| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nimansha Jain, Caroline A Lewis, Jason D Ulrich, David M Holtzma. Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading. The Journal of experimental medicine. vol 220. issue 1. 2022-10-11. PMID:36219197. |
thus, microglia and trem2 are at a critical intersection of aβ and tau pathologies in ad. |
2022-10-11 |
2023-08-14 |
mouse |
| Inge C M Hoogland, Jutka Yik, Dunja Westhoff, Joo-Yeon Engelen-Lee, Merche Valls Seron, Wing-Kit Man, Judith H P M Houben-Weerts, Michael W Tanck, David J van Westerloo, Tom van der Poll, Willem A van Gool, Diederik van de Bee. Microglial Response in Triggering Receptor Expressed on Myeloid Cells 2 (Trem2) Knock-Out Mice After Systemic Stimulation with Escherichia Coli. Neuroscience letters. 2022-10-02. PMID:36183964. |
microglial cell response is a known key player in this process and we hypothesize that the triggering receptor expressed on myeloid cells 2 (trem2) plays an important role in the regulation of this response. |
2022-10-02 |
2023-08-14 |
mouse |
| Kiran K Dayananda, Sahabuddin Ahmed, Daniel Wang, Baruh Polis, Rafiad Islam, Arie Kaffma. Early life stress impairs synaptic pruning in the developing hippocampus. Brain, behavior, and immunity. 2022-09-29. PMID:36174883. |
exposure to both lb and ups reduced the ramification of microglia, impaired their ability to phagocytose synaptic material in vivo and ex vivo, and decreased expression of trem2. |
2022-09-29 |
2023-08-14 |
mouse |
| Na Zhao, Wenhui Qiao, Fuyao Li, Yingxue Ren, Jiaying Zheng, Yuka A Martens, Xusheng Wang, Ling Li, Chia-Chen Liu, Kai Chen, Yiyang Zhu, Tadafumi C Ikezu, Zonghua Li, Axel D Meneses, Yunjung Jin, Joshua A Knight, Yixing Chen, Ligia Bastea, Cynthia Linares, Berkiye Sonustun, Lucy Job, Madeleine L Smith, Manling Xie, Yong U Liu, Anthony D Umpierre, Koichiro Haruwaka, Zachary S Quicksall, Peter Storz, Yan W Asmann, Long-Jun Wu, Guojun B. Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia. The Journal of experimental medicine. vol 219. issue 12. 2022-09-15. PMID:36107206. |
elevating microglia trem2 reduces amyloid seeding and suppresses disease-associated microglia. |
2022-09-15 |
2023-08-14 |
mouse |
| Na Zhao, Wenhui Qiao, Fuyao Li, Yingxue Ren, Jiaying Zheng, Yuka A Martens, Xusheng Wang, Ling Li, Chia-Chen Liu, Kai Chen, Yiyang Zhu, Tadafumi C Ikezu, Zonghua Li, Axel D Meneses, Yunjung Jin, Joshua A Knight, Yixing Chen, Ligia Bastea, Cynthia Linares, Berkiye Sonustun, Lucy Job, Madeleine L Smith, Manling Xie, Yong U Liu, Anthony D Umpierre, Koichiro Haruwaka, Zachary S Quicksall, Peter Storz, Yan W Asmann, Long-Jun Wu, Guojun B. Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia. The Journal of experimental medicine. vol 219. issue 12. 2022-09-15. PMID:36107206. |
trem2 is exclusively expressed by microglia in the brain and is strongly linked to the risk for alzheimer's disease (ad). |
2022-09-15 |
2023-08-14 |
mouse |
| Peng Zhao, Yuanzhong Xu, LuLin Jiang, Xuejun Fan, Leike Li, Xin Li, Hisashi Arase, Yingjun Zhao, Wei Cao, Hui Zheng, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang A. A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease. Science translational medicine. vol 14. issue 661. 2022-09-07. PMID:36070367. |
triggering receptor expressed on myeloid cells 2 (trem2) plays crucial roles in alzheimer's disease (ad) by regulating microglia migration toward, and phagocytosis of oligomeric amyloid-β (oaβ) and amyloid plaques. |
2022-09-07 |
2023-08-14 |
mouse |
| Peng Zhao, Yuanzhong Xu, LuLin Jiang, Xuejun Fan, Leike Li, Xin Li, Hisashi Arase, Yingjun Zhao, Wei Cao, Hui Zheng, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang A. A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease. Science translational medicine. vol 14. issue 661. 2022-09-07. PMID:36070367. |
stronger trem2 activation led to enhanced microglia phagocytosis of the oaβ-lipid complex, migration toward oaβ, and improved microglia survival in vitro. |
2022-09-07 |
2023-08-14 |
mouse |
| Peng Zhao, Yuanzhong Xu, LuLin Jiang, Xuejun Fan, Leike Li, Xin Li, Hisashi Arase, Yingjun Zhao, Wei Cao, Hui Zheng, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang A. A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease. Science translational medicine. vol 14. issue 661. 2022-09-07. PMID:36070367. |
mechanistic studies showed increased trem2 clustering on microglia by the tetravalent ab18 tvd-ig without altering microglial trem2 amount. |
2022-09-07 |
2023-08-14 |
mouse |
| Peng Zhao, Yuanzhong Xu, LuLin Jiang, Xuejun Fan, Leike Li, Xin Li, Hisashi Arase, Yingjun Zhao, Wei Cao, Hui Zheng, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang A. A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease. Science translational medicine. vol 14. issue 661. 2022-09-07. PMID:36070367. |
this study demonstrated the feasibility of engineering multivalent trem2 agonistic ab coupled with tfr-mediated brain delivery to enhance microglia functions and reduce amyloid pathology in vitro and in vivo. |
2022-09-07 |
2023-08-14 |
mouse |
| Bing Zhu, Yan Liu, Spring Hwang, Kailey Archuleta, Huijie Huang, Alex Campos, Rabi Murad, Juan Piña-Crespo, Huaxi Xu, Timothy Y Huan. Trem2 deletion enhances tau dispersion and pathology through microglia exosomes. Molecular neurodegeneration. vol 17. issue 1. 2022-09-02. PMID:36056435. |
trem2 deletion enhances tau dispersion and pathology through microglia exosomes. |
2022-09-02 |
2023-08-14 |
Not clear |
| Xue Han, Xiaolei Cheng, Jiyan Xu, Yujia Liu, Jiawen Zhou, Linhao Jiang, Xiaoping Gu, Tianjiao Xi. Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice. Neuropharmacology. 2022-08-30. PMID:36041498. |
we found that hippocampus-dependent learning and memory were impaired in pocd mice, which was accompanied by activation of microglia and downregulation of trem2. |
2022-08-30 |
2023-08-14 |
mouse |
| Xue Han, Xiaolei Cheng, Jiyan Xu, Yujia Liu, Jiawen Zhou, Linhao Jiang, Xiaoping Gu, Tianjiao Xi. Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice. Neuropharmacology. 2022-08-30. PMID:36041498. |
pretreatment with the trem2 agonist heat shock protein (hsp)60 inhibited surgery-induced microglia activation and alleviated postoperative cognitive impairment. |
2022-08-30 |
2023-08-14 |
mouse |
| Xue Han, Xiaolei Cheng, Jiyan Xu, Yujia Liu, Jiawen Zhou, Linhao Jiang, Xiaoping Gu, Tianjiao Xi. Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice. Neuropharmacology. 2022-08-30. PMID:36041498. |
these results demonstrate that trem2 is involved in the regulation of the inflammatory response mediated by microglia and cognitive impairment following surgery. |
2022-08-30 |
2023-08-14 |
mouse |
| Aymeric Silvin, Stefan Uderhardt, Cecile Piot, Sandro Da Mesquita, Katharine Yang, Laufey Geirsdottir, Kevin Mulder, David Eyal, Zhaoyuan Liu, Cecile Bridlance, Morgane Sonia Thion, Xiao Meng Zhang, Wan Ting Kong, Marc Deloger, Vasco Fontes, Assaf Weiner, Rachel Ee, Regine Dress, Jing Wen Hang, Akhila Balachander, Svetoslav Chakarov, Benoit Malleret, Garett Dunsmore, Olivier Cexus, Jinmiao Chen, Sonia Garel, Charles Antoine Dutertre, Ido Amit, Jonathan Kipnis, Florent Ginhou. Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration. Immunity. 2022-08-05. PMID:35931085. |
we show that the previously identified disease-associated microglia (dam) population detected in murine alzheimer's disease models actually comprises two ontogenetically and functionally distinct cell lineages: embryonically derived triggering receptor expressed on myeloid cells 2 (trem2)-dependent dam expressing a neuroprotective signature and monocyte-derived trem2-expressing disease inflammatory macrophages (dims) accumulating in the brain during aging. |
2022-08-05 |
2023-08-14 |
human |
| Vladimira Durmanova, Juraj Javor, Zuzana Parnicka, Gabriel Minarik, Agata Ocenasova, Barbora Vaseckova, Iliana Kiralyova, Stanislav Sutovsky, Robert Petrovic, Ivana Shawkatov. Journal of integrative neuroscience. vol 21. issue 4. 2022-07-22. PMID:35864757. |
in the human brain, trem2 is primarily expressed on microglia and is involved in cell survival, phagocytosis, and regulation of inflammation. |
2022-07-22 |
2023-08-14 |
human |
| Juan García-Revilla, Antonio Boza-Serrano, Ana M Espinosa-Oliva, Manuel Sarmiento Soto, Tomas Deierborg, Rocío Ruiz, Rocío M de Pablos, Miguel Angel Burguillos, Jose L Vener. Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration. Cell death & disease. vol 13. issue 7. 2022-07-20. PMID:35859075. |
in this review, we summarise the main findings that demonstrate the ability of galectin-3 to interact with key pattern recognition receptors, including, among others, tlr4 and trem2 and the importance of galectin-3 in the regulation of microglia activation. |
2022-07-20 |
2023-08-14 |
Not clear |
| Anna Fracassi, Michela Marcatti, Batbayar Tumurbaatar, Randall Woltjer, Sandra Moreno, Giulio Taglialatel. TREM2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology. Brain pathology (Zurich, Switzerland). 2022-07-11. PMID:35816404. |
based on trem2 role in the scavenging function of microglia, we hypothesize that an efficient microglial phagocytosis of damaged synapses underlies synaptic resilience in ndan, thus protecting from memory deficits. |
2022-07-11 |
2023-08-14 |
human |
| Marino Muxfeldt Bianchin, Zhezu Sno. Primary microglia dysfunction or microgliopathy: A cause of dementias and other neurological or psychiatric disorders. Neuroscience. 2022-06-27. PMID:35760218. |
observations that the impairment of normal microglia function per se could lead to neurological or psychiatric diseases have been mainly obtained from genetic and molecular studies of nasu-hakola disease, caused by tyrobp or trem2 mutations, and from studies of adult-onset leukoencephalopathy with axonal spheroids (alsp), caused by csf1r mutations. |
2022-06-27 |
2023-08-14 |
human |
| Hannah Schwarz, Sarah Bässler, Denise Balta, Eileen Socher, Friederike Zunke, Philipp Arnol. The role of Triggering Receptor Expressed on Myeloid Cells 2 in Parkinson's disease and other neurodegenerative disorders. Behavioural brain research. 2022-06-25. PMID:35752274. |
expressed on phagocytic cells, such as macrophages and microglia, trem2 puts the focus on inflammation associated conditions in pd and provides a molecular target that could at least partly explain the role of immune cells in pd. |
2022-06-25 |
2023-08-14 |
Not clear |
| Darya Khantakova, Simone Brioschi, Martina Molgor. Exploring the Impact of TREM2 in Tumor-Associated Macrophages. Vaccines. vol 10. issue 6. 2022-06-24. PMID:35746551. |
trem2 has been extensively studied in microglia and neurodegenerative diseases and recently emerged as a marker of pro-tumorigenic macrophages. |
2022-06-24 |
2023-08-14 |
Not clear |