| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Ivanchuk, S M Myers, C Eng, L M Mulliga. De novo mutation of GDNF, ligand for the RET/GDNFR-alpha receptor complex, in Hirschsprung disease. Human molecular genetics. vol 5. issue 12. 1997-03-14. PMID:8968758. |
to investigate this role, we examined the gene for glial cell line-derived neurotrophic factor (gdnf), the circulating ligand of the ret receptor complex, for mutations in a panel of sporadic and familial hscr. |
1997-03-14 |
2023-08-12 |
Not clear |
| K E Bowenkamp, D David, P L Lapchak, M A Henry, A C Granholm, B J Hoffer, T J Mahali. 6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat. A possible mechanism for restoration of the nigrostriatal circuit mediated by glial cell line-derived neurotrophic factor. Experimental brain research. vol 111. issue 1. 1997-03-11. PMID:8891630. |
second, the time course of the rescue of dopaminergic neurons after 6-ohda by glial cell line-derived neurotrophic factor (gdnf) was determined using th immunocytochemistry. |
1997-03-11 |
2023-08-12 |
rat |
| P A Lapcha. Therapeutic potentials for glial cell line-derived neurotrophic factor (GDNF) based upon pharmacological activities in the CNS. Reviews in the neurosciences. vol 7. issue 3. 1997-03-11. PMID:8916290. |
therapeutic potentials for glial cell line-derived neurotrophic factor (gdnf) based upon pharmacological activities in the cns. |
1997-03-11 |
2023-08-12 |
Not clear |
| D L Choi-Lundberg, Q Lin, Y N Chang, Y L Chiang, C M Hay, H Mohajeri, B L Davidson, M C Boh. Dopaminergic neurons protected from degeneration by GDNF gene therapy. Science (New York, N.Y.). vol 275. issue 5301. 1997-02-24. PMID:9012352. |
glial cell line-derived neurotrophic factor (gdnf) supports growth and survival of dopaminergic (da) neurons. |
1997-02-24 |
2023-08-12 |
human |
| C Suter-Crazzolara, K Unsicke. GDNF mRNA levels are induced by FGF-2 in rat C6 glioblastoma cells. Brain research. Molecular brain research. vol 41. issue 1-2. 1997-02-20. PMID:8883950. |
glia cell line-derived neurotrophic factor (gdnf), a recently cloned member of the transforming growth factor-beta (tgf-beta) superfamily, has been implicated in the survival, morphological and functional differentiation of midbrain dopaminergic neurons and motoneurons in vitro and in vivo. |
1997-02-20 |
2023-08-12 |
human |
| M Yamamoto, G Sobue, K Yamamoto, S Terao, T Mitsum. Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues. Neurochemical research. vol 21. issue 8. 1997-02-18. PMID:8895847. |
the steady-state mrna levels of the four neurotrophic factors of nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3) and glial cell line-derived neurotrophic factor (gdnf) and their receptors (p75ngfr, trka, trkb and trkc) in the adult human peripheral nervous system (pns) as well as nonneural tissues were examined using quantitative reverse transcription-polymerase chain reaction (rt-pcr). |
1997-02-18 |
2023-08-12 |
human |
| P A Lapchak, P J Miller, S Jiao, D M Araujo, D Hilt, F Collin. Biology of glial cell line-derived neurotrophic factor (GDNF): implications for the use of GDNF to treat Parkinson's disease. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 3. 1997-02-18. PMID:8910897. |
biology of glial cell line-derived neurotrophic factor (gdnf): implications for the use of gdnf to treat parkinson's disease. |
1997-02-18 |
2023-08-12 |
Not clear |
| D H van Weering, J L Bo. Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation. The Journal of biological chemistry. vol 272. issue 1. 1997-02-18. PMID:8995255. |
recently, glial cell line-derived neurotrophic factor (gdnf) has been identified as a ligand for ret. |
1997-02-18 |
2023-08-12 |
Not clear |
| P L Dahia, S P Toledo, L M Mulligan, E R Maher, A B Grossman, C En. Mutation analysis of glial cell line-derived neurotrophic factor (GDNF), a ligand for the RET/GDNF receptor alpha complex, in sporadic phaeochromocytomas. Cancer research. vol 57. issue 2. 1997-02-11. PMID:9000574. |
mutation analysis of glial cell line-derived neurotrophic factor (gdnf), a ligand for the ret/gdnf receptor alpha complex, in sporadic phaeochromocytomas. |
1997-02-11 |
2023-08-12 |
Not clear |
| P L Dahia, S P Toledo, L M Mulligan, E R Maher, A B Grossman, C En. Mutation analysis of glial cell line-derived neurotrophic factor (GDNF), a ligand for the RET/GDNF receptor alpha complex, in sporadic phaeochromocytomas. Cancer research. vol 57. issue 2. 1997-02-11. PMID:9000574. |
recent data have suggested that glial cell line-derived neurotrophic factor (gdnf) is a ligand for ret and acts via a heterotetrameric receptor complex that includes gdnf receptor alpha, which provides ligand binding capabilities, and ret, which provides the signaling component. |
1997-02-11 |
2023-08-12 |
Not clear |
| W A Cas. GDNF selectively protects dopamine neurons over serotonin neurons against the neurotoxic effects of methamphetamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 24. 1997-02-06. PMID:8987838. |
glial cell line-derived neurotrophic factor (gdnf) has pronounced effects on dopaminergic systems in vivo, including partial neuroprotective effects against 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine -induced lesions. |
1997-02-06 |
2023-08-12 |
rat |
| J L Tseng, E E Baetge, A D Zurn, P Aebische. GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 1. 1997-02-04. PMID:8987758. |
to that end, we examined whether low amounts of glial cell line-derived neurotrophic factor (gdnf) continuously released from polymer-encapsulated genetically engineered cells are able to prevent the loss of tyrosine hydroxylase immunoreactivity (th-ir) in sn neurons and ameliorate the amphetamine-induced rotational asymmetry in rats that have been subjected to a unilateral medial forebrain bundle (mfb) axotomy. |
1997-02-04 |
2023-08-12 |
rat |
| K E Bowenkamp, P A Lapchak, B J Hoffer, P C Bickfor. Glial cell line-derived neurotrophic factor reverses motor impairment in 16-17 month old rats. Neuroscience letters. vol 211. issue 2. 1997-01-23. PMID:8830849. |
glial cell line-derived neurotrophic factor (gdnf) has been shown to have neuroprotective and restorative effects on dopaminergic neurons of the nigrostriatal pathway in young rats. |
1997-01-23 |
2023-08-12 |
rat |
| M A Hebert, C G Van Horne, B J Hoffer, G A Gerhard. Functional effects of GDNF in normal rat striatum: presynaptic studies using in vivo electrochemistry and microdialysis. The Journal of pharmacology and experimental therapeutics. vol 279. issue 3. 1997-01-23. PMID:8968339. |
the functional effects of a single dual-site intranigral administration (10 micrograms) of glial cell line-derived neurotrophic factor (gdnf) on dopamine (da) neurons in the basal ganglia of young fischer 344 rats were investigated. |
1997-01-23 |
2023-08-12 |
rat |
| M Yamamoto, G Sobue, K Yamamoto, S Terao, T Mitsum. Expression of glial cell line-derived growth factor mRNA in the spinal cord and muscle in amyotrophic lateral sclerosis. Neuroscience letters. vol 204. issue 1-2. 1997-01-17. PMID:8929992. |
the steady-state expression levels of glial cell line-derived growth factor (gdnf) mrna was studied in the post mortem spinal cord and muscle of patients with amyotrophic lateral sclerosis (als), by reverse transcription followed by polymerase chain reaction (rt-pcr). |
1997-01-17 |
2023-08-12 |
Not clear |
| G D Maxwell, K Reid, A Elefanty, P F Bartlett, M Murph. Glial cell line-derived neurotrophic factor promotes the development of adrenergic neurons in mouse neural crest cultures. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 23. 1996-12-30. PMID:8917581. |
growth of mouse neural crest cultures in the presence of glial cell line-derived neurotrophic factor (gdnf) resulted in a dramatic dose-dependent increase in the number of tyrosine hydroxylase (th)-positive cells that developed when 5% chicken embryo extract was present in the medium. |
1996-12-30 |
2023-08-12 |
mouse |
| C Winkler, H Sauer, C S Lee, A Björklun. Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 22. 1996-12-19. PMID:8929429. |
glial cell line-derived neurotrophic factor (gdnf) has been shown to exert neuroprotective effects on dopamine (da) neurons in vivo. |
1996-12-19 |
2023-08-12 |
rat |
| M Shinoda, B J Hoffer, L Olso. Interactions of neurotrophic factors GDNF and NT-3, but not BDNF, with the immune system following fetal spinal cord transplantation. Brain research. vol 722. issue 1-2. 1996-12-18. PMID:8813361. |
glial cell line-derived neurotrophic factor (gdnf) is known to stimulate survival of dopaminergic and spinal cord motor neurons. |
1996-12-18 |
2023-08-12 |
rat |
| P A Lapchak, S Jiao, P J Miller, L R Williams, V Cummins, G Inouye, C R Matheson, Q Ya. Pharmacological characterization of glial cell line-derived neurotrophic factor (GDNF): implications for GDNF as a therapeutic molecule for treating neurodegenerative diseases. Cell and tissue research. vol 286. issue 2. 1996-12-17. PMID:8854887. |
pharmacological characterization of glial cell line-derived neurotrophic factor (gdnf): implications for gdnf as a therapeutic molecule for treating neurodegenerative diseases. |
1996-12-17 |
2023-08-12 |
Not clear |
| D E Wright, W D Snide. Focal expression of glial cell line-derived neurotrophic factor in developing mouse limb bud. Cell and tissue research. vol 286. issue 2. 1996-12-17. PMID:8854889. |
glial cell line-derived neurotrophic factor (gdnf) is known to support the survival of motoneurons in vitro and in vivo, as well as subpopulations of sensory neurons in vitro. |
1996-12-17 |
2023-08-12 |
mouse |