| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicolau Beckmann, Anna Neuhaus, Stefan Zurbruegg, Pia Volkmer, Claudia Patino, Stefanie Joller, Dominik Feuerbach, Arno Doelemeyer, Tatjana Schweizer, Stefan Rudin, Ulf Neumann, Ramon Berth, Wilfried Frieauff, Fabrizio Gasparini, Derya R Shimshe. Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model. Journal of neuroinflammation. vol 20. issue 1. 2023-02-09. PMID:36755323. |
genetic models of cleavage-reduced and soluble trem2 reveal distinct effects on myelination and microglia function in the cuprizone model. |
2023-02-09 |
2023-08-14 |
mouse |
| Nicolau Beckmann, Anna Neuhaus, Stefan Zurbruegg, Pia Volkmer, Claudia Patino, Stefanie Joller, Dominik Feuerbach, Arno Doelemeyer, Tatjana Schweizer, Stefan Rudin, Ulf Neumann, Ramon Berth, Wilfried Frieauff, Fabrizio Gasparini, Derya R Shimshe. Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model. Journal of neuroinflammation. vol 20. issue 1. 2023-02-09. PMID:36755323. |
triggering receptor expressed on myeloid cells 2 (trem2) is a cell-surface immunoreceptor expressed on microglia, osteoclasts, dendritic cells and macrophages. |
2023-02-09 |
2023-08-14 |
mouse |
| Nicolau Beckmann, Anna Neuhaus, Stefan Zurbruegg, Pia Volkmer, Claudia Patino, Stefanie Joller, Dominik Feuerbach, Arno Doelemeyer, Tatjana Schweizer, Stefan Rudin, Ulf Neumann, Ramon Berth, Wilfried Frieauff, Fabrizio Gasparini, Derya R Shimshe. Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model. Journal of neuroinflammation. vol 20. issue 1. 2023-02-09. PMID:36755323. |
taken together, our data suggest that sustained microglia activation led to increased remyelination, whereas microglia without plasma membrane trem2 and only soluble trem2 had reduced phagocytic activity despite efficient lysosomal function, as observed in bone marrow-derived macrophages, leading to a dysfunctional phenotype with improper myelin debris removal, lack of remyelination and axonal pathology following cuprizone intoxication. |
2023-02-09 |
2023-08-14 |
mouse |
| Mingchen Yu, Yuanhao Chang, You Zhai, Bo Pang, Peng Wang, Guanzhang Li, Tao Jiang, Fan Zen. Frontiers in immunology. vol 13. 2023-01-30. PMID:36713360. |
single-cell analysis and multiple immunohistochemical staining results showed that microglia and macrophage cells expressed trem2. |
2023-01-30 |
2023-08-14 |
Not clear |
| Mingchen Yu, Yuanhao Chang, You Zhai, Bo Pang, Peng Wang, Guanzhang Li, Tao Jiang, Fan Zen. Frontiers in immunology. vol 13. 2023-01-30. PMID:36713360. |
in conclusion, our findings revealed that trem2 was significantly expressed in microglia and macrophage cells and was intimately associated with the tumor immune microenvironment. |
2023-01-30 |
2023-08-14 |
Not clear |
| Sk Chand Basha, Mekala Janaki Ramaiah, Jagannatha Rao Kosagishara. Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-01-23. PMID:36683512. |
untangling the role of trem2 in conjugation with microglia in neuronal dysfunction: a hypothesis on a novel pathway in the pathophysiology of alzheimer's disease. |
2023-01-23 |
2023-08-14 |
Not clear |
| Sk Chand Basha, Mekala Janaki Ramaiah, Jagannatha Rao Kosagishara. Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-01-23. PMID:36683512. |
disease associated microglia (dam), a novel state of microglia with unique transcriptional and functional signatures reported in neurodegenerative conditions, also depend on the trem2 pathway for its differentiation. |
2023-01-23 |
2023-08-14 |
Not clear |
| Zhiyun Qiu, Huilin Wang, Mengdi Qu, Shuainan Zhu, Hao Zhang, Qingwu Liao, Changhong Mia. Consecutive Injection of High-Dose Lipopolysaccharide Modulates Microglia Polarization via TREM2 to Alter Status of Septic Mice. Brain sciences. vol 13. issue 1. 2023-01-21. PMID:36672106. |
consecutive injection of high-dose lipopolysaccharide modulates microglia polarization via trem2 to alter status of septic mice. |
2023-01-21 |
2023-08-14 |
mouse |
| Ivonne Jericó, Janire Vicuña-Urriza, Idoia Blanco-Luquin, Mónica Macias, Leyre Martinez-Merino, Miren Roldán, Ricard Rojas-Garcia, Inmaculada Pagola-Lorz, Alvaro Carbayo, Noemi De Luna, Victoria Zelaya, Maite Mendioro. Profiling TREM2 expression in amyotrophic lateral sclerosis. Brain, behavior, and immunity. 2023-01-21. PMID:36681358. |
trem2 gene plays a crucial role in shaping microglia in neurodegenerative conditions. |
2023-01-21 |
2023-08-14 |
Not clear |
| Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji, Weina Yan. TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro. Molecular neurobiology. 2023-01-20. PMID:36662361. |
triggering receptor expressed on myeloid cells-2 (trem2), a cell surface receptor mainly expressed on microglia, has been shown to play a critical role in alzheimer's disease (ad) pathogenesis and progression. |
2023-01-20 |
2023-08-14 |
mouse |
| Yingyue Zhou, Mari Tada, Zhangying Cai, Prabhakar S Andhey, Amanda Swain, Kelly R Miller, Susan Gilfillan, Maxim N Artyomov, Masaki Takao, Akiyoshi Kakita, Marco Colonn. Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia. Nature immunology. 2023-01-19. PMID:36658241. |
heterozygous hypofunctional trem2 variants impair microglia, accelerating late-onset alzheimer's disease. |
2023-01-19 |
2023-08-14 |
mouse |
| Gunel Ayyubov. TREM2-signaling as a multifaceted player in brain homeostasis and a potential target for Alzheimer's Disease treatment. The European journal of neuroscience. 2023-01-13. PMID:36637116. |
trem2 also ameliorates the pathological effects of activated microglia on neuronal tau pathology, demonstrating its protective anti-inflammatory effects. |
2023-01-13 |
2023-08-14 |
mouse |
| Gunel Ayyubov. TREM2-signaling as a multifaceted player in brain homeostasis and a potential target for Alzheimer's Disease treatment. The European journal of neuroscience. 2023-01-13. PMID:36637116. |
however, since the excessive activation of trem2 signaling can inhibit pro-inflammatory reactions and suppress the role of microglia in immune surveillance, at the late stages of the disease it might promote immune tolerance, which is detrimental. |
2023-01-13 |
2023-08-14 |
mouse |
| Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Joshua I Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E Pizzo, Rachel Prorok, Elliot Thomsen, Laura M Bartos, Philipp Beumers, Anja Capell, Sonnet S Davis, Lis de Weerd, Jason C Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gnörich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T Kunte, Lea H Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O Torres, Hoang N Nguyen, Ida Pesämaa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H Suh, Robert G Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y Joy Yu Zuchero, Dolo Diaz, Mark S Dennis, Fen Huang, Kimberly Scearce-Levie, Ryan J Watts, Christian Haass, Joseph W Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E Sanchez, Kathryn M Monro. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nature neuroscience. 2023-01-12. PMID:36635496. |
in human induced pluripotent stem cell (ipsc)-derived microglia, atv:trem2 induced proliferation and improved mitochondrial metabolism. |
2023-01-12 |
2023-08-14 |
mouse |
| Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Joshua I Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E Pizzo, Rachel Prorok, Elliot Thomsen, Laura M Bartos, Philipp Beumers, Anja Capell, Sonnet S Davis, Lis de Weerd, Jason C Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gnörich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T Kunte, Lea H Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O Torres, Hoang N Nguyen, Ida Pesämaa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H Suh, Robert G Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y Joy Yu Zuchero, Dolo Diaz, Mark S Dennis, Fen Huang, Kimberly Scearce-Levie, Ryan J Watts, Christian Haass, Joseph W Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E Sanchez, Kathryn M Monro. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nature neuroscience. 2023-01-12. PMID:36635496. |
single-cell rna sequencing and morphometry revealed that atv:trem2 shifted microglia to metabolically responsive states, which were distinct from those induced by amyloid pathology. |
2023-01-12 |
2023-08-14 |
mouse |
| Yuanyuan Wang, Roxanne V Kyauk, Yun-An A Shen, Luke Xie, Mike Reichelt, Han Lin, Zhiyu Jiang, Hai Ngu, Kimberle Shen, Jacob J Greene, Morgan Sheng, Tracy J Yue. TREM2-dependent microglial function is essential for remyelination and subsequent neuroprotection. Glia. 2023-01-10. PMID:36625077. |
microglia, and specifically triggering receptor expressed on myeloid cells 2 (trem2), a factor highly expressed in microglia, have been shown to play an important role in remyelination. |
2023-01-10 |
2023-08-14 |
mouse |
| Yuanyuan Wang, Roxanne V Kyauk, Yun-An A Shen, Luke Xie, Mike Reichelt, Han Lin, Zhiyu Jiang, Hai Ngu, Kimberle Shen, Jacob J Greene, Morgan Sheng, Tracy J Yue. TREM2-dependent microglial function is essential for remyelination and subsequent neuroprotection. Glia. 2023-01-10. PMID:36625077. |
trem2 knockout microglia demonstrate defects in migration and phagocytosis of myelin debris. |
2023-01-10 |
2023-08-14 |
mouse |
| Suzanne A E van Wouw, Marlene van den Berg, Maroua El Ouraoui, Amber Meurs, Jenina Kingma, Roelof Ottenhoff, Melanie Loix, Marten A Hoeksema, Koen Prange, Gerard Pasterkamp, Jerome J A Hendriks, Jeroen F J Bogie, Jan B van Klinken, Frederic M Vaz, Aldo Jongejan, Menno P J de Winther, Noam Zelce. Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages. Journal of lipid research. 2023-01-02. PMID:36592658. |
we demonstrate that tmem86a is a direct transcriptional target of lxr in macrophages and microglia and that it is highly expressed in trem2 |
2023-01-02 |
2023-08-14 |
Not clear |
| Jinchao Hou, Yun Chen, Gary Grajales-Reyes, Marco Colonn. TREM2 dependent and independent functions of microglia in Alzheimer's disease. Molecular neurodegeneration. vol 17. issue 1. 2022-12-23. PMID:36564824. |
trem2 dependent and independent functions of microglia in alzheimer's disease. |
2022-12-23 |
2023-08-14 |
mouse |
| Jinchao Hou, Yun Chen, Gary Grajales-Reyes, Marco Colonn. TREM2 dependent and independent functions of microglia in Alzheimer's disease. Molecular neurodegeneration. vol 17. issue 1. 2022-12-23. PMID:36564824. |
given the heightened ad risk posed by rare variants of the microglial triggering receptor expressed on myeloid cells 2 (trem2), we will focus on the studies addressing the impact of this receptor on microglia responses to amyloid plaques, tauopathy and demyelination pathologies in mouse and human. |
2022-12-23 |
2023-08-14 |
mouse |