| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shigeru Ebisawa, Tsugunobu Andoh, Yutaka Shimada, Yasushi Kuraish. Yokukansan Improves Mechanical Allodynia through the Regulation of Interleukin-6 Expression in the Spinal Cord in Mice with Neuropathic Pain. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-04-13. PMID:25866544. |
il-6 immunoreactivity was detected in microglia and astrocytes in the spinal dorsal horn. |
2015-04-13 |
2023-08-13 |
mouse |
| Masaya Yasui, Takashi Yoshimura, So Takeuchi, Kyohei Tokizane, Makoto Tsuda, Kazuhide Inoue, Hiroshi Kiyam. A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation. Glia. vol 62. issue 9. 2015-03-13. PMID:24852223. |
quantification analysis revealed a higher accumulation of microglia in the medial part of layers i-iv of the dorsal horn. |
2015-03-13 |
2023-08-13 |
rat |
| Ming Liu, Kaijun Liao, Changxi Yu, Xuejun Li, Suhuan Liu, Shuyu Yan. Puerarin alleviates neuropathic pain by inhibiting neuroinflammation in spinal cord. Mediators of inflammation. vol 2014. 2015-02-12. PMID:25089076. |
meanwhile, in both models puerarin inhibited the activation of microglia and astroglia in the spinal dorsal horn. |
2015-02-12 |
2023-08-13 |
Not clear |
| Samar Ghorbanpoor, Luis Miguel Garcia-Segura, Ali Haeri-Rohani, Fariba Khodagholi, Masoumeh Jorjan. Aromatase inhibition exacerbates pain and reactive gliosis in the dorsal horn of the spinal cord of female rats caused by spinothalamic tract injury. Endocrinology. vol 155. issue 11. 2014-12-31. PMID:25105782. |
the proportion of microglia with a reactive phenotype and the number of glial fibrillary acidic protein-immunoreactive astrocytes were increased by the injury in the dorsal horn. |
2014-12-31 |
2023-08-13 |
rat |
| Wenling Chen, Wendy Walwyn, Helena S Ennes, Hyeyoung Kim, James A McRoberts, Juan Carlos G Marvizó. BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. The European journal of neuroscience. vol 39. issue 9. 2014-12-17. PMID:24611998. |
nmda-induced nk1r internalization was also enabled in a neuropathic pain model or by activating dorsal horn microglia with lipopolysaccharide. |
2014-12-17 |
2023-08-12 |
mouse |
| Yan-Lu Ying, Xu-Hong Wei, Xue-Bing Xu, Shou-Zhang She, Li-Jun Zhou, Jing Lv, Dai Li, Bin Zheng, Xian-Guo Li. Over-expression of P2X7 receptors in spinal glial cells contributes to the development of chronic postsurgical pain induced by skin/muscle incision and retraction (SMIR) in rats. Experimental neurology. vol 261. 2014-12-17. PMID:25242211. |
the results of immunofluorescence showed that both microglia and astrocytes were activated in the spinal dorsal horn following smir. |
2014-12-17 |
2023-08-13 |
rat |
| Byung-Soo Ahn, Seong-Kyu Kim, Ha Neul Kim, Ji-Hye Lee, Ji-Hwan Lee, Deog Sang Hwang, Hyunsu Bae, Byung-Il Min, Sun Kwang Ki. Gyejigachulbu-Tang Relieves Oxaliplatin-Induced Neuropathic Cold and Mechanical Hypersensitivity in Rats via the Suppression of Spinal Glial Activation. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-12-16. PMID:25505922. |
immunoreactivities of glial fibrillary acidic protein (gfap, astrocyte marker) and ox-42 (microglia marker) in the spinal dorsal horn were significantly increased by an oxaliplatin injection, which were restored by gbt administration. |
2014-12-16 |
2023-08-13 |
rat |
| Shuang-Shuang Li, Wei-Shi Zhang, Dong Ji, Ya-Lan Zhou, Hui Li, Jia-Le Yang, Yuan-Chang Xiong, Yu-Qiu Zhang, Hua X. Involvement of spinal microglia and interleukin-18 in the anti-nociceptive effect of dexmedetomidine in rats subjected to CCI. Neuroscience letters. vol 560. 2014-09-08. PMID:24345418. |
western blotting revealed that dexmedetomidine reduced the activation of microglia and the upregulation of interleukin-18 (il-18) protein expression in the ipsilateral lumbar spinal dorsal horn, while brl44408 pretreatment significantly blocked these effects of dexmedetomidine. |
2014-09-08 |
2023-08-12 |
rat |
| Shuang-Shuang Li, Wei-Shi Zhang, Dong Ji, Ya-Lan Zhou, Hui Li, Jia-Le Yang, Yuan-Chang Xiong, Yu-Qiu Zhang, Hua X. Involvement of spinal microglia and interleukin-18 in the anti-nociceptive effect of dexmedetomidine in rats subjected to CCI. Neuroscience letters. vol 560. 2014-09-08. PMID:24345418. |
immunocytochemistry/immunohistochemistry indicated that the α2a-adrenoceptor was localised to microglia in primary culture, and il-18 predominantly colocalised with the microglial marker iba-1 in the dorsal horn of the spinal cord. |
2014-09-08 |
2023-08-12 |
rat |
| K-I Cheng, H-C Wang, Y-T Chuang, C-W Chou, H-P Tu, Y-C Yu, L-L Chang, C-S La. Persistent mechanical allodynia positively correlates with an increase in activated microglia and increased P-p38 mitogen-activated protein kinase activation in streptozotocin-induced diabetic rats. European journal of pain (London, England). vol 18. issue 2. 2014-09-04. PMID:23868758. |
in experimental early painful diabetic neuropathy, persistent hyperglycaemia induces dys-regulated sodium channel (navs) expression in the dorsal root ganglion (drg) and activates microglia in the spinal dorsal horn (sdh). |
2014-09-04 |
2023-08-12 |
rat |
| Knut Biber, Erik Boddek. Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain. Frontiers in cellular neuroscience. vol 8. 2014-08-22. PMID:25147499. |
the development of neuropathic pain in response to peripheral nerve lesion for a large part depends on microglia located at the dorsal horn of the spinal cord. |
2014-08-22 |
2023-08-13 |
Not clear |
| Knut Biber, Erik Boddek. Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain. Frontiers in cellular neuroscience. vol 8. 2014-08-22. PMID:25147499. |
for long it remained obscure how a nerve injury in the periphery would initiate a microglia response in the dorsal horn of the spinal cord. |
2014-08-22 |
2023-08-13 |
Not clear |
| Yoki Nakamura, Norimitsu Morioka, Hiromi Abe, Fang Fang Zhang, Kazue Hisaoka-Nakashima, Keyue Liu, Masahiro Nishibori, Yoshihiro Nakat. Neuropathic pain in rats with a partial sciatic nerve ligation is alleviated by intravenous injection of monoclonal antibody to high mobility group box-1. PloS one. vol 8. issue 8. 2014-06-15. PMID:23991202. |
also, the injury-induced translocation of hmgb1 from the nucleus to the cytosol occurred mainly in dorsal horn neurons and not in astrocytes and microglia, indicating a neuronal source of hmgb1. |
2014-06-15 |
2023-08-12 |
rat |
| Yoki Nakamura, Norimitsu Morioka, Hiromi Abe, Fang Fang Zhang, Kazue Hisaoka-Nakashima, Keyue Liu, Masahiro Nishibori, Yoshihiro Nakat. Neuropathic pain in rats with a partial sciatic nerve ligation is alleviated by intravenous injection of monoclonal antibody to high mobility group box-1. PloS one. vol 8. issue 8. 2014-06-15. PMID:23991202. |
markers of astrocyte (glial fibrillary acidic protein (gfap)), microglia (ionized calcium binding adaptor molecule 1 (iba1)) and spinal neuron (cfos) activity were greatly increased in the ipsilateral dorsal horn side compared to the sham-operated side 21 days after psnl. |
2014-06-15 |
2023-08-12 |
rat |
| H Matsui, T Ohgomori, T Natori, K Miyamoto, S Kusunoki, K Sakamoto, N Ishiguro, S Imagama, K Kadomats. Keratan sulfate expression in microglia is diminished in the spinal cord in experimental autoimmune neuritis. Cell death & disease. vol 4. 2014-06-12. PMID:24309933. |
ks was positive in 50% microglia in the ventral horn and 20% in the dorsal horn. |
2014-06-12 |
2023-08-12 |
rat |
| Na Li, Grewo Lim, Lucy Chen, Michael F McCabe, Hyangin Kim, Shuzhuo Zhang, Jianren Ma. Spinal expression of Hippo signaling components YAP and TAZ following peripheral nerve injury in rats. Brain research. vol 1535. 2014-05-08. PMID:23998984. |
we found that (1) yap was mainly expressed on cgrp- and ib4-immunoreactive primary afferent nerve terminals without noticeable expression on glial cells, whereas taz was mainly expressed on spinal cord second order neurons as well as microglia; (2) upregulation of yap and taz expression followed two distinct temporal patterns after cci, such that the highest expression of yap and taz was on day 14 and day 1 after cci, respectively; (3) there were also unique topographic patterns of yap and taz distribution in the spinal cord dorsal horn consistent with their distinctive association with primary afferents and second order neurons; (4) changes in the yap expression were selectively induced by cci but not cfa-induced hindpaw inflammation; and (5) the number of nuclear profiles of taz expression was significantly increased after cci, indicating translocation of taz from the cytoplasma to nucleus. |
2014-05-08 |
2023-08-12 |
rat |
| Yu-Ying Li, Xu-Hong Wei, Zhen-He Lu, Jin-Sheng Chen, Qiao-Dong Huang, Qing-Juan Gon. Src/p38 MAPK pathway in spinal microglia is involved in mechanical allodynia induced by peri-sciatic administration of recombinant rat TNF-α. Brain research bulletin. vol 96. 2014-03-19. PMID:23680572. |
these results suggest that activation of the sfks/p38 mapk pathway in microglia and subsequent tnf-α expression in the spinal dorsal horn may contribute to the mechanical hyperalgesic state induced by peri-sciatic administered rrtnf. |
2014-03-19 |
2023-08-12 |
rat |
| Ryutaro Iwasaki, Yusuke Matsuura, Seiji Ohtori, Takane Suzuki, Kazuki Kuniyoshi, Kazuhisa Takahash. Activation of astrocytes and microglia in the C3-T4 dorsal horn by lower trunk avulsion in a rat model of neuropathic pain. The Journal of hand surgery. vol 38. issue 5. 2014-02-11. PMID:23528426. |
activation of astrocytes and microglia in the c3-t4 dorsal horn by lower trunk avulsion in a rat model of neuropathic pain. |
2014-02-11 |
2023-08-12 |
rat |
| Makoto Tsuda, Takahiro Masuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inou. Microglial regulation of neuropathic pain. Journal of pharmacological sciences. vol 121. issue 2. 2014-02-04. PMID:23337437. |
after peripheral nerve injury, microglia transform to reactive states through the expression of various genes such as cell-surface receptors (including purinergic receptors) and proinflammatory cytokines that enhance synaptic transmission in dorsal horn neurons. |
2014-02-04 |
2023-08-12 |
Not clear |
| J Morgenweck, R B Griggs, R R Donahue, J E Zadina, B K Taylo. PPARγ activation blocks development and reduces established neuropathic pain in rats. Neuropharmacology. vol 70. 2013-11-26. PMID:23415633. |
intraperitoneal pioglitazone significantly reduced the nerve injury-induced up-regulation of cd11b, gfap, and p-p38 in the dorsal horn, indicating a mechanism of action involving spinal microglia and/or astrocyte activation. |
2013-11-26 |
2023-08-12 |
rat |