| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Azeez Olakunle Ishola, Aminu Imam, Moyosore Salihu Aja. Datumetine exposure alters hippocampal neurotransmitters system in C57BL/6 mice. Drug and chemical toxicology. 2021-05-07. PMID:32847421. |
immunofluorescence procedure was done to check the distribution of neurons, astrocytes, microglia and major neuronal subtypes in the hippocampus. |
2021-05-07 |
2023-08-13 |
mouse |
| Patrick Szu-Ying Yen, Yen-Chin Liu, Chun-Hsien Chu, Shiou-Lan Che. Upregulation of Glutamatergic Receptors in Hippocampus and Locomotor Hyperactivity in Aged Spontaneous Hypertensive Rat. Cellular and molecular neurobiology. 2021-05-06. PMID:33954807. |
moreover, a down-regulation of microglia in the hippocampus and mpfc was seen in the shr brain. |
2021-05-06 |
2023-08-13 |
rat |
| Anne-Marie Howe, Aoife Cosgrave, Maitiú Ó'Murchú, Conor Britchfield, Aoife Mulvagh, Iván Fernandez-Perez, Megan Dykstra, Aimée C Jones, Derek A Costell. Characterising lipoteichoic acid as an in vitro model of acute neuroinflammation. International immunopharmacology. vol 85. 2021-04-30. PMID:32485352. |
moreover, we find that exposure to lta can enhance sensitivity to subthreshold aβ, promoting an 'm1'-like phenotype in microglia and provoking dysregulation of neuronal activity in acute hippocampal slices. |
2021-04-30 |
2023-08-13 |
Not clear |
| David Val-Laillet, Ameni Kanzari, Sylvie Guérin, Gwénaëlle Randuineau, Nicolas Coquer. A maternal Western diet during gestation and lactation modifies offspring's microglial cell density and morphology in the hippocampus and prefrontal cortex in Yucatan minipigs. Neuroscience letters. vol 739. 2021-04-30. PMID:32950568. |
a maternal western diet during gestation and lactation modifies offspring's microglial cell density and morphology in the hippocampus and prefrontal cortex in yucatan minipigs. |
2021-04-30 |
2023-08-13 |
Not clear |
| Ying Guo, Jianping Xie, Lanchun Zhang, Lingli Yang, Jiaqing Ma, Yufan Bai, Wenjie Ma, Ling Wang, Haofei Yu, Yueqin Zeng, Haiyun Luo, Rongping Zhan. Ginsenoside Rb1 exerts antidepressant-like effects via suppression inflammation and activation of AKT pathway. Neuroscience letters. vol 744. 2021-04-30. PMID:33359924. |
taken together, the results indicate that grb1 prevents crs-induced depression-like behaviors in mice, which may be related to anti-inflammatory effects in hippocampus, serum and microglia and activation of akt pathway. |
2021-04-30 |
2023-08-13 |
mouse |
| Heping Shen, Qiaobing Guan, Xiaoling Zhang, Chao Yuan, Zhengye Tan, Liping Zhai, Yanan Hao, Yanling Gu, Chenyang Ha. New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota. Progress in neuro-psychopharmacology & biological psychiatry. vol 100. 2021-04-28. PMID:32032696. |
consistently, the cognitive impairment was more severe in mice receiving gut microbiota from ad patients than those did not, with activation of microglia in the central hippocampus of mice, and increased expression of neuroinflammatory factors. |
2021-04-28 |
2023-08-13 |
mouse |
| Heping Shen, Qiaobing Guan, Xiaoling Zhang, Chao Yuan, Zhengye Tan, Liping Zhai, Yanan Hao, Yanling Gu, Chenyang Ha. New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota. Progress in neuro-psychopharmacology & biological psychiatry. vol 100. 2021-04-28. PMID:32032696. |
consequently, the intestinal expression of nlrp3 was down-regulated, the cognitive ability of mice was improved, the activation of microglia in central hippocampus was suppressed and the expression of neuroinflammatory factors was also down-regulated. |
2021-04-28 |
2023-08-13 |
mouse |
| Heping Shen, Qiaobing Guan, Xiaoling Zhang, Chao Yuan, Zhengye Tan, Liping Zhai, Yanan Hao, Yanling Gu, Chenyang Ha. New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota. Progress in neuro-psychopharmacology & biological psychiatry. vol 100. 2021-04-28. PMID:32032696. |
although the cognitive ability of mice was not significantly changed, the microglia in the hippocampus of mice were still activated and the expression of inflammatory factors was up-regulated. |
2021-04-28 |
2023-08-13 |
mouse |
| Lídia Cantacorps, Sandra Montagud-Romero, Olga Valverd. Curcumin treatment attenuates alcohol-induced alterations in a mouse model of foetal alcohol spectrum disorders. Progress in neuro-psychopharmacology & biological psychiatry. vol 100. 2021-04-28. PMID:32109509. |
we focused on inflammatory and epigenetic mechanisms by analysing the expression of pro-inflammatory mediators, such as il-6, tnf-α, and nf-κb, in the hippocampus and prefrontal cortex, as well as microglia and astrocyte activation in the dentate gyrus. |
2021-04-28 |
2023-08-13 |
mouse |
| Yue Han, Jiutai Wang, Qiuying Zhao, Xiaofang Xie, Rui Song, Ying Xiao, Xixi Kang, Lijuan Zhang, Yue Zhang, Cheng Peng, Zili Yo. Pioglitazone alleviates maternal sleep deprivation-induced cognitive deficits in male rat offspring by enhancing microglia-mediated neurogenesis. Brain, behavior, and immunity. vol 87. 2021-04-27. PMID:32032783. |
in msd rat offspring, microglial density as determined by immunofluorescence was higher, microglia showed fewer and shorter processes, and neurogenesis in the hippocampus was significantly reduced. |
2021-04-27 |
2023-08-13 |
rat |
| Michael J Butler, Rachel M Cole, Nicholas P Deems, Martha A Belury, Ruth M Barriento. Fatty food, fatty acids, and microglial priming in the adult and aged hippocampus and amygdala. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32544595. |
our results indicate that hfd increased gene expression of microglial markers of activation indicative of microglial priming, including cd11b, mhcii, cx3cr1, and nlrp3, as well as the pro-inflammatory marker il-1β in both hippocampus and amygdala-derived microglia. |
2021-04-27 |
2023-08-13 |
rat |
| Michael J Butler, Rachel M Cole, Nicholas P Deems, Martha A Belury, Ruth M Barriento. Fatty food, fatty acids, and microglial priming in the adult and aged hippocampus and amygdala. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32544595. |
in a separate cohort of young and aged animals, isolated microglia from the hippocampus and amygdala exposed to palmitate in vitro induced an inflammatory gene expression profile mimicking the effects of hfd in vivo. |
2021-04-27 |
2023-08-13 |
rat |
| Okito Hashimoto, Hiroshi Kuniishi, Yuko Nakatake, Mitsuhiko Yamada, Keiji Wada, Masayuki Sekiguch. Early life stress from allergic dermatitis causes depressive-like behaviors in adolescent male mice through neuroinflammatory priming. Brain, behavior, and immunity. vol 90. 2021-04-27. PMID:32950622. |
although ox-treated pd40 mice showed neither behavioral abnormalities nor increases in pro-inflammatory cytokine expression in the brain, this study revealed that they experienced downregulation of cd200r1 expression in the amygdala under basal conditions and that additional lipopolysaccharide (lps) administration induced enhanced neuroinflammatory reaction as the priming effect was accompanied by an increase of iba-1-positive microglia in the amygdala and hippocampus. |
2021-04-27 |
2023-08-13 |
mouse |
| Daniele Lana, Filippo Ugolini, Daniele Nosi, Gary L Wenk, Maria Grazia Giovannin. The Emerging Role of the Interplay Among Astrocytes, Microglia, and Neurons in the Hippocampus in Health and Disease. Frontiers in aging neuroscience. vol 13. 2021-04-24. PMID:33889084. |
the emerging role of the interplay among astrocytes, microglia, and neurons in the hippocampus in health and disease. |
2021-04-24 |
2023-08-13 |
rat |
| Daniele Lana, Filippo Ugolini, Daniele Nosi, Gary L Wenk, Maria Grazia Giovannin. The Emerging Role of the Interplay Among Astrocytes, Microglia, and Neurons in the Hippocampus in Health and Disease. Frontiers in aging neuroscience. vol 13. 2021-04-24. PMID:33889084. |
in the contiguous and interconnected regions of rat hippocampus, ca1 and ca3 stratum radiatum, astrocytes and microglia show a different, finely regulated, and region-specific reactivity, demonstrating that glia responses vary in a significant manner from area to area. |
2021-04-24 |
2023-08-13 |
rat |
| Yassine Ait-Bali, Saadia Ba-M'hamed, Giovanna Gambarotta, Marco Sassoè-Pognetto, Maurizio Giustetto, Mohamed Benni. Pre- and postnatal exposure to glyphosate-based herbicide causes behavioral and cognitive impairments in adult mice: evidence of cortical ad hippocampal dysfunction. Archives of toxicology. vol 94. issue 5. 2021-04-22. PMID:32067069. |
furthermore, gbh-activated microglia and astrocytes, sign of neuroinflammation event in the medial prefrontal cortex and hippocampus. |
2021-04-22 |
2023-08-13 |
mouse |
| J Jia, C Liu, Y Han, H Han, M Zhong, Y Ga. miR-146a alleviates the apoptosis of hippocampal neurons induced by microglia activation via targeting TRAF6. Human & experimental toxicology. vol 39. issue 12. 2021-04-22. PMID:32633138. |
mir-146a alleviates the apoptosis of hippocampal neurons induced by microglia activation via targeting traf6. |
2021-04-22 |
2023-08-13 |
Not clear |
| J Jia, C Liu, Y Han, H Han, M Zhong, Y Ga. miR-146a alleviates the apoptosis of hippocampal neurons induced by microglia activation via targeting TRAF6. Human & experimental toxicology. vol 39. issue 12. 2021-04-22. PMID:32633138. |
to identify the role of mir-146a and tumor necrosis factor receptor-associated factor 6 (traf6) for improving the apoptosis of hippocampal neurons induced by microglia activation. |
2021-04-22 |
2023-08-13 |
Not clear |
| Yiyun Cao, Taotao Liu, Zhengqian Li, Jiao Yang, Lijun Ma, Xinning Mi, Ning Yang, Aihua Qi, Xiangyang Guo, Aizhong Wan. Neurofilament degradation is involved in laparotomy-induced cognitive dysfunction in aged rats. Aging. vol 12. issue 24. 2021-04-20. PMID:33232265. |
evident cognitive dysfunction, excessive microglia activation, neuroinflammatory responses and upregulated nfs in hippocampus were observed in the pocd group. |
2021-04-20 |
2023-08-13 |
rat |
| Alita Soch, Luba Sominsky, Simin Younesi, Simone N De Luca, Maneesha Gunasekara, Steven Bozinovski, Sarah J Spence. The role of microglia in the second and third postnatal weeks of life in rat hippocampal development and memory. Brain, behavior, and immunity. vol 88. 2021-04-06. PMID:32360602. |
the role of microglia in the second and third postnatal weeks of life in rat hippocampal development and memory. |
2021-04-06 |
2023-08-13 |
rat |