| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T M Ganey, S M Love, J A Ogde. Development of vascularization in the chondroepiphysis of the rabbit. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 10. issue 4. 1992-07-28. PMID:1613625. |
three distinct cartilage canal morphologies were identifiable before the formation of the secondary center of ossification: (a) an early phase, in which the canals appeared as infoldings derived from the perichondrium; (b) a reactive phase, occurring simultaneously with chondrocyte hypertrophy and characterized by a very large increase in mesenchymal cells within the cartilage canal; and (c) a vascular phase, coincident with mineralization of the matrix, in which the familiar, unitary canal morphology was replaced by that of a vascular plexus. |
1992-07-28 |
2023-08-11 |
human |
| T M Ganey, S M Love, J A Ogde. Development of vascularization in the chondroepiphysis of the rabbit. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 10. issue 4. 1992-07-28. PMID:1613625. |
while matrix mineralization and the formation of bone seem dependent on critical cellular events, notably chondrocyte hypertrophy, the role that the vascular supply plays in developing sufficient biological inertia for the ossifying transition must not be underestimated. |
1992-07-28 |
2023-08-11 |
human |
| H E Abbou. Growth factors and the mesangium. Journal of the American Society of Nephrology : JASN. vol 2. issue 10 Suppl. 1992-07-15. PMID:1600135. |
growth factors may promote hypertrophy, proliferation, matrix metabolism, and immune-inflammatory and vasoactive properties of mesangial cells. |
1992-07-15 |
2023-08-11 |
Not clear |
| A A Cole, L J Luchene, T F Linsenmayer, T M Schmi. The influence of bone and marrow on cartilage hypertrophy and degradation during 30-day serum-free culture of the embryonic chick tibia. Developmental dynamics : an official publication of the American Association of Anatomists. vol 193. issue 3. 1992-07-10. PMID:1600246. |
if the tibial cartilage is separated from the bony collar and cultured alone in serum-free medium, the nonhypertrophic chondrocytes also hypertrophy; the matrix loses safranin o staining; however, some components of the matrix including type x collagen still remain after 30 days. |
1992-07-10 |
2023-08-11 |
chicken |
| G D Angelini, A J Bryan, H M Williams, A A Soyombo, A Williams, J Tovey, A C Newb. Time-course of medial and intimal thickening in pig venous arterial grafts: relationship to endothelial injury and cholesterol accumulation. The Journal of thoracic and cardiovascular surgery. vol 103. issue 6. 1992-07-06. PMID:1597973. |
between 1 and 4 weeks after grafting, further rapid medial and intimal thickening occurred with no further increase in cell number but with a reduction in cell density, which suggested that cell migration, hypertrophy, and the laying down of extracellular matrix were responsible. |
1992-07-06 |
2023-08-11 |
Not clear |
| G D Angelini, A J Bryan, H M Williams, A A Soyombo, A Williams, J Tovey, A C Newb. Time-course of medial and intimal thickening in pig venous arterial grafts: relationship to endothelial injury and cholesterol accumulation. The Journal of thoracic and cardiovascular surgery. vol 103. issue 6. 1992-07-06. PMID:1597973. |
we conclude that three processes contribute to medial and intimal thickening, namely: (1) an initial phase of rapid smooth muscle cell proliferation, (2) smooth muscle cell migration, hypertrophy, and synthesis of extracellular matrix, and (3) a late phase of slower smooth muscle cell proliferation. |
1992-07-06 |
2023-08-11 |
Not clear |
| M Alini, Y Matsui, G R Dodge, A R Pool. The extracellular matrix of cartilage in the growth plate before and during calcification: changes in composition and degradation of type II collagen. Calcified tissue international. vol 50. issue 4. 1992-06-03. PMID:1571844. |
calcification occurs in the extracellular matrix of the hypertrophic zone of the growth plate when the extracellular matrix volume is reduced to a minimum and alkaline phosphatase content is maximal. |
1992-06-03 |
2023-08-11 |
cattle |
| M Alini, Y Matsui, G R Dodge, A R Pool. The extracellular matrix of cartilage in the growth plate before and during calcification: changes in composition and degradation of type II collagen. Calcified tissue international. vol 50. issue 4. 1992-06-03. PMID:1571844. |
the concentrations within the extracellular matrix of the c-propeptide of type ii collagen, aggregating proteoglycan (aggrecan), and hyaluronic acid all progressively increased in the maturing and hypertrophic zones, being maximal (or near maximal) at the time of initiation of mineralization. |
1992-06-03 |
2023-08-11 |
cattle |
| M Alini, Y Matsui, G R Dodge, A R Pool. The extracellular matrix of cartilage in the growth plate before and during calcification: changes in composition and degradation of type II collagen. Calcified tissue international. vol 50. issue 4. 1992-06-03. PMID:1571844. |
total collagen concentration (measured as hydroxyproline) in the extracellular matrix initially increased through the proliferating and maturing zones but then rapidly decreased in the hypertrophic zone. |
1992-06-03 |
2023-08-11 |
cattle |
| Q Chen, C Linsenmayer, H Gu, T M Schmid, T F Linsenmaye. Domains of type X collagen: alteration of cartilage matrix by fibril association and proteoglycan accumulation. The Journal of cell biology. vol 117. issue 3. 1992-06-02. PMID:1572897. |
the matrix of hypertrophic cartilage contains at least one tissue-specific component, type x collagen. |
1992-06-02 |
2023-08-11 |
Not clear |
| K Ishizeki, N Kuroda, T Naw. Morphological characteristics of the life cycle of resting cartilage cells in mouse rib investigated in intrasplenic isografts. Anatomy and embryology. vol 185. issue 5. 1992-05-21. PMID:1567018. |
in spite of the hypertrophic chondrocytes in the central zone being surrounded by an extensively calcified matrix during days 14-21 after transplantation, these cells had well-preserved organized organelles, except that golgi-associated elements and endoplasmic reticulum revealed a tendency toward degenerative changes. |
1992-05-21 |
2023-08-11 |
mouse |
| K Ishizeki, N Kuroda, T Naw. Morphological characteristics of the life cycle of resting cartilage cells in mouse rib investigated in intrasplenic isografts. Anatomy and embryology. vol 185. issue 5. 1992-05-21. PMID:1567018. |
with increased duration of the grafting period, from 30-60 days, the calcification zone progressed gradually, and the number of hypertrophic chondrocytes embedded in the calcified matrix decreased considerably. |
1992-05-21 |
2023-08-11 |
mouse |
| K Ishizeki, N Kuroda, T Naw. Morphological characteristics of the life cycle of resting cartilage cells in mouse rib investigated in intrasplenic isografts. Anatomy and embryology. vol 185. issue 5. 1992-05-21. PMID:1567018. |
during the present study, we observed no vascular invasion into the calcified matrix, or appearance of bone-related cells, and the morphological changes from the resting chondrocytes to cellular hypertrophy accompanied by the formation of a calcified matrix were observed at day 60. |
1992-05-21 |
2023-08-11 |
mouse |
| B D Boyan, L D Swain, Z Schwartz, V Ramirez, D L Carne. Epithelial cell lines that induce bone formation in vivo produce alkaline phosphatase-enriched matrix vesicles in culture. Clinical orthopaedics and related research. issue 277. 1992-05-07. PMID:1555351. |
hypertrophic chondrocytes and osteoblasts produce alkaline phosphatase (alpase)-enriched matrix vesicles in vivo and in vitro and, along with certain epithelial cell lines and osteoblast precursors, induce bone when implanted in mesenchymal tissues. |
1992-05-07 |
2023-08-11 |
mouse |
| S Byers, B Caterson, J J Hopwood, B K Foste. Immunolocation analysis of glycosaminoglycans in the human growth plate. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 40. issue 2. 1992-04-27. PMID:1372629. |
also present in the extracellular matrix was an oversulfated chondroitin/dermatan sulfate glycosaminoglycan which appeared to be specific to the proliferative and hypertrophic zones of the growth plate. |
1992-04-27 |
2023-08-11 |
human |
| S Byers, B Caterson, J J Hopwood, B K Foste. Immunolocation analysis of glycosaminoglycans in the human growth plate. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 40. issue 2. 1992-04-27. PMID:1372629. |
these changes in matrix glycosaminoglycan content, both in the different zones and within zones, indicate constant subtle alterations in chondrocyte metabolic products as they proceed through their life cycle of proliferation, maturation, and hypertrophy. |
1992-04-27 |
2023-08-11 |
human |
| K D Brand. Transection of the anterior cruciate ligament in the dog: a model of osteoarthritis. Seminars in arthritis and rheumatism. vol 21. issue 3 Suppl 2. 1992-04-08. PMID:1796303. |
this report validates the cruciate-deficient dog as a model of progressive oa and emphasizes that, before full-thickness loss of articular cartilage, oa is marked by a phase of cartilage hypertrophy associated with a striking increase in synthesis of matrix macromolecules by the chondrocyte (compensatory repair). |
1992-04-08 |
2023-08-11 |
dog |
| R M Leach, G E Rosselo. The use of avian epiphyseal chondrocytes for in vitro studies of skeletal metabolism. The Journal of nutrition. vol 122. issue 3 Suppl. 1992-04-06. PMID:1542051. |
under the proper culture conditions, the chondrocytes will become confluent and achieve a hypertrophic morphology followed by mineralization of the extracellular matrix. |
1992-04-06 |
2023-08-11 |
Not clear |
| R Loeser, C S Carlson, H Tulli, W G Jerome, L Miller, R Walli. Articular-cartilage matrix gamma-carboxyglutamic acid-containing protein. Characterization and immunolocalization. The Biochemical journal. vol 282 ( Pt 1). 1992-03-31. PMID:1540125. |
in newborn articular cartilage mgp was present diffusely throughout the matrix, whereas in growth-plate cartilage it was seen mainly in late hypertrophic and calcifying-zone chondrocytes. |
1992-03-31 |
2023-08-11 |
human |
| F Matsumoto, Y Miyamoto, M Nagayam. Light- and electron-microscopic observations on the mandibular condylar cartilages in growing rats on a low-calcium diet. Acta anatomica. vol 142. issue 1. 1992-03-06. PMID:1781238. |
histological changes occurring in the mandibular condylar cartilages of the rats fed on a low-calcium diet were as follows: (1) narrow proliferative and mature cell zones and a wide hypertrophic cell zone, (2) inhibition of development of cell organelles in the mature chondrocytes, (3) decrease in dead cells in the proliferative zone, (4) decrease in glycogen accumulation in the chondrocytes and (5) inhibition of calcification in the extracellular matrix of the hypertrophic cell zone. |
1992-03-06 |
2023-08-11 |
rat |