| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P-S Chen, G-S Peng, G Li, S Yang, X Wu, C-C Wang, B Wilson, R-B Lu, P-W Gean, D-M Chuang, J-S Hon. Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes. Molecular psychiatry. vol 11. issue 12. 2007-02-02. PMID:16969367. |
we have previously demonstrated that vpa prolongs the survival of midbrain da neurons in lipopolysaccharide (lps)-treated neuron-glia cultures through the inhibition of the release of pro-inflammatory factors from microglia. |
2007-02-02 |
2023-08-12 |
rat |
| Melissa K McCoy, Terina N Martinez, Kelly A Ruhn, David E Szymkowski, Christine G Smith, Barry R Botterman, Keith E Tansey, Malú G Tanse. Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 37. 2006-10-20. PMID:16971520. |
in embryonic rat midbrain neuron/glia cell cultures exposed to lps, even delayed administration of xenp345 prevented selective degeneration of da neurons despite sustained microglia activation and secretion of soltnf. |
2006-10-20 |
2023-08-12 |
rat |
| Hiroshi Katsuki, Mitsugi Okawara, Haruki Shibata, Toshiaki Kume, Akinori Akaik. Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture. Journal of neurochemistry. vol 97. issue 5. 2006-07-21. PMID:16638023. |
nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture. |
2006-07-21 |
2023-08-12 |
rat |
| Hiroshi Katsuki, Mitsugi Okawara, Haruki Shibata, Toshiaki Kume, Akinori Akaik. Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture. Journal of neurochemistry. vol 97. issue 5. 2006-07-21. PMID:16638023. |
moreover, depletion of resident microglia from midbrain slices abrogated thrombin-induced no production and dopaminergic cell death, but did not inhibit tissue injury. |
2006-07-21 |
2023-08-12 |
rat |
| Hiroshi Katsuki, Mitsugi Okawara, Haruki Shibata, Toshiaki Kume, Akinori Akaik. Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture. Journal of neurochemistry. vol 97. issue 5. 2006-07-21. PMID:16638023. |
activated microglia are considered to play important roles in degenerative processes of midbrain dopaminergic neurons. |
2006-07-21 |
2023-08-12 |
rat |
| R Shamekh, J Newcomb, J Mallery, C J Cassady, S Saporta, D F Cameron, P R Sanberg, A E Willin. Survival of rat or mouse ventral mesencephalon neurons after cotransplantation with rat sertoli cells in the mouse striatum. Cell transplantation. vol 14. issue 8. 2006-02-09. PMID:16358409. |
transplanting xenografts of rat scs into the mouse striatum with either rat or mouse ventral mesencephalon prevented astrocytic infiltration of the graft site, although all transplants showed activated microglia within the core of the graft. |
2006-02-09 |
2023-08-12 |
mouse |
| A Serrano, J Menéndez, M J Casarejos, R M Solano, E Gallego, M Sánchez, M A Mena, J García de Yebene. Effects of cinnarizine, a calcium antagonist that produces human parkinsonism, in parkin knock out mice. Neuropharmacology. vol 49. issue 2. 2005-10-06. PMID:15993444. |
microglia was hyperactivated in pk-ko midbrain, suggesting inflammation in these animals. |
2005-10-06 |
2023-08-12 |
mouse |
| Giia-Sheun Peng, Guorong Li, Nian-Sheng Tzeng, Po-See Chen, De-Maw Chuang, Yaw-Don Hsu, Sufen Yang, Jau-Shyong Hon. Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia. Brain research. Molecular brain research. vol 134. issue 1. 2005-06-13. PMID:15790540. |
valproate pretreatment protects dopaminergic neurons from lps-induced neurotoxicity in rat primary midbrain cultures: role of microglia. |
2005-06-13 |
2023-08-12 |
rat |
| Robert L Jakab, John F Bowye. Parvalbumin neuron circuits and microglia in three dopamine-poor cortical regions remain sensitive to amphetamine exposure in the absence of hyperthermia, seizure and stroke. Brain research. vol 958. issue 1. 2003-02-25. PMID:12468030. |
in the striatum and midbrain, f-j labeled neurons and activated microglia were absent, but astrogliosis, decreased th immunolabel, and swollen th fibers were detected. |
2003-02-25 |
2023-08-12 |
rat |
| W G Kim, R P Mohney, B Wilson, G H Jeohn, B Liu, J S Hon. Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 16. 2000-08-31. PMID:10934283. |
the positive correlation between abundance of microglia and sensitivity to lps-induced neurotoxicity was further supported by the observation that supplementation with enriched microglia derived from mesencephalon or cortex rendered lps-insensitive cortical neuron-glia cultures sensitive to lps-induced neurotoxicity. |
2000-08-31 |
2023-08-12 |
rat |
| B Liu, L Du, J S Hon. Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. The Journal of pharmacology and experimental therapeutics. vol 293. issue 2. 2000-06-21. PMID:10773035. |
these results suggest that naloxone at least in part interferes with the binding of lps to cell membranes to inhibit microglia activation and protect dopaminergic neurons as well as other neurons in the midbrain cultures from inflammatory damage. |
2000-06-21 |
2023-08-12 |
rat |
| B Liu, L Du, J S Hon. Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. The Journal of pharmacology and experimental therapeutics. vol 293. issue 2. 2000-06-21. PMID:10773035. |
treatment of rat mesencephalic mixed neuron-glia cultures with lipopolysaccharide (lps)-activated microglia, resident immune cells of the brain, to release proinflammatory and neurotoxic factors tumor necrosis factor-alpha, interleukin-1beta, nitric oxide, and superoxide and subsequently caused damage to midbrain neurons, including dopaminergic neurons. |
2000-06-21 |
2023-08-12 |
rat |
| V L Savchenko, J A McKanna, I R Nikonenko, G G Skib. Microglia and astrocytes in the adult rat brain: comparative immunocytochemical analysis demonstrates the efficacy of lipocortin 1 immunoreactivity. Neuroscience. vol 96. issue 1. 2000-04-17. PMID:10683423. |
in general, the density of lipocortin 1 microglia was higher in the forebrain, and lower in the midbrain, and the least in the brainstem and cerebellum. |
2000-04-17 |
2023-08-12 |
rat |
| M Revuelta, J L Venero, A Machado, J Can. Serotonin hyperinnervation in the adult rat ventral mesencephalon following unilateral transection of the medial forebrain bundle. Correlation with reactive microglial and astroglial populations. Neuroscience. vol 91. issue 2. 1999-08-02. PMID:10366014. |
we suggest that a pruning effect may underly the axotomy-induced increase in serotonin immunoreactivity in the ventral mesencephalon, and further, that activated astroglia and microglia may play a role in directing serotoninergic axonal regeneration following axotomy. |
1999-08-02 |
2023-08-12 |
rat |
| M Revuelta, J L Venero, A Machado, J Can. Serotonin hyperinnervation in the adult rat ventral mesencephalon following unilateral transection of the medial forebrain bundle. Correlation with reactive microglial and astroglial populations. Neuroscience. vol 91. issue 2. 1999-08-02. PMID:10366014. |
in addition, the distribution pattern of glial fibrillary acidic protein-immunoreactive astrocytes and ox42-immunoreactive microglia correlated highly with the location of increased serotonin fibre density in the ventral mesencephalon, especially in ventral tegmental area and in the most medial part of substantia nigra. |
1999-08-02 |
2023-08-12 |
rat |
| T Wierzba-Bobrowicz, E Kosno-Kruszewska, E Gwiazda, W Lechowic. The comparison of microglia maturation in different structures of the human nervous system. Folia neuropathologica. vol 36. issue 3. 1999-01-19. PMID:9833392. |
the highest values of ramified microglia were found in mesencephalon, and the lowest in white matter of cerebellum. |
1999-01-19 |
2023-08-12 |
human |
| T Wierzba-Bobrowicz, E Kosno-Kruszewska, E Gwiazda, W Lechowic. The comparison of microglia maturation in different structures of the human nervous system. Folia neuropathologica. vol 36. issue 3. 1999-01-19. PMID:9833392. |
it was indicated that they emerge at the same time in all structures under study, except the ameboid microglia arising earlier in the mesencephalon. |
1999-01-19 |
2023-08-12 |
human |
| A da Cunha, J J Jefferson, W R Tyor, J D Glass, F S Jannotta, J R Cottrell, J H Resa. Transforming growth factor-beta1 in adult human microglia and its stimulated production by interleukin-1. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 17. issue 11. 1998-01-15. PMID:9402103. |
the stimulation of tgf-beta1 by il-1 was dose and time dependent, occurring with ameboid microglia isolated from either frontal cortex or globus pallidus but not midbrain pons. |
1998-01-15 |
2023-08-12 |
human |
| b' A R Harvey, C L Kendall, E Sykov\\xc3\\xa. The status and organization of astrocytes, oligodendroglia and microglia in grafts of fetal rat cerebral cortex. Neuroscience letters. vol 228. issue 1. 1997-08-28. PMID:9197287.' |
immunohistochemical methods were used to study the status and organization of astrocytes, oligodendroglia and microglia in fetal cerebral cortical tissue grafted on to the dorsal surface of the midbrain in newborn host rats. |
1997-08-28 |
2023-08-12 |
rat |
| T Wierzba-Bobrowicz, W Lechowicz, E Kosno-Kruszewsk. A morphometric evaluation of morphological types of microglia and astroglia in human fetal mesencephalon. Folia neuropathologica. vol 35. issue 1. 1997-07-24. PMID:9161098. |
a morphometric evaluation of morphological types of microglia and astroglia in human fetal mesencephalon. |
1997-07-24 |
2023-08-12 |
human |