| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D S Albeck, B J Hoffer, D Quissell, L A Sanders, G Zerbe, A C Granhol. A non-invasive transport system for GDNF across the blood-brain barrier. Neuroreport. vol 8. issue 9-10. 1997-10-07. PMID:9243628. |
glial cell line-derived neurotrophic factor (gdnf) is a neurotrophin which supports midbrain dopaminergic neurons and spinal cord motorneurons. |
1997-10-07 |
2023-08-12 |
Not clear |
| J C Liou, R S Yang, W M F. Regulation of quantal secretion by neurotrophic factors at developing motoneurons in Xenopus cell cultures. The Journal of physiology. vol 503 ( Pt 1). 1997-10-07. PMID:9288681. |
chronic treatment of day-1 cultures with brain-derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3), neurotrophin-4 (nt-4), ciliary neurotrophic factor (cntf) or glial cell line-derived neurotrophic factor (gdnf) for 2 days, increased the ach quantal size of naive motoneurons in a concentration-dependent manner, whereas insulin-like growth factor-1 (igf-1) and basic fibroblast growth factor (bfgf) had no effect, even at high concentrations. |
1997-10-07 |
2023-08-12 |
xenopus_laevis |
| C M Kearns, W A Cass, K Smoot, R Kryscio, D M Gas. GDNF protection against 6-OHDA: time dependence and requirement for protein synthesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 18. 1997-10-03. PMID:9278545. |
glial cell line-derived neurotrophic factor (gdnf) injected intranigrally protects midbrain dopamine neurons against 6-hydroxydopamine (6-ohda) toxicity. |
1997-10-03 |
2023-08-12 |
rat |
| C A Nosrat, A Tomac, B J Hoffer, L Olso. Cellular and developmental patterns of expression of Ret and glial cell line-derived neurotrophic factor receptor alpha mRNAs. Experimental brain research. vol 115. issue 3. 1997-10-02. PMID:9262196. |
glial cell line-derived neurotrophic factor (gdnf) has recently been shown to signal by binding to gdnf receptor-alpha (gdnfr-alpha), after which the gdnf-gdnfr-alpha associates with and activates the tyrosine kinase receptor ret. |
1997-10-02 |
2023-08-12 |
Not clear |
| D J Marsh, Z Zheng, A Arnold, S D Andrew, D Learoyd, A Frilling, P Komminoth, H P Neumann, B A Ponder, B J Rollins, G I Shapiro, B G Robinson, L M Mulligan, C En. Mutation analysis of glial cell line-derived neurotrophic factor, a ligand for an RET/coreceptor complex, in multiple endocrine neoplasia type 2 and sporadic neuroendocrine tumors. The Journal of clinical endocrinology and metabolism. vol 82. issue 9. 1997-10-02. PMID:9284737. |
glial cell line-derived neurotrophic factor (gdnf) and its receptor molecule gdnfr-alpha, have recently been identified as members of the ret ligand binding complex. |
1997-10-02 |
2023-08-12 |
Not clear |
| H Junger, S Varo. Neurotrophin-4 (NT-4) and glial cell line-derived neurotrophic factor (GDNF) promote the survival of corticospinal motor neurons of neonatal rats in vitro. Brain research. vol 762. issue 1-2. 1997-10-01. PMID:9262158. |
neurotrophin-4 (nt-4) and glial cell line-derived neurotrophic factor (gdnf) promote the survival of corticospinal motor neurons of neonatal rats in vitro. |
1997-10-01 |
2023-08-12 |
rat |
| H Junger, S Varo. Neurotrophin-4 (NT-4) and glial cell line-derived neurotrophic factor (GDNF) promote the survival of corticospinal motor neurons of neonatal rats in vitro. Brain research. vol 762. issue 1-2. 1997-10-01. PMID:9262158. |
we have used enriched dissociated, low density cultures of neonatal rat corticospinal motor neurons to evaluate the survival-promoting effect of nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3), neurotrophin-4 (nt-4), and glial cell line-derived neurotrophic factor (gdnf) and the ciliary neurotrophic factor (cntf). |
1997-10-01 |
2023-08-12 |
rat |
| P Naveilhan, W M ElShamy, P Ernfor. Differential regulation of mRNAs for GDNF and its receptors Ret and GDNFR alpha after sciatic nerve lesion in the mouse. The European journal of neuroscience. vol 9. issue 7. 1997-09-25. PMID:9240402. |
glial cell line-derived neurotrophic factor (gdnf), first characterized for its effect on dopamine uptake in central dopaminergic neurons, appears to be a powerful neurotrophic factor for motor neurons. |
1997-09-25 |
2023-08-12 |
mouse |
| K Pong, R Y Xu, K D Beck, T J Zhang, J C Loui. Inhibition of glial cell line-derived neurotrophic factor induced intracellular activity by K-252b on dopaminergic neurons. Journal of neurochemistry. vol 69. issue 3. 1997-09-25. PMID:9282920. |
the c-ret protooncogene encodes ret, the functional tyrosine kinase receptor for glial cell line-derived neurotrophic factor (gdnf). |
1997-09-25 |
2023-08-12 |
Not clear |
| E D Clarkson, W M Zawada, C R Free. GDNF improves survival and reduces apoptosis in human embryonic dopaminergic neurons in vitro. Cell and tissue research. vol 289. issue 2. 1997-09-16. PMID:9211823. |
to address this problem, we added glial cell line-derived neurotrophic factor (gdnf) to cultures of embryonic dopaminergic neurons obtained from human and from bonnet monkey (macaca radiata) in an effort to reduce apoptotic cell death and improve overall cell survival. |
1997-09-16 |
2023-08-12 |
human |
| M A Hebert, G A Gerhard. Behavioral and neurochemical effects of intranigral administration of glial cell line-derived neurotrophic factor on aged Fischer 344 rats. The Journal of pharmacology and experimental therapeutics. vol 282. issue 2. 1997-09-11. PMID:9262339. |
to investigate the efficacy of glial cell line-derived neurotrophic factor (gdnf) in the augmentation of functional dopaminergic (daergic) indices in aged rats, 24-month-old fischer 344 (f344) rats received single intranigral injections of 10 microg gdnf (in 10 microl phosphate-buffered saline) or 10 microl phosphate-buffered saline. |
1997-09-11 |
2023-08-12 |
rat |
| Y Miyoshi, Z Zhang, A Ovadia, P A Lapchak, F Collins, D Hilt, C Lebel, R Kryscio, D M Gas. Glial cell line-derived neurotrophic factor-levodopa interactions and reduction of side effects in parkinsonian monkeys. Annals of neurology. vol 42. issue 2. 1997-09-05. PMID:9266731. |
glial cell line-derived neurotrophic factor (gdnf) stimulates the nigrostriatal dopaminergic pathway and improves motor functions in animal models of parkinsonism. |
1997-09-05 |
2023-08-12 |
monkey |
| E R Woodward, C Eng, R McMahon, R Voutilainen, N A Affara, B A Ponder, E R Mahe. Genetic predisposition to phaeochromocytoma: analysis of candidate genes GDNF, RET and VHL. Human molecular genetics. vol 6. issue 7. 1997-08-28. PMID:9215674. |
glial cell line-derived neurotrophic factor (gdnf) has been recently identified as a natural ligand for ret. |
1997-08-28 |
2023-08-12 |
Not clear |
| P A Lapchak, D M Gash, F Collins, D Hilt, P J Miller, D M Arauj. Pharmacological activities of glial cell line-derived neurotrophic factor (GDNF): preclinical development and application to the treatment of Parkinson's disease. Experimental neurology. vol 145. issue 2 Pt 1. 1997-07-31. PMID:9217068. |
pharmacological activities of glial cell line-derived neurotrophic factor (gdnf): preclinical development and application to the treatment of parkinson's disease. |
1997-07-31 |
2023-08-12 |
Not clear |
| A J Okragly, M Haak-Frendsch. An acid-treatment method for the enhanced detection of GDNF in biological samples. Experimental neurology. vol 145. issue 2 Pt 1. 1997-07-31. PMID:9217096. |
glial cell line-derived neurotrophic factor (gdnf), a distant member of the transforming growth factor-beta (tgfbeta) family, is a protein that is essential for the survival of dopaminergic, motor, and peripheral neurons. |
1997-07-31 |
2023-08-12 |
Not clear |
| J G Hou, G Cohen, C Mytilineo. Basic fibroblast growth factor stimulation of glial cells protects dopamine neurons from 6-hydroxydopamine toxicity: involvement of the glutathione system. Journal of neurochemistry. vol 69. issue 1. 1997-07-24. PMID:9202296. |
here, we investigated whether glial cell line-derived neurotrophic factor (gdnf) and basic fibroblast growth factor (bfgf) could modify the damage to dopamine (da) neurons in mesencephalic cultures caused by the neurotoxin 6-hydroxydopamine (6-ohda). |
1997-07-24 |
2023-08-12 |
Not clear |
| D J Creedon, M G Tansey, R H Baloh, P A Osborne, P A Lampe, T J Fahrner, R O Heuckeroth, J Milbrandt, E M Johnso. Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 13. 1997-07-21. PMID:9192684. |
neurturin (ntn) is a neurotrophic factor that shares homology with glial cell line-derived neurotrophic factor (gdnf). |
1997-07-21 |
2023-08-12 |
rat |
| M Sanicola, C Hession, D Worley, P Carmillo, C Ehrenfels, L Walus, S Robinson, G Jaworski, H Wei, R Tizard, A Whitty, R B Pepinsky, R L Cat. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 12. 1997-07-10. PMID:9177201. |
glial cell line-derived neurotrophic factor (gdnf)-dependent activation of the tyrosine kinase receptor ret is necessary for kidney and enteric neuron development, and mutations in ret are associated with human diseases. |
1997-07-10 |
2023-08-12 |
human |
| R H Baloh, M G Tansey, J P Golden, D J Creedon, R O Heuckeroth, C L Keck, D B Zimonjic, N C Popescu, E M Johnson, J Milbrand. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron. vol 18. issue 5. 1997-06-30. PMID:9182803. |
glial cell line-derived neurotrophic factor (gdnf) and neurturin (ntn) comprise a family of tgf-beta-related neurotrophic factors (trns), which have trophic influences on a variety of neuronal populations. |
1997-06-30 |
2023-08-12 |
Not clear |
| N A Pochon, A Menoud, J L Tseng, A D Zurn, P Aebische. Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridization. The European journal of neuroscience. vol 9. issue 3. 1997-06-27. PMID:9104588. |
glial cell line-derived neurotrophic factor (gdnf) is a potent neurotrophic factor which has been purified on the basis of its ability to promote the survival of dopaminergic neurons in vitro. |
1997-06-27 |
2023-08-12 |
rat |