| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Bai, Xiaoshan Gong, Rui Dong, Zhen Cao, Ce Dou, Chuan Liu, Jianmei Li, Fei Kang, Jingjin Dai, Chunrong Zhao, Zhansong Tian, Jiulin Tan, Qijie Dai, Shiwu Don. Long non-coding RNA HCAR promotes endochondral bone repair by upregulating VEGF and MMP13 in hypertrophic chondrocyte through sponging miR-15b-5p. Genes & diseases vol 9 issue 2 2022 35224160 |
lnc-hcar knockdown in hypertrophic chondrocytes restrained the cartilage matrix remodeling and decrease the cd31 |
2022-02-28 |
2023-01-27 |
Not clear |
| Anthony J Hayes, John Whitelock, James Melros. Regulation of FGF-2, FGF-18 and Transcription Factor Activity by Perlecan in the Maturational Development of Transitional Rudiment and Growth Plate Cartilages and in the Maintenance of Permanent Cartilage Homeostasis. International journal of molecular sciences vol 23 issue 4 2022 35216048 |
cartilage rudiments are transient developmental templates containing chondroprogenitor cells that undergo proliferation, matrix deposition, and hypertrophic differentiation. |
2022-02-26 |
2023-01-27 |
Not clear |
| Changshun He, Bo Jiang, Mo Wang, Pengwei Ren, Sae-Il Murtada, Alexander W Caulk, Guangxin Li, Lingfeng Qin, Roland Assi, Constantinos J Lovoulos, Martin A Schwartz, Jay D Humphrey, George Tellide. mTOR inhibition prevents angiotensin II-induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice. JCI insight vol 7 issue 3 2022 35132962 |
medial thickening results from smooth muscle cell hypertrophy and extracellular matrix accumulation, including matricellular proteins. |
2022-02-08 |
2023-01-27 |
mouse |
| Mapula Razwinani, Keolebogile Shirley Motaun. The influence of friedelin, resinone, tingenone and betulin of compounds on chondrogenic differentiation of porcine adipose-derived mesenchymal stem cells (pADMSCs). Biochimie vol issue 2022 35121053 |
the study investigated the influence of friedelin, resinone, tingenone and betulin plant-based secondary metabolite compounds on cellular proliferation, extracellular matrix (ecm) components synthesis, expression of chondrogenic markers and maturation of differentiated chondrocytes (cell proliferation and hypertrophy) in porcine adipose-derived mesenchymal stem cells (padmscs) undergoing chondrogenic differentiation. |
2022-02-05 |
2023-01-27 |
Not clear |
| Shunuo Zhang, Yixin Zhang, Peiru Mi. Single-Cell and Bulk Transcriptome Data Integration Reveals Dysfunctional Cell Types and Aberrantly Expressed Genes in Hypertrophic Scar. Frontiers in genetics vol 12 issue 2022 35047019 |
hypertrophic scar (hs) is a common skin disorder characterized by excessive extracellular matrix (ecm) deposition. |
2022-01-20 |
2023-01-26 |
Not clear |
| Jinying Liu, Hongjian Lian, Jiang Yu, Jie Wu, Xiangyang Chen, Peng Wang, Lei Tian, Yunfei Yang, Jiaqi Yang, Dong Li, Shuzhen Gu. Study on diverse pathological characteristics of heart failure in different stages based on proteomics. Journal of cellular and molecular medicine vol issue 2022 35048506 |
the results of the kegg pathway enrichment analysis and go function annotation revealed critical pathways associated with the transition from cardiac hypertrophy to heart failure, such as energy pathways and matrix reorganization. |
2022-01-20 |
2023-01-26 |
mouse |
| Jennifer M Petrosino, Jacob Z Longenecker, Colin D Angel, Scott A Hinger, Colton R Martens, Federica Accorner. CCN2 participates in overload-induced skeletal muscle hypertrophy. Matrix biology : journal of the International Society for Matrix Biology vol issue 2022 35045313 |
overall, our study highlights the contribution of muscle-derived extracellular matrix factor ccn2 for proper hypertrophic muscle growth. |
2022-01-19 |
2023-01-26 |
mouse |
| Qingde Zhou, Jianxiang Gong, Jianing Bi, Xuanxin Yang, Li Zhang, Chao Lu, Lijia Li, Min Chen, Jianqiu Cai, Rongshuai Yang, Xiaokun Li, Zhiming Li, Xiaojie Wan. Keratinocyte growth factor-2 regulates signal-transducing adaptor protein-2-mediated signal transducer and activator of transcription 3 signaling and reduces skin scar formation. The Journal of investigative dermatology vol issue 2022 34999107 |
hypertrophic scar (hs) is a common complication of burns, skin trauma, and postoperative trauma, which involves excessive proliferation of fibroblasts and accumulation of a large amount of disorganized collagen fibers and extracellular matrix (ecm). |
2022-01-09 |
2023-01-26 |
Not clear |
| Ying Zhang, Zhengzheng Li, Ying He, Meng Zhang, Yiping Feng, Qian Fang, Tianyou Ma, Xianghua Deng, Jinghong Che. Transforming growth factor-\\xce\\xb2 receptors mediates matrix degradation and abnormal hypertrophy in T-2 toxin-induced hypertrophic chondrocytes. Toxicon : official journal of the International Society on Toxinology vol issue 2022 34995556 |
transforming growth factor-\xce\xb2 receptors mediates matrix degradation and abnormal hypertrophy in t-2 toxin-induced hypertrophic chondrocytes. |
2022-01-07 |
2023-01-26 |
Not clear |
| Ying Zhang, Zhengzheng Li, Ying He, Meng Zhang, Yiping Feng, Qian Fang, Tianyou Ma, Xianghua Deng, Jinghong Che. Transforming growth factor-\\xce\\xb2 receptors mediates matrix degradation and abnormal hypertrophy in T-2 toxin-induced hypertrophic chondrocytes. Toxicon : official journal of the International Society on Toxinology vol issue 2022 34995556 |
this study investigated whether transforming growth factor-\xce\xb2 receptor i (tgf-\xce\xb2ri) and tgf-\xce\xb2rii mediate matrix degradation and abnormal hypertrophy in t-2 toxin-induced hypertrophic chondrocytes. |
2022-01-07 |
2023-01-26 |
Not clear |
| Ying Zhang, Zhengzheng Li, Ying He, Meng Zhang, Yiping Feng, Qian Fang, Tianyou Ma, Xianghua Deng, Jinghong Che. Transforming growth factor-\\xce\\xb2 receptors mediates matrix degradation and abnormal hypertrophy in T-2 toxin-induced hypertrophic chondrocytes. Toxicon : official journal of the International Society on Toxinology vol issue 2022 34995556 |
the upregulated expression of tgf-\xce\xb2ri and tgf-\xce\xb2rii mediates the abnormal chondrocyte hypertrophy and extracellular matrix degeneration observed in t-2 toxin-induced hypertrophic chondrocytes. |
2022-01-07 |
2023-01-26 |
Not clear |
| Michalis Panteli, James S H Vun, Ippokratis Pountos, Anthony J Howard, Elena Jones, Peter V Giannoudi. Biological and molecular profile of fracture non-union tissue: A systematic review and an update on current insights. Journal of cellular and molecular medicine vol issue 2022 34984803 |
there was a lower bmp expression in non-union site and absent in the extracellular matrix, with no difference observed between atrophic and hypertrophic non-unions. |
2022-01-05 |
2023-01-26 |
human |
| Maria Marketou, Joanna Kontaraki, Spyros Maragkoudakis, Christos Danelatos, Sofia Papadaki, Stelios Zervakis, Anthoula Plevritaki, Panos Vardas, Fragiskos Parthenakis, George Kochiadaki. Effects of sodium-glucose cotransporter-2 inhibitors on cardiac structural and electrical remodeling: from myocardial cytology to cardiodiabetology. Current vascular pharmacology vol issue 2021 34961447 |
sglt2i ameliorate myocardial extracellular matrix remodeling, cardiomyocyte stiffness and concentric hypertrophy, achieving beneficial remodeling of the left ventricle with significant implications for the pathogenesis and outcome of heart failure. |
2021-12-28 |
2023-01-26 |
Not clear |
| Ming-Xiao Zhang, Qing-Xin Tian, Jian-Long Li. [The myocardial protective effect of propofol on rats with experimental myocardial infarction and its mechanism]. Sheng li xue bao : [Acta physiologica Sinica] vol 73 issue 6 2021 34961861 |
furthermore, after myocardial infarction, the administration of propofol significantly improved the diastolic strain rate, down-regulated the mrna expression levels of myocardial hypertrophy markers, atrial natriuretic peptide and \xce\xb2-myosin heavy chain, and reversed the up-regulation of matrix metalloproteinase 2 (mmp2), mmp9 and tissue inhibitor of metalloproteinase-2 (timp-2) induced by myocardial infarction. |
2021-12-28 |
2023-01-26 |
rat |
| Hongpeng Zhang, Hao Wang, Cuibao Jiang, Hongwei Wang, Yong Xia, Danpeng Shen, Fan Xie, Nianmin Qi, Kaiyang L. Fractional laser-assisted administration of human umbilical cord mesenchymal stem cells to reduce hypertrophic scars in rabbit ears. Lasers in surgery and medicine vol issue 2021 34962300 |
the formation of hypertrophic scar is due to the abnormal accumulation and remodeling of the extracellular matrix, especially collagen tissue. |
2021-12-28 |
2023-01-26 |
human |
| Muzhe Li, Han Yin, Zineng Yan, Huiyun Li, Jiang Wu, Yue Wang, Fu Wei, Guangzhao Tian, Chao Ning, Hao Li, Cangjian Gao, Liwei Fu, Shuangpeng Jiang, Mingxue Chen, Xiang Sui, Shuyun Liu, Zhiwei Chen, Quanyi Gu. The immune microenvironment in cartilage injury and repair. Acta biomaterialia vol issue 2021 34896634 |
the inflammatory milieu created by cartilage damage is critical for chondrocyte death and hypertrophy, extracellular matrix breakdown, ectopic bone formation, and progression of cartilage injury to osteoarthritis. |
2021-12-13 |
2023-01-26 |
Not clear |
| Jos\\xc3\\xa9 Vald\\xc3\\xa9s-Fern\\xc3\\xa1ndez, Tania L\\xc3\\xb3pez-Mart\\xc3\\xadnez, Purificaci\\xc3\\xb3n Ripalda-Cembor\\xc3\\xa1in, Isabel A Calvo, Borja S\\xc3\\xa1ez, Juan Antonio Romero-Torrecilla, Javier Aldazabal, Emma Mui\\xc3\\xb1os-L\\xc3\\xb3pez, Ver\\xc3\\xb3nica Montiel, Josune Orbe, Jos\\xc3\\xa9 Antonio Rodr\\xc3\\xadguez, Jos\\xc3\\xa9 Antonio P\\xc3\\xa1ramo, Felipe Pr\\xc3\\xb3sper, Froil\\xc3\\xa1n Granero-Molt\\xc3\\xb. Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol 36 issue 11 2021 34173256 |
during secondary fracture healing, vascular invasion and bone growth requires the removal of the cartilage intermediate and the coordinate action of the collagenase matrix metalloproteinase (mmp)-13, produced by hypertrophic chondrocytes, and the gelatinase mmp-9, produced by cells of hematopoietic lineage. |
2021-12-10 |
2023-01-26 |
mouse |
| Harunur Rashid, Haiyan Chen, Amjad Jave. Runx2 is required for hypertrophic chondrocyte mediated degradation of cartilage matrix during endochondral ossification. Matrix biology plus vol 12 issue 2021 34805821 |
runx2 is required for hypertrophic chondrocyte mediated degradation of cartilage matrix during endochondral ossification. |
2021-12-07 |
2023-01-26 |
Not clear |
| Megumi Nakamura, Mu-Chen Yang, Keijyu Ashida, Miyuki Mayanagi, Yasuyuki Sasan. Calcification and resorption of mouse Meckel's cartilage analyzed by von Kossa and tartrate-resistant acid phosphatase histochemistry and scanning electron microscopy/energy-dispersive X-ray spectrometry. Anatomical science international vol issue 2021 34859366 |
the results demonstrated that the intermediate portion of meckel's cartilage is resorbed by chondroclasts after chondrocyte hypertrophy and cartilage matrix calcification and that the mineral concentration of calcified meckel's cartilage is comparable to that of the surrounding bone. |
2021-12-03 |
2023-01-26 |
mouse |
| Yao Wang, Xiaojing Sun, Xianglan Su. The Functions of LncRNA H19 in the Heart. Heart, lung & circulation vol issue 2021 34840062 |
for example, lncrna h19 (h19), also known as a fetal gene abundant in adult heart and skeletal muscles and evolutionarily conserved in humans and mice, has a regulatory role in aortic aneurysm, myocardial hypertrophy, extracellular matrix reconstitution, and coronary artery diseases. |
2021-11-29 |
2023-01-26 |
mouse |