| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charlotte Duwat, Pauline Léal, Audrey Vautheny, Gwennaëlle Aurégan, Charlène Joséphine, Marie-Claude Gaillard, Anne-Sophie Hérard, Caroline Jan, Pauline Gipchtein, Julien Mitja, Stéphane Fouquet, Marie-Laure Niepon, Philippe Hantraye, Emmanuel Brouillet, Gilles Bonvento, Karine Cambon, Alexis-Pierre Bemelman. Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology. Neurobiology of disease. 2023-04-13. PMID:37054900. |
the application of this model to mice deficient in trem2 (triggering receptor expressed on myeloid cells-2, an important genetic risk factor for ad) as well as to 15-month-old mice showed that microglia actively participate in the degeneration of rgcs. |
2023-04-13 |
2023-08-14 |
mouse |
| Yanhui Lu, Xiaofeng Huang, Wenping Liang, Yu Li, Mengen Xing, Wenhao Pan, Yun Zhang, Zhe Wang, Weihong Son. Regulation of TREM2 expression by transcription factor YY1 and its protective effect against Alzheimer's Disease. The Journal of biological chemistry. 2023-04-12. PMID:37044212. |
trem2 encoding the transmembrane receptor protein trem2 is a risk gene of alzheimer's disease (ad), and the impairment of trem2 functions in microglia due to mutations in trem2 may significantly increase the risk of ad by promoting ad pathologies. |
2023-04-12 |
2023-08-14 |
mouse |
| Yanhui Lu, Xiaofeng Huang, Wenping Liang, Yu Li, Mengen Xing, Wenhao Pan, Yun Zhang, Zhe Wang, Weihong Son. Regulation of TREM2 expression by transcription factor YY1 and its protective effect against Alzheimer's Disease. The Journal of biological chemistry. 2023-04-12. PMID:37044212. |
shrna-mediated yy1 silencing significantly reduced the activity of the trem2 minimal promoter and trem2 protein levels in the microglial cell line bv2 and the neuroblastoma neuro2a. |
2023-04-12 |
2023-08-14 |
mouse |
| Akihiro Iguchi, Sho Takatori, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Genta Ito, Haruaki Sato, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomit. INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model. iScience. vol 26. issue 4. 2023-04-10. PMID:37035000. |
the genetic associations of trem2 loss-of-function variants with alzheimer disease (ad) indicate the protective roles of microglia in ad pathogenesis. |
2023-04-10 |
2023-08-14 |
mouse |
| Yun-Fan You, Man Chen, Yue Tang, Wen-Xiang Yu, Xiao-Wei Pang, Yun-Hui Chu, Hang Zhang, Ke Shang, Gang Deng, Luo-Qi Zhou, Sheng Yang, Wei Wang, Jun Xiao, Dai-Shi Tian, Chuan Qi. TREM2 deficiency inhibits microglial activation and aggravates demyelinating injury in neuromyelitis optica spectrum disorder. Journal of neuroinflammation. vol 20. issue 1. 2023-04-04. PMID:37013543. |
triggering receptor expressed on myeloid cells 2 (trem2) is expressed by microglia and promotes microglial activation, survival and phagocytosis. |
2023-04-04 |
2023-08-14 |
mouse |
| Eyiyemisi C Damisah, Anupama Rai, Robert A Hill, Lei Tong, Jaime Grutzendle. TREM2 and APOE do not modulate phagocytic clearance of dying cells in the live mammalian brain. bioRxiv : the preprint server for biology. 2023-03-30. PMID:36993245. |
trem2 and apoe are two major risk factors for alzheimer’s disease (ad) that have been proposed to play crucial roles in microglia pathophysiology by affecting their ability to phagocytose cellular debris or aggregated proteins. |
2023-03-30 |
2023-08-14 |
Not clear |
| Eyiyemisi C Damisah, Anupama Rai, Robert A Hill, Lei Tong, Jaime Grutzendle. TREM2 and APOE do not modulate phagocytic clearance of dying cells in the live mammalian brain. bioRxiv : the preprint server for biology. 2023-03-30. PMID:36993245. |
our findings showed that the deletion of either trem2 or apoe did not affect the dynamics of microglia engagement with dying neurons or their efficiency in phagocytosing corpses. |
2023-03-30 |
2023-08-14 |
Not clear |
| Eyiyemisi C Damisah, Anupama Rai, Robert A Hill, Lei Tong, Jaime Grutzendle. TREM2 and APOE do not modulate phagocytic clearance of dying cells in the live mammalian brain. bioRxiv : the preprint server for biology. 2023-03-30. PMID:36993245. |
interestingly, while microglia that encapsulate amyloid deposits were capable of phagocytosing dying cells without disengaging from plaques or moving their cell bodies; in the absence of trem2, microglia cell bodies were observed to readily migrate towards dying cells, further disengaging from plaques. |
2023-03-30 |
2023-08-14 |
Not clear |
| Wenchuan Zhou, Yutong Zhou, Jincan He, Yuqing Rao, Ping Fei, Jing L. TREM2 deficiency in microglia accelerates photoreceptor cell death and immune cell infiltration following retinal detachment. Cell death & disease. vol 14. issue 3. 2023-03-28. PMID:36977680. |
trem2 deficiency in microglia accelerates photoreceptor cell death and immune cell infiltration following retinal detachment. |
2023-03-28 |
2023-08-14 |
Not clear |
| Wenchuan Zhou, Yutong Zhou, Jincan He, Yuqing Rao, Ping Fei, Jing L. TREM2 deficiency in microglia accelerates photoreceptor cell death and immune cell infiltration following retinal detachment. Cell death & disease. vol 14. issue 3. 2023-03-28. PMID:36977680. |
triggering receptor expressed on myeloid cells 2 (trem2) is an innate immune receptor exclusively expressed on microglial cells in the retina, and has been reported to affect microglial cell homeostasis, phagocytosis and inflammatory responses in the brain. |
2023-03-28 |
2023-08-14 |
Not clear |
| Chloe G McKee, Madison Hoffos, Haley A Vecchiarelli, Marie-Ève Trembla. Microglia: A pharmacological target for the treatment of age-related cognitive decline and Alzheimer's disease. Frontiers in pharmacology. vol 14. 2023-03-27. PMID:36969855. |
preclinical and early phase clinical trials investigating the therapeutic effects of pharmacological agents acting on microglia, including reactive oxygen species, trem2, fractalkine signaling, the complement cascade, and the nlrp3 inflammasome, are currently underway; however, important questions remain unanswered. |
2023-03-27 |
2023-08-14 |
Not clear |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
trem2 gene expression associations with alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. |
2023-03-25 |
2023-08-14 |
Not clear |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
trem2 gene expression of the dorsolateral prefrontal cortex, posterior cingulate cortex, and caudate nucleus was assessed with respect to core pathology of alzheimer's disease (amyloid-β, and tau), cerebrovascular pathology (cerebral infarcts, arteriolosclerosis, atherosclerosis, and cerebral amyloid angiopathy), microglial activation (proportion of activated microglia), and cognitive performance. |
2023-03-25 |
2023-08-14 |
Not clear |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
we found that cortical trem2 levels were positively related to ad diagnosis, cognitive decline, and amyloid-β neuropathology but were not related to the proportion of activated microglia. |
2023-03-25 |
2023-08-14 |
Not clear |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
in contrast, caudate trem2 levels were not related to ad pathology, cognition, or diagnosis, but were positively related to the proportion of activated microglia in the same region. |
2023-03-25 |
2023-08-14 |
Not clear |
| Lijuan Luo, Jie Chen, Qionghui Wu, Binlin Yuan, Chaoqun Hu, Ting Yang, Hua Wei, Tingyu L. Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations. Environmental toxicology and pharmacology. 2023-03-04. PMID:36870407. |
the triggering receptor expressed on myeloid cells 2 (trem2) is revealed to be implicated in a range of microglia functions. |
2023-03-04 |
2023-08-14 |
rat |
| Lijuan Luo, Jie Chen, Qionghui Wu, Binlin Yuan, Chaoqun Hu, Ting Yang, Hua Wei, Tingyu L. Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations. Environmental toxicology and pharmacology. 2023-03-04. PMID:36870407. |
trem2 overexpression partly ameliorated microglia dysfunction and autistic-like behaviors in prenatal vpa-exposed rats. |
2023-03-04 |
2023-08-14 |
rat |
| Lijuan Luo, Jie Chen, Qionghui Wu, Binlin Yuan, Chaoqun Hu, Ting Yang, Hua Wei, Tingyu L. Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations. Environmental toxicology and pharmacology. 2023-03-04. PMID:36870407. |
our findings demonstrated that prenatally vpa exposure is likely to cause autistic-like behavior in the rat offspring via trem2 down-regulation to affect the microglial activation, microglial polarization and synaptic pruning of microglia for the first time. |
2023-03-04 |
2023-08-14 |
rat |
| Miguel Moutinho, Israel Coronel, Andy P Tsai, Gonzalo Viana Di Prisco, Taylor Pennington, Brady K Atwood, Shweta S Puntambekar, Daniel C Smith, Pablo Martinez, Seonggyun Han, Younghee Lee, Cristian A Lasagna-Reeves, Bruce T Lamb, Stephanie J Bissel, Kwangsik Nho, Gary E Landret. TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation. Genome medicine. vol 15. issue 1. 2023-02-22. PMID:36805764. |
trem2 governs the response of microglia to amyloid and tau pathologies in the alzheimer's disease (ad) brain. |
2023-02-22 |
2023-08-14 |
mouse |
| Na Zhao, Guojun B. A TREM2 antibody energizes microglia. Nature neuroscience. 2023-02-10. PMID:36765163. |
a trem2 antibody energizes microglia. |
2023-02-10 |
2023-08-14 |
Not clear |