| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aria W Tarudji, Connor C Gee, Sarah M Romereim, Anthony J Convertine, Forrest M Kievi. Antioxidant thioether core-crosslinked nanoparticles prevent the bilateral spread of secondary injury to protect spatial learning and memory in a controlled cortical impact mouse model of traumatic brain injury. Biomaterials. vol 272. 2021-05-27. PMID:33819812. |
this protection was likely a result of np1-mediated reduction in oxidative stress in the ipsilateral hemisphere as determined by immunofluorescence imaging of markers of oxidative stress and the spread of neuroinflammation into the contralateral hippocampus as determined by immunofluorescence imaging of activated microglia and neuron-astrocyte-microglia triad formation. |
2021-05-27 |
2023-08-13 |
mouse |
| Shu-Ming Li, Bin Li, Ling Zhang, Guang-Fen Zhang, Jie Sun, Mu-Huo Ji, Jian-Jun Yan. A complement-microglial axis driving inhibitory synapse related protein loss might contribute to systemic inflammation-induced cognitive impairment. International immunopharmacology. vol 87. 2021-05-26. PMID:32707491. |
in the present study, we showed that hippocampal complement c3 levels in astrocytes and c3a receptor expressions in microglia were specifically up-regulated after lipopolysaccharide (lps) injection. |
2021-05-26 |
2023-08-13 |
Not clear |
| Limin Lang, Bin Xu, Jianbin Yuan, Shize Li, Shuai Lian, Yan Chen, Jingru Guo, Huanmin Yan. GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways. International immunopharmacology. vol 89. issue Pt B. 2021-05-25. PMID:33166810. |
gaba-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the nlrp3 inflammasome and nf-κb signaling pathways. |
2021-05-25 |
2023-08-13 |
mouse |
| Limin Lang, Bin Xu, Jianbin Yuan, Shize Li, Shuai Lian, Yan Chen, Jingru Guo, Huanmin Yan. GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways. International immunopharmacology. vol 89. issue Pt B. 2021-05-25. PMID:33166810. |
we demonstrated that chronic cold stress induced the activation of microglia, the emergence of neuroinflammation, and the impairment of neurons in the hippocampus, which might be the result of gaba-mediated activation of nod-like receptor protein 3 (nlrp3) inflammasome and the nuclear factor kappa b (nf-κb) signaling pathway. |
2021-05-25 |
2023-08-13 |
mouse |
| Natalí N Guerrero-Vargas, Carmen Zárate-Mozo, Mara A Guzmán-Ruiz, Alfredo Cárdenas-Rivera, Carolina Escoba. Time-restricted feeding prevents depressive-like and anxiety-like behaviors in male rats exposed to an experimental model of shift-work. Journal of neuroscience research. vol 99. issue 2. 2021-05-24. PMID:33078850. |
moreover w-al caused morphological changes in the microglia in the ca3 area of the hippocampus indicating microglial activation. |
2021-05-24 |
2023-08-13 |
rat |
| Zi-Rong Li, Yuan-Shan Han, Zhuo Liu, Hong-Qing Zhao, Jian Liu, Hui Yang, Yu-Hong Wan. GR/NF-κB signaling pathway regulates hippocampal inflammatory responses in diabetic rats with chronic unpredictable mild stress. European journal of pharmacology. vol 895. 2021-05-19. PMID:33465356. |
apart from enhanced depressive behavior, diabetes-depressed condition also up-regulated the expression of hippocampus microglia chemokine Ⅰ receptor (cx3cr1) and secretion of several pro-inflammatory factors, in particular, interleukin 1β (il-1β), interleukin-6 (il-6), interleukin-8 (il-8) and tumor necrosis factor - α (tnf-α). |
2021-05-19 |
2023-08-13 |
rat |
| Nan Sun, Yong Mei, Zhengtao Hu, Wen Xing, Kun Lv, Nengwei Hu, Ting Zhang, Deguo Wan. Ghrelin attenuates depressive-like behavior, heart failure, and neuroinflammation in postmyocardial infarction rat model. European journal of pharmacology. vol 901. 2021-05-18. PMID:33848542. |
results showed that ghrelin substantially improved cardiac dysfunction, infarction size, and cardiac remodeling and modulated the release of inflammatory cytokines and the increase of iba-1 positive microglia and glial fibrillary acidic protein-positive astrocytes in the ca1 area of hippocampus. |
2021-05-18 |
2023-08-13 |
rat |
| Shirin Hosseini, Kristin Michaelsen-Preusse, Klaus Schughart, Martin Kort. Long-Term Consequence of Non-neurotropic H3N2 Influenza A Virus Infection for the Progression of Alzheimer's Disease Symptoms. Frontiers in cellular neuroscience. vol 15. 2021-05-18. PMID:33994946. |
at 2 months of age, mice were infected with h3n2 iav and the detailed analysis of microglia morphology revealed neuroinflammation in the hippocampus already of 6 months old non-infected app/ps1 mice together with impaired spatial learning, however, microglia activation, amyloid-β plaques load and cognitive impairments were even more pronounced in app/ps1 mice upon h3n2 infection. |
2021-05-18 |
2023-08-13 |
mouse |
| Francesca Pagani, Claudia Testi, Alfonso Grimaldi, Giorgio Corsi, Barbara Cortese, Bernadette Basilico, Paola Baiocco, Simone De Panfilis, Davide Ragozzino, Silvia Di Angelantoni. Dimethyl Fumarate Reduces Microglia Functional Response to Tissue Damage and Favors Brain Iron Homeostasis. Neuroscience. vol 439. 2021-05-14. PMID:31738884. |
here, we examine the effects of dmf treatment on microglia functional activities, as phenotype, morphology, processes motility and rearrangement, migration, atp response and iron uptake in mouse primary microglia culture and acute hippocampal slices. |
2021-05-14 |
2023-08-13 |
mouse |
| Ioannis-Alexandros Gampierakis, Yassemi Koutmani, Maria Semitekolou, Ioannis Morianos, Alexia Polissidis, Antonia Katsouda, Ioannis Charalampopoulos, Georgina Xanthou, Achille Gravanis, Katia P Karali. Hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (IBD). Molecular psychiatry. vol 26. issue 4. 2021-05-14. PMID:31969694. |
hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (ibd). |
2021-05-14 |
2023-08-13 |
Not clear |
| Ioannis-Alexandros Gampierakis, Yassemi Koutmani, Maria Semitekolou, Ioannis Morianos, Alexia Polissidis, Antonia Katsouda, Ioannis Charalampopoulos, Georgina Xanthou, Achille Gravanis, Katia P Karali. Hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (IBD). Molecular psychiatry. vol 26. issue 4. 2021-05-14. PMID:31969694. |
notably, we found that acute dss colitis-induced enhanced infiltration of the hippocampus with macrophages and inflammatory myeloid cells from the periphery, along with elevated frequencies of inflammatory m1-like microglia and increased release of pro-inflammatory cytokines. |
2021-05-14 |
2023-08-13 |
Not clear |
| Ioannis-Alexandros Gampierakis, Yassemi Koutmani, Maria Semitekolou, Ioannis Morianos, Alexia Polissidis, Antonia Katsouda, Ioannis Charalampopoulos, Georgina Xanthou, Achille Gravanis, Katia P Karali. Hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (IBD). Molecular psychiatry. vol 26. issue 4. 2021-05-14. PMID:31969694. |
in contrast, increased percentages of tissue-repairing m2-like microglia, along with elevated levels of the anti-inflammatory cytokine, il-10 were observed in the hippocampus during chronic dss colitis. |
2021-05-14 |
2023-08-13 |
Not clear |
| Ying Cai, Baoshan Qiu, Mengshi Liao, Xiaolu Liu, Jing Lin, Linfang Lan, Guangqing Xu, Yuhua Fa. Intermittent Theta Burst Stimulation Improves the Spatial Cognitive Function of Rats with Chronic Hypertension-induced Cerebral Small Vessel Disease. Neuroscience. vol 437. 2021-05-14. PMID:32353458. |
treatment with itbs significantly improved the spatial cognitive function of rhrsps, increased the expression of nr2b, p-camkiiα and glur1 in the hippocampus, and decreased the proliferation of astrocytes and microglia. |
2021-05-14 |
2023-08-13 |
rat |
| Lars H Nelson, Pavan Peketi, Kathryn M Len. Microglia Regulate Cell Genesis in a Sex-dependent Manner in the Neonatal Hippocampus. Neuroscience. vol 453. 2021-05-14. PMID:33129890. |
microglia regulate cell genesis in a sex-dependent manner in the neonatal hippocampus. |
2021-05-14 |
2023-08-13 |
rat |
| Lars H Nelson, Pavan Peketi, Kathryn M Len. Microglia Regulate Cell Genesis in a Sex-dependent Manner in the Neonatal Hippocampus. Neuroscience. vol 453. 2021-05-14. PMID:33129890. |
we examined whether microglia support a known sex difference in neonatal hippocampal neurogenesis and whether juvenile hippocampal neurogenesis was impacted by the loss of neonatal microglia. |
2021-05-14 |
2023-08-13 |
rat |
| Lars H Nelson, Pavan Peketi, Kathryn M Len. Microglia Regulate Cell Genesis in a Sex-dependent Manner in the Neonatal Hippocampus. Neuroscience. vol 453. 2021-05-14. PMID:33129890. |
we used central infusion of liposomal clodronate to selectively deplete microglia and found decreased cell genesis in the male, but not female, dentate gyrus and hippocampus. |
2021-05-14 |
2023-08-13 |
rat |
| Lars H Nelson, Pavan Peketi, Kathryn M Len. Microglia Regulate Cell Genesis in a Sex-dependent Manner in the Neonatal Hippocampus. Neuroscience. vol 453. 2021-05-14. PMID:33129890. |
we found that expression of il1b and tnf were decreased in the hippocampus due to microglia depletion however, there were no sex differences in the expression of any immune genes. |
2021-05-14 |
2023-08-13 |
rat |
| Sana Chintamen, Fatima Imessadouene, Steven G Kerni. Immune Regulation of Adult Neurogenic Niches in Health and Disease. Frontiers in cellular neuroscience. vol 14. 2021-05-14. PMID:33551746. |
recent evidence demonstrates that in adulthood, microglia secrete factors which modulate adult hippocampal neurogenesis by inhibiting cell proliferation and survival both |
2021-05-14 |
2023-08-13 |
Not clear |
| Kenta Sakai, Fuyuko Takata, Gaku Yamanaka, Miho Yasunaga, Kana Hashiguchi, Kazuki Tominaga, Kouichi Itoh, Yasufumi Kataoka, Atsushi Yamauchi, Shinya Dohg. Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice. Journal of pharmacological sciences. vol 145. issue 1. 2021-05-13. PMID:33357774. |
histological analyses of brain pericytes, microglia and astrocytes were performed for up to 28 days after cci in the injured ipsilateral hippocampus. |
2021-05-13 |
2023-08-13 |
mouse |
| Hang Xu, Xiang Yang Zhang, Wei Wen Wang, Jiesi Wan. Hydroxychloroquine Increased Anxiety-Like Behaviors and Disrupted the Expression of Some Related Genes in the Mouse Brain. Frontiers in pharmacology. vol 12. 2021-05-08. PMID:33953673. |
furthermore, hcq decreased the mrna expression of interleukin-1beta, corticotropin-releasing hormone (crh), a serotonin transporter (slc6a4), and a microglia maker (aif1) in the hippocampus and decreased the mrna expression of brain-derived neurotrophic factor (bdnf) in both the hippocampus and amygdala. |
2021-05-08 |
2023-08-13 |
mouse |