| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Zreiqat, C R Howlett, S Gronthos, D Hume, C L Gecz. S100A8/S100A9 and their association with cartilage and bone. Journal of molecular histology. vol 38. issue 5. 2008-03-17. PMID:17636430. |
s100a8 was expressed in alkaline phosphatase-positive hypertrophic chondrocytes, but not in proliferating chondrocytes within the growth plate where the cartilaginous matrix was calcifying. |
2008-03-17 |
2023-08-12 |
human |
| Andrea C Aragon, Phillip G Kopf, Matthew J Campen, Janice K Huwe, Mary K Walke. In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effects on fetal and adult cardiac gene expression and adult cardiac and renal morphology. Toxicological sciences : an official journal of the Society of Toxicology. vol 101. issue 2. 2008-03-07. PMID:17975115. |
tcdd induced mrna expression of genes associated with ecm remodeling (matrix metalloproteinase 9 and 13, preproendothelin-1 [preproet-1]), cardiac hypertrophy (atrial natriuretic peptide, beta-myosin heavy chain, osteopontin), and aryl hydrocarbon receptor (ahr) activation (cytochrome p4501a1, ahr repressor). |
2008-03-07 |
2023-08-12 |
mouse |
| Lars Gullestad, Erik Oie, Thor Ueland, Arne Yndestad, Pål Aukrus. The role of statins in heart failure. Fundamental & clinical pharmacology. vol 21 Suppl 2. 2008-03-06. PMID:18001320. |
beneficial effects include attenuation of cardiac hypertrophy, improvement in endothelial function, anti-inflammatory effects, reduction in the activity of matrix metalloproteinases, reduction in apoptosis, interference with neurohormones, and improved homeostasis. |
2008-03-06 |
2023-08-12 |
human |
| Osman Köse, Ahmad Wasee. Keloids and hypertrophic scars: are they two different sides of the same coin? Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. vol 34. issue 3. 2008-03-06. PMID:18177398. |
keloids and hypertrophic scars are the results of increased fibroblast density and extracellular matrix substances. |
2008-03-06 |
2023-08-12 |
Not clear |
| Yee H Looi, David J Grieve, Anjana Siva, Simon J Walker, Narayana Anilkumar, Alison C Cave, Michael Marber, Mark J Monaghan, Ajay M Sha. Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction. Hypertension (Dallas, Tex. : 1979). vol 51. issue 2. 2008-02-26. PMID:18180403. |
nox2(-/-) mice exhibited less cardiomyocyte hypertrophy, apoptosis, and interstitial fibrosis; reduced increases in expression of connective tissue growth factor and procollagen 1 mrna; and smaller increases in myocardial matrix metalloproteinase-2 activity than wt mice. |
2008-02-26 |
2023-08-12 |
mouse |
| Wojciech Jachec, Ala Foremny, Dorota Domal-Kwiatkowska, Slawomir Smolik, Andrzej Tomasik, Urszula Mazurek, Jan Wodnieck. Expression of TGF-beta1 and its receptor genes (TbetaR I, TbetaR II, and TbetaR III-betaglycan) in peripheral blood leucocytes in patients with idiopathic pulmonary arterial hypertension and Eisenmenger's syndrome. International journal of molecular medicine. vol 21. issue 1. 2008-02-25. PMID:18097622. |
idiopathic pulmonary arterial hypertension (ipah) is characterized by smooth muscle cell, endothelial cell, and fibroblast hypertrophy and an increase in extracellular matrix volume in pulmonary precapillary arterioles. |
2008-02-25 |
2023-08-12 |
Not clear |
| Halil Ibrahim Canter, Ersoy Konas, Onder Bozdogan, Ibrahim Vargel, Bilgen Ozbatir, Filiz Oner, Yucel Er. Effect of slow-release 5-Fluorouracil on capsule formation around silicone breast implants: an experimental study with mice. Aesthetic plastic surgery. vol 31. issue 6. 2008-02-21. PMID:17578639. |
capsule formation around breast implants, development of tendon adhesions after tendon repair, intestinal brits after laparatomies, hypertrophic scars in skin incisions all are the results of excessive collagen synthesis to the extracellular matrix by fibroblasts. |
2008-02-21 |
2023-08-12 |
mouse |
| Sabine Rehm, Roberta A Thomas, Kim S Smith, Rosanna C Mirabile, Tracy L Gales, Scot L Eustis, Rogely W Boyc. Novel vascular lesions in mice given a non-peptide vitronectin receptor antagonist. Toxicologic pathology. vol 35. issue 7. 2008-02-21. PMID:18098042. |
vascular smooth muscle cell (vsmc) necrosis was observed in aorta and renal hilar arteries approximately 6 hours after dosing followed by loss of vsmc, adaptive medial thickening by vsmc hypertrophy and deposition of pas-positive matrix and collagen. |
2008-02-21 |
2023-08-12 |
mouse |
| Lyudmila Mikhaylova, Jennifer Malmquist, Maria Nurminskay. Regulation of in vitro vascular calcification by BMP4, VEGF and Wnt3a. Calcified tissue international. vol 81. issue 5. 2008-02-19. PMID:17982705. |
in this study we demonstrate that factors secreted by the hypertrophic chondrocytes induce matrix mineralization and osteoblastic transformation in cultured mouse vascular smooth muscle cells (vsmcs). |
2008-02-19 |
2023-08-12 |
mouse |
| Cornelia E Farnum, Michelle Tinsley, John W Hermanso. Postnatal bone elongation of the manus versus pes: analysis of the chondrocytic differentiation cascade in Mus musculus and Eptesicus fuscus. Cells, tissues, organs. vol 187. issue 1. 2008-02-06. PMID:18160802. |
bones elongate postnatally by endochondral ossification as cells of the cartilaginous growth plate undergo a differentiation cascade of proliferation, cellular hypertrophy and matrix synthesis. |
2008-02-06 |
2023-08-12 |
mouse |
| Soban Umar, Marleen Hessel, Paul Steendijk, Wilhelmina Bax, Cindy Schutte, Martin Schalij, Ernst van der Wall, Douwe Atsma, Arnoud van der Laars. Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension. Pathology, research and practice. vol 203. issue 12. 2008-02-01. PMID:17913382. |
we investigated whether rv hypertrophy (rvh) and rv failure (rvf) were associated with activation of fak, nos1, and matrix metalloproteinases (mmps). |
2008-02-01 |
2023-08-12 |
rat |
| Christina Cheng, Evan Conte, Nancy Pleshko-Camacho, Chisa Hidak. Differences in matrix accumulation and hypertrophy in superficial and deep zone chondrocytes are controlled by bone morphogenetic protein. Matrix biology : journal of the International Society for Matrix Biology. vol 26. issue 7. 2008-01-31. PMID:17618099. |
differences in matrix accumulation and hypertrophy in superficial and deep zone chondrocytes are controlled by bone morphogenetic protein. |
2008-01-31 |
2023-08-12 |
Not clear |
| Christina Cheng, Evan Conte, Nancy Pleshko-Camacho, Chisa Hidak. Differences in matrix accumulation and hypertrophy in superficial and deep zone chondrocytes are controlled by bone morphogenetic protein. Matrix biology : journal of the International Society for Matrix Biology. vol 26. issue 7. 2008-01-31. PMID:17618099. |
greater accumulation of proteoglycan (pg)-rich matrix in the untreated dzc was associated with a hypertrophic phenotype with large cell diameters and high gene expression levels of runt-related transcription factor-2 (runx2) as well as higher endogenous bmp activity. |
2008-01-31 |
2023-08-12 |
Not clear |
| Bishara S Atiye. Nonsurgical management of hypertrophic scars: evidence-based therapies, standard practices, and emerging methods. Aesthetic plastic surgery. vol 31. issue 5. 2008-01-29. PMID:17576505. |
hypertrophic scars, resulting from alterations in the normal processes of cutaneous wound healing, are characterized by proliferation of dermal tissue with excessive deposition of fibroblast-derived extracellular matrix proteins, especially collagen, over long periods, and by persistent inflammation and fibrosis. |
2008-01-29 |
2023-08-12 |
Not clear |
| Tomoko Shinzato, Yusuke Ohya, Minori Nakamoto, Akio Ishida, Shuichi Takishit. Beneficial effects of pioglitazone on left ventricular hypertrophy in genetically hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension. vol 30. issue 9. 2008-01-29. PMID:18037780. |
we evaluated lv geometry by echocardiography; myocyte hypertrophy, tissue fibrosis, and appearance of myofibroblasts by histological examination; mrna expression by real-time polymerase chain reaction (pcr); protein expression by western blot; activities of matrix metalloproteinase (mmp) by zymography; and production of reactive oxygen species (ros) by electron spin resonance spectroscopy or thiobarbituric acid reactive substances (tbars). |
2008-01-29 |
2023-08-12 |
rat |
| Amy Wang, Fuad N Ziyadeh, Eun Young Lee, Petr E Pyagay, Sun Hee Sung, Steven A Sheardown, Nicholas J Laping, Sheldon Che. Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria. American journal of physiology. Renal physiology. vol 293. issue 5. 2007-12-18. PMID:17804483. |
in the smad3-ko mice, however, the defects that were improved were renal hypertrophy, mesangial matrix expansion, fibronectin overproduction, glomerular basement membrane thickening, plasma creatinine, and the blood urea nitrogen. |
2007-12-18 |
2023-08-12 |
mouse |
| Amy Wang, Fuad N Ziyadeh, Eun Young Lee, Petr E Pyagay, Sun Hee Sung, Steven A Sheardown, Nicholas J Laping, Sheldon Che. Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria. American journal of physiology. Renal physiology. vol 293. issue 5. 2007-12-18. PMID:17804483. |
it seems that the absence of smad3 modifies the natural course of murine diabetic nephropathy, providing renal functional protection and preventing structural lesions relating to kidney hypertrophy and matrix accumulation, even though albuminuria and changes in podocyte morphology persist. |
2007-12-18 |
2023-08-12 |
mouse |
| b' Sherrill L Adams, Arthur J Cohen, Luisa Lassov\\xc3\\xa. Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation. Journal of cellular physiology. vol 213. issue 3. 2007-12-14. PMID:17886256.' |
during endochondral bone formation, chondrocytes undergo a process of terminal differentiation or maturation, during which the rate of proliferation decreases, cells become hypertrophic, and the extracellular matrix is altered by production of a unique protein, collagen x, as well as proteins that promote mineralization. |
2007-12-14 |
2023-08-12 |
Not clear |
| b' Sherrill L Adams, Arthur J Cohen, Luisa Lassov\\xc3\\xa. Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation. Journal of cellular physiology. vol 213. issue 3. 2007-12-14. PMID:17886256.' |
the matrix surrounding the hypertrophic chondrocytes eventually becomes mineralized, and the mineralized matrix serves as a template for bone deposition. |
2007-12-14 |
2023-08-12 |
Not clear |
| Masaaki Imamura, Akihiro Kanematsu, Shingo Yamamoto, Yu Kimura, Isao Kanatani, Noriyuki Ito, Yasuhiko Tabata, Osamu Ogaw. Basic fibroblast growth factor modulates proliferation and collagen expression in urinary bladder smooth muscle cells. American journal of physiology. Renal physiology. vol 293. issue 4. 2007-11-30. PMID:17634401. |
these data suggest that bfgf from the urothelium could act as a paracrine signal that stimulates the proliferation and matrix production of bsmc, thereby contributing to the hypertrophic remodeling of the smooth muscle layer. |
2007-11-30 |
2023-08-12 |
rat |