quantitative assessment of presynaptic nigrostriatal dopaminergic function. |
2003-09-04 |
2023-08-12 |
Not clear |
| Erkki Tupala, Håkan Hall, Kim Bergström, Tuija Mantere, Pirkko Räsänen, Terttu Särkioja, Jukka Hiltunen, Jari Tiihone. Different effect of age on dopamine transporters in the dorsal and ventral striatum of controls and alcoholics. Synapse (New York, N.Y.). vol 48. issue 4. 2003-07-25. PMID:12687640. |
in type 1 alcoholics the lack of correlation between dat density and age may indicate a preexisting dopaminergic deficit in this patient group, whereas age-related decline among type 2 alcoholics resembled that of healthy controls. |
2003-07-25 |
2023-08-12 |
human |
| R Kurosaki, Y Muramatsu, H Watanabe, M Michimata, M Matsubara, Y Imai, T Arak. Role of dopamine transporter against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice. Metabolic brain disease. vol 18. issue 2. 2003-07-24. PMID:12822832. |
in our double-labeled immunostaining with anti-dat and anti-gfap antibodies, dat immunoreactivity was observed only in the nigral dopaminergic neurons, but not in the reactive astrocytes. |
2003-07-24 |
2023-08-12 |
mouse |