| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guangzao Li, Renpeng Zhou, Qi Zhang, Banghong Jiang, Qingkai Wu, Chen Wan. Fibroproliferative effect of microRNA-21 in hypertrophic scar derived fibroblasts. Experimental cell research vol 345 issue 1 2017 27207585 |
hypertrophic scar (hs) is a fibroproliferative disorder caused by abnormal wound healing, which is characterized by excessive deposition of extracellular matrix (ecm) secreted by fibroblasts. |
2017-05-15 |
2023-01-25 |
mouse |
| Kristoffer B Sugg, Michael A Korn, Dylan C Sarver, James F Markworth, Christopher L Mendia. Inhibition of platelet-derived growth factor signaling prevents muscle fiber growth during skeletal muscle hypertrophy. FEBS letters vol 591 issue 5 2017 28129672 |
the results from this study indicate that pdgf signaling is required for fiber hypertrophy, extracellular matrix production, and angiogenesis that occur during muscle growth. |
2017-05-15 |
2023-01-26 |
mouse |
| Hemanth Akkiraju, Jeremy Bonor, Anja Noh. CK2.1, a novel peptide, induces articular cartilage formation in vivo. Journal of orthopaedic research : official publication of the Orthopaedic Research Society vol 35 issue 4 2017 27312334 |
however, it also induces chondrocyte hypertrophy and cartilage matrix degradation. |
2017-05-09 |
2023-01-25 |
mouse |
| Brett E Fenster, Luis Lasalvia, Joyce D Schroeder, Jamey Smyser, Lori J Silveira, J Kern Buckner, Kevin K Brow. Galectin-3 levels are associated with right ventricular functional and morphologic changes in pulmonary arterial hypertension. Heart and vessels vol 31 issue 6 2017 25976729 |
the response of the right ventricle (rv) to pulmonary arterial hypertension (pah) involves changes in contractile function, chamber size, hypertrophy, and extracellular matrix (ecm). |
2017-05-02 |
2023-01-25 |
human |
| Mark J Hackett, Graham N George, Ingrid J Pickering, B Frank Eame. Chemical Biology in the Embryo: In Situ Imaging of Sulfur Biochemistry in Normal and Proteoglycan-Deficient Cartilage Matrix. Biochemistry vol 55 issue 17 2017 26985789 |
levels of both sulfur and sulfate esters decrease as cartilage develops through late phase differentiation (maturation or hypertrophy), suggesting a functional link between cartilage matrix sulfur content and chondrocyte differentiation. |
2017-05-02 |
2023-01-25 |
zebrafish |
| Fengjun Fang, Ru-Lin Huang, Yongchao Zheng, Ming Liu, Ran Hu. Bone marrow derived mesenchymal stem cells inhibit the proliferative and profibrotic phenotype of hypertrophic scar fibroblasts and keloid fibroblasts through paracrine signaling. Journal of dermatological science vol 83 issue 2 2017 27211019 |
hypertrophic scars and keloids, characterized by over-proliferation of fibroblasts and aberrant formation of the extracellular matrix (ecm), are considered fibrotic diseases. |
2017-05-02 |
2023-01-25 |
Not clear |
| Jennifer Fischer, Marlen Ortel, Sebastien Hagmann, Andreas Hoeflich, Wiltrud Richte. Role of PTHrP(1-34) Pulse Frequency Versus Pulse Duration to Enhance Mesenchymal Stromal Cell Chondrogenesis. Journal of cellular physiology vol 231 issue 12 2017 27548511 |
generation of phenotypically stable, articular chondrocytes from mesenchymal stromal cells (mscs) is still an unaccomplished task, with formation of abundant, hyaline extracellular matrix, and avoidance of hypertrophy being prime challenges. |
2017-05-01 |
2023-01-25 |
human |
| Jennifer Fischer, Marlen Ortel, Sebastien Hagmann, Andreas Hoeflich, Wiltrud Richte. Role of PTHrP(1-34) Pulse Frequency Versus Pulse Duration to Enhance Mesenchymal Stromal Cell Chondrogenesis. Journal of cellular physiology vol 231 issue 12 2017 27548511 |
we recently demonstrated that parathyroid hormone-related protein (pthrp) is a promising factor to direct chondrogenesis of mscs towards an articular phenotype, since intermittent pthrp application stimulated cartilage matrix production and reduced undesired hypertrophy. |
2017-05-01 |
2023-01-25 |
human |
| Weishen Chen, Puyi Sheng, Zhiyu Huang, Fangang Meng, Yan Kang, Guangxin Huang, Zhiqi Zhang, Weiming Liao, Ziji Zhan. MicroRNA-381 Regulates Chondrocyte Hypertrophy by Inhibiting Histone Deacetylase 4 Expression. International journal of molecular sciences vol 17 issue 9 2017 27563877 |
chondrocyte hypertrophy, regulated by runt-related transcription factor 2 (runx2) and matrix metalloproteinase 13 (mmp13), is a crucial step in cartilage degeneration and osteoarthritis (oa) pathogenesis. |
2017-05-01 |
2023-01-25 |
Not clear |
| Koh Terauchi, Hajime Kobayashi, Kanaka Yatabe, Naoko Yui, Hiroto Fujiya, Hisateru Niki, Haruki Musha, Kazuo Yudo. The NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13 in Chondrocytes in Osteoarthritis. International journal of molecular sciences vol 17 issue 7 2017 27367673 |
we postulated that sirt1 regulates a hypertrophic chondrocyte lineage and degeneration of articular cartilage through the activation of osteogenic transcriptional activator runx2 and matrix metalloproteinase (mmp)-13 in oa chondrocytes. |
2017-03-21 |
2023-01-25 |
mouse |
| Nadja Z\\xc3\\xb6ller, Anke K\\xc3\\xb6nig, Manuel Butting, Roland Kaufmann, August Bernd, Eva Valesky, Stefan Kippenberge. Water-filtered near-infrared influences collagen synthesis of keloid-fibroblasts in contrast to normal foreskin fibroblasts. Journal of photochemistry and photobiology. B, Biology vol 163 issue 2017 27588716 |
hypertrophic scar development is associated to impaired wound healing, imbalanced fibroblast proliferation and extracellular matrix synthesis. |
2017-03-17 |
2023-01-25 |
Not clear |
| Leilei Yang, Wenlong Li, Bing Liu, Shaoxia Wang, Lin Zeng, Cuiping Zhang, Yang L. iRhom2 (Uncv) mutation blocks bulge stem cells assuming the fate of hair follicle. Archives of dermatological research vol 308 issue 7 2017 27393687 |
in this study, we found irhom2 mutation decreased hair matrix proliferation, however, irhom2 (uncv/uncv) mice displayed hyperproliferation and hyperkeratosis in the interfollicular epidermis along with hypertrophy in the sebaceous glands. |
2017-02-17 |
2023-01-25 |
mouse |
| Miaomiao Lu, Nanchang Yin, Wei Liu, Xiangfei Cui, Shuo Chen, Ermin Wan. Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling. BioMed research international vol 2017 issue 2017 28194406 |
in comparison to mock-treated db/db mice, curcumin-treated mice showed diminished renal hypertrophy, reduced mesangial matrix expansion, and a lower level of albuminuria. |
2017-02-16 |
2023-01-26 |
mouse |
| Shengzhi Mu, Bei Kang, Weihui Zeng, Yaowen Sun, Fan Yan. MicroRNA-143-3p inhibits hyperplastic scar formation by targeting connective tissue growth factor CTGF/CCN2 via the Akt/mTOR pathway. Molecular and cellular biochemistry vol 416 issue 1-2 2017 27075467 |
post-traumatic hypertrophic scar (hs) is a fibrotic disease with excessive extracellular matrix (ecm) production, which is a response to tissue injury by fibroblasts. |
2017-02-06 |
2023-01-25 |
human |
| Manjunatha S Muttigi, Inbo Han, Hun-Kuk Park, Hansoo Park, Soo-Hong Le. Matrilin-3 Role in Cartilage Development and Osteoarthritis. International journal of molecular sciences vol 17 issue 4 2017 27104523 |
matrilin-3 downregulates the expression of matrix-degrading enzymes, such as a disintegrin metalloproteinase with thrombospondin motifs 4 (adamts4) and adamts5, matrix metalloproteinase 13 (mmp13), and collagen x, a hypertrophy marker during development and inflammatory conditions. |
2017-02-06 |
2023-01-25 |
Not clear |
| Naqi Lian, Taiping L. Growth factor pathways in hypertrophic scars: Molecular pathogenesis and therapeutic implications. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol 84 issue 2017 27636511 |
hypertrophic scars represent the most common complication of skin injury and are caused by excessive cutaneous wound healing characterized by hypervascularity and pathological deposition of extracellular matrix (ecm) components. |
2017-02-02 |
2023-01-25 |
Not clear |
| Peng Zhao, Liping Yang, Jiansheng Li, Ya Li, Yange Tian, Suyun L. Combining systems pharmacology, transcriptomics, proteomics, and metabolomics to dissect the therapeutic mechanism of Chinese herbal Bufei Jianpi formula for application to COPD. International journal of chronic obstructive pulmonary disease vol 11 issue 2017 27042044 |
additionally, bjf was previously shown to effectively prevent copd and its comorbidities, such as ventricular hypertrophy, by inhibition of inflammatory cytokine production, matrix metalloproteinases expression, and other cytokine production, in vivo. |
2017-01-12 |
2023-01-25 |
rat |
| Bing Li, Chao Gao, Jian-Sheng Diao, Da-Lei Wang, Fei-Fei Chu, Yang Li, Gang Wang, Shu-Zhong Guo, Wei Xi. Aberrant Notch signalling contributes to hypertrophic scar formation by modulating the phenotype of keratinocytes. Experimental dermatology vol 25 issue 2 2017 26566963 |
hypertrophic scar (hs) is characterized by fibroblast hyperproliferation and excessive matrix deposition. |
2017-01-10 |
2023-01-25 |
rabbit |
| Rik Osinga, Nunzia Di Maggio, Atanas Todorov, Nima Allafi, Andrea Barbero, Fr\\xc3\\xa9d\\xc3\\xa9ric Laurent, Dirk Johannes Schaefer, Ivan Martin, Arnaud Scherberic. Generation of a Bone Organ by Human Adipose-Derived Stromal Cells Through Endochondral Ossification. Stem cells translational medicine vol 5 issue 8 2016 27334490 |
hypertrophic maturation induced upregulation of type x collagen, bone sialoprotein, and matrix metalloproteinase13 (mmp13). |
2016-12-28 |
2023-01-25 |
human |
| Toshina Ishiguro-Oonuma, Masako Suemoto, Muneyoshi Okada, Kazuki Yoshioka, Yukio Hara, Kazuyoshi Hashizume, Keiichiro Kizak. Aberrant gene expression of heparanase in ventricular hypertrophy induced by monocrotaline in rats. The Journal of veterinary medical science vol 78 issue 3 2016 26638897 |
the gene expression levels of heparanase, matrix metalloproteinase 2 (mmp2) and mmp9 were examined in ventricles after treatment with monocrotaline (mct) to induce cardiac hypertrophy in rats. |
2016-12-26 |
2023-01-25 |
rat |