| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Han Gao, Jiawei Di, Bettina Hjelm Clausen, Nanxiang Wang, Xizhong Zhu, Tianlun Zhao, Yanyu Chang, Mao Pang, Yang Yang, Ronghan He, Yuge Wang, Liangming Zhang, Bin Liu, Wei Qiu, Kate Lykke Lambertsen, Roberta Brambilla, Limin Ron. Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders. Cell reports. vol 42. issue 6. 2023-06-08. PMID:37289590. |
here, we identify two distinct phenotypes of microglia and infiltrating myeloid populations dependent on trem2 expression levels at the acute stage and elucidate how they mediate the opposing effects of trem2 in spinal cord injury (sci) versus multiple sclerosis animal models (experimental autoimmune encephalomyelitis [eae]). |
2023-06-08 |
2023-08-14 |
Not clear |
| Han Gao, Jiawei Di, Bettina Hjelm Clausen, Nanxiang Wang, Xizhong Zhu, Tianlun Zhao, Yanyu Chang, Mao Pang, Yang Yang, Ronghan He, Yuge Wang, Liangming Zhang, Bin Liu, Wei Qiu, Kate Lykke Lambertsen, Roberta Brambilla, Limin Ron. Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders. Cell reports. vol 42. issue 6. 2023-06-08. PMID:37289590. |
high trem2 levels sustain phagocytic microglia and infiltrating macrophages after sci. |
2023-06-08 |
2023-08-14 |
Not clear |
| Han Gao, Jiawei Di, Bettina Hjelm Clausen, Nanxiang Wang, Xizhong Zhu, Tianlun Zhao, Yanyu Chang, Mao Pang, Yang Yang, Ronghan He, Yuge Wang, Liangming Zhang, Bin Liu, Wei Qiu, Kate Lykke Lambertsen, Roberta Brambilla, Limin Ron. Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders. Cell reports. vol 42. issue 6. 2023-06-08. PMID:37289590. |
in contrast, moderate trem2 levels sustain immunomodulatory microglia and infiltrating monocytes in eae. |
2023-06-08 |
2023-08-14 |
Not clear |
| Motoaki Yanaizu, Haruka Adachi, Makoto Araki, Kenji Kontani, Yoshihiro Kin. Translational regulation and protein-coding capacity of the 5' untranslated region of human TREM2. Communications biology. vol 6. issue 1. 2023-06-08. PMID:37291187. |
trem2 is a transmembrane receptor expressed in microglia and macrophages. |
2023-06-08 |
2023-08-14 |
human |
| Gongcan Chen, Mengmeng Han, Yi Chen, Yaling Lei, Min Li, Li Wang, Chen Wang, Yangxue Hu, Jinghu Niu, Cong Yang, Yousheng Mo, Qi Wang, Lin Yang, Xiang Chan. Danggui-Shaoyao-San Promotes Amyloid-β Clearance through Regulating Microglia Polarization via Trem2 in BV2 Cells. Journal of integrative neuroscience. vol 22. issue 3. 2023-05-31. PMID:37258433. |
danggui-shaoyao-san promotes amyloid-β clearance through regulating microglia polarization via trem2 in bv2 cells. |
2023-05-31 |
2023-08-14 |
Not clear |
| Peng Su, Jianbin Zhang, Jinxia Wu, Honggang Chen, Wenjing Luo, Min H. TREM2 expression on the microglia resolved lead exposure-induced neuroinflammation by promoting anti-inflammatory activities. Ecotoxicology and environmental safety. vol 260. 2023-05-28. PMID:37245276. |
trem2 expression on the microglia resolved lead exposure-induced neuroinflammation by promoting anti-inflammatory activities. |
2023-05-28 |
2023-08-14 |
Not clear |
| Peng Su, Jianbin Zhang, Jinxia Wu, Honggang Chen, Wenjing Luo, Min H. TREM2 expression on the microglia resolved lead exposure-induced neuroinflammation by promoting anti-inflammatory activities. Ecotoxicology and environmental safety. vol 260. 2023-05-28. PMID:37245276. |
our results showed that pb treatment significantly downregulated trem2 expression and altered the localization of trem2 expression in microglia. |
2023-05-28 |
2023-08-14 |
Not clear |
| Peng Su, Jianbin Zhang, Jinxia Wu, Honggang Chen, Wenjing Luo, Min H. TREM2 expression on the microglia resolved lead exposure-induced neuroinflammation by promoting anti-inflammatory activities. Ecotoxicology and environmental safety. vol 260. 2023-05-28. PMID:37245276. |
furthermore, the phagocytosis and migratory capabilities of microglia, which were impaired due to pb exposure, were alleviated by trem2 overexpression. |
2023-05-28 |
2023-08-14 |
Not clear |
| Peng Su, Jianbin Zhang, Jinxia Wu, Honggang Chen, Wenjing Luo, Min H. TREM2 expression on the microglia resolved lead exposure-induced neuroinflammation by promoting anti-inflammatory activities. Ecotoxicology and environmental safety. vol 260. 2023-05-28. PMID:37245276. |
our in vitro findings were corroborated in vivo, demonstrating that trem2 regulates the anti-inflammatory functions of microglia, thereby mitigating pb-induced neuroinflammation. |
2023-05-28 |
2023-08-14 |
Not clear |
| b' Marzia Moretti, Riccardo Caraffi, Luca Lorenzini, Ilaria Ottonelli, Michele Sannia, Giuseppe Alastra, Vito Antonio Baldassarro, Alessandro Giuliani, Jason Thomas Duskey, Maura Cescatti, Barbara Ruozi, Luigi Aloe, Maria Angela Vandelli, Luciana Giardino, Giovanni Tosi, Laura Calz\\xc3\\xa. "Combo" Multi-Target Pharmacological Therapy and New Formulations to Reduce Inflammation and Improve Endogenous Remyelination in Traumatic Spinal Cord Injury. Cells. vol 12. issue 9. 2023-05-14. PMID:37174731.' |
a strong anti-inflammatory effect was observed in the short term with a reduction of type m1 microglia and glutamate levels, but with a subsequent increase of trem2. |
2023-05-14 |
2023-08-14 |
mouse |
| Rui Sun, Rowland Han, Colin McCornack, Saad Khan, G Travis Tabor, Yun Chen, Jinchao Hou, Haowu Jiang, Kathleen M Schoch, Diane D Mao, Ryan Cleary, Alicia Yang, Qin Liu, Jingqin Luo, Allegra Petti, Timothy M Miller, Jason D Ulrich, David M Holtzman, Albert H Ki. TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma. Science advances. vol 9. issue 19. 2023-05-12. PMID:37172094. |
here, we found that trem2 is highly expressed in myeloid subsets, including macrophages and microglia in human and mouse gbm tumors and that high trem2 expression correlates with poor prognosis in patients with gbm. |
2023-05-12 |
2023-08-14 |
mouse |
| Tingting Zhang, Weilun Pang, Tuancheng Feng, Jennifer Guo, Kenton Wu, Mariela Nunez Santos, Akshayakeerthi Arthanarisami, Alissa L Nana, Quynh Nguyen, Peter J Kim, Joanna L Jankowsky, William W Seeley, Fenghua H. TMEM106B regulates microglial proliferation and survival in response to demyelination. Science advances. vol 9. issue 18. 2023-05-05. PMID:37146150. |
furthermore, tmem106b loss results in a significant decrease in the protein levels of trem2, an innate immune receptor essential for microglia survival and activation. |
2023-05-05 |
2023-08-14 |
mouse |
| Chuan Qin, Sheng Yang, Man Chen, Ming-Hao Dong, Luo-Qi Zhou, Yun-Hui Chu, Zhu-Xia Shen, Dale B Bosco, Long-Jun Wu, Dai-Shi Tian, Wei Wan. Modulation of microglial metabolism facilitates regeneration in demyelination. iScience. vol 26. issue 5. 2023-05-04. PMID:37138776. |
in addition, microglial triggering receptor expressed on myeloid cells 2 (trem2) was greatly involved in the phenotype transition in demyelination, but not indispensable for microglia transition toward pems. |
2023-05-04 |
2023-08-14 |
human |
| Li Li, Qingyou Chen, Yinghui Qin, Guangna Yu, Tingting Qi, Hesong Sui, Xin Qi, Lijuan Huan. Regulation of TREM2 on BV2 inflammation through PI3K/AKT/mTOR pathway. Biotechnology & genetic engineering reviews. 2023-05-01. PMID:37125903. |
this work sought to determine how lipopolysaccharide (lps)-induced pro-inflammatory factor production in bv2 microglia was influenced by myeloid cell 2 (trem2) expressions. |
2023-05-01 |
2023-08-14 |
Not clear |
| Fabia Filipello, Shih-Feng You, Farzaneh S Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A Minaya, Arun Renganathan, Anil G Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K Iyer, Marina Cella, Wendy H Raskind, Laura Piccio, Celeste M Karc. Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation. Acta neuropathologica. 2023-04-28. PMID:37115208. |
defects in lysosomal function and lipid metabolism in human microglia harboring a trem2 loss of function mutation. |
2023-04-28 |
2023-08-14 |
human |
| Fabia Filipello, Shih-Feng You, Farzaneh S Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A Minaya, Arun Renganathan, Anil G Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K Iyer, Marina Cella, Wendy H Raskind, Laura Piccio, Celeste M Karc. Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation. Acta neuropathologica. 2023-04-28. PMID:37115208. |
trem2 is an innate immune receptor expressed by microglia in the adult brain. |
2023-04-28 |
2023-08-14 |
human |
| Fabia Filipello, Shih-Feng You, Farzaneh S Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A Minaya, Arun Renganathan, Anil G Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K Iyer, Marina Cella, Wendy H Raskind, Laura Piccio, Celeste M Karc. Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation. Acta neuropathologica. 2023-04-28. PMID:37115208. |
induced pluripotent stem cell (ipsc)-derived microglia (imgls) were generated from two nhd families: three homozygous trem2 p.q33x mutation carriers (termed nhd), two heterozygous mutation carriers, one related non-carrier, and two unrelated non-carriers. |
2023-04-28 |
2023-08-14 |
human |
| Fabia Filipello, Shih-Feng You, Farzaneh S Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A Minaya, Arun Renganathan, Anil G Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K Iyer, Marina Cella, Wendy H Raskind, Laura Piccio, Celeste M Karc. Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation. Acta neuropathologica. 2023-04-28. PMID:37115208. |
our study provides the first cellular and molecular evidence that the trem2 p.q33x mutation in microglia leads to defects in lysosomal function and that compounds targeting lysosomal biogenesis restore a number of nhd microglial defects. |
2023-04-28 |
2023-08-14 |
human |
| Raz Dvir-Szternfeld, Giulia Castellani, Michal Arad, Liora Cahalon, Sarah Phoebeluc Colaiuta, Hadas Keren-Shaul, Tommaso Croese, Chiara Burgaletto, Kuti Baruch, Tyler Ulland, Marco Colonna, Assaf Weiner, Ido Amit, Michal Schwart. Alzheimer's disease modification mediated by bone marrow-derived macrophages via a TREM2-independent pathway in mouse model of amyloidosis. Nature aging. vol 2. issue 1. 2023-04-28. PMID:37118355. |
in amyloidosis mouse models, activation of microglia was found to be trem2 dependent. |
2023-04-28 |
2023-08-14 |
mouse |
| Logan Brase, Shih-Feng You, Ricardo D'Oliveira Albanus, Jorge L Del-Aguila, Yaoyi Dai, Brenna C Novotny, Carolina Soriano-Tarraga, Taitea Dykstra, Maria Victoria Fernandez, John P Budde, Kristy Bergmann, John C Morris, Randall J Bateman, Richard J Perrin, Eric McDade, Chengjie Xiong, Alison M Goate, Martin Farlow, Greg T Sutherland, Jonathan Kipnis, Celeste M Karch, Bruno A Benitez, Oscar Harar. Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers. Nature communications. vol 14. issue 1. 2023-04-21. PMID:37085492. |
trem2 oligodendrocytes show a dysregulated autophagy-lysosomal pathway, ms4a microglia have dysregulated complement cascade genes, and apoeε4 inhibitory neurons display signs of ferroptosis. |
2023-04-21 |
2023-08-14 |
Not clear |