| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Lemmer, G Ahnert-Hilger, M Höpfner, S Hoegerle, S Faiss, P Grabowski, M Jockers-Scherübl, E O Riecken, M Zeitz, H Scherüb. Expression of dopamine receptors and transporter in neuroendocrine gastrointestinal tumor cells. Life sciences. vol 71. issue 6. 2002-09-17. PMID:12072155. |
to further characterize the dopaminergic system in neuroendocrine gastrointestinal tumor cells, we investigated the expression of both dopamine receptors and the transmembrane dopamine transporter (dat) in the human neuroendocrine pancreatic cell line bon and in the neuroendocrine gut cell line stc-1. |
2002-09-17 |
2023-08-12 |
human |
| Vera Lehmensiek, Eva-Maria Tan, Johannes Schwarz, Alexander Storc. Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro. Neuroreport. vol 13. issue 10. 2002-09-13. PMID:12151787. |
here we report on effects of mutant alpha-synucleins on dopamine transporter (dat)-mediated toxicity of the selective dopaminergic neurotoxin 1-methyl-4-phenylpyridinium ion (mpp+) in vitro. |
2002-09-13 |
2023-08-12 |
human |
| Vera Lehmensiek, Eva-Maria Tan, Johannes Schwarz, Alexander Storc. Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro. Neuroreport. vol 13. issue 10. 2002-09-13. PMID:12151787. |
our data suggest a new mechanism of mpp+-induced dopaminergic toxicity by an interaction between mutant alpha-synucleins and the dat, which is independent of the function of the proteasome. |
2002-09-13 |
2023-08-12 |
human |
| Ana M Carneiro, Susan L Ingram, Jean-Martin Beaulieu, Ava Sweeney, Susan G Amara, Sheila M Thomas, Marc G Caron, Gonzalo E Torre. The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 16. 2002-09-04. PMID:12177201. |
the na+/cl--dependent dopamine transporter (dat) is critical in terminating dopaminergic transmission by removing the transmitter away from the synapse. |
2002-09-04 |
2023-08-12 |
human |
| Lucia Carvelli, José A Morón, Kristopher M Kahlig, Jasmine V Ferrer, Namita Sen, James D Lechleiter, L M Fredrik Leeb-Lundberg, Gerald Merrill, Eileen M Lafer, Lisa M Ballou, Toni S Shippenberg, Jonathan A Javitch, Richard Z Lin, Aurelio Gall. PI 3-kinase regulation of dopamine uptake. Journal of neurochemistry. vol 81. issue 4. 2002-07-12. PMID:12065645. |
these data implicate dat trafficking in the hormonal regulation of dopaminergic signaling, and suggest that a state of chronic hypoinsulinemia, such as in diabetes, may alter synaptic da signaling by reducing the available cell surface dats. |
2002-07-12 |
2023-08-12 |
human |
| G Battaglia, C L Busceti, L Cuomo, F S Giorgi, F Orzi, A De Blasi, F Nicoletti, S Ruggieri, F Forna. Continuous subcutaneous infusion of apomorphine rescues nigro-striatal dopaminergic terminals following MPTP injection in mice. Neuropharmacology. vol 42. issue 3. 2002-06-27. PMID:11897115. |
continuous s.c. infusion of apomorphine starting 40 h following mptp injection rescued striatal dopaminergic terminals, as assessed by measurements of da and its metabolites, as well as th and dat immunostaining after one month. |
2002-06-27 |
2023-08-12 |
mouse |
| Alexander Storch, Stefanie Ott, Yu I Hwang, Rainer Ortmann, Andreas Hein, Stefan Frenzel, Kazuo Matsubara, Shigeru Ohta, Hans Uwe Wolf, Johannes Schwar. Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporter. Biochemical pharmacology. vol 63. issue 5. 2002-05-07. PMID:11911843. |
we addressed the importance of the dat molecule for selective dopaminergic toxicity by testing the differential cytotoxicity of 22 neutral and quaternary compounds from three classes of isoquinoline derivatives (3, iqs; 4,3,4-dihydroisoquinolines and 15, 1,2,3,4-tetrahydroisoquinolines) as well as mpp(+) in non-neuronal and neuronal heterologous expression systems of the dat gene (human embryonic kidney hek-293 and mouse neuroblastoma neuro-2a cells, respectively). |
2002-05-07 |
2023-08-12 |
mouse |
| Alexander Storch, Stefanie Ott, Yu I Hwang, Rainer Ortmann, Andreas Hein, Stefan Frenzel, Kazuo Matsubara, Shigeru Ohta, Hans Uwe Wolf, Johannes Schwar. Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporter. Biochemical pharmacology. vol 63. issue 5. 2002-05-07. PMID:11911843. |
our results suggest that 2[n]-methylated isoquinoline derivatives structurally related to mptp/mpp(+) are selectively toxic to dopaminergic cells via uptake by the dat, and therefore may play a role in the pathogenesis of parkinson's disease. |
2002-05-07 |
2023-08-12 |
mouse |
| Stéphanie Barc, Guylène Page, Laurence Barrier, Lucette Garreau, Denis Guilloteau, Bernard Fauconneau, Sylvie Chalo. Relevance of different striatal markers in assessment of the MPP+-induced dopaminergic nigrostriatal injury in rat. Journal of neurochemistry. vol 80. issue 3. 2002-04-04. PMID:11905985. |
the in vivo binding of (e)-n-(3-iodoprop-2-enyl)-2-beta-carbomethoxy-3beta-(4'-methylphenyl)nortropane (pe2i), a selective and potent inhibitor of the neuronal dopamine transporter (dat) was considered as the reference index of injury of striatal dopaminergic nerve-endings. |
2002-04-04 |
2023-08-12 |
rat |
| S K Michelhaugh, C Fiskerstrand, E Lovejoy, M J Bannon, J P Quin. The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neurons. Journal of neurochemistry. vol 79. issue 5. 2002-01-17. PMID:11739616. |
this study demonstrates by lipid transfection into an immortalized dopaminergic cell line and biolistic transfection into dopamine neurons in neonatal rat midbrain slices that the human nine-repeat dat vntr can enhance transcription. |
2002-01-17 |
2023-08-12 |
human |
| R D Mayfield, R Maiya, D Keller, N R Zahnise. Ethanol potentiates the function of the human dopamine transporter expressed in Xenopus oocytes. Journal of neurochemistry. vol 79. issue 5. 2002-01-17. PMID:11739621. |
these experiments demonstrate that dat-mediated substrate translocation and substrate-associated ionic conductances are sensitive to intoxicating concentrations of ethanol and suggest that dat may represent an important site of action for ethanol's effects on central dopaminergic transmission. |
2002-01-17 |
2023-08-12 |
human |
| G Eisenhofe. The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines. Pharmacology & therapeutics. vol 91. issue 1. 2001-12-19. PMID:11707293. |
in mammals, neuronal uptake of catecholamines involves the dopamine transporter (dat) at dopaminergic neurons and the norepinephrine transporter (net) at noradrenergic neurons. |
2001-12-19 |
2023-08-12 |
Not clear |
| A Laakso, J Bergman, M Haaparanta, H Vilkman, O Solin, E Syvälahti, J Hietal. Decreased striatal dopamine transporter binding in vivo in chronic schizophrenia. Schizophrenia research. vol 52. issue 1-2. 2001-12-18. PMID:11595398. |
together with the finding of unchanged average striatal dat levels in first-episode patients and relative insensitivity of striatal [18f]cft binding to endogenous dopamine and neuroleptic drugs, the result is in line with a relative loss of striatal dopaminergic nerve terminals and/or decreased expression of dat in a subset of chronic schizophrenic patients. |
2001-12-18 |
2023-08-12 |
Not clear |
| A Antonini, R M Moresco, C Gobbo, R De Notaris, A Panzacchi, P Barone, S Calzetti, A Negrotti, G Pezzoli, F Fazi. The status of dopamine nerve terminals in Parkinson's disease and essential tremor: a PET study with the tracer [11-C]FE-CIT. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 22. issue 1. 2001-12-13. PMID:11487195. |
neuroimaging studies of the striatal dopamine transporter (dat) are useful in the assessment of the dopaminergic system in parkinson's disease (pd). |
2001-12-13 |
2023-08-12 |
human |
| R R Gainetdinov, A R Mohn, L M Bohn, M G Caro. Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 20. 2001-12-04. PMID:11572967. |
the dopamine transporter (dat), which reuptakes the released neurotransmitter into presynaptic terminals, is a major determinant of the intensity and duration of the dopaminergic signal. |
2001-12-04 |
2023-08-12 |
mouse |
| F Amenta, E Bronzetti, F Cantalamessa, D El-Assouad, L Felici, A Ricci, S K Tayebat. Identification of dopamine plasma membrane and vesicular transporters in human peripheral blood lymphocytes. Journal of neuroimmunology. vol 117. issue 1-2. 2001-08-23. PMID:11431013. |
plasma membrane dopamine transporter (dat), vesicular monoamine transporters (vmat) type-1 and -2 and the expression of the dopaminergic markers dopamine and tyrosine hydroxylase were assessed in membranes and/or in cytospin centrifuged human peripheral blood lymphocytes. |
2001-08-23 |
2023-08-12 |
human |
| F Amenta, E Bronzetti, F Cantalamessa, D El-Assouad, L Felici, A Ricci, S K Tayebat. Identification of dopamine plasma membrane and vesicular transporters in human peripheral blood lymphocytes. Journal of neuroimmunology. vol 117. issue 1-2. 2001-08-23. PMID:11431013. |
in view of this assessment of lymphocyte dat and vmat transporters can be considered for identifying pathologies characterized by impaired dopaminergic neurotransmission. |
2001-08-23 |
2023-08-12 |
human |
| M Guttman, D Stewart, D Hussey, A Wilson, S Houle, S Kis. Influence of L-dopa and pramipexole on striatal dopamine transporter in early PD. Neurology. vol 56. issue 11. 2001-07-12. PMID:11402115. |
animal data indicate that chronic exposure to dopaminergic drugs can alter levels of the dopamine transporter (dat), which is critically involved in regulation of synaptic dopamine levels. |
2001-07-12 |
2023-08-12 |
Not clear |
| J Holzschuh, S Ryu, F Aberger, W Drieve. Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo. Mechanisms of development. vol 101. issue 1-2. 2001-07-05. PMID:11231083. |
to characterize the formation of the dopaminergic system in the developing zebrafish cns, we cloned cdnas encoding tyrosine hydroxylase (th), an enzyme in dopamine synthesis, and the dopamine transporter (dat), a membrane transport protein which terminates dopamine action by re-uptake. |
2001-07-05 |
2023-08-12 |
zebrafish |
| J Holzschuh, S Ryu, F Aberger, W Drieve. Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo. Mechanisms of development. vol 101. issue 1-2. 2001-07-05. PMID:11231083. |
subsequently, th and dat detection identifies dopaminergic neurons in the olfactory bulb, the pretectum, the retina and the locus coeruleus. |
2001-07-05 |
2023-08-12 |
zebrafish |