| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sonia Sabate-Soler, Sarah Louise Nickels, Cláudia Saraiva, Emanuel Berger, Ugne Dubonyte, Kyriaki Barmpa, Yan Jun Lan, Tsukasa Kouno, Javier Jarazo, Graham Robertson, Jafar Sharif, Haruhiko Koseki, Christian Thome, Jay W Shin, Sally A Cowley, Jens C Schwambor. Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Glia. 2022-03-09. PMID:35262217. |
so far, no studies about the effects of human ipsc-derived microglia on midbrain organoid neural cells have been published. |
2022-03-09 |
2023-08-13 |
human |
| Sonia Sabate-Soler, Sarah Louise Nickels, Cláudia Saraiva, Emanuel Berger, Ugne Dubonyte, Kyriaki Barmpa, Yan Jun Lan, Tsukasa Kouno, Javier Jarazo, Graham Robertson, Jafar Sharif, Haruhiko Koseki, Christian Thome, Jay W Shin, Sally A Cowley, Jens C Schwambor. Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Glia. 2022-03-09. PMID:35262217. |
here we describe an approach to derive microglia from human ipscs and integrate them into ipsc-derived midbrain organoids. |
2022-03-09 |
2023-08-13 |
human |
| Sonia Sabate-Soler, Sarah Louise Nickels, Cláudia Saraiva, Emanuel Berger, Ugne Dubonyte, Kyriaki Barmpa, Yan Jun Lan, Tsukasa Kouno, Javier Jarazo, Graham Robertson, Jafar Sharif, Haruhiko Koseki, Christian Thome, Jay W Shin, Sally A Cowley, Jens C Schwambor. Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Glia. 2022-03-09. PMID:35262217. |
using single nuclear rna sequencing, we provide a detailed characterization of microglia in midbrain organoids as well as the influence of their presence on the other cells of the organoids. |
2022-03-09 |
2023-08-13 |
human |
| Sonia Sabate-Soler, Sarah Louise Nickels, Cláudia Saraiva, Emanuel Berger, Ugne Dubonyte, Kyriaki Barmpa, Yan Jun Lan, Tsukasa Kouno, Javier Jarazo, Graham Robertson, Jafar Sharif, Haruhiko Koseki, Christian Thome, Jay W Shin, Sally A Cowley, Jens C Schwambor. Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Glia. 2022-03-09. PMID:35262217. |
finally, we show that microglia in midbrain organoids affect synaptic remodeling and increase neuronal excitability. |
2022-03-09 |
2023-08-13 |
human |
| Qi-Wen Han, Qian-Hang Shao, Xiao-Tong Wang, Kai-Li Ma, Nai-Hong Chen, Yu-He Yua. CB2 receptor activation inhibits the phagocytic function of microglia through activating ERK/AKT-Nurr1 signal pathways. Acta pharmacologica Sinica. 2022-02-08. PMID:35132190. |
we showed that the application of cb2 receptor agonists jwh015 (1, 10 μm) significantly increased the nuclear nurr1 protein in bv-2 cells and primary midbrain microglia. |
2022-02-08 |
2023-08-13 |
Not clear |
| Maria T Panayotacopoulou, Ismini Papageorgiou, Marianna Pagida, Alexandra E Katsogridaki, Margarita Chrysanthou-Piterou, Nektarios A Valous, Niels Halama, Efstratios Patsouris, Anastasia E Konstantinido. Microglia Activation in the Midbrain of the Human Neonate: The Effect of Perinatal Hypoxic-Ischemic Injury. Journal of neuropathology and experimental neurology. 2022-01-29. PMID:35092294. |
microglia activation in the midbrain of the human neonate: the effect of perinatal hypoxic-ischemic injury. |
2022-01-29 |
2023-08-13 |
human |
| Le Wang, Xiaoli Gong, Yang Liu, Tianshu Du, Zhen Zhang, Ting Zhang, Xiaomin Wan. CD200 maintains the region-specific phenotype of microglia in the midbrain and its role in Parkinson's disease. Glia. vol 68. issue 9. 2021-11-30. PMID:32112601. |
cd200 maintains the region-specific phenotype of microglia in the midbrain and its role in parkinson's disease. |
2021-11-30 |
2023-08-13 |
mouse |
| Le Wang, Xiaoli Gong, Yang Liu, Tianshu Du, Zhen Zhang, Ting Zhang, Xiaomin Wan. CD200 maintains the region-specific phenotype of microglia in the midbrain and its role in Parkinson's disease. Glia. vol 68. issue 9. 2021-11-30. PMID:32112601. |
we hypothesized that microglia in different brain regions respond differently to neuroinflammatory stimulation and that cd200, an anti-inflammatory protein mainly originated from neurons, acts as a local cue inhibiting microglia activation in the midbrain. |
2021-11-30 |
2023-08-13 |
mouse |
| Nicholas J Silva, Leah C Dorman, Ilia D Vainchtein, Nadine C Horneck, Anna V Molofsk. In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain. Nature communications. vol 12. issue 1. 2021-11-02. PMID:34625548. |
we found that ramified microglia increased in synaptic regions of the midbrain and hindbrain between 7 and 28 days post fertilization. |
2021-11-02 |
2023-08-13 |
zebrafish |
| Oihane Uriarte Huarte, Dimitrios Kyriakis, Tony Heurtaux, Yolanda Pires-Afonso, Kamil Grzyb, Rashi Halder, Manuel Buttini, Alexander Skupin, Michel Mittelbronn, Alessandro Michelucc. Single-Cell Transcriptomics and Frontiers in immunology. vol 12. 2021-09-21. PMID:33854507. |
we uncovered a microglia subset, mainly present in the midbrain, displaying an intrinsic transcriptional immune alerted signature sharing features of inflammation-induced microglia. |
2021-09-21 |
2023-08-13 |
Not clear |
| Carla Garza-Lombó, Morrent Thang, Hendrik J Greve, Christen L Mumaw, Evan J Messenger, Chandrama Ahmed, Emily Quinn, Kimberly Sullivan, Michelle L Bloc. Circulating HMGB1 is elevated in veterans with Gulf War Illness and triggers the persistent pro-inflammatory microglia phenotype in male C57Bl/6J mice. Translational psychiatry. vol 11. issue 1. 2021-08-02. PMID:34253711. |
using the lps model of the persistent microglial pro-inflammatory response, male c57bl/6j mice injected with lps (5 mg/kg ip) exhibited persistent changes in microglia morphology and elevated pro-inflammatory markers in the hippocampus, cortex, and midbrain 7 days after lps injection, while the peripheral immune response had resolved. |
2021-08-02 |
2023-08-13 |
mouse |
| Carla Garza-Lombó, Morrent Thang, Hendrik J Greve, Christen L Mumaw, Evan J Messenger, Chandrama Ahmed, Emily Quinn, Kimberly Sullivan, Michelle L Bloc. Circulating HMGB1 is elevated in veterans with Gulf War Illness and triggers the persistent pro-inflammatory microglia phenotype in male C57Bl/6J mice. Translational psychiatry. vol 11. issue 1. 2021-08-02. PMID:34253711. |
microglia isolated at 7 days after lps injection revealed a unique transcriptional profile of 17 genes when compared to the acute 3 h lps response, 6 of which were also upregulated in the midbrain by rhmgb1, highlighting a distinct signature of the persistent pro-inflammatory microglia phenotype. |
2021-08-02 |
2023-08-13 |
mouse |
| Yichao Hou, Xingqi Li, Chang Liu, Ming Zhang, Xiaoying Zhang, Shaoyang Ge, Liang Zha. Neuroprotective effects of short-chain fatty acids in MPTP induced mice model of Parkinson's disease. Experimental gerontology. vol 150. 2021-07-02. PMID:33905875. |
butyrate reached into the midbrain snpc and suppressed microglia over-activation. |
2021-07-02 |
2023-08-13 |
mouse |
| Tertia D Purves-Tyson, Ulrike Weber-Stadlbauer, Juliet Richetto, Debora A Rothmond, Marie A Labouesse, Marcello Polesel, Kate Robinson, Cynthia Shannon Weickert, Urs Meye. Increased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation. Molecular psychiatry. vol 26. issue 3. 2021-05-14. PMID:31168068. |
these data demonstrate that immune-related changes in schizophrenia extend to dopaminergic areas of the midbrain and exist in the absence of changes in microglial cell number, but with putative evidence of microglial and astrocytic activation in the high immune subgroup. |
2021-05-14 |
2023-08-13 |
mouse |
| Jérôme Roy, Laurence Larroquet, Anne Surget, Anthony Lanuque, Franck Sandres, Frederic Terrier, Geneviève Corraze, Jetty Chung-Yung Lee, Sandrine Skiba-Cass. Impact on cerebral function in rainbow trout fed with plant based omega-3 long chain polyunsaturated fatty acids enriched with DHA and EPA. Fish & shellfish immunology. vol 103. 2021-01-25. PMID:32473359. |
however, the mrna expression of transcripts related to cell specification were down regulated, namely tmem119 markers of microglial cell in forebrain and midbrain, gfap markers of astrocyte in the midbrain, and rbfox3 markers of neurons in the midbrain and hindbrain in juveniles fed high ω-3 experimental diet. |
2021-01-25 |
2023-08-13 |
Not clear |
| Oeystein Roed Brekk, Jonathan R Honey, Seungil Lee, Penelope J Hallett, Ole Isacso. Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 44. 2021-01-07. PMID:33060302. |
histological localization of neutral lipids using a fluorescent probe (bodipy) revealed that dopaminergic neurons and midbrain microglia significantly accumulated intracellular lipids in pd sn, while adjacent astrocytes had a reduced lipid load overall. |
2021-01-07 |
2023-08-13 |
mouse |
| Nicole Rosskothen-Kuhl, Heika Hildebrandt, Ralf Birkenhäger, Robert-Benjamin Illin. Astrocyte Hypertrophy and Microglia Activation in the Rat Auditory Midbrain Is Induced by Electrical Intracochlear Stimulation. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29520220. |
astrocyte hypertrophy and microglia activation in the rat auditory midbrain is induced by electrical intracochlear stimulation. |
2020-10-01 |
2023-08-13 |
rat |
| Chih-Hsin Lin, Pei-Cih Wei, Chiung-Mei Chen, Yu-Ting Huang, Jia-Lan Lin, Yen-Shi Lo, Jia-Li Lin, Chung-Yin Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Che. Lactulose and Melibiose Attenuate MPTP-Induced Parkinson's Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32848705. |
meanwhile, expression of the oxidative stress marker 4-hydroxynonenal (4-hne) was up-regulated along with increased microglia and astrocyte reactivity in the ventral midbrain following mptp treatment. |
2020-09-28 |
2023-08-13 |
mouse |
| Miguel Angel Abellanas, Marta Zamarbide, Leyre Basurco, Esther Luquin, Marta Garcia-Granero, Pedro Clavero, Patxi San Martin-Uriz, Amaia Vilas, Elisa Mengual, Sandra Hervas-Stubbs, Maria S Aymeric. Midbrain microglia mediate a specific immunosuppressive response under inflammatory conditions. Journal of neuroinflammation. vol 16. issue 1. 2020-05-14. PMID:31757220. |
midbrain microglia mediate a specific immunosuppressive response under inflammatory conditions. |
2020-05-14 |
2023-08-13 |
Not clear |
| Satoshi Okuyama, Tomoko Kanzaki, Yoshimi Kotani, Mako Katoh, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukaw. Continual Treatment with the Peels of Citrus kawachiensis (Kawachi Bankan) Protects against Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson's Disease. Journal of nutritional science and vitaminology. vol 65. issue 2. 2019-12-19. PMID:31061292. |
our previous study showed that the subcutaneous administration of auraptene (aur) suppresses inflammatory responses including the hyperactivation of microglia in the substantia nigra (sn) of the midbrain of lipopolysaccharide-induced parkinson's disease (pd)-like mice, as well as inhibits dopaminergic neuronal cell death in this region. |
2019-12-19 |
2023-08-13 |
mouse |