| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bartolo Tamburini, Giusto Davide Badami, Marco Pio La Manna, Mojtaba Shekarkar Azgomi, Nadia Caccamo, Francesco Diel. Emerging Roles of Cells and Molecules of Innate Immunity in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569296. |
in this review, we focus on the role of cells (microglia, astrocytes, and oligodendrocytes) and molecules (trem2, tau, and β-amyloid) of the innate immune system in the pathogenesis of alzheimer's disease and their possible exploitation as disease biomarkers and targets of therapeutical approaches. |
2023-08-12 |
2023-08-16 |
Not clear |
| Yongjin Yoo, Gernot Neumayer, Yohei Shibuya, Marius Marc-Daniel Mader, Marius Werni. A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease. Cell stem cell. vol 30. issue 8. 2023-08-04. PMID:37541210. |
for example, loss of function of the microglial gene trem2 renders microglia dysfunctional and causes an early-onset neurodegenerative syndrome, and trem2 variants are among the strongest genetic risk factors for ad. |
2023-08-04 |
2023-08-14 |
mouse |
| Yongjin Yoo, Gernot Neumayer, Yohei Shibuya, Marius Marc-Daniel Mader, Marius Werni. A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease. Cell stem cell. vol 30. issue 8. 2023-08-04. PMID:37541210. |
here, we show that systemic hematopoietic cell transplantation followed by enhancement of microglia replacement restores microglial function in a trem2 mutant mouse model of ad. |
2023-08-04 |
2023-08-14 |
mouse |
| Yung Ning Chu, Aika Akahori, Sho Takatori, Taisuke Tomit. Pathological Roles of INPP5D in Alzheimer's Disease. Advances in experimental medicine and biology. vol 1423. 2023-07-31. PMID:37525057. |
the discovery of the genetic association between triggering receptor expressed on myeloid cells 2 (trem2) with increased ad risk points to a causal link between microglia and ad pathogenesis, and revealed a crucial role of trem2-dependent clustering of microglia around amyloid plaques that prevents aβ toxicity to facilitate tau deposition near the plaques. |
2023-07-31 |
2023-08-14 |
mouse |
| Yung Ning Chu, Aika Akahori, Sho Takatori, Taisuke Tomit. Pathological Roles of INPP5D in Alzheimer's Disease. Advances in experimental medicine and biology. vol 1423. 2023-07-31. PMID:37525057. |
inpp5d seems to exert its function by acting antagonistically at downstream of the trem2 signaling pathway, suggesting that it is a novel regulator of the protective barrier by microglia. |
2023-07-31 |
2023-08-14 |
mouse |
| Yueran Li, Huifang Xu, Huifang Wang, Kui Yang, Jiajie Luan, Sheng Wan. TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-30. PMID:37517293. |
trem2: potential therapeutic targeting of microglia for alzheimer's disease. |
2023-07-30 |
2023-08-14 |
Not clear |
| Yueran Li, Huifang Xu, Huifang Wang, Kui Yang, Jiajie Luan, Sheng Wan. TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-30. PMID:37517293. |
current studies show that triggering receptor expressed on myeloid cells 2 (trem2) is predominantly expressed in microglia of the central nervous system (cns) and is involved in microglia proliferation, survival, migration and phagocytosis. |
2023-07-30 |
2023-08-14 |
Not clear |
| Yueran Li, Huifang Xu, Huifang Wang, Kui Yang, Jiajie Luan, Sheng Wan. TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-30. PMID:37517293. |
specifically, trem2 acts by regulating the function of microglia and promoting the clearance of neuronal toxic substances and abnormal proteins by microglia. |
2023-07-30 |
2023-08-14 |
Not clear |
| Yueran Li, Huifang Xu, Huifang Wang, Kui Yang, Jiajie Luan, Sheng Wan. TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-30. PMID:37517293. |
in addition, trem2 is also involved in regulating inflammatory response and cell signaling pathways, affecting the immune response and regulatory role of microglia. |
2023-07-30 |
2023-08-14 |
Not clear |
| Yueran Li, Huifang Xu, Huifang Wang, Kui Yang, Jiajie Luan, Sheng Wan. TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-30. PMID:37517293. |
the purpose of this review is to provide a comprehensive analysis of the research of trem2, including its regulation of the inflammatory response, lipid metabolism and phagocytosis in microglia of cns in ad, and to explore the potential application prospects as well as limitations of targeting trem2 for the treatment of ad. |
2023-07-30 |
2023-08-14 |
Not clear |
| Manuela Leri, Marzia Vasarri, Federica Carnemolla, Francesco Oriente, Serena Cabaro, Maria Stio, Donatella Degl'Innocenti, Massimo Stefani, Monica Bucciantin. EVOO Polyphenols Exert Anti-Inflammatory Effects on the Microglia Cell through TREM2 Signaling Pathway. Pharmaceuticals (Basel, Switzerland). vol 16. issue 7. 2023-07-29. PMID:37513845. |
evoo polyphenols exert anti-inflammatory effects on the microglia cell through trem2 signaling pathway. |
2023-07-29 |
2023-08-14 |
human |
| Yan He, Kun Yang, Lu Zhang, Meng Zhan, Xiu-Wen Xia, Huai-Fu Wang, Ya Xie, Ling Huang, Ni Yang, Ya-Li Zheng, Hong Yang, Ying-Ning, Jia-Yi Sun, You-Jun Yang, Wei-Jun Din. Electroacupuncture for weight loss by regulating microglial polarization in the arcuate nucleus of the hypothalamus. Life sciences. 2023-07-29. PMID:37516430. |
at the same time, ea induced microglia to exhibit an m2 phenotype, representing reduced inos/tnf-α and increased arg-1/il-10/bdnf, which may be due to the promotion of trem2 expression. |
2023-07-29 |
2023-08-14 |
mouse |
| Chen Yu, Eleonora M Lad, Rose Mathew, Sejiro Littleton, Yun Chen, Kai Schlepckow, Simone Degan, Lindsey Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, Alan D Proia, Marco Colonna, Christian Haass, Daniel R Saba. Microglia at Sites of Atrophy Restrict the Progression of Retinal Degeneration via Galectin-3 and Trem2 Interactions. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502831. |
microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and trem2 interactions. |
2023-07-28 |
2023-08-14 |
mouse |
| Xiuxiu Sun, Xinxin Jin, Xi Liu, Lumeng Wang, Li Li, Junjie Yang, Helong Feng, Zhengdan Lin, Cunlin Zhan, Wanpo Zhang, Changqin Gu, Xueying Hu, Xiaoli Liu, Guofu Chen. Microglia play an important role in PRV infection-induced immune responses of the central nervous system. Virology journal. vol 20. issue 1. 2023-07-14. PMID:37452371. |
this may be associated with the phagocytic ability of microglia because we observed a significant increase in the expression of the membrane receptor trem2 in microglia, which is closely related to phagocytosis, we observed that depletion of microglia exacerbated neurological symptoms, blood-brain barrier breakdown, and peripheral lymphocyte infiltration. |
2023-07-14 |
2023-08-14 |
mouse |
| Tao Yin, Luciano D'Adami. BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer's disease and related dementias. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398330. |
bri2-mediated regulation of trem2 processing in microglia and its potential implications for alzheimer's disease and related dementias. |
2023-07-03 |
2023-08-14 |
Not clear |
| Michael Fassler, Clara Benaim, Jacob Georg. TREM2 Agonism with a Monoclonal Antibody Attenuates Tau Pathology and Neurodegeneration. Cells. vol 12. issue 11. 2023-06-11. PMID:37296669. |
trem2 is a membrane receptor expressed on microglia that plays a pivotal role in the organization and function of these innate immune cell components within the neurodegenerated brain. |
2023-06-11 |
2023-08-14 |
mouse |
| Michael Fassler, Clara Benaim, Jacob Georg. TREM2 Agonism with a Monoclonal Antibody Attenuates Tau Pathology and Neurodegeneration. Cells. vol 12. issue 11. 2023-06-11. PMID:37296669. |
collectively, these observations show that trem2 engagement with an agonistic antibody result in reduced tau burden concomitant with attenuated neurodegeneration ascribed to the education of resident microglia. |
2023-06-11 |
2023-08-14 |
mouse |
| Hongxia Wang, Xiaoling Li, Qi Wang, Jialiang Ma, Xiaohong Gao, Manxia Wan. TREM2, microglial and ischemic stroke. Journal of neuroimmunology. vol 381. 2023-06-11. PMID:37302170. |
the triggering receptor expressed on myeloid cell 2 (trem2) is an immune-related receptor on the surface of microglia. |
2023-06-11 |
2023-08-14 |
Not clear |
| Hongxia Wang, Xiaoling Li, Qi Wang, Jialiang Ma, Xiaohong Gao, Manxia Wan. TREM2, microglial and ischemic stroke. Journal of neuroimmunology. vol 381. 2023-06-11. PMID:37302170. |
this paper reviews the following: 1) the phenotypic changes of microglia in various pathological stages after is and its relationship with inflammatory factors; 2) the relationship between the expression of the trem2 receptor and inflammatory factors; 3) the relationship between phenotypic changes of microglia and its surface receptor trem2; 4) the trem2-related signalling pathway of microglia after is and treatment for trem2 receptor; and finally 5) to clarify the relationship among trem2, inflammation, and microglia phenotype after is, as well as the mechanism among them and the some possible treatment of is targeting trem2. |
2023-06-11 |
2023-08-14 |
Not clear |
| Hongxia Wang, Xiaoling Li, Qi Wang, Jialiang Ma, Xiaohong Gao, Manxia Wan. TREM2, microglial and ischemic stroke. Journal of neuroimmunology. vol 381. 2023-06-11. PMID:37302170. |
moreover, the relationship between the new phenotype of microglia such as sam and trem2 has also been systematically summarized, but there are no relevant research reports on the relationship between trem2 and sam after is. |
2023-06-11 |
2023-08-14 |
Not clear |