| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Engele, B Frank. Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways. Cell and tissue research. vol 286. issue 2. 1996-12-17. PMID:8854892. |
effects of glial cell line-derived neurotrophic factor (gdnf) on dopaminergic neurons require concurrent activation of camp-dependent signaling pathways. |
1996-12-17 |
2023-08-12 |
Not clear |
| J Engele, B Frank. Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways. Cell and tissue research. vol 286. issue 2. 1996-12-17. PMID:8854892. |
glial cell line-derived neurotrophic factor (gdnf) is a highly selective neurotrophic factor for midbrain dopaminergic neurons and might thus be of potential use in the therapy of parkinson's disease. |
1996-12-17 |
2023-08-12 |
Not clear |
| K Krieglstein, F Deimling, C Suter-Crazzolara, K Unsicke. Expression and localization of GDNF in developing and adult adrenal chromaffin cells. Cell and tissue research. vol 286. issue 2. 1996-12-17. PMID:8854896. |
glial cell line-derived neurotrophic factor (gdnf) is a widely distributed member of the transforming growth factor-beta superfamily and a potent neurotrophic molecule for several neuron populations in the peripheral and central nervous system. |
1996-12-17 |
2023-08-12 |
rat |
| M Angrist, S Bolk, M Halushka, P A Lapchak, A Chakravart. Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient. Nature genetics. vol 14. issue 3. 1996-12-16. PMID:8896568. |
germline mutations in glial cell line-derived neurotrophic factor (gdnf) and ret in a hirschsprung disease patient. |
1996-12-16 |
2023-08-12 |
mouse |
| M Angrist, S Bolk, M Halushka, P A Lapchak, A Chakravart. Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient. Nature genetics. vol 14. issue 3. 1996-12-16. PMID:8896568. |
the glial cell line-derived neurotrophic factor (gdnf) is such a molecule. |
1996-12-16 |
2023-08-12 |
mouse |
| R Salomon, T Attié, A Pelet, C Bidaud, C Eng, J Amiel, S Sarnacki, O Goulet, C Ricour, C Nihoul-Fékété, A Munnich, S Lyonne. Germline mutations of the RET ligand GDNF are not sufficient to cause Hirschsprung disease. Nature genetics. vol 14. issue 3. 1996-12-16. PMID:8896569. |
recently, the glial cell line-derived neurotrophic factor (gdnf) has been identified to be a ligand for ret. |
1996-12-16 |
2023-08-12 |
mouse |
| H L Hellmich, L Kos, E S Cho, K A Mahon, A Zimme. Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions. Mechanisms of development. vol 54. issue 1. 1996-12-10. PMID:8808409. |
we describe the cloning of the mouse glial cell line-derived neurotrophic factor (gdnf) gene and its expression during embryogenesis. |
1996-12-10 |
2023-08-12 |
mouse |
| A Kupsch, W H Oertel, C D Earl, J Sautte. Neuronal transplantation and neurotrophic factors in the treatment of Parkinson's disease--update February 1995. Journal of neural transmission. Supplementum. vol 46. 1996-12-10. PMID:8821056. |
in this regard special emphasis is put on the newly characterized glial cell line-derived neurotrophic factor (gdnf). |
1996-12-10 |
2023-08-12 |
Not clear |
| K Krieglstein, C Suter-Crazzolara, K Unsicke. Development of mesencephalic dopaminergic neurons and the transforming growth factor-beta superfamily. Journal of neural transmission. Supplementum. vol 46. 1996-12-10. PMID:8821057. |
tgf-beta 2 and -beta 3 as well as glial cell line-derived neurotrophic factor (gdnf), have recently been shown to be expressed in the developing and adult brain. |
1996-12-10 |
2023-08-12 |
Not clear |
| K Krieglstein, K Unsicke. Proteins from chromaffin granules promote survival of dorsal root ganglionic neurons: comparison with neurotrophins. Brain research. Developmental brain research. vol 93. issue 1-2. 1996-11-29. PMID:8804687. |
using drg neurons from embryonic day (e) 8 chick embryos we show now that this material is (i) as effective as nerve growth factor (ngf), (ii) additive to ngf, neurotrophin-3, or -4, (iii) unlikely to be a neurotrophin, since the survival promoting effect can not be blocked by k252b, a specific inhibitor of the signal transduction pathways of neurotrophin high affinity receptors, (iv) partially blockable by antibodies to transforming growth factor-beta (tgf-beta) 1/2/3, and (v) more potent than any other out of 30 cytokines tested individually, including fibroblast growth factor (fgf)-5, epidermal growth factor (egf), tgf-alpha, platelet-derived growth factor (pdgf)-ab, insulin-like growth factors (igf)-i and -ii, leukemia inhibitory factor (lif), tgf-beta, glial cell line-derived neurotrophic factor (gdnf), stem cell factor, granulocyte-colony stimulating factor (g-csf), oncostatin m, tumor necrosis factor (tnf)-alpha, and interleukins (il)-1 through -12. |
1996-11-29 |
2023-08-12 |
chicken |
| J G Hou, C Mytilineo. Secretion of GDNF by glial cells does not account for the neurotrophic effect of bFGF on dopamine neurons in vitro. Brain research. vol 724. issue 1. 1996-11-29. PMID:8816270. |
these results indicate that although gdnf could be secreted by bfgf stimulated glia, its secretion alone does not account for the trophic effect of bfgf on mesencephalic da neurons. |
1996-11-29 |
2023-08-12 |
Not clear |
| H Hammarberg, F Piehl, S Cullheim, J Fjell, T Hökfelt, K Frie. GDNF mRNA in Schwann cells and DRG satellite cells after chronic sciatic nerve injury. Neuroreport. vol 7. issue 4. 1996-11-27. PMID:8724660. |
glial cell line-derived neurotrophic factor (gdnf) exhibits neurotrophic properties on different types of neurones, including fetal motoneurones and embryonic neurones of sensory ganglia. |
1996-11-27 |
2023-08-12 |
rat |
| M L Price, B J Hoffer, A C Granhol. Effects of GDNF on fetal septal forebrain transplants in oculo. Experimental neurology. vol 141. issue 2. 1996-11-27. PMID:8812151. |
glial cell line-derived neurotrophic factor (gdnf) is a member of the tgf-beta superfamily of growth factors with marked neurotrophic activity on midbrain dopaminergic neurons. |
1996-11-27 |
2023-08-12 |
rat |
| C W Shults, T Kimber, D Marti. Intrastriatal injection of GDNF attenuates the effects of 6-hydroxydopamine. Neuroreport. vol 7. issue 2. 1996-11-25. PMID:8730845. |
our study was designed to determine whether intrastriatal administration of glial cell line-derived neurotrophic factor (gdnf) can attenuate the behavioral effects and injury to the mesostriatal dopaminergic system caused by 6-hydroxydopamine (6-ohda). |
1996-11-25 |
2023-08-12 |
rat |
| Q C Vega, C A Worby, M S Lechner, J E Dixon, G R Dressle. Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 20. 1996-11-25. PMID:8855235. |
this report demonstrates that the glial cell line-derived neurotrophic factor (gdnf) activates ret, as measured by tyrosine phosphorylation of the intracellular catalytic domain. |
1996-11-25 |
2023-08-12 |
Not clear |
| C A Worby, Q C Vega, Y Zhao, H H Chao, A F Seasholtz, J E Dixo. Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase. The Journal of biological chemistry. vol 271. issue 39. 1996-11-18. PMID:8798576. |
glial cell line-derived neurotrophic factor (gdnf), a member of the transforming growth factor-beta family of growth factors, was first identified by its ability to promote the survival of midbrain dopaminergic neurons in culture. |
1996-11-18 |
2023-08-12 |
Not clear |
| E D Clarkson, W M Zawada, C R Free. GDNF reduces apoptosis in dopaminergic neurons in vitro. Neuroreport. vol 7. issue 1. 1996-10-17. PMID:8742438. |
to explore the mechanism by which glial cell line-derived neurotrophic factor (gdnf) improves cell survival, we measured the apoptotic rate of dopamine neurons incubated with gdnf. |
1996-10-17 |
2023-08-12 |
human |
| J Opacka-Juffry, S Ashworth, S P Hume, D Martin, D J Brooks, S B Blun. GDNF protects against 6-OHDA nigrostriatal lesion: in vivo study with microdialysis and PET. Neuroreport. vol 7. issue 1. 1996-10-17. PMID:8742486. |
we have investigated whether glial cell line-derived neurotrophic factor (gdnf) protects against a complete unilateral 6-hydroxydopamine (6-ohda) nigrostriatal lesion, a robust rat model of parkinson's disease. |
1996-10-17 |
2023-08-12 |
rat |
| A D Zurn, L Winkel, A Menoud, K Djabali, P Aebische. Combined effects of GDNF, BDNF, and CNTF on motoneuron differentiation in vitro. Journal of neuroscience research. vol 44. issue 2. 1996-09-26. PMID:8723221. |
we have previously shown that glial cell line-derived neurotrophic factor (gdnf), in addition to promoting the survival of dopaminergic neurons in cultures from embryonic rat ventral mesencephalon,also increases the activity of choline acetyltransferase (chat) in the cranial motoneurons present in these cultures (zurn et al. |
1996-09-26 |
2023-08-12 |
human |
| K D Beck, I Irwin, J Valverde, T J Brennan, J W Langston, F Heft. GDNF induces a dystonia-like state in neonatal rats and stimulates dopamine and serotonin synthesis. Neuron. vol 16. issue 3. 1996-09-20. PMID:8785063. |
to test whether glial cell line-derived neurotrophic factor (gdnf) regulates the development of nigral dopaminergic neurons in vivo, neonatal rats received bilateral injections of gdnf into the striatum. |
1996-09-20 |
2023-08-12 |
rat |