| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G W Miller, M L Kirby, A I Levey, J R Bloomquis. Heptachlor alters expression and function of dopamine transporters. Neurotoxicology. vol 20. issue 4. 1999-12-10. PMID:10499361. |
since dat has been proposed to be the molecular gateway for dopaminergic toxins, such as the parkinsonism-inducing neurotoxin mpp, and vmat2 has been proposed to protect cells from mpp and other toxins by sequestering the toxin into vesicles, the combined effects of heptachlor could increase the susceptibility of the nigrostriatal dopamine system to neurodegeneration. |
1999-12-10 |
2023-08-12 |
mouse |
| M Jaber, B Dumartin, C Sagné, J W Haycock, C Roubert, B Giros, B Bloch, M G Caro. Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter. The European journal of neuroscience. vol 11. issue 10. 1999-12-08. PMID:10564358. |
mice lacking the dopamine transporter (dat) display biochemical and behavioural dopaminergic hyperactivity despite dramatic alteration in dopamine homeostasis. |
1999-12-08 |
2023-08-12 |
mouse |
| Y Fang, O K Ronneklei. Cocaine upregulates the dopamine transporter in fetal rhesus monkey brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516315. |
cocaine is a highly addictive drug that binds to the dopamine transporter (dat), inhibits the reuptake of dopamine, and initiates multiple actions within midbrain dopaminergic systems. |
1999-10-28 |
2023-08-12 |
human |
| A M Kang, M A Palmatier, K K Kid. Global variation of a 40-bp VNTR in the 3'-untranslated region of the dopamine transporter gene (SLC6A3). Biological psychiatry. vol 46. issue 2. 1999-10-25. PMID:10418689. |
the dopamine transporter (dat) is the primary mechanism for dopamine clearance from the synapse in midbrain dopaminergic neurons, and the target of psychostimulant and neurotoxic drugs such as cocaine, amphetamine, and mptp. |
1999-10-25 |
2023-08-12 |
Not clear |
| M Garzón, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Cholinergic axon terminals in the ventral tegmental area target a subpopulation of neurons expressing low levels of the dopamine transporter. The Journal of comparative neurology. vol 410. issue 2. 1999-10-21. PMID:10414527. |
these dopaminergic neurons differentially project to cortical and limbic forebrain regions, where their terminals differ in levels of expression of the plasmalemmal dopamine transporter (dat). |
1999-10-21 |
2023-08-12 |
rat |
| M Garzón, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Cholinergic axon terminals in the ventral tegmental area target a subpopulation of neurons expressing low levels of the dopamine transporter. The Journal of comparative neurology. vol 410. issue 2. 1999-10-21. PMID:10414527. |
we examined immunogold labeling for dat and immunoperoxidase localization of vacht antipeptide antisera in single sections of the rat vta to determine whether dopaminergic somata and dendrites in this region differ in their levels of expression of dat and/or input from cholinergic terminals. |
1999-10-21 |
2023-08-12 |
rat |
| B J Ciliax, G W Drash, J K Staley, S Haber, C J Mobley, G W Miller, E J Mufson, D C Mash, A I Leve. Immunocytochemical localization of the dopamine transporter in human brain. The Journal of comparative neurology. vol 409. issue 1. 1999-07-20. PMID:10363710. |
regional distribution of dat was found in areas with established dopaminergic circuitry, e.g., mesostriatal, mesolimbic, and mesocortical pathways. |
1999-07-20 |
2023-08-12 |
human |
| B J Ciliax, G W Drash, J K Staley, S Haber, C J Mobley, G W Miller, E J Mufson, D C Mash, A I Leve. Immunocytochemical localization of the dopamine transporter in human brain. The Journal of comparative neurology. vol 409. issue 1. 1999-07-20. PMID:10363710. |
double-labeling studies combining dat and tyrosine hydroxylase (th) immunostaining in the ventral mesencephalon showed two subpopulations of dopaminergic neurons differentiated by the presence or absence of dat-immunoreactivity in the a9 and a10 cell groups. |
1999-07-20 |
2023-08-12 |
human |
| A C Kuhlmann, T R Guilart. Regional and temporal expression of the peripheral benzodiazepine receptor in MPTP neurotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. vol 48. issue 1. 1999-06-18. PMID:10330690. |
the integrity of nigrostriatal dopaminergic terminals in the corpus striatum was assessed by measuring high affinity dopamine transporter (dat) levels and dopamine content. |
1999-06-18 |
2023-08-12 |
Not clear |
| A C Kuhlmann, T R Guilart. Regional and temporal expression of the peripheral benzodiazepine receptor in MPTP neurotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. vol 48. issue 1. 1999-06-18. PMID:10330690. |
reductions of both indices of dopaminergic terminal integrity correlated with increased levels of [3h]-pk11195-binding in the striatum (r2 = 0.84 for dat and 0.93 for dopamine content). |
1999-06-18 |
2023-08-12 |
Not clear |
| S H Dresel, M P Kung, X F Huang, K Plössl, C Hou, S K Meegalla, G Patselas, M Mu, J R Saffer, H F Kun. Simultaneous SPECT studies of pre- and postsynaptic dopamine binding sites in baboons. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 40. issue 4. 1999-05-06. PMID:10210226. |
with the successful development of [99mtc]trodat-1, single-isotope imaging studies using this ligand for dat imaging can be complemented by additional use of 123i-labeled d2/d3 receptor ligand co-injected to assess both pre- and postsynaptic sites of the dopaminergic system simultaneously. |
1999-05-06 |
2023-08-12 |
Not clear |
| Y Ito, M Fujita, S Shimada, Y Watanabe, T Okada, H Kusuoka, M Tohyama, T Nishimur. Comparison between the decrease of dopamine transporter and that of L-DOPA uptake for detection of early to advanced stage of Parkinson's disease in animal models. Synapse (New York, N.Y.). vol 31. issue 3. 1999-05-04. PMID:10029235. |
any decrease in dopaminergic neurons was evaluated by in situ hybridization histochemistry (ish) by detection of dat mrna-positive neurons. |
1999-05-04 |
2023-08-12 |
rat |
| B A Rocha, F Fumagalli, R R Gainetdinov, S R Jones, R Ator, B Giros, G W Miller, M G Caro. Cocaine self-administration in dopamine-transporter knockout mice. Nature neuroscience. vol 1. issue 2. 1999-04-20. PMID:10195128. |
in this study we tested whether these properties are limited to the dopaminergic system in mice lacking dat. |
1999-04-20 |
2023-08-12 |
mouse |
| E Bezard, C E Gross, M C Fournier, S Dovero, B Bloch, M Jabe. Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter. Experimental neurology. vol 155. issue 2. 1999-04-07. PMID:10072302. |
mpp+, which is the oxidation product of mptp, is actively transported into presynaptic dopaminergic nerve terminals through the plasma membrane dopamine transporter (dat). |
1999-04-07 |
2023-08-12 |
mouse |
| E Bezard, C E Gross, M C Fournier, S Dovero, B Bloch, M Jabe. Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter. Experimental neurology. vol 155. issue 2. 1999-04-07. PMID:10072302. |
in this study, we used mice lacking the dat by homologous recombination and demonstrated that the mptp-induced dopaminergic cell loss is dependent on the presence of the dat. |
1999-04-07 |
2023-08-12 |
mouse |
| M Batchelor, J O Schen. Protein kinase A activity may kinetically upregulate the striatal transporter for dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 24. 1999-02-25. PMID:9852568. |
the neuronal dopamine transporter (dat) plays a key role in terminating dopaminergic chemical neurotransmission; thus, the study of the regulation of dat activity is important in defining parameters relevant to the control of dopaminergic neurotransmission. |
1999-02-25 |
2023-08-12 |
Not clear |
| R R Gainetdinov, W C Wetsel, S R Jones, E D Levin, M Jaber, M G Caro. Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science (New York, N.Y.). vol 283. issue 5400. 1999-01-28. PMID:9888856. |
mice lacking the gene encoding the plasma membrane dopamine transporter (dat) have elevated dopaminergic tone and are hyperactive. |
1999-01-28 |
2023-08-12 |
mouse |
| M P Martres, B Demeneix, N Hanoun, M Hamon, B Giro. Up- and down-expression of the dopamine transporter by plasmid DNA transfer in the rat brain. The European journal of neuroscience. vol 10. issue 12. 1999-01-14. PMID:9875340. |
the functional role of the dopamine transporter (dat) in central dopaminergic neurotransmission was assessed further by investigating the consequences on dopamine (da) turn-over of up- and down-regulation of this protein induced by a non-viral gene transfer approach. |
1999-01-14 |
2023-08-12 |
rat |
| E C Petrie, R C Veith, P Szo. Bupropion and desipramine increase dopamine transporter mRNA expression in the ventral tegmental area/substantia nigra of rat brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 22. issue 5. 1998-11-18. PMID:9723124. |
these findings suggest that dat mrna expression in the brain may be regulated by both noradrenergic and dopaminergic mechanisms. |
1998-11-18 |
2023-08-12 |
rat |
| S Kitayama, C Mitsuhata, S Davis, J B Wang, T Sato, K Morita, G R Uhl, T Doh. MPP+ toxicity and plasma membrane dopamine transporter: study using cell lines expressing the wild-type and mutant rat dopamine transporters. Biochimica et biophysica acta. vol 1404. issue 3. 1998-10-29. PMID:9739158. |
the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium (mpp+) causes specific cell death in dopaminergic neurons after accumulation by the dopamine transporter (dat). |
1998-10-29 |
2023-08-12 |
rat |